AJCP

Editorial: Updates in the care of the alloimmunized pregnant patient. https://bit.ly/3R3zxmq

Updates in the care of the alloimmunized pregnant patient: A transfusion medicine and clinical laboratory perspective Red blood cell (RBC) alloimmunization usually occurs following exposure to allogeneic blood, most commonly via transfusion or pregnancy. Alloantibodies may deve

The success rate for cancer next-generation sequencing testing depends on tumor type, with ovarian carcinomas exhibiting a high success rate and pancreatic carcinomas exhibiting a lower success rate. Learn more here: https://bit.ly/462WnhQ

Laboratory-developed next-generation sequencing (NGS) panels require thorough validation to ensure the correctness of all clinically relevant data. This study aims to provide comprehensive validation for a large NGS panel assay.

academic.oup.com

Mucosal appendicitis presents with distinctive laboratory and histologic features that can be distinguished from nonappendicitis. Learn more here:

Mucosal appendicitis: How can it be differentiated from nonappendicitis? AbstractObjectives. Mucosal appendicitis is defined by neutrophilic infiltration limited to the mucosa, with no transmural invasion; it is currently a controver

In the November issue: BRAF testing modalities in histiocytic disorders.

academic.oup.com

HER2 and PD-L1 are expressed in 56% and 35% of CCOs, respectively, outlining the eligibility of patients with CCO for clinical trials pertaining to these therapeutic targets.

Clinical Outcome and Morphology-Based Analysis of p53 Aberrant and Mismatch Repair Protein-Deficient Ovarian Clear Cell Carcinoma and Their Association With p16, HER2, and PD-L1 Expression AbstractObjectives. We studied the prevalence and prognostic significance of mismatch repair deficient (MMRD) and p53 aberrant ovarian clear cell carcinoma (CCO

In the November issue: Comparison of TEG 5000 and TEG 6S CK LY30 systems.

Sensitivity and specificity of thromboelastography for hyperfibrinolysis: Comparison of TEG 5000 and TEG 6S CK LY30 systems AbstractObjectives. The sensitivity and specificity of clot lysis at 30 minutes after maximum clot strength (LY30), as measured by thromboelastography (TEG), fo

Concurrent human papillomavirus (HPV) testing in the setting of an unsatisfactory Papanicolaou test result can predict HPV status and findings of squamous intraepithelial lesions on follow-up.

Significance of concurrent HPV testing with unsatisfactory Papanicolaou test for prediction of follow-up HPV, Papanicolaou test, and biopsy results AbstractObjectives. Approximately 1% to 2% of routine cytologic specimens collected for Papanicolaou testing are unsatisfactory for evaluation. The American Soc

Editorial in the November issue: A tool for stewarding the use of 16S rRNA gene amplification and sequencing in diagnostic testing. https://bit.ly/3RUWqca

Editor's choice in the October issue: Utility of TRPS1 immunohistochemistry in confirming breast carcinoma.

Utility of TRPS1 immunohistochemistry in confirming breast carcinoma: Emphasis on staining in triple-negative breast cancers and gynecologic tumors AbstractObjectives. Our aim was to explore the performance of TRPS1 as an immunohistochemical diagnostic marker; find the optimal conditions for its use in brea

Price transparency information for patients receiving outpatient apheresis is improving, but negotiated rates are often unavailable or difficult to interpret. https://bit.ly/3RFrFIa

In the October issue: Development and Validation of a Deep Learning–Based Histologic Diagnosis System for Diagnosing Colorectal Sessile Serrated Lesions.

academic.oup.com

Recognition of myeloid neoplasms (MNs) with germline predisposition is essential for guiding optimal disease management, including therapy, screening related stem cell donors, and genetic counseling. Learn more here:

How I diagnose myeloid neoplasms with germline predisposition AbstractObjectives. Pathologists play a crucial role in the initial diagnosis of germline predisposition to myeloid neoplasia and subsequent surveillance for di

Review: HER2 in uterine serous carcinoma. https://bit.ly/3rygaYo

HER2 in uterine serous carcinoma: Current state and clinical perspectives AbstractObjectives. Uterine cancer has the highest incidence and the second-highest mortality rate among gynecologic malignancies in the United States. Although

These researchers evaluated the peripheral blood findings in patients with acute COVID-19 infection and compared these with findings in other viral respiratory infections.

Systematic Evaluation of Hematologic Parameters and Blood Smear Findings in Patients With SARS-CoV-2 vs Other Viral Respiratory Infections AbstractObjectives. We evaluated and compared the peripheral blood findings in patients with acute COVID-19 vs other viral respiratory infections.Methods. We re

This study describes clinicopathologic features of Lobular capillary hemangioma in a cohort of GI cases:

Lobular capillary hemangioma (pyogenic granuloma) of the gastrointestinal tract: Clinicopathologic analysis of 34 cases AbstractObjectives. Lobular capillary hemangioma (LCH) rarely involves the gastrointestinal (GI) tract. This study describes clinicopathologic features of LCH i

Guided anthropomorphic logic diagnostics can surpass pure deep learning and achieve expert-level accuracy with a smaller sample size. Read the paper here:

Development and Validation of a Deep Learning–Based Histologic Diagnosis System for Diagnosing Colorectal Sessile Serrated Lesions AbstractObjectives. The histopathologic diagnosis of colorectal sessile serrated lesions (SSLs) and hyperplastic polyps (HPs) is of low consistency among pathol

This review discusses the clinical perspective of HER2 overexpression/gene amplification in USC as well as likely areas of future investigation. Read it here: https://bit.ly/3rygaYo

Histologic examination of bleb resections for spontaneous pneumothorax with ancillary testing for cases with ambiguous features is essential for detection of early pleural mesothelioma. Learn more here:

Clinically Occult Diffuse Pleural Mesothelioma in Patients Presenting With Spontaneous Pneumothorax AbstractObjectives. To report histologic features of unsuspected diffuse pleural mesothelioma (DPM) in surgical specimens for pneumothorax and demonstrate how a

These authors developed a system-wide electronic health record intervention to reduce wasteful duplicate genetic testing. Read their results here:

Reducing duplicate genetic testing in inpatient and outpatient settings across a large safety-net system AbstractObjectives. To develop a system-wide electronic health record (EHR) intervention at a large safety-net hospital system to reduce wasteful duplicate gene

In this liquid chromatography/tandem mass spectrometry-based study of 12 pe**le amyloidosis cases, AL-type amyloid was most common, followed by keratin-type and ATTR (transthyretin)-type amyloid.

Proteomic and Clinicopathologic Assessment of Pe**le Amyloidosis: A Single Institutional Review of 12 Cases AbstractObjectives. There is a paucity of data on pe**le amyloidosis. We aimed to assess the frequency of different amyloid types in surgical specimens from the

These researchers examined CD200 expression by immunohistochemistry in EBV+ LBCL and evaluated its diagnostic utility in the differential diagnosis with CHL. Learn more here:

Diagnostic Utility of CD200 Immunohistochemistry in Distinguishing EBV-Positive Large B-Cell Lymphoma From Classic Hodgkin Lymphoma AbstractObjectives. Epstein-Barr virus–positive large B-cell lymphoma (EBV+ LBCL) is a heterogeneous group of diseases that may resemble classic Hodgkin lymphom

A standardized, customized electronic health record–based blood product administration module and system improve documentation of blood product administration. Learn more here:

Improving documentation of blood product administration using a standardized electronic health record–based system: a single-institution experience AbstractObjectives. To improve documentation of blood product administration by assessing the completion status of blood transfusions. In this way, we can ensur

This study represents the first reported standardized, validated, and automated approach for calculating and tracking blood culture contamination. Read it here:

academic.oup.com

Many factors contribute to interpretation errors between the frozen sections and final diagnosis, some of which may be institution dependent. Learn more here:

Patterns of Major Frozen Section Interpretation Error: An In-Depth Analysis From a Complex Academic Surgical Pathology Practice AbstractObjectives. To establish baseline error rates due to misinterpretation and to identify scenarios in which major errors were most common and potentially

Cold agglutinin disease is a small B-cell lymphoproliferative disease of the bone marrow with low incidence of evolution to lymphoma but with secondary morbidity, mostly anemia and Raynaud phenomenon. Read the review here:

The Histopathology of Cold Agglutinin Disease–Associated B-Cell Lymphoproliferative Disease AbstractObjectives. Primary cold agglutinin disease is a type of autoimmune hemolytic anemia caused by circulating antibodies against I antigen, a carbohydrate

Editorial: regulation of laboratory-developed tests.

Regulation of laboratory-developed tests: scoping the issue Hospital laboratories perform hundreds, even thousands of different tests to support the care of the patients they serve. These tests vary considerably, ranging

The hook effect is a preanalytical error that results in falsely decreased analyte concentrations in immunoassays. How common is it in testing?

Hook Effect in Semiquantitative SARS-CoV-2 Antispike Total Antibody Assay AbstractObjectives. The hook effect is a common preanalytical error that results in falsely decreased analyte concentrations in immunoassays. We present here an

The piloted platform presented here is promising and can be a foundation for future larger-scale studies in countries with developing health systems.

International health initiative: Development and pilot testing of a molecular diagnostics training program in Romania AbstractObjectives. The implementation of nucleic acid testing in laboratory medicine has revolutionized clinical diagnosis. Unfortunately, incorporation of the

A standardized, customized electronic health record–based blood product administration module and system improve documentation of blood product administration.

Improving documentation of blood product administration using a standardized electronic health record–based system: a single-institution experience AbstractObjectives. To improve documentation of blood product administration by assessing the completion status of blood transfusions. In this way, we can ensur

This is the first report of a validated, standardized definition of blood culture contamination and the first dashboard tracking blood culture contamination based on automated data queries.

Development and validation of a standardized blood culture contamination definition and metric dashboard for a large health care system AbstractObjectives. Blood culture contamination is a major problem in health care, with significant impacts on both patient safety and cost. Initiatives to redu

The percentage of solid architecture in epithelioid mesotheliomas does not correlate with a specific altered gene. Learn more here:

Characterizing the distribution of alterations in mesothelioma and their correlation to morphology AbstractObjectives. Mesothelioma is a lethal disease that arises from the serosal lining of organ cavities. Several recurrent alterations have been observed in

Patients with cyclin D1–positive AL had fewer secondary cytogenetic abnormalities and a poorer prognosis than those with cyclin D1–negative AL.

Clinical Characteristics and Outcomes of Cyclin D1–Positive AL Amyloidosis AbstractObjectives. To demonstrate the clinical features and prognostic impact of cyclin D1 positivity in patients with amyloid light chain amyloidosis (AL).Met

The overall rate of calcification detection (benign and malignant) was 74.8% with the standard 3 levels in a large contemporary cohort of stereotactic core needle biopsy specimens.

In Search of Calcifications : Histologic Analysis and Diagnostic Yield of Stereotactic Core Needle Breast Biopsies AbstractObjectives. Stereotactic core needle biopsy (SCNB) is used in the diagnostic assessment of suspicious mammographic calcifications to rule out breast duc

This study suggests that women with UPT and negative HPV cotest may be safely called back at an interval longer than 4 months. https://bit.ly/3QwGcp3

HPV Cotesting of Unsatisfactory Papanicolaou Tests: Implications for Follow-up Intervals AbstractObjectives. The 2019 American Society of Colposcopy and Cervical Pathology management guidelines recommend that patients with an unsatisfactory Papanico

Peritumoral mucosal changes could mimic chronic atrophic gastritis. Gastroenterologists are encouraged to biopsy gastric mucosa away from the tumor.

Clinicopathologic features of non–type 1/2 gastric neuroendocrine tumors and their associated mucosal changes AbstractObjectives. The pathogenesis for non–type 1/2 gastric neuroendocrine tumors (G-NETs) remains unclear. The aim of this study was to examine the clinicopa

Sustainability practices such as recycling can be implemented in the clinical laboratory to reduce the impact of biomedical waste. Learn more here:

Opportunities for recycling in an automated clinical chemistry laboratory produced by the comprehensive metabolic panel AbstractObjectives. Clinical laboratories perform a variety of tests for which biomedical waste is a byproduct. Of these, the complete metabolic panel (CMP) pro

Viral encephalitis is challenging to diagnose because of the wide range of causative agents and the overlapping histologic features with other inflammatory brain lesions.

Double-stranded RNA immunohistochemistry as a screening tool for viral encephalitis AbstractObjectives. Viral infections of the central nervous system can be challenging to diagnose because of the wide range of causative agents and nonspecific

The HLA-DQA1*05 (rs2097432) variant is associated with increased risk of immunogenicity to anti–tumor necrosis factor agents. Learn more here:

Validation of a rapid HLA-DQA1*05 pharmacogenomics assay to identify at-risk resistance to anti–tumor necrosis factor therapy among patients with inflammatory bowel disease AbstractObjectives. The HLA-DQA1*05 variant (rs2097432) is associated with increased risk of immunogenicity to tumor necrosis factor antagonists, with subsequen

This study suggests that women with UPT and negative HPV cotest may be safely called back at an interval longer than 4 months.

HPV Cotesting of Unsatisfactory Papanicolaou Tests: Implications for Follow-up Intervals AbstractObjectives. The 2019 American Society of Colposcopy and Cervical Pathology management guidelines recommend that patients with an unsatisfactory Papanico