CUSP Neurotherapeutics

Breaking news today! Told you it was gonna happen soon!

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Which AEDs also treat bipolar disorder? Do you know?

First generation AEDs are carbamazepine, clonazepam, ethosuximide, phenobarbital, primidone, phenytoin, valproic acid. They were developed early and are associated with more toxicity, complicated PK, and DDIs.

Common board, test, and quiz question: which AEDs are associated with development of kidney stones?

Lecanemab and aducanumab are revolutionary disease modifying drugs that must be used in early mild Alzheimer’s dementia (before massive Neuro degeneration has occurred) to slow disease progression. However it’s effect on slowing decline in cognition is probably only modest.

Quiz hint

Lecanemab, a disease modifying drug, which is a monoclonal antibody directed against beta-amyloid (similar to aducanumab), was recently received accelerated approval from the FDA in January 2023.

Alzheimer's drug lecanemab can slow cognitive decline, study shows Dr. Leah Croll, a neurology professor at Temple University, breaks down promising findings with the new Alzheimer's drug lecanemab.

"Objective: Antiseizure medications (ASMs) remain the mainstay of epilepsy treatment. These ASMs have mainly been tested in trials in adults with epilepsy, which subsequently led to the market authorization (MA). For treatment of -especially young- children with epilepsy, several ASMs do not have a MA and guidelines are lacking, subsequently leading to “off-label” use of ASMs. Even though “off-label” ASM prescriptions for children could lead to more adverse events, it can be clinically appropriate and rational if the benefits outweigh the risks. This could be the case if “on-label” ASM, in mono- or polytherapy, fail to achieve adequate seizure control...

Significance: We report the relatively common use of “off-label” prescriptions that underlines the need for targeted and appropriately designed clinical trials, including younger patients, which will also result in the ability to generate evidence-based guidelines."

Find this new Epilepsia Open Journal article from the Medical Therapy in Children Task Force of the ILAE Pediatrics Commission at doi.org/10.1002/epi4.12666.