Zivak Technologies

Maple Syrup Urine Disease
Maple syrup urine disease (MSUD) is a rare but serious inherited condition. It means the body cannot process certain amino acids, causing a harmful build-up of substances in the blood and urine.
Normally, our bodies break down protein foods such as meat and fish into amino acids. Any amino acids that are not needed are usually broken down and removed from the body.
Babies with MSUD are unable to break down amino acids called leucine, isoleucine and valine. Very high levels of these amino acids are harmful.
One of the characteristic symptoms of MSUD is sweet-smelling urine, which gives the condition its name.
Symptoms of MSUD usually appear within the first few days of weeks after birth. More general symptoms include:
sweet-smelling urine and sweat
poor feeding or loss of appetite
weight loss
Children diagnosed with MSUD are first referred to a specialist metabolic dietition and given a low-protein diet. The diet is tailored to reduce the amount of amino acids received, especially leucine, valine, and isoleucine.
High-protein foods need to be limited,including:
Meat
Fish
Cheese
Eggs
Pulses
Nuts
You can learn the amount of leucine, valine and isoleucine level with the Zivak Amino acid kit, by LC-MS/MS.
For detailed information www.zivak.com

Vanillylmandelic Acid (VMA)
Vanillylmandelic acid (VMA) is one of the breakdown products of epinephrine and norepinephrine. Epinephrine and norepinephrine belong to a group of similar hormones called catecholamines.
This test measures the amount of VMA that is passed into the urine, typically over a 24-hour period, to detect excess epinephrine and norepinephrine. It is used to detect tumors called neuroblastomas and other neuroendocrine tumors.
The hormone releases can cause illness and signs and symptoms, such as persistent hypertension, severe headaches, palpitations, sweating, nausea, anxiety and tingling in the extremities.
Reference Values

Benzoic Acid
Benzoic acid was one of the compounds first found to be elevated in urine from patients with intestinal bacterial overgrowth of various origins.
Many people with intestinal bacterial overgrowth resulting from cystic fibrosis, unclassified enteritis, celiac disease or short bowel syndrome have elevated benzoic acid along with varying degrees of elevated phenylacetate, p-hydroxybenzoate and p-hydroxyphenylacetate.
What does it mean if your benzoic acid result is too high?
Elevated benzoic acid is a confirmatory marker for inadequacy of glycine or pantothenic acid for conjugation reactions.
Abnormalities of urinary benzoic acid may reveal clinically significant detoxification or dysbiosis.
The urine level of benzoic acid optimal results is 0-0.05 mmol/mol creatinine.
You can learn the amount of benzoic acid level with the Zivak Gut Microbiota Dysbiosis Marker kit, by LC-MS/MS.

For detailed information www.zivak.com

Organic acids occur as physiologic intermediates in a variety of metabolic pathways. Organic acidurias are a group of disorders an which one or more of these pathways are blocked, resulting in a deficiency of normal products and an abnormal accumulation of intermediate metabolites in the body. These excess metabolites are excreted in the urine.
Organic acidurias typically present with either an acute life-threatening ilness in early infancy or unexplained developmental delay with intercurrent episodes of metabolic decompensations in later childhood. A situation of severe and persistent metabolic acidosis of unexplained origin, elevated anion gap and severe neurologic manifestations, such as seizures, should be considered strong diagnostic indicators of one of these diseases.
Organic acidurias typically present with either an acute life-threatening ilness in early infancy or unexplained developmental delay with intercurrent episodes of metabolic decompensations in later childhood. A situation of severe and persistent metabolic acidosis of unexplained origin, elevated anion gap and severe neurologic manifestations, such as seizures, should be considered strong diagnostic indicators of one of these diseases.

Vitamin E
Vitamin E is a fat soluable vitamin with several forms, but alpha-tocopherol is the only one used by the human body. Its main role is to act as an antioxidant, scavenging loose elecktrons that can damage cells. It also enhances immune function and prevents clots from forming in heart arteries.
Vitamin E has the ability to protect cells from free radical damage as well as reduce the production of free radicals in certain situations.
People who have digestive disorders or do not absorb fat properly can develop a vitamin E deficiency. The following are common signs of a deficiency:
*Retinopathy
*Peripheral neuropathy
*Ataxia
*Decreased immune function
The serum level of Vitamin E optimal results is 7-25 mg/L. You can learn the amount of Vitamin E level with the Zivak ADE kit, by APCI LC-MS/MS.
For detailed information www.zivak.com

Arginine is a conditionally essential amino acid that is critical for your cardiovascular health and detoxification functions. The amino acid, arginine, is used to make the powerful blood vessel regulator,nitric oxide.
Nitric oxide acts to lower blood pressure.
Too little arginine can lead to high blood pressure. Too much arginine can lead to increased aging from oxidative damage.
Arginine is measured in serum and markers of arginine insufficiency are measured in urine.
The essential amino acid lysine needs to be present in amounts balanced with arginine to ensure healthy immune system functions.
High levels are often associated with a functional block in the urea cycle. Low arginine is associated with elevated ammonia.
The serum level of arginine is 29-137 µmol/L.
You can learn the amount of arginine with Zivak Amino Acid kit, by LC-MS/MS analysis.
For detailed information www.zivak.com

Orotic Acid

Elevations are most commonly associated with ammonia toxicity. Elevated ammonia may result from drug toxicity to the liver, viral liver infection, gastrointestinal bleeding, or inborn errors of ammonia metabolism. Confirmation of a genetic disorder requires testing plasma amino acids.
Orotic acid is classified as a pyrimidinemonocarboxylic acid. Orotic acid is broadly classified as an organic acid. Abnormally high levels of organic acids in the blood (organic acidemia),urine(organic aciduria)the brain and other tissues lead to general metabolic acidosis. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis, the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone and lack of energy. These can progress to heart abnormalities, seizures, coma and possibly death. Many affected children with organic acidemias experience intellectual disability or delayed development. In adult’s acidosis or aciddemia is characterized by headaches, confusion feeling tired, tremors, sleepiness and seizures.
The urine level of Orotic acid is 0.26-3.20 µmol/mmol creatinine. You can learn the amount of Orotic Acid with the Zivak Organic Acid kit, by LC-MS/MS analysis.









Orotic Acid

Elevations are most commonly associated with ammonia toxicity. Elevated ammonia may result from drug toxicity to the liver, viral liver infection, gastrointestinal bleeding, or inborn errors of ammonia metabolism. Confirmation of a genetic disorder requires testing plasma amino acids.
Orotic acid is classified as a pyrimidinemonocarboxylic acid. Orotic acid is broadly classified as an organic acid. Abnormally high levels of organic acids in the blood (organic acidemia),urine(organic aciduria)the brain and other tissues lead to general metabolic acidosis. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis, the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone and lack of energy. These can progress to heart abnormalities, seizures, coma and possibly death. Many affected children with organic acidemias experience intellectual disability or delayed development. In adult’s acidosis or aciddemia is characterized by headaches, confusion feeling tired, tremors, sleepiness and seizures.
The urine level of Orotic acid is 0.26-3.20 µmol/mmol creatinine. You can learn the amount of Orotic Acid with the Zivak Organic Acid kit, by LC-MS/MS analysis.









Orotic Acid

Elevations are most commonly associated with ammonia toxicity. Elevated ammonia may result from drug toxicity to the liver, viral liver infection, gastrointestinal bleeding, or inborn errors of ammonia metabolism. Confirmation of a genetic disorder requires testing plasma amino acids.
Orotic acid is classified as a pyrimidinemonocarboxylic acid. Orotic acid is broadly classified as an organic acid. Abnormally high levels of organic acids in the blood (organic acidemia),urine(organic aciduria)the brain and other tissues lead to general metabolic acidosis. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis, the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone and lack of energy. These can progress to heart abnormalities, seizures, coma and possibly death. Many affected children with organic acidemias experience intellectual disability or delayed development. In adult’s acidosis or aciddemia is characterized by headaches, confusion feeling tired, tremors, sleepiness and seizures.
The urine level of Orotic acid is 0.26-3.20 µmol/mmol creatinine. You can learn the amount of Orotic Acid with the Zivak Organic Acid kit, by LC-MS/MS analysis.









Orotic Acid

Elevations are most commonly associated with ammonia toxicity. Elevated ammonia may result from drug toxicity to the liver, viral liver infection, gastrointestinal bleeding, or inborn errors of ammonia metabolism. Confirmation of a genetic disorder requires testing plasma amino acids.
Orotic acid is classified as a pyrimidinemonocarboxylic acid. Orotic acid is broadly classified as an organic acid. Abnormally high levels of organic acids in the blood (organic acidemia),urine(organic aciduria)the brain and other tissues lead to general metabolic acidosis. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis, the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone and lack of energy. These can progress to heart abnormalities, seizures, coma and possibly death. Many affected children with organic acidemias experience intellectual disability or delayed development. In adult’s acidosis or aciddemia is characterized by headaches, confusion feeling tired, tremors, sleepiness and seizures.
The urine level of Orotic acid is 0.26-3.20 µmol/mmol creatinine. You can learn the amount of Orotic Acid with the Zivak Organic Acid kit, by LC-MS/MS analysis.

Vitamin D is both a nutrient we eat and a hormone our bodies make. It is a fat-soluble vitamin that help the body absorb and retain calcium and phosphorus; both are critical for building bone. Laboratory studies show that vitamin D can reduce cancer cell growth, help control infections and reduce inflammation. D2 is produced in plants and fungi and D3 in animals, including humans. Vitamin D production in the skin is the primary natural source of vitamin D, but many people have insufficient levels because they live in places where sunlight is limited in winter, or because they have limited sun exposure due to being inside much of the time. People with darker skin tend to have lower blood levels of vitamin D because the pigment (melanin) acts like a shade, reducing production of vitamin D.
Vitamin D Reference Values
80 ng/mL: Toxicity Possible

For detailed information www.zivak.com

Serotonin (5-hydroxytryptamine, 5-HT)
Symptoms of low serotonin levels:
– Depression / Low mood
– Anxiety
– Sleep difficulties
– Uncontrolled appetite / Carbohydrate cravings
– Headaches
– Hot flashes
– Constipation

Vitamin A (Retinol) , also called retinol. In addition to helping the eyes adjust to light changes, vitamin A plays an important role in bone growth, tooth development, reproduction, cell division, gene expression, and regulation of the immune system. The skin, eyes, and mucous membranes of the mouth, nose, throat and lungs depend on vitamin A to remain moist. Vitamin A is also an important antioxidant that may play a role in the prevention of certain cancers.
Vitamin A deficiency is when your body lacks the amount of vitamin A it needs to function properly. Vitamin A deficiency can cause vision loss and blindness. It can also lead to complications with your skin, heart, lungs, tissues and immune system.
Vitamin A deficiency can lead to many complications, including:
• Eye problems: Vitamin A is a key factor in many functions of your eyes. Vision loss and blindness can occur.
• Skin issues: A lack of vitamin A can cause dry, scaly and/or itchy skin.
• Infertility: Vitamin A plays an important role in your reproductive system. Vitamin A deficiency can lead to trouble conceiving and infertility.
• Growth issues: Vitamin A deficiency can cause delayed growth and development in children.
• Respiratory tract infections: Vitamin A deficiency can cause problems with your immune system. This can lead to infections in your chest and throat.
You can learn the amount of Vitamin A level with the Zivak ADE APCI LC-MS/MS Analysis Kit. For detailed information www.zivak.com

You can learn the amount of Furan-2,5-dicarboxylic Acid and Furancarbonylglycine with the Zivak Gut Microbiota Dysbiosis Marker kit, by LC-MS/MS analysis.
Inflammatory Bowel Disease (IBD)
Obesity
Type 1 and Type 2 Diabetes
Autism
Irritable Bowel Syndrome (IBS)
Gastrointestinal Cancer

Kynurenic Acid (KYNA) and Quinolinic Acid (QUIN) (2,3-pyridinedicaroxylic acid)
Kynurenic acid levels are also important as a biomarker of chronic infection in the body. Increased kynurenic acid levels have been associated with Alzheimer's, Parkinson's and Huntington's diseases. The normal level of kynurenic acid is 0- 7.1 mmol/mol creatine. Read More https://www.zivak.com/academic-papers

The Organic Acids Test Assists in Evaluating :

Krebs Cycle Abnormalities , Neurotransmitter Levels ,Nutritional Deficiencies, Antioxidant Deficiencies and More !

Zivak Organic Acids Kit quantifies 73 markers in human urine

Is the little brain in the gut tells us everything of body ? Zivak Gut Microbiota Dysbiosis Kit quantifies 26 markers in human urine.

Gut Microbiota Dysbiosis Markers Urine LC-MS/MS kit was developed for quantitative detection of the 26 organic acids in human urine samples. LC-MS/MS is influential device for the study of metabolic disorders and LC-MS/MS analysis gives results in 20 minutes with minimal sample preparation

Thanks to you for the Germany Great
Organic Acids Kit Sales in May .

New Hemoglobin Variants HPLC kit gives results for F, A0, A2, S, and C in 4 minute.