TRC

📢We'll be in Singapore next month for the Dioxin 2024 – 44th International Symposium on Halogenated Persistent Organic Pollutants (POPs)!

👋Meet our LGC APAC team at booth B10 to discuss your analytical needs. Don't miss out on our presentation on Oct 1, 2024!

Our very own Dr Dan Biggerstaff and Dr Davide Gastaldello will present "𝗣𝗙𝗔𝗦 𝗥𝗲𝗳𝗲𝗿𝗲𝗻𝗰𝗲 𝗠𝗮𝘁𝗲𝗿𝗶𝗮𝗹 𝗢𝗽𝘁𝗶𝗺𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗢𝘁𝗵𝗲𝗿 𝗡𝗲𝘄 𝗗𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁𝘀" at the symposium.

⬇ Explore our complete portfolio of PFAS reference materials in our brand new catalogue: https://okt.to/Ce3qhp

Download our latest white paper to learn everything you need to know about "Smart Nanoparticles" (NPs): https://okt.to/uXWKCJ

A new generation of smart NPs has emerged, capable not only of improving drug solubility and bioavailability but also of responding to internal and external cues such as biomarkers, pH, temperature and light to achieve specific disease targeting.

This white paper considers ☑ expert opinions, drug approvals, and clinical trials that illustrate the progress and potential of these technologies.
☑ We also explore the power of artificial intelligence to guide development of these technologies and ☑ acknowledge the challenges associated with their use, including toxicology and scale up barriers.

LGC Standards will be exhibiting at analytica Anacon India & India Lab Expo next month. Let us know in the comments if you're attending too!

📍Don't forget to visit our booth at Hall 2, A11 from September 26 to 28.

We look forward to meeting you there! Check out our comprehensive solutions spanning across food, environmental, pharma, and industrial sectors.https://okt.to/izCw6W

𝗡𝗲𝘄 𝗟𝗲𝗮𝗿𝗻𝗶𝗻𝗴 𝗮𝗻𝗱 𝗠𝗲𝗺𝗼𝗿𝘆 𝗧𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰 𝗧𝗮𝗿𝗴𝗲𝘁 𝗜𝗱𝗲𝗻𝘁𝗶𝗳𝗶𝗲𝗱

Our ability to form new long-term memories fades as we age! Understanding the complex molecular mechanisms behind this process is crucial for designing new therapeutics to keep us sharp, happy, and healthy into old age.

, known as the hormone of darkness, is synthesised at night based on the length of the period of darkness. New research from Japan using our research chemicals reveals that long-term memory formation in the hippocampus is enhanced at night when melatonin levels are high.

Discover more about these findings in the Pineal Research: https://okt.to/uQ4sq2

💡 View our complete solution to your laboratory’s needs – from research, drug design and development to manufacturing and qualification: https://okt.to/3A4NfD

Next month, we'll be in Madrid for the tenth edition of the . We're excited to participate in one of the most important trade fairs for the pharmaceutical industry in Spain. 🇪🇸

👇Let us know in the comments if you're attending. Our team of experts is looking forward to meeting you at stand F28.

Come explore our complete solution to your lab's needs- from research and drug development to manufacturing and qualification. Visit https://okt.to/pc4rVG to learn more.

𝗛𝗼𝗽𝗲 𝗳𝗼𝗿 𝗛𝗲𝗮𝗿𝘁 𝗙𝗮𝗶𝗹𝘂𝗿𝗲 𝗣𝗮𝘁𝗶𝗲𝗻𝘁𝘀: 𝗔 𝗡𝗲𝘄 𝗧𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰 𝗔𝗽𝗽𝗿𝗼𝗮𝗰𝗵
Heart failure is a devastating condition with a high mortality rate despite significant medical progress. Many studies have suggested that mitochondrial dysfunction plays a crucial role in heart failure, but until now, there haven't been any therapies directly targeting this issue.

Exciting research by scientists at the University of Washington, using our TRC research chemicals, has found that boosting levels of the enzyme cofactor NAD+ through administration of precursors such as nicotinamide riboside chloride can effectively combat heart failure.

These mechanisms reveal the important regulator of mitochondrial function, SDR 3 as a promising therapeutic target. Discover more about these findings in Circulation: https://okt.to/UOIiA5

🔬Explore our comprehensive range of impurity analytical standards, covering over 10,000 impurities today: https://okt.to/VD1d9p

We offer a comprehensive range of pharmaceutical impurity analytical standards, covering over 10,000 impurities, for routine quality control to ensure batch-to-batch consistency in manufacturing pharmaceutical products.

Each TRC impurity standard comes with a detailed certificate of analysis (CoA) and comprehensive documentation, supporting researchers in verifying the quality and identity of the standards.

💻Explore now:
https://okt.to/42Ol6u

Given the significant health risks associated with reported unsafe levels of PFAS in food and their potential to migrate from FCMs, detecting PFAS in food matrices and packaging materials has become a critical focus in recent years.

📜This whitepaper examines the scale and severity of PFAS contamination in food with recent toxicology data and evaluates global regulatory progress. Discover more insights in the whitepaper now: https://okt.to/yN1Dg3

𝗕𝗿𝗲𝗮𝗸𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝗶𝗻 𝗗𝗶𝗮𝗯𝗲𝘁𝗶𝗰 𝗥𝗲𝘁𝗶𝗻𝗼𝗽𝗮𝘁𝗵𝘆 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵

Diabetic retinopathy (DR) is a chronic microvascular complication of diabetes, affecting over 100 million people worldwide. It causes progressive damage to the capillaries of the inner retina, leading to vision impairment and blindness.

Scientists at Roche Pharma R&D and Massachusetts Institute of Technology (MIT) used our research chemical (D-Mannitol) in developing a groundbreaking ophthalmic model on a chip, designed to represent DR. Explore more about this product (TRC-M165000): https://okt.to/Q65LRh

Discover more about this pioneering research in Nature Communications: https://okt.to/dWhj1H

Have you seen the latest PFAS catalogue?
Explore the complete range of PFAS reference materials and research chemiclas, including the latest mixtures to support the EU Drinking Water Directive, UCMR 5 and EPA Method 1633.

Download the catalogue now: https://okt.to/q3EgJL

After months of chilly weather, the teams at the Toronto site celebrated the arrival of summer with an ice cream event.

Thanks to the EWC (Engagement & Wellbeing Committee) team for coordinating and organising this summer event- bringing everyone together for a fun afternoon of frozen treats and good company.

📸 Check out the moments we captured during the event!

Explore the key aspects of forced degradation testing, also known as stress testing, in our latest : 𝗔 𝗚𝘂𝗶𝗱𝗲 𝘁𝗼 𝗣𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹 𝗦𝘁𝗿𝗲𝘀𝘀 𝗧𝗲𝘀𝘁𝗶𝗻𝗴
⬇ https://okt.to/YlAsDk

The whitepaper offers best practices for ensuring drug stability, regulatory compliance, and designing robust stability-indicating methods. Download the whitepaper for more insights!

𝗣𝗿𝗲𝘀𝗰𝗿𝗶𝗯𝗶𝗻𝗴 𝗳𝗼𝗿 𝗮 𝗡𝗲𝘄 𝗚𝗲𝗻𝗲𝗿𝗮𝘁𝗶𝗼𝗻: 𝗔𝗻𝘁𝗶-𝗢𝗯𝗲𝘀𝗶𝘁𝘆 𝗗𝗿𝘂𝗴𝘀
The new generation of anti-obesity drugs like Orlistat has the potential to tackle the root causes of the diabetes epidemic, which could significantly improve the life prospects of millions of people globally.

However, many pharmaceuticals can interfere with other medications, and Orlistat is no exception. Research into drug metabolism pathways in the body is essential to inform physicians about optimal prescribing practices and to aid in the design of alternative therapeutics.

We are thrilled to share that TRC research chemicals were used to demonstrate how Orlistat is metabolized through carboxylesterase 2 (CES2) enzymes in the body. This enzyme pathway is crucial as it metabolizes a variety of medications, including the widely-used chemotherapy drug Irinotecan and the antiplatelet drug Clopidogrel.

Understanding these interactions helps in managing potential drug-drug interactions and enhancing therapeutic efficacy. Discover more about these findings in Drug Metabolism and Disposition: https://okt.to/nZib9S

💡TRC offers a large and novel collection of API analytical standards, which have enormous utility in pharmaceutical applications - ranging from identity standards to activity assays. Explore more at https://okt.to/IKVwph

Evaluation of Drug-Drug Interactions via Inhibition of Hydrolases by Orlistat, an Anti-Obesity Drug Drug-drug interactions (DDI) have a significant impact on drug efficacy and safety. It has been reported that orlistat, an anti-obesity drug, inhibits the hydrolysis of p -nitrophenol acetate, a common substrate of the major drug-metabolizing hydrolases, carboxylesterase (CES) 1, CES2, and arylaceta...

What are the key principles of compound design when developing stable isotope labelled (SIL) reference standards that are suitable for use in drug safety and toxicology research studies?

Responding to rising demand from the medical research community, TRC has increased its development of novel stable labelled drug and drug metabolite standards. Check out our poster for novel synthesis routes for SIL drug reference standards. 👇https://okt.to/axEgA5

Explore our extensive range of SIL reference standards at
https://okt.to/HhmQne

We're excited to be heading to South Korea for CPHI Korea next month!

If you plan to attend, visit us at stand K24 and discover how our comprehensive solutions can address your laboratory’s needs – from research, drug design and development to manufacturing and qualification.

Visit lgcstandards.com to learn more!

Join us at the AOAC INTERNATIONAL Annual Meeting & Exposition next month!

Our team of experts will be at booth 105, showcasing our wide range of reference materials and proficiency testing schemes, across various sectors- from food to environmental and pharmaceutical.

Our world-leading chemists engineer specific solutions for customers, and we have a uniquely large range– featuring APIs, impurities, metabolites, building blocks, SILS and many novel bioactive molecules for research into areas including cancer, infectious diseases, and neuroscience.

Visit https://okt.to/TRNyzg to explore our portfolio.

𝗡𝗲𝘄 '𝗟𝗶𝘃𝗲𝗿 𝗼𝗻 𝗮 𝗖𝗵𝗶𝗽' 𝗦𝘆𝘀𝘁𝗲𝗺 𝘁𝗼 𝗘𝗻𝗵𝗮𝗻𝗰𝗲 𝗗𝗿𝘂𝗴 𝗦𝗮𝗳𝗲𝘁𝘆 𝗣𝗿𝗲𝗱𝗶𝗰𝘁𝗶𝗼𝗻
Predictive, easy-to-use models are essential for simulating the metabolism and clearance of pharmaceuticals in the body. These models play a critical role in drug discovery and post-market surveillance, ensuring the safety and efficacy of medications.

In a study recently published in the European Journal of Pharmaceutical Sciences, researchers at the University of Helsinki used our TRC research chemicals to develop a liver on a chip microsystem for modelling drug safety and metabolism. Read more about encouraging findings from the study: https://okt.to/e37Y9D

Explore our API Reference Standards & Research Materials at https://okt.to/MXfPe4

📢 Next month, we'll be exhibiting at American Chemical Society in Denver, CO!

We will be at booth 1713 to showcase our reference materials and research chemicals across various sectors- from food to pharmaceutical.

💻Explore more: https://okt.to/TbhLcZ

Nanotechnology is revolutionising drug delivery by tackling the key challenges in solubility and bioavailability that significantly impact drug efficacy.

Some of the most promising nano drug delivery systems currently being studied are metal-organic frameworks (MOFs), carbon nanotubes (C**s), mesoporous silica nanoparticles (MSNs), nanoemulsions, and solid lipid nanoparticles.

Read our latest blog post to explore the key issues and trends in nano drug delivery techniques at https://okt.to/fgrvZQ

𝗕𝗿𝗲𝗮𝗸𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝗶𝗻 𝟯𝗗 𝗣𝗿𝗶𝗻𝘁𝗶𝗻𝗴 𝗡𝗮𝗻𝗼𝘁𝗲𝗰𝗵 𝗜𝗺𝗽𝗿𝗼𝘃𝗲𝘀 𝗗𝗲𝗹𝗶𝘃𝗲𝗿𝘆 𝗼𝗳 𝗛𝘆𝗱𝗿𝗼𝗽𝗵𝗼𝗯𝗶𝗰 𝗗𝗿𝘂𝗴𝘀 𝗹𝗶𝗸𝗲 𝗜𝗯𝘂𝗽𝗿𝗼𝗳𝗲𝗻

Our ibuprofen research chemical was utilised in a study recently published in the European Journal of Pharmaceutics and Biopharmaceutics.

Researchers from Uppsala University in Sweden used 3D printing to incorporate drug-loaded magnesium carbonate nanomaterials into formulations. This approach improves drug loading and solubility for poorly soluble medications like ibuprofen.

Explore our ibuprofen research chemicals: https://okt.to/TNzXv1

Read the study: https://okt.to/OGb62B

𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫 𝐭𝐡𝐞 𝐤𝐞𝐲 𝐭𝐨 𝐞𝐧𝐬𝐮𝐫𝐢𝐧𝐠 𝐝𝐫𝐮𝐠 𝐬𝐭𝐚𝐛𝐢𝐥𝐢𝐭𝐲 𝐚𝐧𝐝 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐨𝐫𝐲 𝐜𝐨𝐦𝐩𝐥𝐢𝐚𝐧𝐜𝐞 𝐰𝐢𝐭𝐡 𝐨𝐮𝐫 𝐧𝐞𝐰 𝐰𝐡𝐢𝐭𝐞 𝐩𝐚𝐩𝐞𝐫 𝐨𝐧 𝐟𝐨𝐫𝐜𝐞𝐝 𝐝𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧 𝐬𝐭𝐮𝐝𝐢𝐞𝐬!

This essential guide integrates industry insights, scientific literature, and regulatory guidelines to help you design effective stress testing protocols. Learn how to identify real-world degradation pathways, create robust stability-indicating methods, and enhance drug approval and formulation processes.

Enhance your pharmaceutical testing and development with our white paper: https://okt.to/nGi20S

The World Health Organisation has released draft guidelines to combat the presence of potentially carcinogenic nitrosamine impurities in medicines.

These guidelines, building on the efforts of the FDA and EMA, offer detailed advice on Good Manufacturing Practices, risk assessment, root cause analysis, and analytical procedures. This critical update aims to enhance the safety of drug products by ensuring rigorous identification and control of nitrosamine impurities, thereby maintaining the global supply of essential medicines.

Read the article to learn more: https://okt.to/aEWXO5

WHO releases new guidelines for preventing nitrosamine contamination | LGC Standards The World Health organisation (WHO) has released new recommendations for limiting the presence of potentially carcinogenic nitrosamine impurities in medicines.

𝗡𝗮𝗻𝗼𝗽𝗮𝗿𝘁𝗶𝗰𝗹𝗲-𝗗𝗲𝗹𝗶𝘃𝗲𝗿𝗲𝗱, 𝗨𝗩-𝗔𝗰𝘁𝗶𝘃𝗮𝘁𝗲𝗱 𝗖𝗵𝗲𝗺𝗼𝘁𝗵𝗲𝗿𝗮𝗽𝘆 𝗘𝗳𝗳𝗲𝗰𝘁𝗶𝘃𝗲 𝗶𝗻 𝗕𝗿𝗲𝗮𝘀𝘁 𝗖𝗮𝗻𝗰𝗲𝗿 𝗠𝗼𝗱𝗲𝗹𝘀

Breast cancer, a disease affecting millions worldwide, often requires chemotherapy, which can cause serious side effects due to off-target toxicity.

Improved, targeted drug delivery technologies aim to enhance efficacy and reduce toxicity by precisely targeting tumours, thereby improving outcomes and minimizing side effects.

We're excited to share a study using our TRC research chemicals to develop a gold nanoparticle system for delivering the chemotherapy drug doxycycline, which can be activated at the tumour site using UV light.

Recently published by Turkish scientists at Hacettepe University, these preclinical studies show promising progress. Read on at https://okt.to/HxeVPQ.

💡 TRC supports you from target identification to drug development and toxicology, view our extensive range at https://okt.to/FegMKB

Nanotechnology is revolutionising drug delivery by tackling the key challenges in solubility and bioavailability that significantly impact drug efficacy.

Some of the most promising nano drug delivery systems currently being studied are metal-organic frameworks (MOFs), carbon nanotubes (C**s), mesoporous silica nanoparticles (MSNs), nanoemulsions, and solid lipid nanoparticles.

Read our latest blog post to explore the key issues and trends in nano drug delivery techniques at https://okt.to/p1omJu

Nanotechnology in Drug Delivery | LGC Standards Nanotechnology is revolutionising drug delivery by tackling the solubility and bioavailability challenges that lead to many drugs failing clinical trials.

𝗡𝗮𝗻𝗼𝗽𝗮𝗿𝘁𝗶𝗰𝗹𝗲𝘀 𝗦𝘂𝗰𝗰𝗲𝘀𝘀𝗳𝘂𝗹𝗹𝘆 𝗗𝗲𝗹𝗶𝘃𝗲𝗿 𝗔𝗻𝘁𝗶𝗿𝗲𝘁𝗿𝗼𝘃𝗶𝗿𝗮𝗹 (𝗔𝗥𝗧) 𝗗𝗿𝘂𝗴𝘀 𝘁𝗼 𝘁𝗵𝗲 𝗕𝗿𝗮𝗶𝗻
The progress in HIV/AIDS treatment, with many patients achieving undetectable virus levels through effective antiretroviral therapy (ART) regimens, showcases the success of modern drug discovery.

However, HIV can invade the brain as early as eight days post-infection, residing in white blood cells. The limited ability of ART to cross the blood-brain barrier presents a significant challenge, leading to numerous HIV-associated brain disorders. Improvements in drug formulation and targeting are needed to meet these clinical needs.

We’re delighted to learn about the use of our darunavir research chemical in a study that developed polymer-coated nanoparticles to deliver ART drugs into mice brains. Published recently in Pharmaceutics, these findings offer hope for a clinical breakthrough for HIV-related CNS infections.

Learn more about the research chemical and related product citations at https://okt.to/0l7UoE

Darunavir Nanoformulation Suppresses HIV Pathogenesis in Macrophages and Improves Drug Delivery to the Brain in Mice Although antiretroviral therapy (ART) can suppress peripheral HIV, patients still suffer from neuroHIV due to insufficient levels of ART drugs in the brain. Hence, this study focuses on developing a poly lactic-co-glycolic acid (PLGA) nanoparticle-based ART drug delivery system for darunavir (DRV) u...

Discover the power of precision medicine in cancer treatment with this insightful infographic!

Gain a deeper understanding of how personalized therapies can make a difference in the lives of cancer patients. This infographic highlights the importance of targeting mutations in cancer and how it can revolutionize patient care.

Download the infographic at https://okt.to/uS1e67

🍁Happy Canada Day🇨🇦!
We hope you all enjoy the long weekend and have a wonderful time with family and friends.

Targeting all KRAS oncogenic variants: a viable path to tangible therapeutic impact?

KRAS was at one time considered undruggable. However, persistent efforts led to the approval of two KRAS mutant inhibitors. Here we review further KRAS inhibition strategies and consider their enormous therapeutic potential.

Read our white paper today: https://okt.to/x7o1pX

Recently, researchers have explored the potential benefits of ayahuasca. This Amazonian plant medicine contains the psychedelic compound DMT and harmine alkaloids and is believed to offer therapeutic effects for patients with affective and mental health disorders.

However, the way ayahuasca is processed in the body causes problems for clinical use. We are thrilled to share that our TRC research chemicals were used to support a study in which researchers have developed an enhanced formulation currently in clinical trials. Read the findings in the journal Frontiers in Pharmacology: https://okt.to/jnoAJa

Frontiers | Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine Recently, the Amazonian plant medicine “ayahuasca”—containing the psychedelic compound N,N-dimethyltryptamine (DMT) and numerous β-carboline alkaloids, such ...