Aging as a skill

https://www.nature.com/articles/s41598-022-22123-1 - klotho

A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine - Scientific Reports Klotho is an anti-aging protein with several therapeutic roles in the pathophysiology of different organs, such as the skeletal muscle and kidneys. Available evidence suggests that exercise increases Klotho levels, regardless of the condition or intervention, shedding some light on this anti-aging p...

https://pubmed.ncbi.nlm.nih.gov/38766160/

High dose dietary vitamin D allocates surplus calories to muscle and growth instead of fat via modulation of myostatin and leptin signaling - PubMed Obesity occurs because the body stores surplus calories as fat rather than as muscle. Fat secretes a hormone, leptin, that modulates energy balance at the brain. Changes in fat mass are mirrored by changes in serum leptin. Elevated leptin prompts the brain to decrease appetite and increase energy ex...

https://www.aginganddisease.org/EN/10.14336/AD.2024.0258

Inflammatory Markers Associated with Physical Frailty and Cognitive Impairment In older adults, physical frailty and cognitive impairment contribute to adverse outcomes. However, the research on mechanisms underlying physical frailty and cognitive impairment is limited. Low-grade chronic inflammation is a characteristic of aging. Particularly, an imbalance in pro- and anti-...

https://neurosciencenews.com/mitochondria-aging-alzheimers-26122/

Mitochondrial Boost Reverses Protein Clumping in Aging and Alzheimer's - Neuroscience News A new study in worms reveals a core set of insoluble proteins linked to both aging and Alzheimer's disease.

https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1362239/full

Frontiers | Role of microbiota-gut-brain axis in natural aging-related alterations in behavior IntroductionAging is a complex, time-dependent biological process that involves a decline of overall function. Over the past decade, the field of intestinal ...

https://www.annualreviews.org/content/journals/10.1146/annurev-clinpsy-082719-104030 - stress and mito

Stress and Psychiatric Disorders: The Role of Mitochondria | Annual Reviews In seeking to understand mental health and disease, it is fundamental to identify the biological substrates that draw together the experiences and physiological processes that underlie observed psychological changes. Mitochondria are subcellular organelles best known for their central role in energe...

https://www.sciencedirect.com/science/article/pii/S1756464623000373

The association between dietary fiber intake and sarcopenia The study aims to understand the effects of dietary fiber on muscle quality parameters and sarcopenia.Study data were collected from the National Heal…

https://pubmed.ncbi.nlm.nih.gov/32295007/ - Fiber

Dietary Fibre May Mitigate Sarcopenia Risk: Findings from the NU-AGE Cohort of Older European Adults - PubMed Sarcopenia is characterised by a progressive loss of skeletal muscle mass and physical function as well as related metabolic disturbances. While fibre-rich diets can influence metabolic health outcomes, the impact on skeletal muscle mass and function is yet to be determined, and the moderating effec...

https://link.springer.com/article/10.1007/s13668-024-00539-7

Modulation of Gut Microbiota Through Dietary Intervention in Neuroinflammation and Alzheimer’s and Parkinson’s Diseases - Current Nutrition Reports Purpose of Review The gut microbiota plays a crucial role in the pathogenesis of neuroinflammation and Alzheimer’s and Parkinson’s diseases. One of the main modulators of the gut microbiota is the diet, which directly influences host homeostasis and biological processes. Some dietary patterns ca...

https://www.biorxiv.org/content/10.1101/2024.04.25.591184v1

Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging. Mitochondrial dysfunction is a prominent hallmark of aging contributing to the functional decline of metabolic plasticity in late life. While genetic distortions of mitochondrial integrity elicit premature aging, the mechanisms leading to "natural" aging of mitochondria are less clear. Here we initi...

https://www.sciencedirect.com/science/article/pii/S156816371830134X

The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans Age-related loss of skeletal muscle mass and function, sarcopenia, is associated with physical frailty and increased risk of morbidity (chronic diseas…

https://www.sciencedirect.com/science/article/pii/S2213453021000112

The role of glutamine in supporting gut health and neuropsychiatric factors Recent research has shown that the amino acid glutamine can positively affect gut health by supporting the gut microbiome, gut mucosal wall integrity,…

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560162/
Sauna

Does sauna bathing protect against dementia? Repeated heat exposure like sauna bathing is suggested to beneficially affect against dementia development. The epidemiological evidence is, however, scarce. Therefore, we studied the association between heat exposure during sauna bathing (i.e., the frequency ...

https://www.nutraingredients-usa.com/Article/2024/04/22/polyphenol-potential-to-counteract-age-related-epigenetic-changes

Polyphenol potential to counteract age-related epigenetic changes A new review highlights the potential of polyphenol-rich compounds to counteract age-related epigenetic alterations associated with increased disease risk through microbiome modulation.

fil:///C:/Users/scott/Downloads/The%20Cognitive%20Enhancement%20Blueprint%20(BDNF%20Guide)%20(1).pdf

https://www.sciencedirect.com/science/article/pii/S2095254624000553

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