Mouth Cancer Surgeon
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What are some known risk factors of oral cancer?
Human Papillomavirus (HPV)
◉ The human papillomavirus (HPV) is a family of viruses that are known to cause cancer of the mouth, throat and cervix. Especially HPV type 16,18 are associated with oral and oropharyngeal cancers.
◉ They cause cancer by binding to tumour suppressor genes and stopping the activity leading to uncontrolled proliferation of cells.
◉ HPV-associated cancer patients are usually young with no history of to***co use.
◉ They have a better prognosis when compared to to***co-related cancers.
What are some known risk factors of oral cancer?
◉Alcohol is recognized as an independent risk factor for oral cancer. The chances of oral cancer increase when alcohol is taken in combination with to***co as it increases the absorption of carcinogens.
◉The other constituents of alcohol can have carcinogenic potential.
◉Immunity is reduced in chronic alcoholics.
◉Metabolism is deranged due to liver damage in chronic alcoholics, which can result in nutritional deficiency.
What are some known risk factors of oral cancer?
◉ The risk for oral cancer increases with an increase in the frequency of smoking.
◉ Black or air-cured to***co is commonly used in pipe smoking and ci**rs. Black to***co is more carcinogenic and has three times more risk of oral cancer when compared to blond to***co.
◉ Smoking cessation reduces the risk of oral cancer, but it is never reduced to the baseline level of never smokers.
What are the some known risk factors of oral cancer?
1. To***co chewing
> In India, to***co is usually consumed in the smokeless/chewing form as a part of betel, quid, gutka, zarda, mawa, khaini etc.
> About 30 carcinogens are present in to***co.
> The most common of these are polycyclic aromatic hydrocarbons and nitrosamines etc.
> There is a strong association between the site of placement of smokeless to***co and the site of oral cancer.
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