Rainero Lab

New preprint from our lab by Sherry & Rachele: "The protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25"

The protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25 Ovarian cancer is the 3rd most common gynaecological malignancy worldwide, with a 5-year survival rate of less than 30% in the presence of metastasis. Metastatic progression is characterised by extensive remodelling of the extracellular matrix, primarily mediated by secreted matrix metalloproteinase...

Huge congratulations to Dr Sherry on brilliantly passing her PhD viva!!!

🎉 Excited to share our latest article published in :

The extracellular matrix supports breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism Breast tumors are embedded in a collagen-rich extracellular matrix (ECM) network, where nutrients are scarce due to limited blood flow and elevated tumor growth. This study shows that invasive breast cancer cells use macropinocytosis-dependent uptake and lysosomal degradation of ECM to promote their...

New preprint from our lab, by Montse Llanses Martínez, Keqian Nan, , Rachele Bacchetti, Shengnan Yuan and : internalisation of integrin-bound modulates invasive carcinoma cell migration

Internalisation of integrin-bound extracellular matrix modulates invasive carcinoma cell migration The interaction between cancer cells and the extracellular matrix (ECM) plays a pivotal role in tumour progression. While the extracellular degradation of ECM proteins has been well characterised, ECM endocytosis and its impact on cancer cell progression, migration and metastasis is poorly understoo...

Congratulations on you graduation
Montse Llanses Martínez!!! You've been an amazing student, best of luck for the next step in your career! We'll have a manuscript on bioRxiv soon, stay tuned

Amazing talks by Shahd and Sherry at today's PGR symposium! 👏👏👏

Congratulations to Montse on passing her PhD viva!!!🎉🎉🎉

Bian from our lab has been shortlisted for the Best Lab Manager Award 2022!!! She's truly amazing, please vote for her here:

Best Lab Manager Award Best lab manager award now open for nominations! Proteintech is offering a $1000 award for the most outstanding lab manager.

We are challenging ourselves to walk 30K each in November as part of Pancreatic Cancer awareness month, organised by Pancreatic Cancer UK. All donations go to the charity, please support us!!

ER HM Lab

Rachele, Montse and Bian are at NEPG Conference! Go and have a look at their posters - you can find ECMatrix, cancer cell migration, growth and invasion in Zebrafish

Huge congratulations to Mona & Nan!!! It's been amazing having you as the first 2 PhD students in the lab!

Amazing day at the NECB forum today! Great talk by Montse and Shahd won 🏆 the poster price!!

Rainero Lab updated their info in the about section.

a new addition to the wall of fame: 2nd PhD thesis by
Nan Keqian, in his native language 🇨🇳

🎉🎉🎉Congratulation Dr Nan on passing your viva!!! 🎉🎉🎉 Thanks Emily and Martin for examining

Our review is featured on the cover!!!!

Cancers Cancers, an international, peer-reviewed Open Access journal.

"Success is failure turned inside out" - Don't quit, Edgar Guest

Latest review from the lab is here!!! Great job by Bian Yanes!!!!

The Interplay between Cell-Extracellular Matrix Interaction and Mitochondria Dynamics in Cancer The tumor microenvironment, in particular the extracellular matrix (ECM), plays a pivotal role in controlling tumor initiation and progression. In particular, the interaction between cancer cells and the ECM promotes cancer cell growth and invasion, leading to the formation of distant metastasis. Al...

📢📢📢 Review accepted!!!! Stain tuned! Great job Bian! 🎉🎉🎉

We are now in instagram!!! Follow us at ERainero_lab! You can see all the exciting things going on in our lab

Lab-inspired cookies for today's lab meeting! Great effort by Rachele & Shahd

A novel live-cell imaging assay reveals regulation of endosome maturation A novel, inexpensive, easy-to-use method to analyse traffic along the endosomal pathway in mammalian cells shows that there is coordination between Rab conversion and acidification, but almost none between Rab conversion and recycling.

This digital-hygiene routine will protect your scholarship Simple, regular checks could squelch some pernicious practices by unscrupulous publishers and preserve your digital presence.

This marks the beginning of the wall of fame in my office: 1st PhD thesis by Mona, written in her native language 🇮🇷

"I believe in the potential of young scientists, I believe they deserve the best possible introduction to bench science, I believe they benefit enormously from close interaction with experienced scientists, and I believe this is something I can do to make a difference"
https://totalinternalreflectionblog.com/2021/10/07/mentoring-the-next-generation/

Mentoring the next generation My lab might be closing soon because of insufficient research productivity. Is it really because I supervised too many undergraduate students? And if so, should I regret it?

First pre-print from the lab is now online!!!! Great work primarily led by Mona, together with Bian and Montse. Funded by Cancer Research UK

The extracellular matrix promotes breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism Breast cancer tumours are embedded in a collagen I rich extracellular matrix (ECM) network where nutrients are scarce due to limited blood flow and elevated tumour growth. Metabolic adaptation is required for breast cancer cells to endure these conditions. Here, we demonstrated that the presence of....