Dhaka University Pharma Club

𝑪𝒐𝒖𝒏𝒕𝒅𝒐𝒘𝒏 𝑻𝒐 𝑮𝒍𝒐𝒓𝒚!

Let the excitement build as the schedule and finalists for 𝗜𝗻𝗱𝗼𝗼𝗿 𝗚𝗮𝗺𝗲𝘀 𝗖𝗮𝗿𝗻𝗶𝘃𝗮𝗹 𝟮𝟬𝟮𝟯 𝗮𝗿𝗿𝗮𝗻𝗴𝗲𝗱 𝗯𝘆 𝗗𝗨𝗣𝗖 is revealed and meet the powerhouse teams and players that set to compete in the finals 𝒕𝒐𝒎𝒐𝒓𝒓𝒐𝒘.

The stage is set, and anticipation is high. So, don’t miss out on the fascinating games about to take place and come to cheer for them at 𝗗𝗵𝗮𝗸𝗮 𝗨𝗻𝗶𝘃𝗲𝗿𝘀𝗶𝘁𝘆 𝗚𝘆𝗺𝗻𝗮𝘀𝗶𝘂𝗺 tomorrow at the given schedule.

Let the games begin! 🏸🃏♟️🏓

𝑯𝒂𝒑𝒑𝒚 𝑺𝒑𝒐𝒓𝒕𝒊𝒏𝒈!!!

𝑻𝒓𝒊𝒖𝒎𝒑𝒉 𝑼𝒏𝒗𝒆𝒊𝒍𝒆𝒅!

Commencing the indoor sports event on a triumphant note.

𝐃𝐚𝐲-𝟎𝟏 of 𝐼𝑛𝑑𝑜𝑜𝑟 𝑆𝑝𝑜𝑟𝑡𝑠 𝐶𝑎𝑟𝑛𝑖𝑣𝑎𝑙 2023 𝑎𝑟𝑟𝑎𝑛𝑔𝑒𝑑 𝑏𝑦 𝐷𝑈𝑃𝐶 marked by success with the presence of the honorable 𝗗𝗲𝗮𝗻 𝗼𝗳 𝗙𝗮𝗰𝘂𝗹𝘁𝘆 𝗼𝗳 𝗣𝗵𝗮𝗿𝗺𝗮𝗰𝘆, 𝗗𝗿. 𝗦𝗶𝘁𝗲𝘀𝗵 𝗖𝗵𝗮𝗻𝗱𝗿𝗮 𝗕𝗮𝗰𝗵𝗮𝗿 𝘀𝗶𝗿, 𝗖𝗵𝗮𝗶𝗿𝗺𝗮𝗻 𝗼𝗳 𝗗𝗲𝗽𝗮𝗿𝘁𝗺𝗲𝗻𝘁 𝗼𝗳 𝗣𝗵𝗮𝗿𝗺𝗮𝗰𝘆 𝗗𝗿. 𝗙𝗶𝗿𝗼𝗷 𝗔𝗵𝗺𝗲𝗱 𝘀𝗶𝗿 𝗮𝗻𝗱 𝗗𝗿. 𝗠𝗱. 𝗔𝘀𝗹𝗮𝗺 𝗛𝗼𝘀𝘀𝗮𝗶𝗻 𝘀𝗶𝗿 with a spirited competition.

Here's to a journey of excellence on the courts!

𝑯𝒂𝒑𝒑𝒚 𝑺𝒑𝒐𝒓𝒕𝒊𝒏𝒈!!!

𝑮𝒓𝒂𝒕𝒊𝒕𝒖𝒅𝒆 𝒊𝒏 𝒆𝒗𝒆𝒓𝒚 𝒎𝒐𝒗𝒆!

A heartfelt thank you to 𝗗𝗵𝗮𝗸𝗮 𝗨𝗻𝗶𝘃𝗲𝗿𝘀𝗶𝘁𝘆 𝗖𝗵𝗲𝘀𝘀 𝗖𝗹𝘂𝗯 for an incredible collaboration. Together, we're making strides in intellect and strategy.

#𝐃𝐔𝐏𝐂×𝐃𝐔𝐂𝐂 ♟️💊

𝑾𝒉𝒐 𝑨𝒓𝒆 𝒀𝒐𝒖𝒓 𝑹𝒊𝒗𝒂𝒍𝒔?

Step into a world of enchantment as DUPC unveils fixtures of the segments for-
𝟏. Badminton (Men's Doubles)
𝟐. Table Tennis (Men's Doubles)
𝟑. Chess

Best of luck to the participants and let us all gather at 𝐃𝐡𝐚𝐤𝐚 𝐔𝐧𝐢𝐯𝐞𝐫𝐬𝐢𝐭𝐲 𝐆𝐲𝐦𝐧𝐚𝐬𝐢𝐮𝐦 on 𝟏𝟖 𝐍𝐨𝐯𝐞𝐦𝐛𝐞𝐫, 𝟐𝟎𝟐𝟑 (𝐒𝐚𝐭𝐮𝐫𝐝𝐚𝐲) at 𝟖:𝟑𝟎 𝐀.𝐌. for an unforgettable experience.

Lace up, get ready and be a part of the sporting excitement.

𝑯𝒂𝒑𝒑𝒚 𝑺𝒑𝒐𝒓𝒕𝒊𝒏𝒈!!!

𝑹𝒆𝒈𝒊𝒔𝒕𝒓𝒂𝒕𝒊𝒐𝒏 𝑪𝒍𝒐𝒔𝒆𝒅!

The stage for an epic Indoor Games Carnival has been set.

𝙇𝒆𝙩 𝙩𝒉𝙚 𝙜𝒂𝙢𝒆𝙨 𝙗𝒆𝙜𝒊𝙣! 🏆🏅

𝐈𝐭’𝐬 𝐇𝐞𝐫𝐞!

Get ready to make your mark and embrace the competition!

Check out the 𝐭𝐢𝐦𝐞𝐭𝐚𝐛𝐥𝐞 for our 𝐼𝑛𝑑𝑜𝑜𝑟 𝑆𝑝𝑜𝑟𝑡𝑠 𝐶𝑎𝑟𝑛𝑖𝑣𝑎𝑙 2023 𝑜𝑟𝑔𝑎𝑛𝑖𝑧𝑒𝑑 𝑏𝑦 𝐷𝑈𝑃𝐶. 🏸🃏♟️🏓

Anticipating you presence at the face-off!

𝑁.𝐵. 𝑆𝑐ℎ𝑒𝑑𝑢𝑙𝑒 𝑚𝑎𝑦 𝑣𝑎𝑟𝑦 𝑑𝑢𝑒 𝑡𝑜 𝑢𝑛𝑎𝑣𝑜𝑖𝑑𝑎𝑏𝑙𝑒 𝑐𝑖𝑟𝑐𝑢𝑚𝑠𝑡𝑎𝑛𝑐𝑒𝑠.

𝐓𝐡𝐫𝐢𝐥𝐥𝐢𝐧𝐠 𝐔𝐩𝐝𝐚𝐭𝐞!

Deadline for registration has been 𝒆𝒙𝒕𝒆𝒏𝒅𝒆𝒅 𝒇𝒐𝒓 𝟔 𝒉𝒐𝒖𝒓𝒔! If you have not registered yet, here is your chance!!!

𝐑𝐞𝐠𝐢𝐬𝐭𝐫𝐚𝐭𝐢𝐨𝐧 𝐋𝐢𝐧𝐤: https://forms.gle/tGbopWn1zXPgqF8h9

𝐀𝐧𝐧𝐨𝐮𝐧𝐜𝐞𝐦𝐞𝐧𝐭!!

After massive requests, the 𝐅𝐞𝐦𝐚𝐥𝐞 Events in Badminton and Table Tennis has been changed from 𝐃𝐨𝐮𝐛𝐥𝐞𝐬 to 𝐒𝐢𝐧𝐠𝐥𝐞𝐬!

𝐑𝐞𝐠𝐢𝐬𝐭𝐫𝐚𝐭𝐢𝐨𝐧 𝐥𝐢𝐧𝐤:
https://forms.gle/tGbopWn1zXPgqF8h9

𝑬𝒂𝒓𝒍𝒚 𝒃𝒊𝒓𝒅 𝒓𝒆𝒈𝒊𝒔𝒕𝒓𝒂𝒕𝒊𝒐𝒏 𝒊𝒔 𝒄𝒍𝒐𝒔𝒆𝒅.

But, you can join the adventure through general registration starting now!
General Registration fee is now 𝟑𝟎 𝐭𝐚𝐤𝐚 per segment (Previously 50). So, you are getting a 𝟒𝟎% 𝒅𝒊𝒔𝒄𝒐𝒖𝒏𝒕!!!

𝐃𝐞𝐚𝐝𝐥𝐢𝐧𝐞: Nov 30

𝐑𝐞𝐠𝐢𝐬𝐭𝐫𝐚𝐭𝐢𝐨𝐧 𝐋𝐢𝐧𝐤: https://rb.gy/n6yv3n

𝐄𝐯𝐞𝐧𝐭 𝐋𝐢𝐧𝐤: https://fb.me/e/3cU1dm68z

𝑯𝒂𝒑𝒑𝒚 𝑸𝒖𝒆𝒔𝒕𝒊𝒏𝒈!!!🏴‍☠️

𝐑𝐞𝐦𝐢𝐧𝐝𝐞𝐫!📧

Participants are requested to 𝐜𝐡𝐞𝐜𝐤 𝐭𝐡𝐞𝐢𝐫 𝐞-𝐦𝐚𝐢𝐥𝐬 for session 𝐥𝐢𝐧𝐤 𝐚𝐧𝐝 𝐝𝐞𝐭𝐚𝐢𝐥𝐬 of the '2 Days Free Webinar: Writing Manuscript for High Impact Publications - Do's and Don'ts.'

The countdown is on! ⏰

Don't miss out!📝

𝑬𝒗𝒆𝒏𝒕 𝑳𝒊𝒏𝒌: https://fb.me/e/6GiqDiAUV

As some participants have notified us that they haven't received the email with session details, we are providing the Zoom link here,

𝐋𝐢𝐧𝐤 𝐭𝐨 𝐖𝐞𝐛𝐢𝐧𝐞𝐫:
https://us06web.zoom.us/j/7994354313?pwd=QmVYZmRidURuYWs0ek5Sa2x2Tng1Zz09

𝟏𝐬𝐭 𝐈𝐧𝐝𝐨𝐨𝐫 𝐒𝐩𝐨𝐫𝐭𝐬 𝐂𝐚𝐫𝐧𝐢𝐯𝐚𝐥 𝟐𝟎𝟐𝟑 𝐨𝐫𝐠𝐚𝐧𝐢𝐳𝐞𝐝 𝐛𝐲 𝐃𝐔𝐏𝐂!

𝗗𝗵𝗮𝗸𝗮 𝗨𝗻𝗶𝘃𝗲𝗿𝘀𝗶𝘁𝘆 𝗣𝗵𝗮𝗿𝗺𝗮 𝗖𝗹𝘂𝗯 𝗽𝗿𝗲𝘀𝗲𝗻𝘁𝘀 𝘁𝗵𝗲 𝟭𝘀𝘁 𝗜𝗻𝗱𝗼𝗼𝗿 𝗦𝗽𝗼𝗿𝘁𝘀 𝗖𝗮𝗿𝗻𝗶𝘃𝗮𝗹 𝟮𝟬𝟮𝟯!
Are you ready to unleash your inner athlete and compete in a variety of exciting indoor sports? This carnival is the perfect opportunity to test your skills, challenge yourself, and have some fun with friends.
Whether you're a seasoned athlete or just starting out, there's something for everyone at the Indoor Sports Carnival. We'll have a variety of events to choose from, including badminton, table tennis and more.
So, what are you waiting for? Gather your team and register today!

𝗖𝗿𝗶𝘁𝗲𝗿𝗶𝗮:
• Every individual should register for every different segment.
• One can participate in as many segments as he/she wants, but he/she must register and pay for each segment separately.
• A team can be of highest 2 members.
• If you want to participate in multiple segments, fill up the form individually for each segment you want to participate.
• In case of team participation only one team member is required to fill up the form.

𝗘𝘃𝗲𝗻𝘁 𝗟𝗶𝗻𝗸:
https://facebook.com/events/s/1st-indoor-sports-carnival-202/1712503969260531/

𝗥𝘂𝗹𝗲𝘀:
𝟭. 𝗕𝗮𝗱𝗺𝗶𝗻𝘁𝗼𝗻:
https://docs.google.com/document/d/1U92DhtrXuqreME9uBCT3GmrabvlU7YtJuAqJT3NABBU/edit
𝟮. 𝗧𝗮𝗯𝗹𝗲 𝗧𝗲𝗻𝗻𝗶𝘀:
https://docs.google.com/document/d/1DSenAp0n-MoP0DMy0vUSrxe1yo4oo7Mxq84kAvbGzYY/edit
𝟯. 𝗖𝗵𝗲𝘀𝘀:
https://docs.google.com/document/d/1xU2tk_IBLqLrq2NpYyMrCIoRD8RApybwxI5pisNdoyI/edit
𝟰. 𝟮𝟵 𝗖𝗮𝗿𝗱𝘀 𝗚𝗮𝗺𝗲:
https://docs.google.com/document/d/1olsIx6g4cqeLWTr854zl3fMUoekPhc08ZHRypDz-p1o/edit

𝗦𝗰𝗵𝗲𝗱𝘂𝗹𝗲:
18th November, Saturday (8AM - 2PM)
19th November, Sunday (1PM - 4PM)
20th November, Monday (2PM - 5PM) (Finals!)

𝗣𝗹𝗮𝗰𝗲:
Dhaka University Gymnasium

𝗥𝗲𝗴𝗶𝘀𝘁𝗿𝗮𝘁𝗶𝗼𝗻:
You must pay 𝟓𝟎 𝐓𝐊 𝐟𝐨𝐫 𝐄𝐚𝐜𝐡 𝐒𝐞𝐠𝐦𝐞𝐧𝐭 via Bkash/Nagad. In case of team participation, only one team member needs to pay 𝟏𝟎𝟎 𝐓𝐊 𝐟𝐨𝐫 𝐄𝐚𝐜𝐡 𝐓𝐞𝐚𝐦

𝗥𝗲𝗴𝗶𝘀𝘁𝗿𝗮𝘁𝗶𝗼𝗻 𝗹𝗶𝗻𝗸:
https://forms.gle/tGbopWn1zXPgqF8h9

𝗗𝗲𝗮𝗱𝗹𝗶𝗻𝗲: 17/11/2023, 12PM

𝙃𝙖𝙥𝙥𝙮 𝙎𝙥𝙤𝙧𝙩𝙞𝙣𝙜!!!

𝑵𝒐𝒕𝒊𝒄𝒆!

1 more day to go till early bird registration closes!!! What are you waiting for? Don’t miss out and join us in this adventure.

𝐑𝐞𝐠𝐢𝐬𝐭𝐫𝐚𝐭𝐢𝐨𝐧 𝐋𝐢𝐧𝐤: https://rb.gy/n6yv3n

𝑬𝒗𝒆𝒏𝒕 𝑳𝒊𝒏𝒌: https://facebook.com/events/s/pharma-quest-2023/3595668317384844/

𝐇𝐚𝐩𝐩𝐲 𝐐𝐮𝐞𝐬𝐭𝐢𝐧𝐠!!! 🏴‍☠️

𝐑𝐞𝐦𝐢𝐧𝐝𝐞𝐫!📧

Participants are requested to 𝐜𝐡𝐞𝐜𝐤 𝐭𝐡𝐞𝐢𝐫 𝐞-𝐦𝐚𝐢𝐥𝐬 for session 𝐥𝐢𝐧𝐤 𝐚𝐧𝐝 𝐝𝐞𝐭𝐚𝐢𝐥𝐬 of the '2 Days Free Webinar: Writing Manuscript for High Impact Publications - Do's and Don'ts.'

The countdown is on! ⏰

Don't miss out!📝

𝑬𝒗𝒆𝒏𝒕 𝑳𝒊𝒏𝒌: https://fb.me/e/6GiqDiAUV

𝐑𝐞𝐠𝐢𝐬𝐭𝐫𝐚𝐭𝐢𝐨𝐧 𝐋𝐢𝐧𝐤: https://forms.gle/tU7cRaSDwTZ6uo8b9

May this festival bring joy, laughter, and togetherness to our family. Happy Diwali!

𝐁𝐢𝐨𝐥𝐨𝐠𝐢𝐜 𝐌𝐞𝐝𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬 𝐟𝐨𝐫 𝐭𝐡𝐞 𝐓𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭 𝐨𝐟 𝐏𝐬𝐨𝐫𝐢𝐚𝐬𝐢𝐬

Psoriasis is a very common long-lasting skin condition, showing symptoms of red scaly patches and in some cases white ones on the skin too.

The landscape on treatment of people living with chronic moderate-to-severe plaque psoriasis suitable for systemic therapy or phototherapy is changing quickly. On one hand, the arrival of biologic remedies stands among the most impressive advancements in handling psoriasis patients.

𝐁𝐢𝐨𝐥𝐨𝐠𝐢𝐜’𝐬 𝐑𝐨𝐥𝐞 𝐢𝐧 𝐭𝐡𝐞 𝐌𝐚𝐧𝐚𝐠𝐞𝐦𝐞𝐧𝐭 𝐨𝐟 𝐏𝐬𝐨𝐫𝐢𝐚𝐬𝐢𝐬.
Historically, the management of psoriasis has included topical treatments, phototherapy, and systemic treatments, including methotrexate, cyclosporine, among other agents. Despite their successes, these therapies are accompanied by limitations like systemic toxicity and long-term reactions. However, biologic treatments for psoriasis proved to be game changers in how we approach management of this condition because they offer targeted intervention addressing the actual immunologic mechanisms at play in the disease.
Currently, biologics are considered the initial and preferred systemic therapy for patients with chronic mild to moderate to severe plaque psoriasis who have been considered suitable candidates for systemic therapy or phototherapy. These drugs are usually used in situations where topical treatment and light therapy do not work well enough or cannot be used due to certain disadvantages. Factors such as disease severity, treatment side effects, patient’s choice, and treatment outcomes influence the decision for initiating biologic therapy.

𝐌𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐦𝐬 𝐨𝐟 𝐀𝐜𝐭𝐢𝐨𝐧
Biologic medications used in the treatment of psoriasis target specific components of the immune system that play a crucial role in the development of the disease. The most common targets include tumour necrosis factor-alpha (TNF-α), interleukin-17 (IL-17), and interleukin-23 (IL-23). These cytokines are known to be overactive in individuals with psoriasis, leading to excessive inflammation and abnormal skin cell growth.

𝗧𝗡𝗙-α 𝗜𝗻𝗵𝗶𝗯𝗶𝘁𝗼𝗿𝘀: Medications work by inhibiting TNF-α, a pro-inflammatory cytokine. By blocking TNF-α, these biologics reduce inflammation and slow down the progression of psoriatic skin lesions.
Main agents under this group includes: etanercept, infliximab, adalimumab and certolizumab pegol.

𝗘𝘁𝗮𝗻𝗲𝗿𝗰𝗲𝗽𝘁: Etanercept is approved for patients aged four years or older.
Infliximab: the onset of action of infliximab is faster than several other commercially available biologic agents (according to systematic review)

𝗖𝗲𝗿𝘁𝗼𝗹𝗶𝘇𝘂𝗺𝗮𝗯 𝗽𝗲𝗴𝗼𝗹: A pegylated humanized antibody Fab fragment with specificity for TNF-alpha.
A potential advantage of certolizumab pegol is minimal transfer across the placenta.

𝗜𝗟-𝟭𝟳 𝗜𝗻𝗵𝗶𝗯𝗶𝘁𝗼𝗿𝘀: Drugs target IL-17, another key player in psoriasis-related inflammation. These biologics help normalize immune responses and alleviate psoriatic symptoms.
Main agents under this group includes: Secukinumab, Ixekizumab, Brodalumab and Bimekizumab

𝗕𝗿𝗼𝗱𝗮𝗹𝘂𝗺𝗮𝗯: In the US, use of the drug will require participation in a REMS program due to concerns regarding risk for suicidal ideation. However, causal relationship between Brodalumab treatment and suicidal ideation and behaviour has not been confirmed.

𝗜𝗟-𝟮𝟯 𝗜𝗻𝗵𝗶𝗯𝗶𝘁𝗼𝗿𝘀: target IL-23, which is involved in the differentiation and activation of T cells. By blocking IL-23, these medications interrupt the autoimmune response that drives psoriasis.
Main agents under this group includes: Ustekinumab, Guselkumab, Tildrakizumab and Risankizumab

𝐔𝐬𝐭𝐞𝐤𝐢𝐧𝐮𝐦𝐚𝐛: Ustekinumab is a human monoclonal antibody that targets IL-12 and IL-23.
Ustekinumab is approved for treatment of adults and children 12 years and older with moderate to severe psoriasis.

𝗥𝗶𝘀𝗮𝗻𝗸𝗶𝘇𝘂𝗺𝗮𝗯: Risankizumab is a humanized monoclonal antibody directed against the p19 subunit of IL-23 and IL-39

𝐂𝐨𝐧𝐜𝐥𝐮𝐬𝐢𝐨𝐧
With biologicals changing the treatment game for psoriasis. They provide a precise approach that attacks the immune mechanisms fueling the illness, often resulting in marked improvement in disease symptoms and the patient’s overall quality of life. These drugs work very well but must be utilized judiciously, through cautious patient selection and monitoring for safety. With growing knowledge about the pathophysiology of psoriasis, we can expect innovative biologics will emerge, which can provide better control over this chronic dermatitis for sufferers.

𝐀𝐮𝐭𝐡𝐨𝐫
Avoy Ghosh
B.Pharm Professional Year-IV
Batch: 54
Department Of Pharmacy
University of Dhaka

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𝐀𝐥𝐢𝐜𝐞 𝐈𝐧 𝐓𝐡𝐞 𝐖𝐨𝐧𝐝𝐞𝐫𝐥𝐚𝐧𝐝 𝐒𝐲𝐧𝐝𝐫𝐨𝐦𝐞 (𝐀𝐈𝐖𝐒)
Alice in Wonderland syndrome (AWS) is a rare condition that causes temporary episodes of distorted perception and disorientation. It disrupts your brain’s ability to process sensory input. The disruption affects how you perceive the size of things you see around you, the feel or look of your own body, or both. It can also distort your sense of reality. You may feel larger or smaller than you actually are. You may also find that the room you’re in — or the surrounding furniture — seems to shift and feel further away or closer than it really is. These episodes aren’t the result of a problem with your eyes or a hallucination. They’re caused by changes in how your brain perceives the environment you’re in and how your body looks. This syndrome can affect multiple senses, including vision, touch, and hearing. You may also lose a sense of time. Time may seem to pass faster or slower than you think.
AWS is also known as Todd’s syndrome. That’s because it was first identified in the 1950s by Dr. John Todd, a British psychiatrist. He noted that the symptoms and recorded anecdotes of this syndrome closely resembled episodes that the character Alice Liddell experienced in Lewis Carroll’s novel “Alice’s Adventures in Wonderland.”
The symptoms that can happen with AIWS break down into two categories: self-perception symptoms or visual perception symptoms. People can also have both kinds of symptoms, but visual perception symptoms are much more comtime

𝐒𝐞𝐥𝐟-𝐩𝐞𝐫𝐜𝐞𝐩𝐭𝐢𝐨𝐧 𝐬𝐲𝐦𝐩𝐭𝐨𝐦𝐬
Your brain monitors and manages your body’s functions. This is extremely important, as it keeps you safe and healthy. However, it’s also possible for something to go wrong with that ability, which is what happens with self-perceptive symptoms of AIWS. They include:
Changes in your perception of your body
Derealization
Depersonalization
Feeling of being split in two
Disruption in sense of time

𝐕𝐢𝐬𝐮𝐚𝐥 𝐩𝐞𝐫𝐜𝐞𝐩𝐭𝐢𝐨𝐧 𝐬𝐲𝐦𝐩𝐭𝐨𝐦𝐬
The most common symptoms of AIWS affect visual perception. That means the symptoms affect the way you see things around you. They include:
Changes in size
Changes in distance
Changes in both size and distance
People appearing smaller than they actually are
Changes in object appearance

It’s not clear what causes AWS, but doctors are trying to better understand it. The possible causes include, but aren’t limited to:

Migraines
Infections
Seizures
Certain types of strokes
Mental health conditions
Medications
Recreational drugs and inhalants
Degenerative brain diseases
Brain tumor
Stress
Cough medicine
Use of hallucinogenic drugs
Epilepsy

𝐑𝐞𝐟𝐞𝐫𝐞𝐧𝐜𝐞𝐬

https://my.clevelandclinic.org/health/diseases/24491-alice-in-wonderland-syndrome-aiws
https://www.healthline.com/health/alice-in-wonderland-syndrome

𝐀𝐮𝐭𝐡𝐨𝐫

Md. Asir Hamim
B.Pharm Professional Year-II
Department of Pharmacy
University of Dhaka

𝐀𝐥𝐢𝐞𝐧 𝐇𝐚𝐧𝐝 𝐒𝐲𝐧𝐝𝐫𝐨𝐦𝐞
Alien hand syndrome, also known as Dr. Strangelove syndrome, is a phenomenon in which one hand is not under control of the mind. The person loses control of the hand, and it acts as if it has a mind of its own. The etiology includes neurosurgery, tumors, aneurysms, and rarely stroke. This case is presented to create awareness of this interesting clinical scenario, which can be terrifying to the patients and confusing to the physicians who are not aware of it.
It was first described in 1908. It is an interesting situation in which a person loses control of his or her hand, which starts to act independently. These motions are often completely unnecessary or inappropriate at the time and can be terrifying to experience. It describes involuntary complex goal-directed activity of one limb. Recent usage of the term “alien hand” is more liberal and requires having observable involuntary motor activity along with the feeling that the limb is foreign or that it has a will of its own. The syndrome has been reported after surgery on the corpus callosum and with brain tumors, aneurysms, degenerative diseases of the brain, and uncommonly stroke. Alien hand as a manifestation of cardioembolic stroke is extremely rare, with only a few cases reported in the literature.
Film buffs may remember that the title character of the classic 1964 dark comedy Dr. Strangelove, or: How I Learned to Stop Worrying and Love the Bomb had what looked like alien hand syndrome. Dr. Strangelove's hand would perform what appeared to be purposeful acts but were in fact unintentional. This quirk was used for comic effect in the movie, but in real life the condition can be distressing—and can present in varying ways. One hand may swat at the other involuntarily, or an arm may inexplicably shoot into the air.
In a report documented in the medical literature, a man's alien hand started undoing the buttons on his shirt as his other hand buttoned them. In other case reports, patients have said they awoke from sleep to find their hands choking them.
Lesions implicated in causing alien hand syndrome include those in the corpus callosum and posterior parietal cortex, supplementary motor area, and the anterior cingulate cortex. Functional MRI has been used to study brain activity in patients with alien hand syndrome. In normal individuals, initiation of motor activity shows activation of multiple extensive neural networks. However, in patients with alien hand syndrome, only isolated activation of the contralateral primary motor cortex is observed. It has been proposed that lesions in the parietal cortex result in isolated activation of the contralateral primary motor area due to its release from the intentional planning systems. Damage to the parietal cortex can also cause lack of awareness of movements due to loss of proprioceptive feedback or left hemineglect. The combination of these factors results in initiation of spontaneous movements without the patient's knowledge or will.
Alien hand syndrome has been reported to be associated with several abnormal involuntary movements when different regions of the brain, like the corpus callosum, parietal region, or frontal region, are involved. It can be classified into at least four categories: 1) diagnostic dyspraxia/intermanual conflict (when one hand performs actions contrary to the other hand); 2) alien hand sign (a subjective feeling that the hand is not one's own); 3) syndrome of anarchic hand (when the affected hand performs goal-directed activity not under the will of the person); and 4) supernumerary hand (a feeling of having an extra limb). Another type of alien hand is the levitating hand, where the affected limb tends to levitate without volitional action.
Alien hand might manifest as a self-groping behavior and self-oppositional behavior. Autocriticism has also been reported, with the person slapping the alien hand with the normal hand. The person loses control of the affected hand as if it is being controlled by an external force. The alien hand might grab onto things and the person might have to use the other limb to release the objects from it. At extremes, the alien hand has been reported to even suffocate the patient.
𝐕𝐞𝐫𝐬𝐢𝐨𝐧𝐬 𝐨𝐟 𝐀𝐥𝐢𝐞𝐧 𝐇𝐚𝐧𝐝 𝐒𝐲𝐧𝐝𝐫𝐨𝐦𝐞

Alien hand syndrome is essentially the same thing as alien limb syndrome. The broader name reflects the fact that a similar condition can happen to your legs too. So far, people have only had one limb affected at a time.
There are three main categories of alien hand syndrome based on the part of your brain that’s causing the condition. They are the:
Frontal lobe version: This is the only version reported that affects your right hand.
Callosal version: This involves the corpus callosum area of your brain.
Posterior version: This involves your parietal lobe.
There is no established treatment for alien hand. It has been reported to last for several days to several years. Alien hand as a manifestation of cardioembolic transient ischemic attack has been reported only once based on our review (6). The extremely short duration of alien hand in this case report (30 minutes) is the shortest reported duration of this phenomenon recorded.
𝐀𝐥𝐢𝐞𝐧 𝐇𝐚𝐧𝐝 𝐒𝐲𝐧𝐝𝐫𝐨𝐦𝐞 𝐂𝐚𝐮𝐬𝐞𝐬
There isn’t one universal cause for alien hand syndrome. But it’s always caused by some kind of damage to your brain in a way that disrupts your movement and control.
Usually, when someone chooses to start moving their arm, they activate multiple extensive neural networks within their brain. In people with AHS, the areas of activation are more isolated.
On a broader level, causes of brain damage that can lead to AHS include:
Brain tumors
Stokes
Aneurysms
Brain damage from an injury
As a side effect of brain surgery
Parry–Romberg Syndrome
Creutzfeldt–Jakob
Atypical Parkinson’s variants, like corticobasal syndrome
Various other neurodegenerative diseases
Keep in mind that this is a very rare side effect of most of these conditions. For example, it’s highly unlikely that you’ll develop AHS if you have a stroke.
But for some specific conditions, the rate can be surprisingly high. Data indicates that it appears in 30% of people with the Parkinson’s variant — corticobasal syndrome. It also occurs in 4% of people with Creutzfeldt–Jakob disease.
In some cases, the condition is idiopathic — meaning that the exact cause remains unknown.

𝐀𝐮𝐭𝐡𝐨𝐫:

Md. Asir Hamim
B.Pharm Professional Year -II
Department of Pharmacy
University of Dhaka

𝐑𝐞𝐟𝐞𝐫𝐞𝐧𝐜𝐞𝐬:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059570/
https://www.webmd.com/brain/what-is-alien-hand-syndrome
https://www.brainandlife.org/articles/what-is-alien-hand-syndrome
https://www.sciencedirect.com/topics/neuroscience/alien-hand-syndrome
https://n.neurology.org/content/91/11/527
https://www.medlink.com/articles/alien-hand-syndrome

© Nazmus Sakib
B.Pharm professional Year-III
Batch- 56
Department of Pharmacy
University of Dhaka.

𝐀𝐧𝐭𝐢𝐬𝐨𝐜𝐢𝐚𝐥 𝐏𝐞𝐫𝐬𝐨𝐧𝐚𝐥𝐢𝐭𝐲 𝐃𝐢𝐬𝐨𝐫𝐝𝐞𝐫 (𝐀𝐒𝐏𝐃):
Have you ever seen someone around you who enjoys making other people suffer? If yes, that person may have a mental disorder which we will discuss today.

𝐎𝐕𝐄𝐑𝐕𝐈𝐄𝐖 Antisocial Personality Disorder (ASPD), sometimes also called sociopathy, is a mental health condition in which a person behaves in a harmful manner towards others without remorse. About 3% of men and 1% of women possess antisocial personality disorder. Certain infamous people, such as serial killers John Wayne Gacy, Jefferey Dahmer, and Ted Bundy did have antisocial personality disorder. A person with ASPD ignores the rights and feelings of others, often violates the law, becoming criminals. They may lie, behave violently or impulsively, and have problems with drug and alcohol use. They do not perform their responsibilities properly related to family, work or school.

𝐒𝐘𝐌𝐏𝐓𝐎𝐌𝐒: Symptoms of ASPD include repeatedly:
👉 Ignoring right and wrong.
👉Telling lies to take advantage of others.
👉 Being hostile, aggressive, violent or threatening to others.
👉Having a sense of superiority and ignoring others opinion.
👉 Having problems with the law, including criminal behavior.
👉 Feeling no guilt about harming others.
👉Doing dangerous things with no regard for the safety of self or others.
👉 Being irresponsible and failing to fulfill financial responsibilities.
👉 Have difficulty sustaining long-term relationships.
👉Always blame others for problems in their lives.

𝐂𝐀𝐔𝐒𝐄𝐒 personality causes are complex, but may be associated with environmental factors as well as genetics.
👉 Genes may make you vulnerable to develop antisocial personality disorder and life situations, especially neglect and abuse, may trigger its development. Exact gene responsible is yet to be identified by researchers.
👉 Childhood trauma may trigger ASPD. For example: Negligence from parents, torture, sexual abuse, malnutrition etc. If parents engage in criminal activity, their children are more likely to inherit behavioral problems.
👉 Social and home environments can also be responsible for the development of ASPD. DIAGNOSIS There's no physical tests to diagnose ASPD as it is a mental disease. Diagnosis should be conducted by a licensed psychologist and it can only be made if the person is aged 18 years or older and at least 3 of the following criteria behaviors apply:
👉 repeatedly breaking the law
👉repeatedly being deceitful
👉being irritable and aggressive
👉having a reckless disregard for their safety or the safety of others
👉being impulsive or incapable of planning ahead
👉being consistently irresponsible
👉 lack of remorse

𝐂𝐎𝐌𝐏𝐋𝐈𝐂𝐀𝐓𝐈𝐎𝐍𝐒: Criminals behavior is a key feature of ASPD and it's obvious that someone with the disorder will commit crimes and will be imprisoned at some point in their life. Spouse abuse or child abuse, problems with alcohol or drugs, trying to kill someone for a small reason, financial or social instability is very common with these ASPD patients. Moreover, they have an increased risk of dying prematurely as a result of reckless behavior or attempting su***de.

𝗧𝗥𝗘𝗔𝗧𝗠𝗘𝗡𝗧:ASPD is one of the most difficult types of personality disorders to treat. A person with ASPD are not likely to seek help on their own. If you suspect that a friend or family member may have the condition, you might gently suggest that person to visit a mental health provider.
Healthcare providers may recommend a combination of medications and psychotherapy:

𝐌𝐞𝐝𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬: Medications can help treat symptoms like aggression and mood changes. For example, Antidepressants drugs, which can regulate serotonin levels in brain.  Psychotherapy: Cognitive behavioral therapy (CBT) is a type of counseling that focuses on changing of thinking and behavior. Therapy can help the patient to see how their behavior affects others. They may be benefited from individual therapy, group therapy or family therapy.

𝐏𝐑𝐄𝐕𝐄𝐍𝐓𝐈𝐎𝐍 There's no sure way to prevent ASPD from developing in those at risk. Because antisocial behavior is thought to have its roots in childhood. Parents, teachers and pediatricians may be able to see early warning signs. It may help to try to identify the disorder and taking extra care of them from beginning.
𝐖𝐡𝐚𝐭 𝐢𝐬 𝐎𝐔𝐑 𝐃𝐔𝐓𝐘 𝐭𝐨𝐰𝐚𝐫𝐝 𝐭𝐡𝐞 𝐀𝐒𝐏𝐃 𝐯𝐢𝐜𝐭𝐢𝐦𝐬?

Victims of ASPD may be one of our family members or friends. So we also have some responsibility toward them. There are lots of positive things we can do to support them. We should be calm & patient with them, remind them of their positive traits and not to ignore them if they seek help. We must set a boundary of interaction and last but not least, we have to be cautious for any sudden action by them for our own safety.



𝐑𝐄𝐅𝐄𝐑𝐄𝐍𝐂𝐄𝐒
1. Antisocial personality disorder, https://en.m.wikipedia.org/wiki/Antisocial_personality_disorder?fbclid=IwAR3c8MrX3xv_hZnmeSnE0J 9LBLiZVfOq_rlW8BI8w5wV7vjmWV
2.Everything you need to know about ASPD, https://my.clevelandclinic.org/health/diseases/9657-antisocial-personalitydisorder?fbclid=IwAR2Cei4UjnVoAPpSZ0WBv5yhlnv6A9IjVzWBzbSbQoqIvNJgTsCOp4ptFtQ 3. Antisocial Personality Disorder, https://www.webmd.com/mental-health/antisocial-personality-disorder-overview?fbclid=IwAR2WCo2swmEVz2Dalcs5NExyG5NNeuQW2SS-Bl9AtYtjx6MsC8QRxYZ-6g
4. What is antisocial personality disorder? https://www.health.harvard.edu/a_to_z/antisocial-personality-disorder-a-toz?fbclid=IwAR1G3uOskb4OQoTzeioXMtAi4e5jJvkoMMoRO472saXhaJLa2DXAAxuSyOE 5. How 'Sociopath' Relates to Symptoms of Antisocial Personality Disorder, https://www.health.com/condition/antisocial-personality-disorder/sociopathtraits #:~:text=Signs%20of%20Antisocial%20Personality%20Disorder&text=One%20of%20the%20signa ture%20signs,they%20may%20be%20to%20others

𝐀𝐔𝐓𝐇𝐎𝐑:
Md Mehedi Hasan Munna
B.pharm professional year-III
Batch-56
Department of Pharmacy
University of Dhaka.

Get ready for a thrilling surprise that DUPC is about to unveil! Can you guess what's coming next?

𝑩𝑷𝑷𝑽: 𝑨 𝒑𝒆𝒓𝒊𝒑𝒉𝒆𝒓𝒂𝒍 𝒗𝒆𝒓𝒕𝒊𝒈𝒐 𝒅𝒊𝒔𝒐𝒓𝒅𝒆𝒓

𝐎𝐯𝐞𝐫𝐯𝐢𝐞𝐰
Have you ever felt like your surroundings are spinning even if you are not? If yes, then you have experienced vertigo. Vertigo is not a disease itself but a symptom of several other diseases. Among them 𝗕𝗲𝗻𝗶𝗴𝗻 𝗣𝗮𝗿𝗼𝘅𝘆𝘀𝗺𝗮𝗹 𝗣𝗼𝘀𝗶𝘁𝗶𝗼𝗻𝗮𝗹 𝗩𝗲𝗿𝘁𝗶𝗴𝗼 (𝗕𝗣𝗣𝗩) is one of the most common ones.

BPPV is the sudden sensation of spinning or feeling that the inside of the head is spinning. It is a common inner ear disorder that causes brief episodes of mild to intense dizziness. It usually occurs among people over the age of 65 and rarely among children.

𝐒𝐲𝐦𝐩𝐭𝐨𝐦𝐬
The signs and symptoms of BPPV can come and go and usually last less than one minute. The onset of BPPV may be frightening. People may think they are having a stroke. The common symptoms are:
● Dizziness
● Vertigo
● Loss of balance
● Nausea and vomiting

𝐂𝐚𝐮𝐬𝐞𝐬
BPPV is thought to be caused when otoconia (tiny calcium crystals) come loose from the utricle (a sensory organ in the inner ear). The utricle is a part of the balancing system. It detects the accelerations, especially the horizontal acceleration. An injury or degeneration of the utricle is thought to be the cause of escape of the crystals. When these crystals escape into the fluid that are filled into the canals of the inner ear, the balance system is interfered.

BPPV can be caused by-
● Head injury
● Keeping the head in the same position for a long period of time.
● Bike riding on rough trails
● High intensity aerobics

Activities that bring about the signs and symptoms of BPPV can vary from person to person, but are almost always brought on by a change in head position. Some people also feel out of balance when standing or walking.
In some cases, BPPV may be a symptom of another inner ear condition, such as:
● Labyrinthitis
● Vestibular neuritis
● Acoustic neuroma

𝐃𝐢𝐚𝐠𝐧𝐨𝐬𝐢𝐬
BPPV is rarely serious and the diagnosis is simple enough to be conducted through physical examination performed by a doctor and answering questions regarding symptoms. A MRI or CT scan of the brain is usually not needed.

𝐓𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭
BPPV can be treated successfully with simple exercises. They involve sequentially turning the head in a way that helps remove the crystals and help them float out of the semicircular canal.
Medications are given to relieve the symptoms of motion sickness.

In many cases, BPPV goes away on its own eventually. However, it is suggested to visit a healthcare provider and learn how to manage recurring symptoms.

𝐀𝐮𝐭𝐡𝐨𝐫
Mohammad Sami Rahman
B.Pharm Professional Year-IV
Department of Pharmacy
University of Dhaka.

𝐑𝐞𝐟𝐞𝐫𝐞𝐧𝐜𝐞𝐬:
1. https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/benign-paroxysmal-positional-vertigo-bppv
2. https://www.mayoclinic.org/diseases-conditions/vertigo/symptoms-causes/syc-20370055
3. https://my.clevelandclinic.org/health/diseases/11858-benign-paroxysmal-positional-vertigo-bppv
4. https://www.hopkinsmedicine.org/health/conditions-and-diseases/benign-paroxysmal-positional-vertigo-bppv