The Bottom Line
Summary and Critique of the landmark papers in Critical Care
@WICSBottomLine Welcome to The Bottom Line (TBL). We hope you enjoy!
This site has been built to create a compendium of all the landmark papers which are shaping the way we manage our critically ill patients. Each paper has been summarised and critiqued using a standard template and ends with a 'bottom line' paragraph to allow a quick reminder of the key points. The papers are reviewed and cross checked by the editorial group. We take this seriously and spend time
06/11/2023
442 STRESS-L: Landiolol and Organ Failure in Patients With Septic Shock
Article by
Review by
https://www.thebottomline.org.uk/summaries/stress-l/
24/10/2023
441: UK-REBOA - Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage
https://www.thebottomline.org.uk/summaries/icm/emergency-department-resuscitative-endovascular-balloon-occlusion-of-the-aorta-in-trauma-patients-with-exsanguinating-hemorrhage/
Article by
Review by
19/10/2023
440: CRYOSTAT-2 - Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury
https://www.thebottomline.org.uk/summaries/early-and-empirical-high-dose-cryoprecipitate-for-hemorrhage-after-traumatic-injury/
Article by
Review by
11/10/2023
439: ECLS-SHOCK - Extracorporeal Life Support in Infarct-Related Cardiogenic Shock
https://www.thebottomline.org.uk/summaries/ecls-shock/
Article by
Review by
22/09/2023
438: ARREST - Expedited transfer to a cardiac arrest centre for non-ST-elevation out-of-hospital cardiac arrest
https://www.thebottomline.org.uk/summaries/arrest-2/
Article by
Review by Achilleos
12/08/2023
Mini: ADVOR: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload
https://www.thebottomline.org.uk/summaries/tbl-mini-advor/
Article by
Review by
28/07/2023
437: PACER - Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia
https://www.thebottomline.org.uk/blog/ebm/platelet-transfusion-before-cvc-placement-in-patients-with-thrombocytopenia/
Article by van Baarle
Review by Ryo Ueno
02/07/2023
436: DEVICE - Video versus Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults
https://www.thebottomline.org.uk/summaries/device/
Article by Prekker
Review by
20/06/2023
435
PATCH - Prehospital Tranexamic Acid for Severe Trauma
https://www.thebottomline.org.uk/summaries/icm/patch-2/
Article by Review
20/06/2023
434
TAME - Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest
https://www.thebottomline.org.uk/blog/ebm/tame/
Article by Eastwood Review
24/04/2023
433: AID-ICU - Haloperidol for the Treatment of Delirium
Article by
review by
https://www.thebottomline.org.uk/summaries/aid-icu/
27/02/2023
431 INCEPTION - Early Extracorporeal CPR for Refractory Out-Of-Hospital Cardiac Arrest
https://www.thebottomline.org.uk/summaries/inception/
Article by Suverein
Review by
27/02/2023
430: EFFORT - Higher vs Lower Protein in Critically Ill Patients With High Nutritional Risk
https://www.thebottomline.org.uk/summaries/icm/effort/
Article by
Review by Achilleos
27/02/2023
429: ECMO-CS - Extracorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock
https://www.thebottomline.org.uk/summaries/ecmo-cs/
Article by Ostadal
Review by Brown
23/01/2023
427: PREPARE II - Effect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation
https://www.thebottomline.org.uk/uncategorized/prepare-ii/
Article by
Review by
13/01/2023
426: Pro-MEDIC - Prophylactic melatonin for delirium in intensive care - A randomized controlled trial
https://www.thebottomline.org.uk/summaries/icm/pro-medic/
Article by Wibrow
Review by
10/12/2022
425: TEAM Trial - Early Active Mobilization during Mechanical
Ventilation in the ICU
thebottomline.org.uk/summaries/team/
Article by
Review by
03/12/2022
424: PILOT trial - Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation
https://www.thebottomline.org.uk/summaries/icm/pilot-draft/
Article by Semler
Review by
15/11/2022
Mini 423: Operative vs Nonoperative Treatment of Acute Unstable Chest Wall Injuries: A Randomised Clinical Trial
https://www.thebottomline.org.uk/summaries/tbl-mini-rib-fixation/
Article by Niloofar Dehghan
Review by
10/11/2022
421: DOSEVF - Double Sequential External Defibrillation or Vector-change Defibrillation vs. Standard Defibrillation for Refractory VF
https://www.thebottomline.org.uk/summaries/dosevf/
Article by
Review by
08/11/2022
420: Oxygen Targets in Comatose Survivors of Cardiac Arrest
https://www.thebottomline.org.uk/summaries/box-oxygen/
Article by Henrik Schmidt
Review by
15/10/2022
419: Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest
https://www.thebottomline.org.uk/summaries/box-trial-bloodpressure/
Article by Kjaergaard
Review by Brown
20/08/2022
417: LOVIT - Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit
https://www.thebottomline.org.uk/summaries/lovit-trial/
Article by
Review by
20/08/2022
416: CandiSep - (1 → 3)-β-D-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial
https://www.thebottomline.org.uk/summaries/candisep/
Article by Bloos
Review by
16/07/2022
415: Early vs Late Supplemental Parenteral Nutrition in Patients Undergoing Abdominal Surgery
https://www.thebottomline.org.uk/summaries/supplemental-parental-nutrition-and-abdominal-surgery/
Article by Gao
Review by: