Journal of Stem Cells and Regenerative Therapy - JSCRT

Stem cells transformed into brain cells to treat 's
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Animal study raises the prospect of using freshly grown dopamine-producing cells to treat people with Parkinson's

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Stem cells transformed into brain cells to treat Parkinson's disease Animal study raises the prospect of using freshly grown dopamine-producing cells to treat people with Parkinson's

Modern Alchemy: Cellular and
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The early conversion of a terminally differentiated somatic cell nucleus to totipotency by nuclear transfer and the consequent development of a whole organism pioneered the field of cellular reprogramming. Since then, several studies have demonstrated that the forced expression of lineage-specific transcription factors in adult cell types can convert cell fate from one lineage to another. The consequent breakthrough of generating induced pluripotent stem cells by reprogramming adult fibroblasts to pluripotency using the transduction of the Yamanaka factors (Oct4, Sox2, Klf4 and c-Myc), opened new horizons in the fields of regenerative and personalized medicine. But the problems of reprogramming efficiency and tumor formation associated with iPSCs called for the development of other reprogramming techniques such as direct reprogramming both in vitro and in vivo. Direct cellular reprogramming in vivo, also known as in situ Transdifferentiation, is a new method to alter cell fate within the tissue that requires replacement or repair. This can be time and cost effective and may overcome some of the disadvantages associated with other methods of cellular reprogramming. In this article, we review the history of cellular reprogramming, highlighting the recent development of in situ transdifferentiation.

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Modern Alchemy: Cellular Reprogramming and Transdifferentiation

Singapore scientists identify new method of tackling treatment-resistant
Read more at https://www.channelnewsasia.com/news/singapore/new-cancer-treatment-study-astar-gis-scientists-singapore-10972036

Singapore scientists identify new method of tackling treatment-resistant cancer SINGAPORE: A new approach to cancer treatment identified by a team in Singapore has left its scientists optimistic about tackling ...

Recent Advancements in Stem Cell Treatments
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Stem cells are undifferentiated cells with a high degree of self-renewal, that can differentiate into many different specialized cell types. Stem cells can be manipulated to provide treatment for illness and disease.
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Recent Advancements in Stem Cell Treatments Stem cells are undifferentiated cells with a high degree of self-renewal, that can differentiate into many different specialized cell types. Stem cells can be manipulated to provide treatment for illness and disease.

Process in which one stem cell develops into two differentiated daughter cells, another stem cell undergoes mitosis and produces two identical stem cells is called ?
A. stochastic differentiation
B. asymmetric replication
C. potency
D. self-renewal

First UK patient receives stem cell treatment to cure loss of vision
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Experimental transplant uses eye cells grown in a lab and if successful could be used to treat hundreds of thousands of macular degeneration sufferers in UK

First UK patient receives stem cell treatment to cure loss of vision Experimental transplant uses eye cells grown in a lab and if successful could be used to treat hundreds of thousands of macular degeneration sufferers in UK

Stem cell therapy gives hope to MS patients

Stem cell therapy gives hope to MS patients High-risk transplant treatment which ‘reboots immune system’ allows some with multiple sclerosis to recover mobility

'Beating Heart' Patch Offers New Hope for Desperately Ill Patients

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‘Beating Heart’ patch offers new hope for desperately ill patients Researchers are using stem cells to fabricate tiny patches they hope will be able to restore function to damaged cardiac tissue.

Mouse study reveals how chronic stress promotes , identifies as effective therapy

Mouse study reveals how chronic stress promotes breast cancer stem cells, identifies vitamin C as effective therapy Cancer: The word alone evokes dread, anxiety, and fear. Accordingly, many women living with the disease and undergoing treatment experience chronic stress and depression. Scientists have demonstrated, in studies with rodents and humans, that stress can exacerbate cancer's progression, but it wasn't....

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Women left blind by unregulated stem cell treatments in Florida Three elderly women got suckered into paying for unproven “stem cell” eye treatments at a Florida clinic and went virtually blind.

shots linked to outbreak of

Stem cell shots linked to outbreak of bacterial infection At least 12 patients in Florida, Texas and Arizona became infected after getting injections, the Centers for Disease Control and Prevention said.

Macular degeneration is a leading cause of blindness in seniors world wide. Up to know the disease has been incurable and the only treatment is injections to slow the progress of the disease. If a safe and reliable stem cell procedure could be discovered to halt or reverse the damage from this condition it would improve the quality of life for millions of people.

Stem Cells to Treat Visual Impairments in Elderly A team of US scientists will kick off later this year clinical trials to treat visual impairments in the elderly, caused by macular degeneration, a common disorder that usually affects people after 65. Using stem cells, the team from the National Eye

: The Next for

Stem Cells: The Next Battleground for Leukemia Treatment By targeting acute myeloid leukemia stem cells that remain after chemotherapy, researchers can greatly reduce the risk of relapse.

Therapy a Possible for

Stem Cell Therapy a Possible Treatment for Rheumatoid Arthritis As the world of stem cell research advances, more options may become available to patients with RA and other autoimmune diseases.

Hundreds of Clinics Offer Often Unproven Stem Cell Treatments
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Stem cells — they work almost like magic, generating new tissue, secreting mysterious “factors” that cause other cells to regenerate, replacing cancer-ridden bone marrow and performing other miracles.

Little wonder, then, that clinics offering treatments using these cells are popping up all over the place.

A new study published Thursday finds hundreds of clinics advertising often unproved stem cell treatments for serious diseases such as muscular dystrophy, for autism and for cosmetic procedures such as face lifts and breast enlargements.

Although they don’t accuse any of them of committing fraud, the researchers say they worry at least some of the clinics are exploiting a lack of regulation and a lack of education about stem cells.

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Hundreds of Stem Cell Clinics Offer Often Unproven Treatments Two experts found more than 570 clinics offering "stem cell" treatments, many with little or no proof they work or are even legal.

New hope for stem cell approach to treating diabetes
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Scientists working to develop more effective treatments for diabetes are turning to stem cells. Such cells can be transformed into cells that produce insulin, the hormone that controls blood sugar.

But there's a major challenge: the amount of insulin produced by theses cells is difficult to control.

Now, by tweaking the recipe for coaxing human stem cells into insulin-secreting beta cells, a team of researchers at Washington University School of Medicine in St. Louis has shown that the resulting cells are more responsive to fluctuating glucose levels in the blood.

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New hope for stem cell approach to treating diabetes: Insulin-producing cells more responsive to fluctuating glucose levels Researchers have tweaked the recipe for coaxing human stem cells into insulin-secreting beta cells and shown that the resulting cells are more responsive to fluctuating glucose levels in the blood.

Stem cell shots linked to outbreak of bacterial infection
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Health officials on Thursday reported an outbreak of bacterial infections in people who got injections of stem cells derived from umbilical cord blood.

At least 12 patients in three states — Florida, Texas and Arizona — became infected after getting injections for problems like joint and back pain, the Centers for Disease Control and Prevention said. All 12 were hospitalized, three of them for a month or longer. None died.

Investigators don't think the contamination occurred at the clinics where the shots were given, because they found bacteria in unopened vials provided by the distributor, Liveyon, based in Yorba Linda, California.

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Stem cell shots linked to outbreak of bacterial infection At least 12 patients in Florida, Texas and Arizona became infected after getting injections, the Centers for Disease Control and Prevention said.

Endothelial cells can produce copious amounts of adult stem cells: Study
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Promises broad clinical benefits, from bone marrow transplantation to therapies for heart, brain, skin and lungs
In a leap toward making stem cell therapy widely available, researchers at the Ansary Stem Cell Institute at Weill Cornell Medical College have discovered that endothelial cells, the most basic building blocks of the vascular system, produce growth factors that can grow copious amounts of adult stem cells and their progeny over the course of weeks. Until now, adult stem cell cultures would die within four or five days despite best efforts to grow them.

"This is groundbreaking research with potential application for regeneration of organs and inhibition of cancer cell growth," said Dr. Antonio M. Gotto Jr., the Stephen and Suzanne Weiss Dean of Weill Cornell Medical College and Provost for Medical Affairs of Cornell University. "We are indebted to Shahla and Hushang Ansary for founding this Institute and to the Starr Foundation Tri-Institutional Stem Cell Initiative for ongoing support."

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Endothelial cells can produce copious amounts of adult stem cells: Study In a leap toward making stem cell therapy widely available, researchers at the Ansary Stem Cell Institute at Weill Cornell Medical College have discovered that endothelial cells, the most basic building blocks of the vascular system, produce growth factors that can grow copious amounts of adult stem...

Trial using donated eye tissue offers stem cell surgery hope
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People with sight problems could benefit from a surgical trial advance that has been shown to help restore the surface of the eye.

Doctors made the world-first step by carrying out a clinical trial using stem cells from donors to create tissue that was transplanted into patients with a condition that causes blindness.

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Trial using donated eye tissue offers stem cell surgery hope People with sight problems could benefit from a surgical trial advance that has been shown to help restore the surface of the eye.

'Coaxing' stem cells to form new bone tissue
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New research has identified a possible way to manipulate certain stem cells to generate new bone tissue. The results of this investigation could vastly improve the outcome for people with skeletal injuries or conditions such as osteoporosis.

Stem cells are undifferentiated cells that have the potential to specialize and undertake any function.

Much recent research has focused on how best to use stem cells for therapeutic purposes. Researchers are particularly interested in how to manipulate them to create new tissue that can successfully replace damaged sets of cells or those that are no longer functional.

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'Coaxing' stem cells to form new bone tissue New research finds out how to drive stem cells to form new bone tissue, and these results could help improve outcomes for spinal surgeries.

Honeybees may hold the secret to stem cell youth
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Royal jelly is a gelatinous substance that honeybees produce to feed their young. This intriguing food also holds the mysterious power of helping some honeybee larvae grow into new queen bees. Some people believe that royal jelly can unlock the fountain of youth. Is there any truth in that?

In the complex hierarchy of the beehive, the queen bee is the sacred matriarch who keeps the colony alive and organized.
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Honeybees may hold the secret to stem cell youth The royal jelly that honeybees make to produce new queen bees seems to contain a secret ingredient that can keep stem cells 'young' and powerful.

Stem Cell Treatment Offers Hope for Sickle Cell Anemia Cure
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The disease was reversed in a Canadian woman using a bone marrow transplant involving stem cells. Researchers hope the method will work for others.

A therapy for sickle cell anemia could give new hope to people with the disease, although the treatment comes with its own risks.

A Canadian woman was declared cured this month after receiving a bone marrow transplant using stem cells from her sister. She’s the first adult to be cured of sickle cell anemia using this method in Canada. She expressed hope that her recovery could lead to more adults undergoing the procedure.

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Sickle Cell Anemia Cure With Stem Cell Treatment The disease was reversed in a Canadian woman using a bone marrow transplant involving stem cells. Researchers hope the method will work for others.

In a developing embryo, stem cells can differentiate into:
A. ectoderm
B. endoderm
C. mesoderm
D. all of above

Stem cell proliferation is controlled directly by nervous system, scientists find
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Somatic stem cells are microscopic workhorses, constantly regenerating cells throughout the body: skin and the lining of the intestine, for example. And to University of Illinois neuroscientists, they represent untapped potential.

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Stem cell proliferation is controlled directly by nervous system, scientists find A new study demonstrates that stem cell proliferation is directly controlled by the autonomic nervous system.

Helping blood cells regenerate after radiation therapy
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Patients with blood cancers such as leukemia and lymphoma are often treated by irradiating their bone marrow to destroy the diseased cells. After the treatment, patients are vulnerable to infection and fatigue until new blood cells grow back.

MIT researchers have now devised a way to help blood cells regenerate faster. Their method involves stimulating a particular type of stem cell to secrete growth factors that help precursor cells differentiate into mature blood cells.

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Helping blood cells regenerate after radiation therapy: Method boosts differentiation of stem cells into mature blood cell types, may help leukemia and lymphoma patients Researchers have devised a way to help blood cells regenerate faster, by stimulating a particular type of stem cell to secrete growth factors that help blood cell precursor cells differentiate into mature blood cells. This could help repopulate blood cells in cancer patients who receive bone marrow....

'Cellular dust' provides new hope for regenerative medicine
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While stem cells have the most therapeutic potential, the benefits of regenerative medicine may best be mobilised using extracellular vesicles (EVs), also known in the past as "cellular dust." A team of researchers from CNRS, AP-HP, INSERM and Paris Descartes and Paris Diderot Universities have tested these vesicles for the first time in a porcine model for the treatment of post-operative digestive fistulas. Their results, which yielded a 100% success rate and appear in the 23 October 2018 edition of ACS Nano, open the door to testing in humans and broader possibilities for applications.

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'Cellular dust' provides new hope for regenerative medicine While stem cells have the most therapeutic potential, the benefits of regenerative medicine may best be mobilized using extracellular vesicles (EVs), also known in the past as 'cellular dust'. A team of researchers have tested these vesicles for the first time in a porcine model for the treatment of...

Skeletal stem cells regress when tasked with extensive regeneration
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Adult mouse skeletal stem cells in the jaw revert to a more developmentally flexible state when called upon to regenerate large portions of bone and tissue, according to a study by researchers at the Stanford University School of Medicine.

The finding is the first to show that mammalian adult stem cells can march backward along the developmental timeline in a process called de-differentiation to become more primitive in response to environmental signals. In particular, the cells appeared to regress to a cell type that normally occurs within weeks of conception in humans and that gives rise to the bones, cartilage and connective tissue of the head and face.

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Skeletal stem cells regress when tasked with extensive regeneration New research shows that skeletal stem cells in mice assume a more primitive developmental state in response to extensive regeneration needs and environmental cues.

Biologists use 'mini retinas' to better understand connection between eye and brain
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IUPUI biologists are growing 'mini retinas' in the lab from stem cells to mimic the growth of the human retina. The researchers hope to use the research to restore sight when critical connections between the eye and the brain are damaged. These models also allow the researchers to better understand how cells in the retina develop and are organized. These results are published online in Scientific Reports, a Nature Research journal.

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Biologists use 'mini retinas' to better understand connection between eye and brain: Research could lead to cell replacement therapies that could restore sight Biologists are growing 'mini retinas' in the lab from stem cells to mimic the growth of the human retina. The researchers hope to restore sight when critical connections between the eye and the brain are damaged. These models also allow researchers to better understand how cells in the retina develo...

Stem cells are present in:
A. unicellular organisms
B. multicellular organisms
C. non-living things
D. viruses

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