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Cannabis contains a variety of alkaloids, but the most well-known and studied are the cannabinoids. Let's break this down:

1. **Major Cannabinoids**:
- **THC (Tetrahydrocannabinol)**: Known for its psychoactive effects, it also possesses analgesic (pain-relieving), antiemetic (anti-vomiting), and appetite-stimulating properties.
- **CBD (Cannabidiol)**: Non-psychoactive and has gained attention for its potential therapeutic benefits, including anti-inflammatory, anti-anxiety, and neuroprotective properties.
- **CBG (Cannabigerol)**: Considered a minor cannabinoid, it has potential anti-inflammatory, anti-bacterial, and neuroprotective effects.

2. **Terpenes and Flavonoids**: While not alkaloids, these compounds contribute to the overall therapeutic profile of cannabis. Terpenes, especially, can work synergistically with cannabinoids in what's known as the entourage effect, enhancing therapeutic benefits.

3. **Holistic Medicinal Benefits**:
- **Pain Management**: THC and CBD have shown efficacy in managing both chronic and acute pain, offering a potential alternative to opioids.
- **Neurological Disorders**: CBD has shown promise in treating conditions like epilepsy, with the FDA approving a CBD-based drug for certain types of epilepsy.
- **Mental Health**: CBD has potential anxiolytic (anxiety-reducing) effects, and preliminary studies suggest it might be beneficial for conditions like PTSD and anxiety disorders.
- **Inflammation**: Both THC and CBD exhibit anti-inflammatory properties, which can benefit conditions like arthritis.
- **Cancer**: While research is in early stages, some studies suggest cannabinoids may have anti-cancer properties, though more research is needed.

A holistic approach to cannabis recognizes the plant's complex chemistry and the synergistic interactions between its various compounds. This means considering the whole plant extract (full-spectrum) rather than isolated compounds, as the combination might offer enhanced therapeutic effects with fewer side effects. However, it's essential to note that while cannabis has potential medicinal benefits, it's crucial to consult with healthcare professionals and be aware of local regulations and laws.

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Something that must also be taken into consideration when talking about getting real bang for your buck is bioavailability. Bioavailability is, simply put, how effectively CBD is absorbed into your body and the strength of the compound, when it reaches the site of physiological activity.

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