Pharmacology MCQs

Today's Question :

False statement about Chloramphenicol is -

A. Bioavailability is higher when given via oral route than I.V route
B. It's a bacteriostatic drug
C. Agranulocytosis is dose dependent for this antibiotic
D. Recovery from "Gray baby syndrome" is usually partial with residual deformities.

Answer to yesterday's question is C. Naltrexone.

Since this patient is having features of depression, Naltrexone will block mu opioid receptor and hence cause dysphoria which will further contribute to her depression.

Today's Question :

29 yrs female was brought to the psychiatrist with complaints of persistent low mood, lack of energy, decreased appetite and agitation for the past 4 months. On taking detailed history she told about her alcohol addiction and now that she's willing to get rid of it, all of the following drugs can be given to her except -

A. Ondansetron
B. Topiramate
C. Naltrexone
D. Acamprosate

Answer to yesterday's question is C. Miglitol.

In the question the patient had IBS-D, hence SSRI + Loperamide were given. However on getting diagnosed with T2 DM following treatment with Glyburide his FBS came down to Impaired glucose tolerance level but the same didn't happen to PPBS, hence to control post prandial hyperglycemia an add on was necessary. Since Miglitol is an alpha glucosidase inhibitor it will lead to complex carbohydrate overload in the gut, which will certainly flare up IBS, hence it should be avoided in this patient.

Today's MCQ :

A 26 yrs male patient with complaints of frequented pain abdomen with diarrhoea was prescribed escitalopram and loperamide who came after a year with his blood sugar report that showed FBS 138 mg/dl and PPBS : 349 mg/dl. He was put on Glyburide tablets and after 3 months his FBS was found to be 124 and PPBS as 298. Which of the following add ons should be avoided in him?

A. Pramlinitide
B. Semaglutide
C. Miglitol
D. Linagliptin