Winssinger Lab

We’re Xcited to share our work extending bioluminescence into the optimal tissue transparency window with a semisynthetic NanoLuciferaceBright Red

[ASAP] Bioluminescence from Semisynthetic NanoLuc (sNLuc)

Faculté des sciences - UNIGE Université de Genève

Bright Red Bioluminescence from Semisynthetic NanoLuc (sNLuc) Red-shifted bioluminescence is highly desirable for diagnostic and imaging applications. Herein, we report a semisynthetic NanoLuc (sNLuc) based on complementation of a split NLuc (LgBiT) with a synthetic peptide (SmBiT) functionalized with a fluorophore for BRET emission. We observed exceptional BR...

More News Stories from our latest work (Université de Genève Faculté des sciences - UNIGE) in Nature Biotechnology in collaboration with PayneResearch University of Sydney.

Could a safer, improved anticoagulant be within reach? Researchers are working to develop a unique anticoagulant (blood thinner) that would bring a lower risk of bleeding than the options currently on the market.

Experimental Blood Thinner Can Be Reversed With Fast Acting Antidote Researchers developed an experimental anticoagulant, or blood thinner, that blocks the activity of a protein involved in the formation of blood clots. The drug’s action can be rapidly reversed with an “antidote.”

🌟We're thrilled to welcome our newest team member to the lab! He just finished his BS in Chemistry at Kasetsart University, THA. He is joining us for a six-month stint. Welcome aboard! We can't wait to see all your incredible contributions. 🔬 🌟

Our team's recent developments in reversible anticoagulants in collaboration with the Payne lab in Sydney University were shared on RTS. Stay tuned for more updates!

Anticoagulant, coproduction en santé, botanique et araignée Un anticoagulant sans risque dʹhémorragie développé entre Genève et Sydney Les brèves du jour Unisanté et lʹUNIL lancent une chaire novatrice dédiée à la coproduction en santé "Tu sais quoi?": Le Conservatoire botanique de Genève fête ses 200 ans Lʹartiste de cirque et contorsionniste...

Zwischen Genf und Sydney wurde ein Antikoagulans ohne Blutungsrisiko entwickelt – rts.ch Wissenschaftler der Universität Genf (UNIGE) haben in Zusammenarbeit mit Kollegen in Australien einen neuen Typ von Antikoagulans entwickelt, dessen Wirkung schnell gestoppt werden kann. Dadurch könnte das Risiko schwerer Blutungen deutlich verringert werden. Antikoagulanzien-Behandlungen sind fü...

Thrilled to announce our latest publication: "Development of Supramolecular Anticoagulants with On-Demand Reversibility." A successful collaboration between Winsingerlab, Richard Payne Lab Pedro Jose Barbosa Pereira. Special congratulations to our co-authors Milly Dockerill
and Simona Angerani for their incredible work! 🧪👩‍🔬 recherche chimie
https://lnkd.in/eevBPG-i

🌟We're thrilled to welcome Guixian Zhao, who has recently joined us as a postdoctoral fellow! Coming from a strong background in Chemical Biology, we're eager to see the contributions Guixian will bring to our projects! 🔬🧪 🌟 Faculté des sciences - UNIGE Université de Genève

A huge round of applause for Vitoria on her thesis defense success last Friday! 🎓 Your dedication and effort have truly shone through. We're so proud of you and excited for the next chapter in your journey. Many thanks also to the jury! Faculté des sciences - UNIGE Université de Genève

📚 Join us on 07.03.2024 for an enlightening seminar by Professor Georgios Vassilikogiannakis! 🌟 Explore "Photocatalytic Cascade Sequences in both Batch and Flow settings, in Synthesis and Bioconjugation." 🤓 Faculté des sciences - UNIGE Université de Genève

🌟 Exciting update from our team! We're thrilled to welcome Clément Narbonne Zuccarelli, who has recently joined us for his Masters! We're looking forward to the contributions you'll bring to our projects! 🔬🧪 🌟

🎉 Congratulations to Victoria for winning the Best Poster in the Molecular & Cellular Biosciences category at the LS2 Annual Meeting 2024! 🏆 Your hard work and dedication is starting to paid off!

🌟 Inspired by Yesterday's Conference from Professor Eva Hevia 🌟

🎿⛷️ Great day out skiing with our amazing lab team at Morgins! For some, it was their first time hitting the slopes. Despite the challenging conditions, poor visibility, and slushy snow, everyone showed incredible spirit. Faculté des sciences - UNIGEUniversité de Genève

Congratulations to Arthur for winning the Best Presentation Award at the Geneva Chemistry and Biochemistry Days 2024! His presentation, truly stood out. Enjoy taking care of the crystal until next year!

Faculty of Science | University of Geneva University of Geneva - Department of Organic Chemistry

🌟 Exciting news from our team! A warm welcome to Alex Gobbi, who joined us last week! We're thrilled to have you on board and can't wait to see the amazing contributions you'll bring. Here's to new beginnings and great achievements ahead! 🚀👩‍🔬👨‍🔬

🎳🎄✨ Throwing it back to our fantastic lab Christmas outing! We went bowling and had a blast! It's not just about the science, but also the amazing team behind it. Here's to many more strikes, both in the lab and on the lanes! 🎳🔬🥳

Lab coats hit the pavement at the 45th Course de l'Escalade last Saturday! 🏃‍♂️🔬 Students in the lab swapped pipettes for sneakers, racing with scientific flair. 🧪🥼 From the bench to the streets, we're accelerating science and fun! 👟💨" @ Faculté des sciences - UNIGE Unige

Could the double edge knife properties of anticoagulants be dulled rapidly in case of injury?
Check out our preprint on the development of on-demand reversibility of anticoagulants.
https://biorxiv.org/content/10.1101/2023.11.12.566735v1

Thanks , Prof. Jackson and Dr. Pereira (IBMC).

Faculté des sciences - UNIGE, Université de Genève

Thank you all for making this happen and thanks Miguel for bringing the e.e. to perfection.
https://onlinelibrary.wiley.com/doi/10.1002/hlca.202300110
Faculté des sciences - UNIGEUniversité de Genève@

The 2023 Nobel Prize in Chemistry was awarded for the discovery and synthesis of quantum dots, small particles with big colours. Here's a summary of this prize-winning research and its applications: https://www.compoundchem.com/2023/10/04/2023nobelchemistry/

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2023 Nobel Prize in Chemistry to Moungi G. Bawendi, Louis E. Brus and Alexei I. Ekimov “for the discovery and synthesis of quantum dots.”

The 2023 Nobel Prize in Chemistry rewards the discovery and development of quantum dots, nanoparticles so tiny that their size determines their properties. These smallest components of nanotechnology now spread their light from televisions and LED lamps, and can also guide surgeons when they remove tumour tissue, among many other things.

Everyone who studies chemistry learns that an element’s properties are governed by how many electrons it has. However, when matter shrinks to nano-dimensions quantum phenomena arise; these are governed by the size of the matter.

The 2023 Nobel Prize laureates in chemistry have succeeded in producing particles so small that their properties are determined by quantum phenomena. The particles, which are called quantum dots, are now of great importance in nanotechnology.

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Coming up: the announcement of the 2023 Nobel Prize in Chemistry is in just a few hours.

We'll be streaming the announcement live on our page and website: nobelprize.org

www.linkedin.com

The announcement of the 2023 Nobel Prize in Chemistry is coming one week today. Join us when we break the news live on our page and at nobelprize.org.

Quick facts about the chemistry prize:
- Chemistry prizes: 114
- Individuals awarded the chemistry prize: 189
- Youngest laureate: 35
- Oldest laureate: 97
- Double chemistry laureates: 2

The Nobel Prize in Physics 2023 has been awarded for experiments with light that capture the shortest of moments.

This year’s physics laureates Pierre Agostini, Ferenc Krausz and Anne L’Huillier have conducted experiments that demonstrate a method for producing pulses of light that are brief enough to capture images of processes inside atoms and molecules.

Electrons’ movements in atoms and molecules are so rapid that they are measured in attoseconds. An attosecond is to one second as one second is to the age of the universe.

Attosecond pulses make it possible to measure the time it takes for an electron to be tugged away from an atom, and to examine how the time this takes depends on how tightly the electron is bound to the atom’s nucleus. It is possible to reconstruct how the distribution of electrons oscillates from side to side or place to place in molecules and materials; previously their position could only be measured as an average.

Attosecond pulses can be used to test the internal processes of matter, and to identify different events. These pulses have been used to explore the detailed physics of atoms and molecules, and they have potential applications in areas from electronics to medicine.

For example, attosecond pulses can be used to push molecules, which emit a measurable signal. The signal from the molecules has a special structure, a type of fingerprint that reveals what molecule it is, and the possible applications of this include medical diagnostics.

Now that the attosecond world has become accessible, these short bursts of light can be used to study the movements of electrons. It is now possible to produce pulses down to just a few dozen attoseconds, and this technology is developing all the time.

The 2023 Nobel Prize in Physics has been awarded to Pierre Agostini, Ferenc Krausz and Anne L’Huillier “for experimental methods that generate attosecond pulses of light for the study of electron dynamics in matter.”

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Press release: https://bit.ly/457nZ51
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BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2023 Nobel Prize in Physics to Pierre Agostini, Ferenc Krausz and Anne L’Huillier “for experimental methods that generate attosecond pulses of light for the study of electron dynamics in matter.”

The 2023 Nobel Prize laureates in physics are being recognised for their experiments, which have given humanity new tools for exploring the world of electrons inside atoms and molecules. Pierre Agostini, Ferenc Krausz and Anne L’Huillier have demonstrated a way to create extremely short pulses of light that can be used to measure the rapid processes in which electrons move or change energy.

The laureates’ contributions have enabled the investigation of processes that are so rapid they were previously impossible to follow.

There are potential applications in many different areas. In electronics, for example, it is important to understand and control how electrons behave in a material. Attosecond pulses can also be used to identify different molecules, such as in medical diagnostics.

Learn more
Press release: https://bit.ly/457nZ51
Popular information: https://bit.ly/3rnZXox
Advanced information: https://bit.ly/4644RWO