TRC
You may also like
TRC has over 40 years specialised in the production of quality products for innovative research.
๐ขWe'll be in Singapore next month for the Dioxin 2024 โ 44th International Symposium on Halogenated Persistent Organic Pollutants (POPs)!
๐Meet our LGC APAC team at booth B10 to discuss your analytical needs. Don't miss out on our presentation on Oct 1, 2024!
Our very own Dr Dan Biggerstaff and Dr Davide Gastaldello will present "๐ฃ๐๐๐ฆ ๐ฅ๐ฒ๐ณ๐ฒ๐ฟ๐ฒ๐ป๐ฐ๐ฒ ๐ ๐ฎ๐๐ฒ๐ฟ๐ถ๐ฎ๐น ๐ข๐ฝ๐๐ถ๐บ๐ถ๐๐ฎ๐๐ถ๐ผ๐ป ๐ฎ๐ป๐ฑ ๐ข๐๐ต๐ฒ๐ฟ ๐ก๐ฒ๐ ๐๐ฒ๐๐ฒ๐น๐ผ๐ฝ๐บ๐ฒ๐ป๐๐" at the symposium.
โฌ Explore our complete portfolio of PFAS reference materials in our brand new catalogue: https://okt.to/Ce3qhp
Download our latest white paper to learn everything you need to know about "Smart Nanoparticles" (NPs): https://okt.to/uXWKCJ
A new generation of smart NPs has emerged, capable not only of improving drug solubility and bioavailability but also of responding to internal and external cues such as biomarkers, pH, temperature and light to achieve specific disease targeting.
This white paper considers โ expert opinions, drug approvals, and clinical trials that illustrate the progress and potential of these technologies.
โ We also explore the power of artificial intelligence to guide development of these technologies and โ acknowledge the challenges associated with their use, including toxicology and scale up barriers.
LGC Standards will be exhibiting at analytica Anacon India & India Lab Expo next month. Let us know in the comments if you're attending too!
๐Don't forget to visit our booth at Hall 2, A11 from September 26 to 28.
We look forward to meeting you there! Check out our comprehensive solutions spanning across food, environmental, pharma, and industrial sectors.https://okt.to/izCw6W
๐ก๐ฒ๐ ๐๐ฒ๐ฎ๐ฟ๐ป๐ถ๐ป๐ด ๐ฎ๐ป๐ฑ ๐ ๐ฒ๐บ๐ผ๐ฟ๐ ๐ง๐ต๐ฒ๐ฟ๐ฎ๐ฝ๐ฒ๐๐๐ถ๐ฐ ๐ง๐ฎ๐ฟ๐ด๐ฒ๐ ๐๐ฑ๐ฒ๐ป๐๐ถ๐ณ๐ถ๐ฒ๐ฑ
Our ability to form new long-term memories fades as we age! Understanding the complex molecular mechanisms behind this process is crucial for designing new therapeutics to keep us sharp, happy, and healthy into old age.
, known as the hormone of darkness, is synthesised at night based on the length of the period of darkness. New research from Japan using our research chemicals reveals that long-term memory formation in the hippocampus is enhanced at night when melatonin levels are high.
Discover more about these findings in the Pineal Research: https://okt.to/uQ4sq2
๐ก View our complete solution to your laboratoryโs needs โ from research, drug design and development to manufacturing and qualification: https://okt.to/3A4NfD
Next month, we'll be in Madrid for the tenth edition of the . We're excited to participate in one of the most important trade fairs for the pharmaceutical industry in Spain. ๐ช๐ธ
๐Let us know in the comments if you're attending. Our team of experts is looking forward to meeting you at stand F28.
Come explore our complete solution to your lab's needs- from research and drug development to manufacturing and qualification. Visit https://okt.to/pc4rVG to learn more.
๐๐ผ๐ฝ๐ฒ ๐ณ๐ผ๐ฟ ๐๐ฒ๐ฎ๐ฟ๐ ๐๐ฎ๐ถ๐น๐๐ฟ๐ฒ ๐ฃ๐ฎ๐๐ถ๐ฒ๐ป๐๐: ๐ ๐ก๐ฒ๐ ๐ง๐ต๐ฒ๐ฟ๐ฎ๐ฝ๐ฒ๐๐๐ถ๐ฐ ๐๐ฝ๐ฝ๐ฟ๐ผ๐ฎ๐ฐ๐ต
Heart failure is a devastating condition with a high mortality rate despite significant medical progress. Many studies have suggested that mitochondrial dysfunction plays a crucial role in heart failure, but until now, there haven't been any therapies directly targeting this issue.
Exciting research by scientists at the University of Washington, using our TRC research chemicals, has found that boosting levels of the enzyme cofactor NAD+ through administration of precursors such as nicotinamide riboside chloride can effectively combat heart failure.
These mechanisms reveal the important regulator of mitochondrial function, SDR 3 as a promising therapeutic target. Discover more about these findings in Circulation: https://okt.to/UOIiA5
๐ฌExplore our comprehensive range of impurity analytical standards, covering over 10,000 impurities today: https://okt.to/VD1d9p
We offer a comprehensive range of pharmaceutical impurity analytical standards, covering over 10,000 impurities, for routine quality control to ensure batch-to-batch consistency in manufacturing pharmaceutical products.
Each TRC impurity standard comes with a detailed certificate of analysis (CoA) and comprehensive documentation, supporting researchers in verifying the quality and identity of the standards.
๐ปExplore now:
https://okt.to/42Ol6u
Given the significant health risks associated with reported unsafe levels of PFAS in food and their potential to migrate from FCMs, detecting PFAS in food matrices and packaging materials has become a critical focus in recent years.
๐This whitepaper examines the scale and severity of PFAS contamination in food with recent toxicology data and evaluates global regulatory progress. Discover more insights in the whitepaper now: https://okt.to/yN1Dg3
๐๐ฟ๐ฒ๐ฎ๐ธ๐๐ต๐ฟ๐ผ๐๐ด๐ต ๐ถ๐ป ๐๐ถ๐ฎ๐ฏ๐ฒ๐๐ถ๐ฐ ๐ฅ๐ฒ๐๐ถ๐ป๐ผ๐ฝ๐ฎ๐๐ต๐ ๐ฅ๐ฒ๐๐ฒ๐ฎ๐ฟ๐ฐ๐ต
Diabetic retinopathy (DR) is a chronic microvascular complication of diabetes, affecting over 100 million people worldwide. It causes progressive damage to the capillaries of the inner retina, leading to vision impairment and blindness.
Scientists at Roche Pharma R&D and Massachusetts Institute of Technology (MIT) used our research chemical (D-Mannitol) in developing a groundbreaking ophthalmic model on a chip, designed to represent DR. Explore more about this product (TRC-M165000): https://okt.to/Q65LRh
Discover more about this pioneering research in Nature Communications: https://okt.to/dWhj1H
Have you seen the latest PFAS catalogue?
Explore the complete range of PFAS reference materials and research chemiclas, including the latest mixtures to support the EU Drinking Water Directive, UCMR 5 and EPA Method 1633.
Download the catalogue now: https://okt.to/q3EgJL
After months of chilly weather, the teams at the Toronto site celebrated the arrival of summer with an ice cream event.
Thanks to the EWC (Engagement & Wellbeing Committee) team for coordinating and organising this summer event- bringing everyone together for a fun afternoon of frozen treats and good company.
๐ธ Check out the moments we captured during the event!
Explore the key aspects of forced degradation testing, also known as stress testing, in our latest : ๐ ๐๐๐ถ๐ฑ๐ฒ ๐๐ผ ๐ฃ๐ต๐ฎ๐ฟ๐บ๐ฎ๐ฐ๐ฒ๐๐๐ถ๐ฐ๐ฎ๐น ๐ฆ๐๐ฟ๐ฒ๐๐ ๐ง๐ฒ๐๐๐ถ๐ป๐ด
โฌ https://okt.to/YlAsDk
The whitepaper offers best practices for ensuring drug stability, regulatory compliance, and designing robust stability-indicating methods. Download the whitepaper for more insights!
๐ฃ๐ฟ๐ฒ๐๐ฐ๐ฟ๐ถ๐ฏ๐ถ๐ป๐ด ๐ณ๐ผ๐ฟ ๐ฎ ๐ก๐ฒ๐ ๐๐ฒ๐ป๐ฒ๐ฟ๐ฎ๐๐ถ๐ผ๐ป: ๐๐ป๐๐ถ-๐ข๐ฏ๐ฒ๐๐ถ๐๐ ๐๐ฟ๐๐ด๐
The new generation of anti-obesity drugs like Orlistat has the potential to tackle the root causes of the diabetes epidemic, which could significantly improve the life prospects of millions of people globally.
However, many pharmaceuticals can interfere with other medications, and Orlistat is no exception. Research into drug metabolism pathways in the body is essential to inform physicians about optimal prescribing practices and to aid in the design of alternative therapeutics.
We are thrilled to share that TRC research chemicals were used to demonstrate how Orlistat is metabolized through carboxylesterase 2 (CES2) enzymes in the body. This enzyme pathway is crucial as it metabolizes a variety of medications, including the widely-used chemotherapy drug Irinotecan and the antiplatelet drug Clopidogrel.
Understanding these interactions helps in managing potential drug-drug interactions and enhancing therapeutic efficacy. Discover more about these findings in Drug Metabolism and Disposition: https://okt.to/nZib9S
๐กTRC offers a large and novel collection of API analytical standards, which have enormous utility in pharmaceutical applications - ranging from identity standards to activity assays. Explore more at https://okt.to/IKVwph
Evaluation of Drug-Drug Interactions via Inhibition of Hydrolases by Orlistat, an Anti-Obesity Drug Drug-drug interactions (DDI) have a significant impact on drug efficacy and safety. It has been reported that orlistat, an anti-obesity drug, inhibits the hydrolysis of p -nitrophenol acetate, a common substrate of the major drug-metabolizing hydrolases, carboxylesterase (CES) 1, CES2, and arylaceta...
What are the key principles of compound design when developing stable isotope labelled (SIL) reference standards that are suitable for use in drug safety and toxicology research studies?
Responding to rising demand from the medical research community, TRC has increased its development of novel stable labelled drug and drug metabolite standards. Check out our poster for novel synthesis routes for SIL drug reference standards. ๐https://okt.to/axEgA5
Explore our extensive range of SIL reference standards at
https://okt.to/HhmQne
We're excited to be heading to South Korea for CPHI Korea next month!
If you plan to attend, visit us at stand K24 and discover how our comprehensive solutions can address your laboratoryโs needs โ from research, drug design and development to manufacturing and qualification.
Visit lgcstandards.com to learn more!
Join us at the AOAC INTERNATIONAL Annual Meeting & Exposition next month!
Our team of experts will be at booth 105, showcasing our wide range of reference materials and proficiency testing schemes, across various sectors- from food to environmental and pharmaceutical.
Our world-leading chemists engineer specific solutions for customers, and we have a uniquely large rangeโ featuring APIs, impurities, metabolites, building blocks, SILS and many novel bioactive molecules for research into areas including cancer, infectious diseases, and neuroscience.
Visit https://okt.to/TRNyzg to explore our portfolio.
๐ก๐ฒ๐ '๐๐ถ๐๐ฒ๐ฟ ๐ผ๐ป ๐ฎ ๐๐ต๐ถ๐ฝ' ๐ฆ๐๐๐๐ฒ๐บ ๐๐ผ ๐๐ป๐ต๐ฎ๐ป๐ฐ๐ฒ ๐๐ฟ๐๐ด ๐ฆ๐ฎ๐ณ๐ฒ๐๐ ๐ฃ๐ฟ๐ฒ๐ฑ๐ถ๐ฐ๐๐ถ๐ผ๐ป
Predictive, easy-to-use models are essential for simulating the metabolism and clearance of pharmaceuticals in the body. These models play a critical role in drug discovery and post-market surveillance, ensuring the safety and efficacy of medications.
In a study recently published in the European Journal of Pharmaceutical Sciences, researchers at the University of Helsinki used our TRC research chemicals to develop a liver on a chip microsystem for modelling drug safety and metabolism. Read more about encouraging findings from the study: https://okt.to/e37Y9D
Explore our API Reference Standards & Research Materials at https://okt.to/MXfPe4
๐ข Next month, we'll be exhibiting at American Chemical Society in Denver, CO!
We will be at booth 1713 to showcase our reference materials and research chemicals across various sectors- from food to pharmaceutical.
๐ปExplore more: https://okt.to/TbhLcZ
Nanotechnology is revolutionising drug delivery by tackling the key challenges in solubility and bioavailability that significantly impact drug efficacy.
Some of the most promising nano drug delivery systems currently being studied are metal-organic frameworks (MOFs), carbon nanotubes (C**s), mesoporous silica nanoparticles (MSNs), nanoemulsions, and solid lipid nanoparticles.
Read our latest blog post to explore the key issues and trends in nano drug delivery techniques at https://okt.to/fgrvZQ
๐๐ฟ๐ฒ๐ฎ๐ธ๐๐ต๐ฟ๐ผ๐๐ด๐ต ๐ถ๐ป ๐ฏ๐ ๐ฃ๐ฟ๐ถ๐ป๐๐ถ๐ป๐ด ๐ก๐ฎ๐ป๐ผ๐๐ฒ๐ฐ๐ต ๐๐บ๐ฝ๐ฟ๐ผ๐๐ฒ๐ ๐๐ฒ๐น๐ถ๐๐ฒ๐ฟ๐ ๐ผ๐ณ ๐๐๐ฑ๐ฟ๐ผ๐ฝ๐ต๐ผ๐ฏ๐ถ๐ฐ ๐๐ฟ๐๐ด๐ ๐น๐ถ๐ธ๐ฒ ๐๐ฏ๐๐ฝ๐ฟ๐ผ๐ณ๐ฒ๐ป
Our ibuprofen research chemical was utilised in a study recently published in the European Journal of Pharmaceutics and Biopharmaceutics.
Researchers from Uppsala University in Sweden used 3D printing to incorporate drug-loaded magnesium carbonate nanomaterials into formulations. This approach improves drug loading and solubility for poorly soluble medications like ibuprofen.
Explore our ibuprofen research chemicals: https://okt.to/TNzXv1
Read the study: https://okt.to/OGb62B
๐๐ข๐ฌ๐๐จ๐ฏ๐๐ซ ๐ญ๐ก๐ ๐ค๐๐ฒ ๐ญ๐จ ๐๐ง๐ฌ๐ฎ๐ซ๐ข๐ง๐ ๐๐ซ๐ฎ๐ ๐ฌ๐ญ๐๐๐ข๐ฅ๐ข๐ญ๐ฒ ๐๐ง๐ ๐ซ๐๐ ๐ฎ๐ฅ๐๐ญ๐จ๐ซ๐ฒ ๐๐จ๐ฆ๐ฉ๐ฅ๐ข๐๐ง๐๐ ๐ฐ๐ข๐ญ๐ก ๐จ๐ฎ๐ซ ๐ง๐๐ฐ ๐ฐ๐ก๐ข๐ญ๐ ๐ฉ๐๐ฉ๐๐ซ ๐จ๐ง ๐๐จ๐ซ๐๐๐ ๐๐๐ ๐ซ๐๐๐๐ญ๐ข๐จ๐ง ๐ฌ๐ญ๐ฎ๐๐ข๐๐ฌ!
This essential guide integrates industry insights, scientific literature, and regulatory guidelines to help you design effective stress testing protocols. Learn how to identify real-world degradation pathways, create robust stability-indicating methods, and enhance drug approval and formulation processes.
Enhance your pharmaceutical testing and development with our white paper: https://okt.to/nGi20S
The World Health Organisation has released draft guidelines to combat the presence of potentially carcinogenic nitrosamine impurities in medicines.
These guidelines, building on the efforts of the FDA and EMA, offer detailed advice on Good Manufacturing Practices, risk assessment, root cause analysis, and analytical procedures. This critical update aims to enhance the safety of drug products by ensuring rigorous identification and control of nitrosamine impurities, thereby maintaining the global supply of essential medicines.
Read the article to learn more: https://okt.to/aEWXO5
WHO releases new guidelines for preventing nitrosamine contamination | LGC Standards The World Health organisation (WHO) has released new recommendations for limiting the presence of potentially carcinogenic nitrosamine impurities in medicines.
๐ก๐ฎ๐ป๐ผ๐ฝ๐ฎ๐ฟ๐๐ถ๐ฐ๐น๐ฒ-๐๐ฒ๐น๐ถ๐๐ฒ๐ฟ๐ฒ๐ฑ, ๐จ๐ฉ-๐๐ฐ๐๐ถ๐๐ฎ๐๐ฒ๐ฑ ๐๐ต๐ฒ๐บ๐ผ๐๐ต๐ฒ๐ฟ๐ฎ๐ฝ๐ ๐๐ณ๐ณ๐ฒ๐ฐ๐๐ถ๐๐ฒ ๐ถ๐ป ๐๐ฟ๐ฒ๐ฎ๐๐ ๐๐ฎ๐ป๐ฐ๐ฒ๐ฟ ๐ ๐ผ๐ฑ๐ฒ๐น๐
Breast cancer, a disease affecting millions worldwide, often requires chemotherapy, which can cause serious side effects due to off-target toxicity.
Improved, targeted drug delivery technologies aim to enhance efficacy and reduce toxicity by precisely targeting tumours, thereby improving outcomes and minimizing side effects.
We're excited to share a study using our TRC research chemicals to develop a gold nanoparticle system for delivering the chemotherapy drug doxycycline, which can be activated at the tumour site using UV light.
Recently published by Turkish scientists at Hacettepe University, these preclinical studies show promising progress. Read on at https://okt.to/HxeVPQ.
๐ก TRC supports you from target identification to drug development and toxicology, view our extensive range at https://okt.to/FegMKB
Nanotechnology is revolutionising drug delivery by tackling the key challenges in solubility and bioavailability that significantly impact drug efficacy.
Some of the most promising nano drug delivery systems currently being studied are metal-organic frameworks (MOFs), carbon nanotubes (C**s), mesoporous silica nanoparticles (MSNs), nanoemulsions, and solid lipid nanoparticles.
Read our latest blog post to explore the key issues and trends in nano drug delivery techniques at https://okt.to/p1omJu
Nanotechnology in Drug Delivery | LGC Standards Nanotechnology is revolutionising drug delivery by tackling the solubility and bioavailability challenges that lead to many drugs failing clinical trials.
๐ก๐ฎ๐ป๐ผ๐ฝ๐ฎ๐ฟ๐๐ถ๐ฐ๐น๐ฒ๐ ๐ฆ๐๐ฐ๐ฐ๐ฒ๐๐๐ณ๐๐น๐น๐ ๐๐ฒ๐น๐ถ๐๐ฒ๐ฟ ๐๐ป๐๐ถ๐ฟ๐ฒ๐๐ฟ๐ผ๐๐ถ๐ฟ๐ฎ๐น (๐๐ฅ๐ง) ๐๐ฟ๐๐ด๐ ๐๐ผ ๐๐ต๐ฒ ๐๐ฟ๐ฎ๐ถ๐ป
The progress in HIV/AIDS treatment, with many patients achieving undetectable virus levels through effective antiretroviral therapy (ART) regimens, showcases the success of modern drug discovery.
However, HIV can invade the brain as early as eight days post-infection, residing in white blood cells. The limited ability of ART to cross the blood-brain barrier presents a significant challenge, leading to numerous HIV-associated brain disorders. Improvements in drug formulation and targeting are needed to meet these clinical needs.
Weโre delighted to learn about the use of our darunavir research chemical in a study that developed polymer-coated nanoparticles to deliver ART drugs into mice brains. Published recently in Pharmaceutics, these findings offer hope for a clinical breakthrough for HIV-related CNS infections.
Learn more about the research chemical and related product citations at https://okt.to/0l7UoE
Darunavir Nanoformulation Suppresses HIV Pathogenesis in Macrophages and Improves Drug Delivery to the Brain in Mice Although antiretroviral therapy (ART) can suppress peripheral HIV, patients still suffer from neuroHIV due to insufficient levels of ART drugs in the brain. Hence, this study focuses on developing a poly lactic-co-glycolic acid (PLGA) nanoparticle-based ART drug delivery system for darunavir (DRV) u...
Discover the power of precision medicine in cancer treatment with this insightful infographic!
Gain a deeper understanding of how personalized therapies can make a difference in the lives of cancer patients. This infographic highlights the importance of targeting mutations in cancer and how it can revolutionize patient care.
Download the infographic at https://okt.to/uS1e67
๐Happy Canada Day๐จ๐ฆ!
We hope you all enjoy the long weekend and have a wonderful time with family and friends.
Targeting all KRAS oncogenic variants: a viable path to tangible therapeutic impact?
KRAS was at one time considered undruggable. However, persistent efforts led to the approval of two KRAS mutant inhibitors. Here we review further KRAS inhibition strategies and consider their enormous therapeutic potential.
Read our white paper today: https://okt.to/x7o1pX
Recently, researchers have explored the potential benefits of ayahuasca. This Amazonian plant medicine contains the psychedelic compound DMT and harmine alkaloids and is believed to offer therapeutic effects for patients with affective and mental health disorders.
However, the way ayahuasca is processed in the body causes problems for clinical use. We are thrilled to share that our TRC research chemicals were used to support a study in which researchers have developed an enhanced formulation currently in clinical trials. Read the findings in the journal Frontiers in Pharmacology: https://okt.to/jnoAJa
Frontiers | Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine Recently, the Amazonian plant medicine โayahuascaโโcontaining the psychedelic compound N,N-dimethyltryptamine (DMT) and numerous ฮฒ-carboline alkaloids, such ...
Click here to claim your Sponsored Listing.
Videos (show all)
Category
Contact the business
Website
Address
20 Martin Ross Avenue
Toronto, ON
M3J2K8
Toronto
www.earthcalm.ca started September 2007, is dedicated to promoting the healthiest, most sensible, most effective healing solution to EMFs available, anywhere..
16 Yonge Street
Toronto, M5E2A1
Trilex Laboratories is a playground where science and creativity meet to develop, research, and explore new ideas.
Toronto
Praedictum Bio is a Canadian company offering technologies to improve the health of our children
63 Galaxy Boulevard, Unit 1
Toronto, M9W5R7
Splice Biotechnics Inc. is a Toronto based healthcare product developer and biotech consulting firm.
Toronto, M5V2G3
Locke Bio develops new and scalable direct-to-consumer platforms that provide personalized healthcare for patients while creating value for every aspect of the pharmaceutical suppl...
Psyence Group Inc, 200 Bay Street
Toronto
Psyence Group is a life science biotechnology platform providing science forward natural products for psychedelic therapy, experience and wellness.
Toronto
At Elpida Therapeutics our main goal is to deliver Gene Therapies to patients in need.
63 Galaxy Boulevard, Unit 1
Toronto, M9W5R7
Splice Biotechnics specializes in non prescription drugs, natural health products and novel medical device development through cutting edge biotech and biomedical research. SHOP:...
Toronto
Our point-of-care devices will rapidly identify patients at-risk of adverse drug effects.
Toronto
Peptby peptide synthesis | Order High quality custom and premade research peptides at www.peptby.com
705 Progress Avenue
Toronto, M1H2X1
Welcome to Clinivex! Clinivex is a fast-growing ISO 9001:2015 certified worldwide leading manufacturer and supplier of high-quality, innovative research chemicals, pharmaceutical...
77 King Street West, Suite 2905
Toronto, M5K1H1
Ethnobotanical drug discovery company focused on R&D of mescaline-containing cacti.