Pyxis Laboratories, Inc

Don't forget that alcohol is the most prevalent drug of abuse in the US.

The rate of alcohol-related deaths in the U.S. rose 30% in the first year of COVID Two reports from the CDC provided details on which groups have the highest death rates and which states are seeing the largest numbers.

NEW PRODUCT: Pyxis now offers Estradiol-6-BSA antigen conjugate. For more information about estradiol, please read our latest blog, Estradiol, the Everything Estrogen:

Estradiol, the Everything Estrogen - Pyxis Labs Estradiol is an estrogen steroid hormone found in most vertebrates, crustaceans, and insects. While there are several different hormones in the estrogen category, estradiol is the most prevalent and powerful. In humans, it is produced especially in females’ ovarian follicles as well as in testicle...

https://www.cnn.com/2021/11/17/health/drug-overdose-deaths-record-high/index.html

Drug overdose deaths top 100,000 annually for the first time, driven by fentanyl, CDC data show America's drug epidemic is the deadliest it has ever been, new federal data suggests.

https://www.latimes.com/california/story/2021-11-10/prosecutors-want-to-charge-fentanyl-drug-dealers-with-murder

Prosecutors want to charge fentanyl drug dealers with murder, sparking legal battle Some prosecutors are pursuing murder charges for dealers linked to fentanyl deaths. But a public defender said such moves are outside the scope of the law.

https://www.usatoday.com/story/news/health/2021/10/23/fentanyl-epidemic-deaths-overdose-symptoms-dangers/8256591002/

Why is fentanyl so dangerous? The illicit drug has ruined lives during COVID pandemic Overdose deaths tied to fentanyl have increased in the last five years and since the COVID-19 pandemic. Here's why the drug is so dangerous.

https://www.cnn.com/2021/10/25/health/ma*****na-teen-va**ng-wellness/index.html

Va**ng ma*****na by teens doubles in last seven years, study says Ma*****na va**ng by teens rose 7-fold in a mere 7 years, with potentially harmful consequences to adolescent health, a new study found.

https://www.news-medical.net/news/20211021/Study-highlights-major-role-of-polysubstance-use-in-drug-overdose.aspx

Study highlights major role of polysubstance use in drug overdose risk Even as the opioid epidemic dominated national attention over the past decade, the rate of overdose deaths involving co***ne, m**hamphetamine and other stimulants tripled, a new study in veterans suggests.

https://www.biorxiv.org/content/10.1101/2021.07.31.454575v2.full

Environmental enrichment mitigates the long-lasting sequelae of perinatal fentanyl exposure The opioid epidemic is a rapidly evolving societal issue that stems from the use of prescription and illicit opioids, including increasing use of synthetic opioids like fentanyl. Fentanyl use among women has increased substantially in the last decade, leading to a 40-fold increase in the number of p...

https://ktla.com/news/california/california-ends-mandatory-minimum-drug-sentences-under-bill-signed-by-gov-newsom/

California ends mandatory minimum drug sentence rules under bill signed by Gov. Newsom California Gov. Gavin Newsom ended mandatory minimum sentences for nonviolent drug crimes in the nation’s most populous state on Tuesday, giving judges more discretion to impose alternative s…

https://www.rheumatologyadvisor.com/home/topics/pain-management/utility-of-urine-drug-tests-to-monitor-prescription-misuse-in-chronic-pain/

Urine Drug Tests Provide Actionable Data for Identifying Opioid Prescription Misuse in Chronic Pain The utility of urine drug tests for identifying potential opioid prescription misuse was examined in this study.

https://www.drugtargetreview.com/news/98076/statistical-model-defines-how-ketamine-anaesthesia-affects-the-brain/

Statistical model defines how ketamine anaesthesia affects the brain MIT study uses first statistical model to finely characterise how ketamine anaesthesia affects the brain, possibly improving patient outcomes.

https://www.psypost.org/2021/10/mdma-assisted-psychotherapy-associated-with-sleep-improvements-among-ptsd-patients-61819

MDMA-assisted psychotherapy associated with sleep improvements among PTSD patients MDMA-assisted psychotherapy might help improve sleep in patients suffering from post-traumatic stress disorder, according to a secondary analysis of data ...

https://www.cbc.ca/news/canada/montreal/recall-notice-for-prescription-drug-1.6206443

Quebec company issues recall for prescription drug due to packaging error | CBC News Laboratoire Riva Inc. is recalling one lot of Riva-Risperidone 0.25 mg tablets. According to a Health Canada release, some bottles may incorrectly contain only Riva-Gabapentin 100 mg capsules, which is a different prescription drug.

Study: Domain-selective BET inhibition attenuates transcriptional and behavioral responses to co***ne

Domain-selective BET inhibition attenuates transcriptional and behavioral responses to co***ne Epigenetic pharmacotherapies have emerged as a promising treatment option for substance use disorder (SUD) due to their ability to reverse maladaptive transcriptional and behavioral responses to drugs of abuse. In particular, inhibitors of bromodomain and extra terminal domain (BET) reader proteins....

https://www.npr.org/2021/10/06/1043686720/americas-other-drug-crisis-new-efforts-to-fight-a-surge-in-m**h

America's Other Drug Crisis: New Efforts To Fight A Surge In M**h : Consider This from NPR M**h-related overdoses have tripled in recent years. In the west, 70 percent of police departments identify m**h as their biggest problem. Now one state — California — is on the brink of implementing a major new treatment program that would pay drug users to stay clean. KQED's April Dembosky rep...

https://www.rollcall.com/2021/09/30/house-committee-advances-bill-to-legalize-ma*****na/

House committee advances bill to legalize ma*****na - Roll Call Republicans Matt Gaetz of Florida and Tom McClintock of California joined House Judiciary Democrats to advance the ma*****na bill.

https://www.news-medical.net/news/20210929/Ketamine-use-on-patients-with-excited-delirium-and-co***ne-intoxication-increases-intubation-rate.aspx

Ketamine use on patients with excited delirium and co***ne intoxication increases intubation rate Patients with excited delirium who are combative, aggressive or agitated before being transported to the hospital or in an emergency department setting require immediate treatment for their safety and others.

https://www.npr.org/2021/10/04/1041979845/a-landmark-opioid-trial-puts-spotlight-on-pharmacy-chains-cvs-walmart-and-walgre

A landmark opioid trial puts spotlight on pharmacy chains CVS, Walmart and Walgreens The country's biggest name-brand pharmacy chains face a high-profile civil trial beginning Monday in Cleveland, Ohio over their role in the nation's deadly opioid epidemic.

https://www.npr.org/2021/09/27/1040899776/dea-public-safety-alert-fake-prescription-drugs-fentanyl

The DEA Is Warning Of A Rise In Overdose Deaths From Fake Drugs Laced With Fentanyl In its first public safety alert in six years, the Drug Enforcement Administration says many counterfeit prescription drugs sold online contain a potentially lethal dose of the opioid.

Study suggests legalization of ma*****na does not result in dramatic usage increase among teens.

Ma*****na use did not climb following legalization in states: Study Ma*****na use may be more legal across the country, but that hasn't led to a rise in pot users, a study found.

California takes unique approach to treat m**h addiction: cash.

To Combat M**h, California Will Try A Bold Treatment: Pay Drug Users To Stop Using Fatal drug overdoses, including from m**h, have soared. California is preparing to roll out a controversial but proven treatment that involves paying stimulant users small sums of money not to use.

US House of Representatives passes bill to eliminate crack vs. powder co***ne sentencing disparities.

U.S. House passes bill to end disparities in crack co***ne sentences The U.S. House of Representatives on Tuesday overwhelmingly passed a bill to permanently end the sentencing disparities between crack co***ne and powder, a policy that has led to the disproportionate incarceration of African Americans.

https://www.reuters.com/legal/litigation/controlling-cannabis-classification-delta-8-thc-2021-09-22/

Controlling cannabis and the classification of Delta-8 THC Alex Malyshev and Sarah Ganley of Carter Ledyard & Milburn LLP discuss differing industry and government views and approaches to classifying a less-concentrated cannabis product known as Delta-8 THC.

Study of raw domestic wastewater reveals M**hamphetamine abuse consumption of 65mg/day per 1000 residents of rural south China region studied:

Occurrence, mass loads, and ecological risks of amphetamine-like substances in a rural area of South China The occurrence and levels of amphetamine like substances (ALSs) in various environments, as a group of illicit psychoactive substances, have attracted…

"The finding that endocannabinoids underlie the synaptic actions of amphetamine may open a new avenue for the treatment of psychostimulants addiction." STUDY:

www.jneurosci.org

Univ. of Minnesota enters trials of opioid vaccine:

U of M leads groundbreaking clinical trial of opioid vaccine Research underway at the University of Minnesota has the potential to change the way substance use disorder is treated.

A bill was introduced to restrict police use of ketamine to sedate agitated suspects.
https://kdvr.com/news/problem-solvers/ketamine-bill-introduced-at-federal-level-two-years-after-death-of-elijah-mcclain/

Ketamine bill introduced at federal level, 2 years after Elijah McClain’s death Congressman Joe Neguse introduced a federal bill on Monday that would restrict the use of ketamine to sedate people who are involved police incidents.

Interesting possible link between Vitamin D and opioid addiction susceptibility:
https://www.consumeraffairs.com/news/lack-of-vitamin-d-may-increase-risk-of-opioid-addiction-study-finds-061421.html

Lack of vitamin D may increase risk of opioid addiction, study finds A new study conducted by researchers from Massachusetts General Hospital explored how low levels of vitamin D can impact consumers’ addiction behaviors.

U.S. Navy resumes drug testing as COVID restrictions wane. https://www.military.com/daily-news/2021/06/01/navy-restarts-regular-pee-tests-pandemic-winds-down.html

Navy Restarts Regular P*e Tests as Pandemic Winds Down The service canceled a March 27, 2020, order that gave commanders leeway in conducting drug tests.

https://www.nytimes.com/2021/05/31/us/guernsey-wyoming-police-chief.html

How a Police Chief in Wyoming’s Ranchlands Lost Her War on Drugs A campaign over m**h, money and accountability cost law enforcement officers in Guernsey, Wyo., their jobs. Now their lawsuits are prying open the town’s secrets.