Imgene

The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry 2020 to

Emmanuelle Charpentier
Max Planck Unit for the Science of Pathogens, Berlin, Germany

Jennifer A. Doudna
University of California, Berkeley, USA

“for the development of a method for genome editing”

https://youtu.be/1CSYHLTPVzg

Announcement of the 2020 Nobel Prize in Chemistry The Nobel Prize in Chemistry 2020 was awarded jointly to Emmanuelle Charpentier and Jennifer A. Doudna "for the development of a method for genome editing." ...

Looking forward to our next "IMGENE Summer School"! We are happy to invite you to attend and participate in these masterclasses exploring the prospects and challenges of translational science.
Dates: September 1 - 3, 2020
Registration: https://forms.gle/uJeB8yYtMTynvdxa7

CRISPR in Drug Discovery 2020
https://elrig.org/portfolio/2020-crispr-drug-discovery/

2020 – CRISPR in Drug Discovery The second CRISPR in Drug Discovery: From Targets to Therapeutics meeting will be held at the Babraham Institute, Cambridge, 4th and 5th March 2020. Genome Engineering, including zinc-finger nucleases, TALENs and most recently CRISPR/Cas9, has become a powerful tool in the drug discovery pipeline. T...

Have a look at a new interesting paper from one of our IMGENE fellows.
Exploring a new approach to "Expand the editable genome".
A cutting-free strategy (In-trans paired nicking) implement CRISPR-Cas9 veratility!
https://academic.oup.com/nar/article/48/2/974/5651333

Expanding the editable genome and CRISPR–Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking Abstract. Genome editing typically involves recombination between donor nucleic acids and acceptor genomic sequences subjected to double-stranded DNA breaks (D

https://www.bric.ku.dk/newslist/news/2020/outreach-successfully-introducing-the-world-of-crispr-at-srp-high-school-course-2020/?utm_campaign=838133_BRICnews_20200124&utm_medium=email&utm_source=Main+list+-+Live+data-All_Users

Outreach: Successfully introducing the world of CRISPR at SRP high school course 2020 On 14-15 January 2020, 13 students from Danish high schools across the country participated in the two-day SRP course. The SRP high school course is an annual event hosted by BRIC and this year the theme of the course was CRISPR.

Here is the last paper of the month of the 2019 👨‍🔬🎄👩‍🔬: Improved Cas9 activity by specific modifications of the tracrRNA

https://imgene.ku.dk/paper-of-the-month/december-2019/

December 2019 Improved Cas9 activity by specific modifications of the tracrRNA Tristan Scott, Ryan Urak, Citradewi Soemardy & Kevin V. Morris

Each of these handprints were made by researchers and staff who all engage in the daily fight against cancer through research!

Check out this paper of month October on the IMGENE webpage: Super-mendelian inheritance mediated by CRISPR-Cas9 in the female mouse germline https://imgene.ku.dk/paper-of-the-month/paper-of-the-month-october-2019/

Paper of the month October 2019 Super-mendelian inheritance mediated by CRISPR-Cas9 in the female mouse germline Hannah A. Grunwald1,5, Valentino M. Gantz1,5, Gunnar Poplawski2,4,5, Xiang-Ru S. Xu1, Ethan Bier1,3 and Kimberly L. Cooper1,3*

IMGENE summer meeting 2019 in Porto Great succes! Good feedback from project officer Julien Giordani and rewiever Chiara Bovolenta

Gone for a cold beer: ventilation system broken and heat wave in Denmark..this is temparature in the office

Paper of the month
Fellows in the IMGENE network will explain a research papers on CRISPR in 500 words once a month.
Please check out this month (August) paper: Improving CRISPR-Cas9 Genome Editing Efficiency by Fusion with Chromatin-Modulating Peptides.

https://imgene.ku.dk/paper-of-the-month/paper-of-the-month-august/

Paper of the month August 2019 Improving CRISPR-Cas9 Genome Editing Efficiency by Fusion with Chromatin-Modulating Peptides

Check out the new Paper of the Month on IMGENE page.
This month we talk about a new Nickase Cas9 version with improved ability of stimulate HDR!
https://imgene.ku.dk/paper-of-the-month/paper-of-the-month-june-2019/

Paper of the Month June 2019 Development of hRad51-Cas9 nickase fusions that mediate HDR without double-stranded breaks.

was present in Washington D.C. at the where one of the young PhD Student had the chance to present his work - supported by the Marie Skłodowska-Curie Action - and received the Travel Award for Meritorious Abstracts.
Taking part in such international events is pivotal for the development of young inquisitive minds.
Keep it On!

New unit at Novo Nordisk; Denmark recruiting a scientist with hands-on experience in gene editing, CRISPR/Cas9, and cell biology.
https://www.novonordisk.com/careers/working-at-novo-nordisk/job-ad-display.10419.en_GB.html

Paper of the Month April 2019: Read this exciting resume of: Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy
https://imgene.ku.dk/paper-of-the-month/paper-of-the-month-april-2019/

Paper of the Month April 2019 Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy

Eating Popcorn while learning about CRISPR! Our IMGENE fellows Minyan Li and Nadja Bischoff watched "Human Nature" at the Copenhagen International Documentary Film Festival!

Human Nature Documentary Film Trailer The biggest tech revolution of the 21st century isn’t digital, it’s biological. A breakthrough called CRISPR gives us unprecedented control over the…

Paper of the Month March 2019: Read this exciting resume of: Engineering of CRISPR-Cas12b for human genome editing

https://imgene.ku.dk/paper-of-the-month/paper-of-the-month-march/

Paper of the Month March 2019 Engineering of CRISPR-Cas12b for human genome editing

This paper of the month: Predictable and precise template-free CRISPR editing of pathogenic variants

https://imgene.ku.dk/paper-of-the-month/paper-of-the-month-february-2019/

Paper of the Month February 2019 Predictable and precise template-free CRISPR editing of pathogenic variants

The coolest ever! Genome editing is definetely one of the most exciting topics in science. Scientists make an huge effort to develop the best approach to find solutions of our current problems, such as genetic diseases, the effects of resource shortages and climate change in agriculture and many more. Thanks to CRISPR, our effort is now one step closer to our goal.

IMGENE Winther meeting

Students nicely showed the progress in their projects. We had a lot of interesting scientific discussions and social networking as well.

Thanks IMG in Prague for hosting us

It has been over 4 months since our amazing Summer School in Berlin! Our Fellows and P*s are excited to meet again in Prague this week and learn about the latest scientfic results within the network!

Paper of the Month January 2019: Covalent linkage of the DNA repair template to the CRISPRCas9 nuclease enhances homology-directed repair https://imgene.ku.dk/paper-of-the-month/

Paper of the month Fellows in the IMGENE network will explain a research papers on CRISPR in 500 words once a month. Please follow us and learn more

All of us at IMGENE wish you a Happy New Year!

IMGENE researchers from Laboratory Animal Science at i3S in Porto, Prof. Anna Olsson and fellow Pedro Ramos, share their thoughts on genome editing and some ethical questions around it!

De fazer bebés à medida a outras polémicas da edição genética (mas também coisas boas) Um cientista alterou o ADN de bebés para serem imunes ao vírus da sida. É a mais recente polémica da edição genética. O CRISPR trouxe possibili...

Full House at the mini-symposium "Genome Editing using CRISPR/Cas9" Nielsine Nielsen auditorium, Panum, Denmark

This week several IMGENE colleagues have attended the INFRAFRONTIER/IMPC Stakeholder Meeting on "Advancing Rare Disease Research and Gene Therapy Applications with Animal Models" in Munich. Two days fully packed with interesting talks!