Science and Technology Division in Canada

📢The TIE Award 2023 Is Now Open For Registration Until May 31! We invite all startups from around the world to join us!

🏆The winners will receive various award benefits, including cash prizes, partial subsidies for business trips and opportunities to partner with Taiwanese semiconductor companies, and national-level research institutes.

✴️Registration for the 2023 TIE Award👉https://reurl.cc/XLkjpM

✴️Registration for Online Briefing Sessions👉https://forms.gle/hSMpJ9YSyyPKwmuG7

Please feel free to contact us if you have any questions, thank you.

【Webinar Information】

👉CTSTA Webinar: ACADEMIC CAREER IN TAIWAN

👉Guest speaker:
Prof. Su is an associate professor of Mechanical Engineering at National Taiwan University (NTU). Dr. Su received his BS and MS from NTU in 2004 and 2006, respectively, and his Ph.D. from the University of Toronto in 2014.
His research interests include vibration energy harvesting, vehicle dynamics, and mechatronics.
He is currently running two laboratories at NTU and holding several collaboration projects with the industry.

👉Registration fee: Free

👉Time and Date (EST): 24/09/2022, 8:00 am

👉Registration: https://ctsta.ca/event/ctsta-webinar-academic-career-in-taiwan/

The Taiwanese government, Ministry of Science and Technology (MOST) and Ministry of Economic Affairs (MOEA) will host the first “Tech Innovation Excellence Award (TIE Award)” this year to promote innovative applications of semiconductors in cutting-edge technologies. We would like to invite startups, research institutions, and legal entities to showcase your innovation solutions for Cash Prizes, a free booth at Taiwan Innotech Expo in October 2022, and opportunities to partner with Taiwanese semiconductor companies.
The details of the award are as follows:
1. Registration ends on August 7, 2022. (Extended till Aug 11)
2. No registration fees.
3. TIE Award is to promote innovative applications that fits within AI & AIoT, Sensors, Efficient energy conservation, Communications/satellite, Smart manufacturing, Autonomous vehicles, New energy, and Others.
4. Startups must be legally registered after January 1, 2014.
5. The total prize of TIE Award is up to USD 109,000:
1. 1st Place: USD 30,000
2. 2nd Place: USD 20,000
3. 3rd Place: USD 10,000
4. 7 Honorable mentions: USD 7,000 each
6. The winning teams must attend the Taiwan Innotech Expo 2022 (October 13-15) in person, and will be granted a free booth to exhibit at the Taiwan Innotech Expo.
· Winning teams from overseas will receive partial subsidy for flight tickets and accommodation for 4 nights (details to follow).
· Teams that fail or refuse to fulfill this condition will forfeit all awards and prizes won.

Links to the TIE Award videos as listed below:

-Introduction to TIE Award-
https://youtu.be/qKNGL07pZ9w

-TIE Award Step by Step-
https://youtu.be/u67f33Bjjyk

Click here to Register Now :
https://www.futuretech.org.tw/futuretech/index.php?action=tieaward&web_lang=en-us

未來科技館 Future Tech, FUTEX - TIE Award Guidelines 未來科技館由科技部攜手中央研究院、教育部、衛生福利部共同打造，展覽主題聚焦精準健康生態系、電子光電、AI 與 AIoT 應用、新穎材料等領域之前瞻科研成果，並提供One-On-One 商務媒合平台，增進跨界交流機會及產學媒合。

【徵才訊息】
國立中興大學生命科學院生命科學系誠徵「動物生理學」專長專任教師

一、 教師職等：專任教師(助理教授含以上)一名。
二、 專長領域：「動物生理學」專長，須開設動物生理學及普通生物學等相關課程，並配合全英語授課。
三、資格條件：具博士學位及至起聘日前具一年(含)以上博士後研究經驗，或在國內外學術界或業界專業領域具有優秀成就且具博士學位者，其具體事蹟應提供明確資料佐證。符合教育部EMI相關規範者優先，EMI教師員額定義為「不得為我國公私立大專校院及學術研究機構現職編制內專任教師及研究人員，並應協助雙語計畫推動或EMI課程教學」。
四、 起聘日期：2023年2月1日
五、 公告日期： 2022年7月31日止
六、繳交資料採線上作業，所有資料之電子檔皆須於2022年7月31日前上傳完成，逾期不受理。
七、 報名網址(請以google chrome開啟並登入個人帳號)：
https://forms.gle/D5gvoGhjBgczxMDG8
八、表格下載(請以google chrome開啟並登入個人帳號)：
https://drive.google.com/....../1j8PfqjY2Pm5LrUlH_Rk.....
九、 聯絡方式：
(1) 聯絡人：王秀玲小姐
(2) 聯絡電話：04-22840416 #302
(3) E-mail：[email protected]

【Press Release】

May 11th, 2022

Engaged Literary Studies: Bridging Literature and Medicine

In recent years, the global academic community has placed a growing emphasis on medical humanities studies. Starting with integrating humanistic perspectives into medical education, medical humanities has developed into a remarkably forward-looking interdisciplinary field, where humanities scholars can actively contribute to the understanding of health sciences, supporting the goal of shaping society through literature. In 2018 the Ministry of Science and Technology funded a project entitled “Engaged Literary Studies: Interdisciplinary Research in Medical Humanities,” headed by Pin-chia Feng, Lifetime Chair Professor of the Department of Foreign Languages and Literatures at the National Yang Ming Chiao Tung University. By publishing scholarly essays and books and organizing academic events, the project has successfully encouraged literary scholars, especially junior scholars, to engage in this promising research field.

One of the highlights of the project is the three international workshops in which scholars gathered to discuss the latest issues in the medical humanities. In November 2018, Yin Wang, Associate Professor of the Department of Foreign Languages and Literature at the National Cheng Kung University, organized the first workshop, “Uneven Distribution of Humanity.” The workshop invited renowned scholars in disability studies and gerontology from the United States and Canada to discuss the issues of power relations, ideologies, and institutionalization within Western technological modernity. Furthermore, the workshop covered a range of historical analyses on the evolution of Eastern and Western legal discourses, political rationality, and concepts such as the nation-state, civil society, gendered bodies, and sexuality.

In 2019, Chen-Hsing Tsai, Professor of the Department of English at the Tamkang University, hosted the second workshop—“Interdisciplinary Medical Humanities in the Age of Anthropocene”—where prominent scholars in narrative medicine and critical medical humanities from the United Kingdom and the United States led discussions on the formations and functioning of “normative” discourses. In 2021, Jade Lee, Professor of the Department of English at the National Kaohsiung Normal University, organized the third workshop: “Walk with the Elderly: Representations and Writings of Ageing and the Elderly.” At this event, scholars from the United States and Taiwan explored ideas germane to issues of ageing, such as how to talk and think about ageing, and how to better understand and care for the elderly. The discussions focused on various humanistic topics, such as the elderly and ageing body, desire, cultural significance, population ageing, long-term care for the elderly, and the ways to create an ageing-friendly environment in Taiwan.

Additionally, the project has organized more than 20 lectures to date. The topics of the lectures from 2018 to 2020 were related to the major themes of the three workshops. The speakers of the lecture series in 2021, organized by Shin-Ju Kuo, Associate Professor of the Center for General Education at the China Medical University, included doctors, public health experts, and artists. In 2022, we try to approach medical humanities from the perspectives of environmentalism, animal studies, and speculative imagination, aiming to introduce emerging issues in medical humanities. These events moved online in 2020 because of the Covid-19 pandemic, and this adjustment has greatly expanded the coverage and depth of the research, and allowed more people to attend them.

Moreover, in April 2021, “A Symposium on Health Humanities, Literature, and Life Narrative” took place at the National Sun Yat-sen University, to further promote the research of medical humanities in southern Taiwan. In August, in an online symposium, the world-class environmental humanities scholar Scott Slovic talked about the emergence of a new field which he terms “medical-environmental humanities.” Two other virtual seminars were held in November 2021 and January 2022, where six Taiwanese scholars from different parts of the island shared their latest research. The initial research results of this project were published as a collection of essays in 2020 under the title of Literature, Visual Culture, and Medicine, which consists of eight research papers. A new collection of essays is forthcoming in late 2022. In addition, an international conference is scheduled to take place at the end of 2022, which will gather scholars from around the world to explore the most recent development in medical humanities.

Thus far, this project has successfully fulfilled its aims. It not only showcases how literary studies can contribute to science and society, but also links the study of culture, literature, and medicine, promoting humanistic perspectives in the field of medical humanities. By effectively building a platform for multidisciplinary interactions, this project has set an excellent example for future interdisciplinary research.

Research Contact：
Pin-chia Feng, PhD
Lifetime Chair Professor, Department of Foreign Languages and Literatures
Director of Asian American Studies Research Center
Director of Interdisciplinary Medical Humanities Research Center
National Yang Ming Chiao Tung University
TEL: +886-3-5712121 #58102
Email: [email protected]

Media Contact
Wen-chun Lan
Program Manager
Department of Humanities and Social Sciences
Ministry of Science and Technology
TEL: +886-2-27377460
Email: [email protected]

【科技部新聞稿】
日期：2022年5月11日

以文淑世：文學與醫學之跨域橋接

醫療人文的思維起源於二十世紀中期的歐美醫學教育界，當時的醫學教育工作者逐漸意識到醫學技術並非醫學教育的全部，開始以社會科學輔助醫學教育。回顧醫療人文在國內醫學教育界的發展，醫療人文的主導力量大多來自醫學界，較少以人文學科的觀點探討相關議題。多年來，國內醫學院的人文教育改革蔚為風潮，醫學倫理、生死學等相關人文教育課程成為必修，目的在於培養未來的醫療從業人員聆聽病患、瞭解病患的能力。然而，醫學系的學生，真的能透過修得這些學分，進而瞭解「人」甚至是「自己」嗎？

隨著近年人文學界有關失能研究、生命書寫、高齡社會等研究興起，以及醫護人員與病患及其家屬透過自傳／傳記式文學刻劃生命的百態，愈發強化了敘事醫學（narrative medicine）研究的深度並引起更多共鳴，如：華裔美籍醫生陳葆琳的回憶錄《最後期末考》，細膩又深刻地體現出書寫與療癒在敘事醫學中的重要性。人文學者也於此找到了醫療人文研究的著眼點：以敘事為本，並從人的觀點，反觀醫療、病痛與生死。為達到文學淑世的目的，在科技部經費支持下，國立陽明交通大學外國語文學系馮品佳終身講座教授於107年開始執行「以文淑世：醫療人文跨領域人才培育計畫」，由文學研究角度切入醫療人文，促使人文學者在醫療人文研究領域發聲，並帶動國內外各領域的菁英學者進行學術交流，並透過複合式學術活動所做的多面向推廣(包含研習營、讀書會及國際研討會等)，開啟醫療、文學與大眾的對話。

計畫執行初期以學術研究切入，以研討醫療人文批判理論為出發點，在文本與理論並重的前提下，藉由兩者的對話為醫療人文的概念奠基。計畫第一年以「不等值的生命」為題，透過失能研究挑戰人們對於生命理所當然的認知，第二年「人類紀中的醫療人文」則進入疾病與治療，批判人類價值的形成與運作，揭露所謂「正常」話語如何被操弄，第三年的「老化與老年再現與書寫」則實踐社會關懷，正視臺灣乃至於全球高齡化社會下的老化與長照議題。未來更可拓展至醫療資源分配正義，乃至動物關懷及人工智能發展等議題。

計畫執行期間適逢全球新冠疫情日益嚴峻，醫學界提供不可或缺的醫療救護與疫苗防禦，而人類在面疾病與疫情的焦慮和生死離別及其心理狀態，亦是本計畫長期關注的焦點。人文研究學者聆聽醫病經驗，自各種形式的文學書寫及創作媒介中挖掘出醫者、病患及家屬最深層同時也是最真實的感受，如：醫療漫畫《醫院也瘋狂》、《急診鋼鐵人》等圖像醫療（graphic medicine）；而疫情爆發後，疫疾創作、隔離日記，如雨後春筍般出現，更提供本計畫諸多分析的素材。疫情是個契機，所有議題藉疫情這個缺口紛紛冒現，也讓人們意識到「醫」與「人」密不可分。人文教育最重視的開放思考與批判能力對醫療而言也很重要。

進行醫療人文跨領域人才培育計畫，最大的意義在於凸顯人文學者在此領域承先啟後的角色，敦促本土的文學研究者在國際醫療人文研究出類拔萃，使得臺灣成為亞洲相關領域之研究重鎮。本計畫一開始即以淑世為目的，藉由開啟人文與醫學研究之間的對話，推動文學與醫學之跨域橋接，反思當前臺灣社會的現況。而隨著社群媒體上的議題推廣，觸及更為廣大的受眾，普及醫療人文的概念。而計畫具體的影響力，可以從近幾年科技部有關醫療人文研究議題申請案件，以及醫療人文社交媒體參與人數的持續成長可見一斑。因此，本計畫的成果並非科技發現或是數據分析，而是跨領域的相互交融與增長，以期具體實踐「以文淑世」的願景。

報告人：國立陽明交通大學外國語文學系 馮品佳終身講座教授

發稿單位：科技部人文司
聯絡人：藍文君助理研究員
電話：(02)2737-7460
E-mail：[email protected]

【Hybrid Seminar】

🎉🎉U of T Engineering’s second annual Engineering Research Day is here❗

➡When： Thursday, May 19, 2022, 9:00 am - 5:00 pm

➡Where： Hybrid event.

➡Who： open to all students, alumni, staff and faculty at U of T Engineering, as well as current and prospective partners and key stakeholders across the research ecosystem.

➡How： Visit the event page on Airmeet to see the full schedule and register. 🖱🖱

Engineering Research Day 2022: Building a Sustainable Future Checkout this event on Airmeet

【Press Release】
2022.04.27

The Multi-Module Clinical Decision Support System-Shared Decision Making (CDSS-SDM), a breakthrough technique in AI healthcare, allows personalization in clinical use of lung Cancer

The Ministry of Science and Technology (MOST) has been supporting healthcare technology development for several years, which strengthens the academic research and industrial development. Under the MOST funding, the team led by Professor Cheng-Yu Chen at Taipei Medical University has successfully built the Multi-Module Clinical Decision Support System-Shared Decision Making (CDSS-SDM). The system has been awarded latest FUTEX Future Tech Award and Nation Innovation Award.

Lung cancer is the leading cause of cancer death in Taiwan. Early diagnosis and precision treatment are the only paths to defeat lung cancer. However, several factors must be considered, for instance, early diagnosis requires reliable imaging technology, treatment and medication are decided by the factors such as EGFR and KRAS genes. The patient must race with time since the first day of diagnosis, and in ten days, there are expected at least four decision sessions for the patient to make according to the discussion with the experienced doctors about the result and the treatment. With big data and artificial intelligence support at the early stage, precision treatment can maximize the performance by giving the best medicine that is the most effective to the cancer types.

The team has developed the CDSS-SDM based on deep learning and the real clinical scenarios to provide patients with best prediction on the diagnosis, treatment and survival. The radiogenomic CT algorithms is a novel technology for lung cancer gene mutation prediction. The technology allows for accurate detection and segmentation of the tumor in hundreds of CT images in minutes and infers the best prediction of EGFR gene mutation if present. Once the gene mutation prediction is made, the demographic module can further gather patient’s information to provide prediction for possible early brain metastases and likely treatment responses.

Taipei Medical University has collaborated with AetherAI, one of the technology leading companies in Taiwan, for three years to build up a groundbreaking technique in identifying cancer cell instantly on digital pathology. With this technique, the team has developed a gene mutation prediction model for lung cancer base on digital pathology slides.

Another break-through technology is the NLP, the natural language processing for Pathology Report analytic system. This system can break down a single sheet of pathology report into 50 text features and then provides drug selection suggestion for the best survival based on 3000 lung cancer patient data by matching those features using AI technology. The concept is very similar to gathering more than ten experts’ experiences for the best treatment option. An addition to the NLP technology is the novel automatic matching system for clinical trials worldwide for patients with late stage of lung cancer or who unfortunately has metastasis. Again, this technology is based on a single sheet of pathology report.

With the support by the MOST, the team from Taipei Medical University has made a first successful step in building a proof-of-concept CDSS-SDM system that may potentially help doctors and patients to decide the best treatment option in the critical first 10 days after the initial diagnosis. The team represents a cast of multi-disciplinary experts from bioinformatics to medicine to build up this novel platform consisting of low-dose CT, pathology slides, clinical data, genomics and pathology report modules. The platform aims to make the early diagnosis, personalized treatment and shared decision possible.

Research Contact
Prof. Sandy, Cheng-Yu Chen
Vice President, Taipei Medical University
TEL: +886-2-66382736 #1995
Email: [email protected]

Media Contact
Yo-Chi Chang
Program Manager
Department of Life Sciences
Ministry of Science and Technology
TEL: +886-2-27377544
Email: [email protected]

【科技部新聞稿】

AI醫療科技新突破─台灣首創個人化「肺癌臨床智能決策輔助系統」

科技部長期深耕醫療科技研究，支持國內研究人員進行各項醫療技術發展，強化我國學術研究與產業發展的結合。本次成果在科技部補助下，由臺北醫學大學陳震宇特聘教授研究團隊，執行肺癌大數據精準醫療人工智慧系統計畫，以「早期預防、精確診斷、精準用藥」為目標，成功打造全台第一個醫病決策共享的「肺癌臨床智能決策輔助系統」(Clinical Decision Support System-Shared Decision Making, CDSS-SDM)，傑出的研究成果甫榮獲最新一屆FUTEX未來科技獎與國家新創獎。

肺癌是國人癌症的頭號殺手，唯有早期診斷、精準治療才能戰勝肺癌。肺癌治療決策需要多方面考量，臨床上肺癌早期診斷需要精準影像，治療與藥物選擇則需參考致癌基因變異等多重因素。肺癌從影像診斷的第一天起，病人就和時間賽跑，關鍵的前10天至少有4次檢查結果必須與經驗豐富的醫師共同討論治療決策，使用大數據和人工智慧有助於早期決策，提高醫療效能、達到肺癌精準臨床治療願景。

在科技部支持下，計畫團隊以深度學習為基礎，發展「肺癌臨床智能決策輔助系統」，根據臨床實際病程發生的流程，提供醫師與病患診斷、用藥、預後評估。團隊開發的「全自動低劑量電腦斷層肺癌基因突變預測模型」可自動從300多張電腦斷層影像自動偵測腫瘤，並精確切割運算，判斷腫塊類型和可能的基因突變，自動報告肺結節的處理建議。團隊更將電腦斷層預測結果和臨床大數據結合，透過肺腺癌病患醫療大數據和自動機器學習方法建立腦轉移、預後與藥物反應預測模組，當電腦斷層影像發現新發個案時，可立即預測腦轉移風險和選藥建議。

臺北醫學大學與臺灣醫療科技大廠雲象科技合作，開發可在全玻片數位病理浩瀚的細胞影像結構中，高速搜尋癌細胞並進行判讀之技術，並以此延伸開發全新的「全自動數位肺腺癌病理基因突變預測選藥模型」，可快速自動標註，並預測表皮生長因子受體(EGFR)最常見基因的突變狀態，結合病理與千人臨床數據，有助於提早精準用藥，相關成果，目前正積極申請海內外專利。

此外，團隊更以突破性技術開發「病理報告自然語言處理(NLP)自動判讀選藥建議系統」與「肺腺癌全基因用藥建議模型」，以人工智慧自然語言處理技術，輸入病人的一份病理報告即可自動得到存活率較高的健保與自費用藥推薦。並將治療效果和存活期做串聯，篩選出與病患相似且預後最佳的選藥治療建議，如同集合幾十個閱讀過上百份病理報告的專家共同所做的決策，有助於醫師和病人之間的決策分享，並依最新發展更新，讓醫病共享發揮到極致。對於晚期肺癌無法開刀或已經轉移復發，系統自動將病人狀況媒和全球新藥試驗場域，讓病人有機會媒合最適合的臨床試驗，為患者帶來新興的治療方向。

「肺癌臨床智能決策輔助系統」由臺北醫學大學與科技部攜手，集合跨領域生醫專家，將AI大數據加值，運用創新人工智慧肺癌模組，輔助臨床電腦斷層攝影與數位病理影像判讀，結合臨床數據與基因資料，成功開發出創新平台，將臺灣研究成果推向國際。讓肺癌早期診斷，個人化精準治療的醫病共享決策模式變成可能，進而創造科技突破造福人群，為患者帶來治癒的新希望。

研究成果聯絡人
陳震宇 特聘教授
臺北醫學大學醫學系
聯絡電話 (公): 02-6638-2736 #1995
電子郵件信箱：[email protected]

發稿單位：生命科學研究發展司
聯絡人：張友琪副研究員
電話：(02) 2737-7544
E-mail：[email protected]

*陳震宇副校長研發團隊合影，左起張資昊教授、許明暉教授、陳志榮教授、陳震宇副校長、黎阮國慶助理教授、蕭世欣醫師

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👉計畫緣起：培育獎助國人海外求學及科研，並強化我國人文社科在國際學術界之連結資源

👉申請資格：
1.博士候選人：就讀於教育部公告「外國大學參考名冊」收錄之海外大學校院人文及社會科學領域研究所之在學全職博士生，於申請截止日前已取得博士候選人資格者。
2.年輕學者：取得博士學位後10年內，現任職於海外人文及社會科學領域大學或學術研究機構，為該機構專任教師或全職研究人員(不含博士後研究)。

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【Press Release】

March 30th, 2022

The Impact of Boredom on Attention Deficit Hyperactivity Disorder (ADHD)

The Ministry of Science and Technology (MOST) has deeply engaged in basic research, and it has promoted the application of bran imaging equipment (MRI, NEG) to mental health research in order to provide new insight to the mysteries of bran. By the support of MOST, assistant professor Chia-Fen Hsu (Graduate Institute of Behavioral Science, Chang Gung University) conducted a brain imaging research project to explore the relationships between brain function and behavior in children with Attention Deficit Hyperactivity Disorder (ADHD). The research findings provide reference for clinical treatment of ADHD.

ADHD is one of the most common neurodevelopmental disorders of childhood. Children with ADHD are characterized by difficulty focusing, managing energy levels and controlling impulses. ADHD-related behaviors can continue into adolescence and adulthood, affecting family functioning, academic performance and work achievement. Feeling bored and unwilling to wait are common complaints of children, but ADHD makes these problems more unbearable. Boredom has been viewed as a type of attention failure, but previous research had seldom investigated the experience of boredom in children with ADHD. Assistant professor Hsu conducted the research project to explore feeling of boredom, delay aversion and inattention in children with ADHD. The findings may enhance understanding of psychopathy in ADHD, and facilitate the development of coping strategies in family, educational and medical settings for children with ADHD.

Assistant professor Hsu dedicates to research and clinical services to improve mental health and wellbeing of individuals with neurodevelopmental conditions. Her research expertise particularly focuses on cognitive, emotional and brain deficits in children with ADHD. She was awarded the Kramer-Pollnow Young Investigator Award at 2016 International conference of European Network for Hyperkinetic Disorders (EUNETHYDIS). In 2017, she was selected as the Young Taiwaner by Health Promotion Administration, Ministry of Health and Welfare to attend the European Health Forum Gastein in Austria and used this experience to help the organization of Global Health Forum in Taiwan. Assistant professor Hsu is the leader of Developmental Cognitive Neuroscience Laboratory. She is a licensed clinical psychologist. Over the years she has led graduate students in clinical psychology program to investigate neuropsychological function of children, adolescents and adults with ADHD. The research team developed measures of boredom and delay aversion. They investigated the association between behavior and brain using questionnaires, psychological tests, electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI).

Assistant professor Hsu’s research team investigated boredom proneness, delay aversion and state of boredom after completing a task required sustained attention between children with and without ADHD. They found that there were moderate to strong correlations among boredom proneness, delay aversion and ADHD symptom severity. Boredom proneness affected delay aversion, which in turn affected ADHD-related behaviors. Moreover, children with ADHD reported a higher level of boredom proneness. They felt more bored than typical developing children after completing the task required sustained attention. The more attention errors they made, the more boring they were. In addition, boredom was involved in the brain’s default mode network (DMN). The DMM was active during mind wandering. When children with ADHD were waiting or performing an attention task, the neural activities of DMN were not effectively attenuated, which were related to disrupted behaviors.

The related findings were published in Psychiatry Research, 2020, 286:112861. Based on theoretical and research findings, Assistant professor Hsu provided parenting suggestions. Scolding and physical punishment cannot fully solve ADHD-related problems. Children with ADHD need their parents to be patient and provide clear rules to improve their behaviors. Boredom and attention are two-sided swords. For example, when kids feel bored with homework, their attention become poor. On the other hand, kids with poor attention get bored with homework easily. What can we do when our children feel bored? The solution of coping with boredom is to provide children something interesting and can be engaged mental effort in, rather than stuffing them with more things to do. Eliminating boredom can improve attention performance.

Research Contact：
Chia-Fen Hsu, PhD
Assistant Professor
Graduate Institute of Behavioral Science, c/o Department of Occupational Therapy
Chang Gung University
Tel: +886 3 2118800 ext. 5732
Email：[email protected]

【科技部新聞稿】

「無聊」如何影響過動兒

日期：2022年3月30日

科技部長期深耕基礎研究，並積極推廣以腦部造影儀器（MRI、MEG）應用於心智活動相關研究，期能對人類行為提供另一種解釋資料探索大腦的奧秘。在科技部的支持下，長庚大學職治系暨行為科學所許嘉芬助理教授運用腦造影分析，探索注意力不足過動症（俗稱過動症、ADHD）的兒童行為與大腦結構與功能的關係，研究成果可作為ADHD兒童治療策略的參考。

ADHD是兒童時期常見的神經發展疾患之一，過動兒主要的問題表現包括注意力不易集中、活動量過高及行為衝動，而此症狀可能延續到青少年或成人，並且擴及影響到患者的家庭關係、學習表現和工作成就。眾所周知，感到無聊與討厭等待是一般兒童常見的抱怨，而無聊被學者視為是一種注意力失誤，患有ADHD的孩子難以忍受無聊和等待，卻少有研究提及，無聊的感受對ADHD兒童的認知、情緒及困擾行為有何影響。許嘉芬助理教授執行的科技部研究計畫，即是探討ADHD兒童的無聊感受、討厭等待與其注意力不集中的關係，此研究成果有助於暸解ADHD兒童的心理病理，協助發展在家庭與教育環境的因應策略。

許嘉芬助理教授致力於兒童心理衛生研究工作與臨床服務，研究專長著重於ADHD的認知、情緒與大腦功能缺損。許助理教授曾獲得歐洲過動症國際研討會（EUNETHYDIS）所頒發Kramer-Pollnow年輕研究者獎，亦曾獲臺灣國民健康署甄選為年輕學者代表，至奧地利出席歐洲衛生論壇，並且協助在國內舉辦的全球衛生論壇。許助理教授擔任認知神經發展研究室的主持人，具有臨床心理師執照，多年來，她帶領臨床心理組碩士生研究ADHD兒童青少年與成人的神經心理功能，並且發展出檢測臺灣兒童的無聊傾向與討厭等待的測量工具，透過問卷調查、心理測驗工具、腦波及核磁造影，探索ADHD患者的行為與大腦功能間之關係。

許助理教授的研究團隊透過比較典型發展兒童與ADHD兒童的無聊傾向、討厭等待，以及在完成持續注意力測驗後的無聊狀態後發現，無聊傾向、討厭等待與ADHD症狀嚴重度有中度至高度的正相關，也就是，感受到無聊會影響個體對等待的厭惡感，進而影響ADHD問題行為的發生。研究也發現，ADHD兒童較典型發展兒童有較高的無聊傾向，在完成持續注意力作業後容易感受到無聊，當注意力表現越差、失誤越多的時候，個體就越容易感到無聊。而無聊涉及大腦的預設模式網路（Default mode network, DMN），此網路在發呆、做白日夢時特別活躍，ADHD兒童在等待與進行注意力作業時，無法有效降低此網路的神經活動，推測其問題行為可能與此有關。

許助理教授研究團隊除了將研究成果發表在2020年國際級學術期刊《精神醫學研究》第286卷 (Psychiatry Research 286:112861)之外，也根據理論與研究發現，提出教養ADHD兒童的建議。對於ADHD孩子來說，其問題行為無法以打罵的方式改善，而是需要保持耐心，並且給孩子清楚的規則。孩子感受到無聊，對其注意力的影響可能是雙向的，例如，當孩子開始覺得寫作業很無聊，其注意力表現就越差；而注意力越差的孩子，也越容易覺得寫作業很無聊。而當孩子感到無聊的時候該怎麼辦呢？解決ADHD孩子無聊的方法並不是塞給孩子更多事情做，而是協助他們找到能感到興趣，並且主動投入心力的事物，如此即可大幅降低孩子們的無聊感受，進而改善其注意力表現。

研究成果聯絡人
許嘉芬助理教授 長庚大學職治系暨行為科學研究所
電話：03-2118800-5732 0920837343
Email：[email protected]

發稿單位：科技部人文司
聯絡人：洪鈺惠助理研究員
電話：(02)2737-7552
E-mail：[email protected]

【Press Release】
EEG breakthrough - towards precision treatment in migraine

March 22, 2022

To focus on the development of research with Taiwan characteristics and potentiality for international cooperation, the Ministry of Science and Technology (MOST) has promoted “Taiwan Brain Technology Development and International Raising Program”. This program aims to develop innovative research and key technologies research in brain and neuroscience, to drive the development of precision medicine and related industries. In the past few years, a solid foundation and strong research energy for brain science have been established in Taiwan. With the support of the MOST program, the research team leading by Prof. Shuu-Jiun Wang of National Yang Ming Chiao Tung University has been focusing their works on headache and pain. A series of clinical studies are completed in close cooperation between the Brain Research Center, National Yang Ming Chiao Tung University and the Neurological Institute, Taipei Veterans General Hospital.

The World Health Organization ranks migraine as one of the top 10 chronic diseases. According to the latest Global Burden of Disease Study, migraine has been the second leading cause of disability in the past three decades. Among population aged between 15 to 49 years old, migraine is the number one cause of disability. According to the diagnostic criteria of The International Classification of Headache Disorders (ICHD-3) published by the International Headache Society, migraine is recurrent headache disorder manifesting in attacks lasting 4-72 hours. Typical characteristics of the headache are unilateral location, pulsating quality, moderate or severe intensity, aggravation by routine physical activity and association with nausea, vomiting, sensitive to light and sound. According to a survey by the VGH-YM Headache Research Team, there are as many as 2 million people in Taiwan suffering from migraine, of which female patients are three times as many as male patients. Based on an online migraine questionnaire conducted by the Taiwan Headache Society in July 2021, it was found that nearly half of the respondents did not know that excessive use of painkillers may worsen headaches, and only about one-third of them knew that migraine headaches can be treated with prophylactics.

Migraine can seriously affect patients' lives, and preventive treatment can reduce the frequency and severity of headaches. According to the clinical guidelines published by the International Headache Society, preventive treatment should be considered when there are more than four headache attacks per month. In addition, those with special forms of migraine attacks, migraine attacks that seriously affect daily life, failure of acute treatments, contraindications of acute treatments, excessive use of pain killers (more than 10 days per month), also need to consider preventive treatment. However, about 40% of patients reveal limited treatment response, and moreover, it is still difficult to predict who will benefit.

With the support of the Ministry of Science and Technology, the VGH-YM Headache Research Team collected a large number of clinical data on migraine patients, including headache profiles, sociopsychological information, and physiological measurements such as electroencephalograms (EEG), to explore the predictability of EEG in treatment response among patients with migraine. They found that patients with chronic migraine who did not show abnormal augmentation of alpha waves in the visual area were around eight times more likely to have significant improvement, namely more than 50% reduction in headache frequency, after treatment. In other words, an EEG assessment for migraine patients prior to preventive treatment can be used to predict who will response to the preventive treatment. The results of this study have been accepted in Pain, an authoritative journal in the International Association for the Study of Pain (IASP), on October 13, 2021. This predictive model can assist physicians in prescribing precise and personalized migraine treatment. In the future, wearable wireless EEG cap are expected to be used for rapid evaluation in outpatient settings.

Article Information:
Pan, Li-Ling Hope; Chen, Wei-Ta; Wang, Yen-Feng; Chen, Shih-Pinc; Lai, Kuan-Lin; Liu, Hung-Yu; Hsiao, Fu-Jung*; Wang, Shuu-Jiun* Resting-state occipital alpha power is associated with treatment outcome in patients with chronic migraine, PAIN: October 13, 2021 doi: 10.1097/j.pain.0000000000002516
Full-text available at: https://journals.lww.com/pain/abstract/9000/resting_state_occipital_alpha_power_is_associated.97859.aspx

Research Contact
Shuu-Jiun Wang, M.D.
Vice Dean, College of Medicine, National Yang Ming Chiao Tung University
Director, Brain Research Center, National Yang Ming Chiao Tung University
Director, Neurological Institute, Taipei Veterans General Hospital
TEL: +886-2-28267578
Email: [email protected]

Media Contact
Yo-Chi Chang
Program Manager
Department of Life Sciences
Ministry of Science and Technology
TEL: +886-2-27377544
Email: [email protected]

【科技部新聞稿】
邁向偏頭痛的精準治療—腦波應用新突破

科技部為聚焦發展具台灣特色及國際合作潛力主題研究，推動「臺灣腦科技發展及國際躍升計畫」開發腦與神經科學之創新研究與關鍵技術，驅動精準醫療與相關產業發展。過去數年在此專案支持下，我國腦科技研究已奠定相當紮實的基礎與厚實的研究能量。國立陽明交通大學腦科學研究中心及臺北榮民總醫院神經醫學中心組成的研究團隊，在王署君教授領軍之下透過執行專案計畫密切合作，進行一系列頭痛及疼痛相關臨床研究。

世界衛生組織將偏頭痛列為十大重要疾病之一，根據最新《全球疾病負擔研究》，過去30年間偏頭痛高居導致失能疾病的第二位，而在介於15至49歲的年輕族群中，偏頭痛更是造成失能的第一大原因。根據國際頭痛學會所制定的第三版國際頭痛分類(The International Classification of Headache Disorders, ICHD-3)診斷標準，若頭痛至今有超過5次，而每次持續4至72小時，同時伴隨著噁心、嘔吐、畏光、怕吵等症狀，並且有以下其中一項特徵：搏動性庝痛、單邊、至少為中等程度疼痛、頭痛因身體活動而加劇，即符合偏頭痛定義。根據榮陽頭痛研究團隊的調查，台灣大約有高達200萬人患有偏頭痛，其中女性患者又是男性患者的3倍之多。台灣頭痛學會於2021年7月進行偏頭痛線上問卷調查，結果發現竟有近一半的受訪者不知道過度使用止痛藥可能會造成頭痛更加惡化，而且只有約三分之一的民眾知道偏頭痛可以利用預防性藥物進行治療。

偏頭痛會嚴重影響患者生活，採取預防性治療可以減少頭痛發生的頻率與嚴重度。根據國際頭痛學會所發表的臨床治療指引，每月頭痛超過4天時，需考慮給予患者預防性治療。此外，若有以下狀況時也需要考慮預防性治療，包括：特殊形式的偏頭痛發作、偏頭痛發作會嚴重影響日常生活、急性治療藥物失敗或是有禁忌症、過度使用急性治療藥物者 (每個月使用10天以上)。然而，臨床上即使根據指引施以治療，仍然約有四成患者的治療成效有限，且治療前無法預測其療效。

榮陽頭痛團隊因此進行研究，收集臨床偏頭痛患者資料，包含頭痛情形、情緒壓力、及腦波等生理量測，以探討慢性偏頭痛患者治療前的腦波與接受三個月治療後成效的關聯性。結果發現慢性偏頭痛患者，治療前的大腦視覺區腦波，顯著反映出與治療療效的關聯性。當病患大腦視覺區的α波強度無異常強化時，相對來說約有8倍的機會在治療後頭痛發作次數減少一半以上。簡單來說，偏頭痛患者在接受預防性治療前，若進行一次腦波評估，將可預測這種預防性治療是否有效。本項研究成果已於2021年10月13日獲得國際疼痛研究協會(International Association for the Study of Pain, IASP)官方期刊，也是疼痛領域的權威期刊《疼痛(PAIN)》接受刊登。此項預測模式將可協助醫師訂定個人化偏頭痛的精準治療，未來更有望以穿戴式無線腦波進行門診快速評估，造福廣大偏頭痛病患。

文章連結：
https://journals.lww.com/pain/abstract/9000/resting_state_occipital_alpha_power_is_associated.97859.aspx

研究成果聯絡人
王署君 醫師/講座教授
國立陽明交通大學醫學院副院長/講座教授
國立陽明交通大學腦科學研究中心主任
臺北榮民總醫院神經醫學中心主任
聯絡電話(公)：(02) 28757578
電子郵件信箱：[email protected]

發稿單位：生命科學研究發展司
聯絡人：張友琪副研究員
電話：(02) 2737-7544
E-mail：[email protected]