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1/8 🧬 In the quest for longevity, NAD and its precursors NMN & NR have emerged as potential contenders. NAD is a critical molecule involved in 500+ metabolic reactions in our body, but its levels decrease with age. Could supplementing with NAD help reverse aging?

2/8 💊 However, NAD is poorly absorbed, making oral supplementation impractical. Scientists have turned to NAD precursors, NMN & NR, which show greater bioavailability. But the evidence supporting their benefits is still largely theoretical.

3/8 📚 A recent study on 80 healthy adults aged 40-65 given varying doses of NMN for 60 days found that NMN supplementation led to significant increases in blood NAD concentrations and was safe and well-tolerated.

4/8 📈 The study also suggested a potential age-preserving effect of NMN supplementation and improved endurance. But the study's methodology and choice of metrics have been criticized.

5/8 📉 The Aging.Ai 3.0 calculator used to gauge blood biological age has been questioned for its accuracy and reliability. And the six-minute walking test (6MWT) used to measure endurance may not be a valid measure of fitness in healthy adults.

6/8 🏃‍♀️ The study also did not take into account other factors such as heart rate, perceived exertion, and recovery time, which could provide a more holistic understanding of physical performance.

7/8 📊 The study's results were statistically significant, but they may not have clinical significance. This means they may not be practically important or meaningful in a real-world context.

8/8 🧪 In conclusion, while the study shows that NMN supplementation raises circulating NAD, the results on aging and clinically relevant physical performance do not provide solid evidence of the health or longevity benefits of NMN. More rigorous studies are needed.

1/🧵 Exciting research suggests that stretching might have an impact on longevity! Let's dive into the science behind it.

2/ A study on mice showed that the deletion of a specific stretch in the huntingtin protein, which is involved in Huntington's disease, led to a significant increase in lifespan. This was linked to an increase in autophagy, a cellular recycling process. [Link to study](https://europepmc.org/articles/pmc2816686?pdf=render)

3/ Autophagy is a process that helps clear out damaged cells, allowing for the regeneration of healthier cells. This process is crucial for maintaining muscle health, which could be stimulated by regular stretching.

4/ The study suggests that enhancing autophagy may be beneficial not only in treating neurodegenerative disorders like Huntington's disease but also in increasing longevity in normal mammals.

5/ While this research is promising, it's important to note that it was conducted on mice. More research is needed to understand the full impact of stretching on human longevity.

6/ Nevertheless, the potential benefits of stretching, including increased flexibility, improved muscle health, and now possibly enhanced longevity, make it a worthwhile addition to our daily routines.

7/ So, why not add some stretching to your day? Your future self might thank you!

Remember, always consult with a healthcare professional before starting any new exercise regimen.

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1/7 🧵 Mangoes, often referred to as the "king of fruits," are not just delicious but also packed with numerous health benefits. Here's a thread on why you should consider incorporating this tropical fruit into your diet.

2/7 Mangoes are a rich source of vitamins A and C. Vitamin A supports eye health and boosts immunity, while Vitamin C is essential for your skin health and immune function.

3/7 The high fiber content in mangoes aids in digestion and helps prevent constipation. A healthy digestive system is key to overall health and well-being.

4/7 Mangoes are packed with antioxidants such as mangiferin, which has been studied for its potential anti-inflammatory, anti-viral, and anti-cancer properties.

5/7 The potassium in mangoes helps maintain a healthy heart by controlling heart rate and blood pressure. It also supports muscle strength and nerve function.

6/7 Mangoes are also good for your skin. They help clear clogged pores and eliminate pimples. The Vitamin C in mangoes also promotes collagen production for healthy, youthful skin.

7/7 In conclusion, mangoes are not just a tasty treat but a powerhouse of essential nutrients. Enjoy them in moderation as part of a balanced diet for a health boost. Remember, health is wealth! 🥭 🧵

❓❓❓ WHY BOTHER SLEEPING ❓❓❓

1/7 🧵 Sleep is not just a luxury, it's a necessity! Scientific research has shown numerous benefits of a good night's sleep. Let's dive into the science of sleep.

2/7 Sleep helps improve our skills. A study found that awareness modifies the skill-learning benefits of sleep. So, if you're learning a new skill, a good night's sleep might just give you the edge you need. [1]

3/7 Ever heard of banking sleep? Research shows that extending sleep improves alertness and performance during subsequent sleep restriction and impacts the rate at which these are restored by recovery sleep. [2]

4/7 Sleep can also have a positive impact on cardiovascular health. Treating obstructive sleep apnea, a sleep disorder, in coronary artery disease patients has been associated with a decrease in the occurrence of new cardiovascular events. [3]

5/7 However, sleep doesn't always enhance all types of learning. For instance, a study found that sleep did not enhance probabilistic motor sequence learning. This shows that the benefits of sleep can vary depending on the type of learning. [4]

6/7 Short naps can also be beneficial, especially after a night of sleep restriction. A 10-minute afternoon nap was found to provide an immediate improvement in alertness and cognitive performance. [5]

7/7 In conclusion, sleep plays a crucial role in our health, learning, and performance. So, make sure to prioritize your sleep for a healthier and more productive life.

References:

[1] Awareness Modifies the Skill-Learning Benefits of Sleep:
https://doi.org/10.1016/j.cub.2004.01.027 ↩

[2] Banking Sleep: Realization of Benefits During Subsequent Sleep Restriction and Recovery:
https://doi.org/10.1093/sleep/32.3.311 ↩

[3] Benefits of obstructive sleep apnea treatment in coronary artery disease: a long-term follow-up study:
https://doi.org/10.1016/j.ehj.2004.02.008 ↩

[4] Sleep Does Not Benefit Probabilistic Motor Sequence Learning:
https://doi.org/10.1523/jneurosci.2062-07.2007 ↩

[5] The Short-Term Benefits of Brief and Long Naps Following Nocturnal Sleep Restriction:
https://doi.org/10.1093/sleep/24.3.293 ↩

❓❓❓The Magic Weight Loss Drug❓❓❓
❓❓❓What is Semaglutide❓❓❓

1/7 🧵 Semaglutide, a medication primarily used for type 2 diabetes, is showing promise for weight loss and appetite suppression. Let's dive into the science behind it.

2/7 Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA). A study found that it led to a lower energy intake during meals, resulting in a 24% reduction in total energy intake throughout the day.

3/7 Not only does Semaglutide reduce energy intake, but it also impacts our eating behavior. It's associated with less hunger, fewer food cravings, better control of eating, and a lower preference for high-fat foods.

4/7 The result? A reduction in body weight, predominantly from body fat mass. This makes Semaglutide a promising agent for weight management.

5/7 But it's not just about weight loss. Semaglutide has shown significant benefits on cardiovascular protection, which is crucial as cardiovascular disease is a major risk for people with obesity and type 2 diabetes.

6/7 However, like all medications, Semaglutide is not without its risks. More research is needed to fully understand its potential risks, especially when used in combination with other drugs.

7/7 In conclusion, Semaglutide is showing promise as a weight loss agent by reducing energy intake and improving eating behaviors. But remember, always consult with a healthcare professional before starting any new medication.

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References:
[1] Effects of once‐weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity
[2] LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept
[3] Cardiovascular Actions and Clinical Outcomes With Glucagon-Like Peptide-1 Receptor Agonists and Dipeptidyl Peptidase-4 Inhibitors
[4] Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes

📣 Exciting News! Sneak Peek of MyFitnessCoach App's AI Personal Trainer Features! 📱💪

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