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Médicaments pour la perte de poids : ce que vous devez savoir https://buff.ly/4devs6x

CBC: Taking all those pills may not be necessary https://buff.ly/3SmkmEu Pillcheck is a personalized medication management solution helping people to improve therapy and avoid medication-induced side effects. https://buff.ly/3WxKwXs

Taking all those pills may not be necessary | CBC News Taking too many prescription pills may cause side-effects and potential problems. Deprescribing from medications that are no longer necessary to a patient’s health may relieve side-effects and improve health.

Frequency of pharmacogenomic variation and medication exposures among All of Us Participants https://buff.ly/4eykL03 Excellent study highlights the high frequency of clinically relevant variants in ethnically diverse populations.

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Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes https://buff.ly/4c7qhW6 Excellent study. It would be great to see more data on GIPR variants as weight loss with GLP1R agonists.

Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes - Nature Metabolism Molecular pharmacological characterization and association testing of human GIPR genetic variants with follow-up analysis in mice shows that β-arrestins regulate GIPR signalling and thereby strongly contribute to metabolic outcomes.

Médecine de précision, ménopause, dépression : traitement des bouffées de chaleur avec des antidépresseurs https://buff.ly/4chiwMP

Comment vos médicaments sont-ils affectés par le café, les ci******es et votre génétique? https://buff.ly/3RKWJWf

He suffers debilitating side effects from a common medication. A simple test could have spared him. https://buff.ly/45m8J5R While provinces do not cover pharmacogenetic tests, some benefits plans reimburse these. Check your plan https://buff.ly/3Rktr0k

He suffers debilitating side effects from a common medication. A simple test could have spared him. Why won’t Ontario and other provinces make the tests more widely available? The U.K. aims to make pharmacogenomic tests more accessible, saying systematic testing “has the potential to transform patient’s lives.”

Another study shows that the use of antidepressants and other CYP2D6 inhibitors blocks the efficacy of opioid pain medications leading to high incidence of ER visits https://buff.ly/3VnpqL1 Pillcheck can help to optimize therapy for chronic pain and depression https://buff.ly/2AWovuq

VA study shows continued mortality risk of people who were hospitalized with COVID-19. Note high rates of neurological and mental health problems: https://buff.ly/3X0de3W Personalized therapy can reduce the risk of drug-induced complications for people with Long COVID https://buff.ly/30DBY47

Three-year outcomes of post-acute sequelae of COVID-19 - Nature Medicine Analyses from the US Department of Veterans Affairs databases reported residual elevated risk and health burden of long COVID at 3 years in hospitalized individuals after SARS-CoV-2 infection.

Treatment for H pylori reduces the incidence of cancer in people with a genetic predisposition to stomach cancer. https://buff.ly/455SMAw Personalized PPI prescribing improves H pylori therapy and can deliver even better results. https://buff.ly/3X1ZENF

H pylori Treatment and Gastric Cancer Risk Among Patients With High Genetic Risk This cohort study examines whether outcomes of primary prevention strategies for gastric cancer, including Helicobacter pylori treatment, differ by genetic risk profile among adults in China.

Check our short webinar on Controlling the Urge - Precision Medicine for Overactive Bladder

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Two recent studies link antihypertensive medications with the risk of falls and fractures in the elderly: VA study and Medicare cohort https://buff.ly/3wBUKfg. Starting or stopping antihypertensive therapy greatly increases the risk of falls. Pillcheck-guided antihypertensive therapy could help to improve blood pressure control. https://buff.ly/3sR5VMo

Antihypertensive Medication and Fracture Risk in Older Veterans Health Administration Nursing Home Residents - PubMed Findings indicated that initiation of antihypertensive medication was associated with elevated risks of fractures and falls. These risks were numerically higher among residents with dementia, higher baseline blood pressures values, and no recent antihypertensive medication use. Caution and additiona...

Cholesterol Denialism is Pseudoscience https://buff.ly/4dJtgFa Personalized statin selection and dosing can reduce the risk of side effects, improve adherence to lifesaving therapy https://buff.ly/33TJmxd

Cholesterol Denialism is Pseudoscience Early research on cholesterol's role in atherosclerosis warranted skepticism, but there is no place for modern-day doubters given the supportive evidence for lipid lowering, writes Chris Labos, MD.

Decoding pharmacogenomic test interpretation and application to patient care - American College of Clinical Pharmacy endorses standardized guideline-based interpretation of PGx testing results. https://buff.ly/3WCdINu Pillcheck adheres to these guidelines.

Diabetes/Weight Loss Med Linked to Repeat Spinal Surgery https://buff.ly/4b8V4RZ GLP1 agonists should be prescribed and taken carefully to avoid complications https://buff.ly/44SlvJn

Diabetes/Weight Loss Med Linked to Repeat Spinal Surgery The diabetes/weight loss drug semaglutide is associated with a significantly greater risk for repeat operations in patients with diabetes who require lumbar surgery.

Workplace Injury a Preventable Risk for Opioid-Related Harms https://buff.ly/3UTsqxl Pillcheck helped many people to find more effective pain therapy while reducing the risk of opioid abuse https://buff.ly/2Yj5V8g

Workplace Injury a Preventable Risk for Opioid-Related Harms Risks for opioid-related poisonings and behavioral disorders were higher among injured workers in almost all occupations compared with the general population.

Increased incidence of migraines is another complication linked to long-term use of PPIs. Interestingly, the risk of migraine is not related to magnesium. Pillcheck can help to identify whether you need a different dose of PPIs https://buff.ly/3Yw0sJb

Use of acid reflux drugs linked to higher risk of migraine People who take acid-reducing drugs may have a higher risk of migraine and other severe headache than people who do not take these medications, according to a new study. The acid-reducing drugs include proton pump inhibitors such as omeprazole and esomeprazole, histamine H2-receptor antagonists, or....

Serious Bleeding in Patients With Atrial Fibrillation Using Diltiazem With Apixaban or Rivaroxaban

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Statins Tied to Lower Mortality, Even With Comorbid Dementia https://buff.ly/43pVekR Most people discontinue statins due to minor side effects. PGx-guided stain selection can help sustain better health https://buff.ly/33TJmxd

Statins Tied to Lower Mortality, Even With Comorbid Dementia Statins have historically been discouraged in elderly nursing home residents with dementia, but new findings suggest their use can reduce mortality risk in this population.

Hormonal contraceptives, depression and blood clots

Hormonal contraceptives, depression and blood clots Hormonal contraception is a widely used and very effective method of birth control, but it is not without risks. Depression and blood clots can be dangerous complications. Understanding your genetic profile can help you lower your risk.

Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6-catalyzed metabolism of solanidine https://buff.ly/3SW5SdZ We need to expand the research on the role of regulatory regions on expression and activity of crucial PGx genes.

Overcoming Barriers to Discovery and Implementation of Equitable Pharmacogenomic Testing in Oncology https://buff.ly/3uEKCSd Equitable access to lifesaving technology is a challenge not only for cancer patients but also for people with common conditions, including heart disease, chronic pain and depression.

Methadone pharmacokinetics in opioid agonist treatment: Influencing factors and clinical implications https://buff.ly/49ikifN interesting gender effects due to use of CYP2B6 inducers in women.

Methadone pharmacokinetics in opioid agonist treatment: Influencing factors and clinical implications Background A considerable inter-individual variability has been reported in the relationship between methadone doses applied and serum concentrations achieved in methadone maintenance treatment. How...

Global distribution of functionally important CYP2C9 alleles and their inferred metabolic consequences With increased global migration, PGx tests must include ethnic-specific alleles to provide accurate results irrespective of patients' background. Pillcheck includes multiple alleles in CYP genes and drug transporters: https://buff.ly/2Ruo6rf

Global distribution of functionally important CYP2C9 alleles and their inferred metabolic consequences - Human Genomics Background Genetic variability in the cytochrome P450 CYP2C9 constitutes an important predictor for efficacy and safety of various commonly prescribed drugs, including coumarin anticoagulants, phenytoin and multiple non-steroidal anti-inflammatory drugs (NSAIDs). A global map of CYP2C9 variability a...

Les antidépresseurs pendant la grossesse sont-ils sûrs ? La réponse est dans votre ADN.

Les antidépresseurs pendant la grossesse sont-ils sûrs ? La réponse est dans votre ADN. Alors que de nombreux antidépresseurs sont considérés comme sûrs pendant et après la grossesse, il est essentiel de prendre en compte les éventuelles variations dans leur efficacité et les risques d'effets secondaires au cours de cette période. Nous expliquerons dans cet article comment votr...

Le métabolisme des médicaments chez les femmes : Les effets de la grossesse, de la contraception et de la thérapie de remplacement hormonal sur la réponse médicamenteuse

Le métabolisme des médicaments chez les femmes : Les effets de la grossesse, de la contraception et de la thérapie de remplacement hormonal sur la réponse médicamenteuse Ce n'est pas seulement notre ADN qui influence la réponse aux médicaments, surtout chez les femmes. Le genre, l'âge et les hormones peuvent également avoir un impact sur le métabolisme des médicaments. Approfondissez votre connaissance des impacts de la grossesse, de la contraception et de la ...

Integrating rare genetic variants into DPYD pharmacogenetic testing may help preventing fluoropyrimidine-induced toxicity https://buff.ly/3O5WjYF High sensitivity PGx testing panels or sequencing, such as Pillcheck, are essential to ensure accurate predictions of altered drug metabolism.

Integrating rare genetic variants into DPYD pharmacogenetic testing may help preventing fluoropyrimidine-induced toxicity - The Pharmacogenomics Journal Variability in genes involved in drug pharmacokinetics or drug response can be responsible for suboptimal treatment efficacy or predispose to adverse drug reactions. In addition to common genetic variations, large-scale sequencing studies have uncovered multiple rare genetic variants predicted to ca...

Age of onset for increased dose-adjusted serum concentrations of antidepressants and association with s*x and genotype: An observational study of 34,777 individuals https://buff.ly/48yTFTk Excellent study showing decreased clearance of (es)citalopram, venlafaxine and mirtazapine, primarily in females over the age of 50.

Age of onset for increased dose-adjusted serum concentrations of antidepressants and association with s*x and genotype: An observational study of 34,777 individuals - European Journal of Clinical Pharmacology Purpose The aim of this study was to examine the age of onset for increased dose-adjusted serum concentrations (C/D ratio) of common antidepressant drugs and to explore the potential association with s*x and CYP2C19/CYP2D6 genotype. Methods Serum concentrations and prescribed daily doses for citalop...

How real-world data can facilitate the development of precision medicine treatment in psychiatry https://buff.ly/3vsauAP Taking into consideration patient-reported medication experience can further enhance the clinical utility of PGx data