AGCT Research

A genomic analysis of catalogue of gene has identified genetic variants that influence age at natural menopause. The results implicate mechanisms such as DNA-damage repair and give useful insights into the potential for predicting and treating early menopause.

Read complete article: https://bit.ly/3yDItTs

AGCT GENOMICS’s Nutrigenomics testing can be the best shout to gain personalized nutritional health, especially during the covid pandemic when immunity is the only shield against viral diseases. Immunity can be achieved, through personalized dietary consumption based on your unique genetics. Such offerings are still young in regular clinical and diagnostic practices. Most people are not aware of genetic testing for rare diseases or cancer, let alone nutrigenomics testing which itself is still evolving.
Nutrigenomics promises great potential in ensuring personalized nutritional health especially, in preventing diet-related genetic diseases or conditions.

Learn more: https://medium.com/ideoloji/prospects-of-nutrigenomics-for-personalised-nutritional-health-6a2fa46cf0d6

DeepMind along with other research partners have released a database containing the 3D structures of nearly every protein in the human body, as computationally determined by the breakthrough protein folding system called AlphaFold. The freely available database represents an enormous advance and convenience for scientists across hundreds of disciplines and domains, and may very well form the foundation of a new phase in biology and medicine.

Why do we age? And why do some people age faster than others?

The secret lies in our telomeres and the enzyme telomerase which was first discovered by Nobel Laureate Elizabeth Blackburn and affects the way our cells age.

Blackburn was awarded the Nobel Prize in Physiology or Medicine alongside Carol Greider and Jack Szostak in 2009. The Medicine Laureates solved a major problem in biology: how the chromosomes can be copied in a complete way during cell divisions and how they are protected against degradation. Their discoveries explained how the ends of the chromosomes are protected by the telomeres and that they are built by telomerase. Telomere and telomerase disfunction is now linked with a number of disease states.

The biology of aging, is the active field of research at AGCT Research How we age and cell biology progress over time along with some mutations during this process causes rare genetic disorders.

Image: A chromosome with telomeres highlighted in pink.

Credits: Nobel Prize

To go back to post-pandemic era, Brobdingnagian numbers of dedicated field experts will have to continue working intensely in the months and years ahead. A series of complex challenges are still ahead of us, as production is ramped up and rollout are planned and executed. We need to think, work and innovate in collaborative approach to contain this pandemic permanently.
Read more https://bit.ly/3cO8Td9

Risks and Challenges of the Global COVID-19 vaccine AGCT GENOMICS is a Research driven patient centric genomics company. Striving for providing decentralized personal healthcare to everyone.

Researchers have completely mapped mutations that escape three leading anti-SARS-CoV-2 antibodies. Their work more broadly provides a tool to help enable immediate interpretation of the effects of mutations cataloged by viral genomic surveillance.

Read more in Science: https://fcld.ly/lcr5h6

Credits: Science

AGCT GENOMICS wishing you all very happy and healthy year around the globe. 😊

Synthetic biology is not just the future of medicine but the future of a mankind. It transforms us from creatures to creators for artificial life form.
We can eliminate the entire infections or viral outbreak even before it starts. Children with disabilities could get equal learning opportunities as normal. We can eliminate genetic disorders and cancer before it starts to occupy human cellular life. But it needs extraordinary work to revolutionize human life completely. With its positive impacts on human life, synthetic biology has some serious threats to the homo sapiens as well. Which could just not destroy the human species, can make it extinct from the face of the planet earth completely.
Now it is up to us to find new ways to accept this challenge and defining pathways to moving forward ethically and positively.

Photo by National Cancer Institute

Eid Mubarak 🎉

Wishing you all a happy and peaceful Eid-ul-Azha!

AGCT RESEARCH is building machine learning models to help local officials and health-care providers better predict the spread of COVID-19 as areas begin to reopen. We’re partnering with the different universities on district-level projections for Karachi.

Antibiotics are not effective in treating novel coronavirus (Covid-19). However, antibiotics reduce any chances of getting infections.

What's the difference in Social distancing, Isolation and Quarantine?

Recently Scientists, in an attempt to stop Breast Cancer, finds out a therapeutic way to stop cancer cells from spreading by converting them into fat cells during a drug combination model study in mice.

Read full article at
https://link.medium.com/sYSBRZApD2

A Novel Therapeutic Approach to eliminate Breast Cancer In quest to stop and cure cancer, Researchers have successfully converted cancerous cells into harmless fat cells.

“FIRST-EVER ‘PIG-MONKEY CHIMERAS’ BORN IN CHINESE LAB” aiming to achieve human organ development inside the animals in lab, could be revolutionary with some ethical questions? But it's still far away becoming the reality, needs a lot of research before making it possible.

Read the full article here https://link.medium.com/I9S1qduoe2

FIRST-EVER “PIG-MONKEY CHIMERAS” BORN IN CHINESE LAB But died within a week, created to achieve a goal of developing Organs for human’s use inside animals.

The GABAₐ receptor - Best way to transport Cl- ions across a cell membrane since 600.000.000 BC

Credits: Ribosome Studio

Werner Heisenberg, born on this day in 1901, was only 31 when he was awarded the 1932 Physics Prize for the creation of quantum mechanics.

He is known for his uncertainty principle which says if you know the exact position of a particle you cannot know its exact momentum and vice versa.

Nobel prize in Physiology or Medicine:

The Nobel Assembly at Karolinska Institutet has today decided to award the 2019 Nobel Prize in Physiology or Medicine jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza “for their discoveries of how cells sense and adapt to oxygen availability.”

Animals need oxygen for the conversion of food into useful energy. The fundamental importance of oxygen has been understood for centuries, but how cells adapt to changes in levels of oxygen has long been unknown.

William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza discovered how cells can sense and adapt to changing oxygen availability. They identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen.

The seminal discoveries by this year’s Nobel Laureates revealed the mechanism for one of life’s most essential adaptive processes. They established the basis for our understanding of how oxygen levels affect cellular metabolism and physiological function. Their discoveries have also paved the way for promising new strategies to fight anaemia, cancer and many other diseases.

Credits: The Royal Swedish Academy of Sciences

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2019 Nobel Prize in Chemistry to John B. Goodenough, M. Stanley Whittingham and Akira Yoshino “for the development of lithium-ion batteries.”

Lithium-ion batteries are used globally to power the portable electronics that we use to communicate, work, study, listen to music and search for knowledge. Lithium-ion batteries have also enabled the development of long-range electric cars and the storage of energy from renewable sources, such as solar and wind power.

The foundation of the lithium-ion battery was laid during the oil crisis in the 1970s. Stanley Whittingham worked on developing methods that could lead to fossil fuel-free energy technologies. He started to research superconductors and discovered an extremely energy-rich material, which he used to create an innovative cathode in a lithium battery. This was made from titanium disulphide which, at a molecular level, has spaces that can house – intercalate – lithium ions.

The battery’s anode was partially made from metallic lithium, which has a strong drive to release electrons. This resulted in a battery that literally had great potential, just over two volts. However, metallic lithium is reactive and the battery was too explosive to be viable.

John Goodenough predicted that the cathode would have even greater potential if it was made using a metal oxide instead of a metal sulphide. After a systematic search, in 1980 he demonstrated that cobalt oxide with intercalated lithium ions can produce as much as four volts. This was an important breakthrough and would lead to much more powerful batteries.

With Goodenough’s cathode as a basis, Akira Yoshino created the first commercially viable lithium-ion battery in 1985. Rather than using reactive lithium in the anode, he used petroleum coke, a carbon material that, like the cathode’s cobalt oxide, can intercalate lithium ions.

The result was a lightweight, hardwearing battery that could be charged hundreds of times before its performance deteriorated. The advantage of lithium-ion batteries is that they are not based upon chemical reactions that break down the electrodes, but upon lithium ions flowing back and forth between the anode and cathode.

Lithium-ion batteries have revolutionised our lives since they first entered the market in 1991. They have laid the foundation of a wireless, fossil fuel-free society, and are of the greatest benefit to humankind.

Credits: The Royal Swedish Academy of Sciences

The Royal Swedish Academy of Sciences has decided to award the 2019 Nobel Prize in Physics “for contributions to our understanding of the evolution of the universe and Earth’s place in the cosmos” with one half to James Peebles “for theoretical discoveries in physical cosmology” and the other half jointly to Michel Mayor and Didier Queloz “for the discovery of an exoplanet orbiting a solar-type star.”

This year’s Nobel Prize in Physics rewards new understanding of the universe’s structure and history, and the first discovery of a planet orbiting a solar-type star outside our solar system.

James Peebles took on the cosmos, with its billions of galaxies and galaxy clusters. His theoretical framework, which he developed over two decades, starting in the mid-1960s, is the foundation of our modern understanding of the universe’s history, from the Big Bang to the present day. Peebles’ discoveries have led to insights about our cosmic surroundings, in which known matter comprises just five percent of all the matter and energy contained in the universe. The remaining 95 percent is hidden from us. This is a mystery and a challenge to modern physics.

Michel Mayor and Didier Queloz have explored our home galaxy, the Milky Way, looking for unknown worlds. In 1995, they made the very first discovery of a planet outside our solar system, an exoplanet, orbiting a solar-type star. Their discovery challenged our ideas about these strange worlds and led to a revolution in astronomy. The more than 4,000 known exoplanets are surprising in their richness of forms, as most of these planetary systems look nothing like our own, with the Sun and its planets. These discoveries have led researchers to develop new theories about the physical processes responsible for the birth of planets.

This year’s laureates have transformed our ideas about the cosmos. While James Peebles’ theoretical discoveries contributed to our understanding of how the universe evolved after the Big Bang, Michel Mayor and Didier Queloz explored our cosmic neighbourhoods on the hunt for unknown planets. Their discoveries have forever changed our conceptions of the world.

(Credit: The Royal Swedish Academy of Sciences)