Evosep

Aiding the development of new treatment pathways for cancer is important for the scientific community.

Discover how Evosep One, used in a targeted workflow, was instrumental in uncovering a promising CAR-T therapy, AZD0754, which demonstrated potent efficacy in challenging immunosuppressive environments.


Read publication here:
https://www.jci.org/articles/view/169655

Say hello to our new Product Specialist, Gabriel Bracamontes!

With a master’s degree in chemistry from UC San Diego focusing on proteomics and molecular biology, Gabriel brings a decade of laboratory experience. Here at Evosep, Gabriel looks forward to supporting our users and ensuring their instruments run smoothly in the US Western area.

A warm welcome to the team.

On Thursday, we look forward to hosting another edition of the Evosep Webinar, this time focusing on tumor tissue proteomics using Evosep One workflows. Matthew Holt from Baylor College of Medicine shares his research on how proteogenomic characterization, combined with SEPepQuant algorithm and targeted proteomics, can be used to gain new mechanistic insights into chemotherapy resistance.

Join here: https://www.evosep.com/webinars/tumour-tissue-proteomics/

Innovation is a community effort, and we are privileged to work with leading mass spectrometry suppliers. Last Monday evening, Evosep hosted the yearly SCIEX workshop in Odense, ahead of DAPSOC, focusing on the science of how LC-MS can translate into clinical applications and, for example, mitigate antimicrobial resistance.

We extend our gratitude to Anders Dahl Knudsen and Mats Garmer for organizing this event with us, and we look forward to hosting you in our new office next year.

Single cell proteomics is a field in rapid development and holds the potential to transform the landscape of cell biology, offering an unbiased glimpse into the proteome at the individual cell level. Learn how the Jesper Olsen Group set a new standard for scalable single-cell proteomics in a recent BioRxiv manuscript. This entire workflow which is commercially available for single-cell analysis enables the identification of more than 5000 proteins from a single cell.

Read blog on our website at: https://www.evosep.com/news-and-views/setting-new-standards-for-scalable-single-cell-proteomics-identification-of-over-5000-proteins-in-a-single-hela-cell/

It’s quiz time!🎄
Join the 12 Days of Christmas with Evosep and win both daily prizes and the grand prize, a MEGA Evotip scale model. Until December 18, a new question will be released every day at 09:00 CET. By answering each question correctly daily, you increase your chances of winning the grand prize.

Join here: https://www.evosep.com/12-days-of-christmas-2023/

Next week we are hosting another Evosep Webinar where we dive into the world of tumour tissue proteomics.

Make sure to join when Roman Fischer, from University of Oxford shares his latest development and application of systematic spatial proteome analysis in human tumour tissue with perspectives of resolving the spatial context of the tumour proteome. Register now here at: https://www.evosep.com/webinars/tumour-tissue-proteomics/

Do you feel the Christmas fever settling in? We've got the cure.

Celebrate the Christmas spirit with us and get the daily question right in our quiz to win cool prizes. A winner will be announced every day for 12 work days.

Go to today's question: https://www.evosep.com/12-days-of-christmas-2023/

The last few months, we have had the pleasure of having Gijs, who is studying International Engineering at Summa College Eindhoven, as our intern in the R&D department.

During his time, he has been working on developing solutions to improve the quality control system with 3D printing and automation. Being present at the Evosep Office every day, Gijs has appreciated the mix of both a commercial office culture and hands-on workspace environments. He has enjoyed working on larger systems that involve multiple components simultaneously.

In his own words: “It’s nice to learn how to create larger systems since the challenges are quite different from those of smaller systems. Dealing with multiple challenges at once and transitioning from one small problem to more complex ones forces you to solve and keep track of different projects and parts that need to work together.”

He also adds that working on “real-life” projects that add value for our colleagues and the company is a great feeling. Here at Evosep, we share the same appreciation for having such dedicated colleagues on our team.

Stay ahead in the lab with our year-end offer on columns.
For the rest of 2023, you can buy 5 columns and only pay for 4*.

Use promo code: Columns23

Visit our webshop to stock up:
https://www.evosep.com/shop/

*You get the cheapest for free

Five days to travel across four cities in China might seem ambitious but it was well worth it!

Last week, our team went to China to engage with KOLs, MS vendors, and IVD customers. It was especially inspiring to visit the π-Hub project in Guangzhou and hear about their vision to create the proteomics navigator of the human body.
In Hangzhou we also had the opportunity to co-host a seminar with Tiannan Guo at Westlake University, where we witnessed a great turnout and an engaged audience.

The proteomic landscape in China looks bright and we are looking forward to following their journey.

Learn how scientists from Sinai Health, University of Toronto, utilized the Evosep One to uncover intricate cell signaling mechanisms. Their work, detailed in the document, sheds light on essential protein interactions, providing profound insights into cellular behavior and potential therapeutic targets.

Read publication here: https://www.biorxiv.org/content/10.1101/2023.11.09.566449v1

A warm welcome to Joan Skov, our new scientist in the R&D group! Joan has been the principal lead on method development and method validation within various chromatographic disciplines, in contract laboratories servicing the pharmaceutical industry.

With her background in small molecule analysis, Joan joins the R&D team where she is a great match to explore new innovation avenues.

Do you feel the Christmas fever settling in? We've got the cure.

Celebrate the Christmas spirit with us and get the daily question right in our quiz to win cool prizes.

We will start on December 1st. Join our Christmas list to get notified on the first day of the quiz: https://www.evosep.com/12-days-of-christmas-2023/

Wishing you a happy Thanksgiving filled with warmth, joy, and the company of those you cherish from all of us here at Evosep.

Immunopeptidomics is vital for understanding immune system function, disease mechanisms, and therapeutic development. By characterizing peptides presented by MHC molecules, it contributes to immune response regulation, identifies disease biomarkers, aids in vaccine design, and offers insights into autoimmune disorders and allergies.

Learn more about Evosep One and streamlined enrichment of soluble HLA peptides from plasma in the recent ReSyn Biosciences webinar with Maria Wahle, PhD student in the Mann lab at the Max Planck Institute of Biochemistry.

EMERGE Episode 16: The potential of plasma HLA peptides beyond neoepitopes Maria Wahle, a PhD student working in the lab of Matthias Mann at the Max-Planck-Institute of Biochemistry in Munich, presents her research on a new method f...

Last Friday, we had our annual Christmas Office Party, celebrating another year gone by at Evosep.

The day was filled with activities, including a proteomic showdown on the go-kart tracks and navigating the curves like sharp peaks on a chromatogram.
After the fast-paced races, we celebrated a year of teamwork and advancements in proteomics technology with dinner, drinks, and the lively tunes of our local party band, The Cell Mates. Cheers 🥂
Slagteriet

Next week, Morten Bern, Erik Verschuuren, Nicolai Bache, and Dorte Breinholdt Bekker-Jensen will visit Shanghai, Hangzhou, Guangzhou, and Jinan to meet with the Chinese proteomic communities.

Besides adhering to a tight travel schedule, the team will also host a Evosep Seminar together with Tiannan Guo at Westlake University in Hangzhou on Wednesday November 22. Learn more about the seminar on our landing site and register today: https://www.evosep.com/china-westlake/

In collaboration with Cellenion we are thrilled to introduce proteoCHIP™ EVO 96 for high throughput single cell proteomics analysis with Evosep One.

The proteoCHIP EVO 96 combines our expertise in liquid chromatography technology with Cellenion’s cutting-edge single-cell isolation and dispensing platforms.

This innovative platform enables high-throughput single cell proteomics analysis, offering researchers unmatched capabilities and accuracy for studying cellular heterogeneity at the highest level.

Key features include:
⏺ High throughput
⏺ Precision isolation
⏺ Enhanced sensitivity
⏺ Streamlined workflow

Nicolai Bache, VP Proteomics Research of Evosep, expressed their enthusiasm for the proteoCHIP EVO 96, saying, “Scaling single cell proteomics is now easier with the proteoCHIP EVO 96. It enables efficient direct transfer of digested single cells to Evotips, allowing reproducible, standardized, and scalable 96-sample processing, with secure sample storage until LC/MS analysis 96. It enables efficient direct transfer of digested single cells to Evotips, allowing reproducible, standardized, and scalable 96-sample processing, with secure sample storage until LC/MS analysis.”

Read more about this new standard for single-cell proteomics in our recent press release here:https://www.evosep.com/wp-content/uploads/2023/11/2023_Press-release-proteoCHIP-EVO96-enables-high-throughput-single-cell-proteomics-analysis.pdf

Last week, we opened our office for the Hybrid MRM Targeted Quantitation Workshop, hosted in collaboration with MRM Proteomics Inc., Agilent Technologies, and Skyline.

The workshop started with a livestream from Odense, where onsite participants received practical training on how to use the MRM PeptiQuant kits for highly multiplexed mass spectrometry-based targeted quantitation of proteins on the Evosep One and Agilent 6495C.
Application manager, Dorte Breinholdt Bekker-Jensen, provided a lecture on standardized clinical proteomics enabled by the Evosep One.

Help increase the Evosep presence from Boston!

We are seeking a motivated and experienced Vice President of Business Development to help broaden our reach in the U.S. pharmaceutical market. Your role will involve identifying and cultivating new business opportunities for our innovative LC-MS-based proteomics technology, particularly within the pharmaceutical drug development sector.

Please visit our website to read the full job posting here: https://www.evosep.com/available-positions/?hr=show-job%2F170023%26locale%3Den_US

Learn more about immunopeptidomics using Evosep One. Maria Wahle from Max Planck Institute presents at the ReSyn Biosciences EMERGE webinar tomorrow describing the potential of plasma HLA peptides. With Whisper 40 SPD method through an automated workflow on the Agilent Technologies Bravo, 5000 HLA class I peptides are quantified from plasma.

Welcome! You are invited to join a webinar: EMERGE Episode 16 with Maria Wahle and “The potential of plasma HLA peptides beyond neoepitopes”. After registering, you will receive a confirmation email about joining the webinar. Soluble HLA (sHLA) peptides are thought to have great potential as biomarkers for different diseases such as cancer. However, efficient enrichment of sHLA peptides from body fluids like plasma has been a bottleneck, requiring 3-5 ml per patient. Here we present IMBAS-MS, an automated magnetic bead b...

should be scalable and easy to use in any lab while compatible with most workflows – but what would you prefer?

This Thursday, Application Manager at Evosep, Dorte Bekker-Jensen will highlight the use of a standardized and fully automated workflow for deep proteome profiling of integrated with direct loading on Evotips.

Automated sample preparation combined with the Evosep One accelerates , by optimizing throughput and reducing costs, making it ideal for labs of all experience levels. With automation you can streamline the entire sample preparation process, crucial when dealing with large sample cohorts.

Learn more about the speakers and register here: https://www.evosep.com/webinars/webinar-030-automation/

Join our LinkedIn poll here to share your thoughts: https://www.linkedin.com/feed/update/urn:li:activity:7127275474086449152

Evosep Webinars I Join in to get the latest update from Evosep Join our Evosep Webinars to get the latest update from Evosep One users and our collaboraters. Each month we will zoom in on a new exciting topic.

Can high-throughput clinical benefit from automated sample preparation?

Anders Kverneland, MD & Postdoctoral Researcher at CCIT - Center for Cancer Immune Therapy, Denmark, Herlev Hospital and University of Copenhagen evaluated just that.

He has adopted our fully automated protocol for integrated sample digestion and Evotip loading as part of a workflow to discover the effects of cancer immune therapy on the proteome in metastatic melanoma patients.

With the increased sensitivity and shortened analysis tim​e due to modern mass spectrometers, sample-preparation remains a bottleneck and source of variability when studying large cohorts.

Learn how to address this and meet Anders in our webinar next week: https://www.evosep.com/automation/

Evosep is on the move!

Last week, Ole Watson graciously invited the Odense team for a sneak peek at the construction site of our new offices slated for next year. The visit included a comprehensive tour of the building site, offering insights into the new facilities and the philosophy behind the design. Central to layout is the well-being of our colleagues and providing a platform for future innovation.

To cap off the day, we enjoyed a classic Danish hotdog.

We are proud to work closely with the leading vendors to provide more labs around the world with fast and robust .

Last week was all about pushing boundaries for sensitive single cell analysis and exploring the unique opportunities in plasma proteomics using automated end-to-end workflows combined with the Evosep One and the Orbitrap Astral mass spectrometer.

Thanks for an exciting week and for hosting us at the Thermo Fisher Scientific application development lab in San Jose, CA.

Meet Nikunj Gevariya, our new Sales Specialist based in Canada!

This month, Nikunj visited our Odense office for an introduction to the company, to familiarize himself with the Evosep culture, and to meet the entire team. Nikunj holds a PhD in Cell and Molecular Biology and has experience working with MS to enhance clinical diagnostics.

Last week he was on the CFABS tour, and this week he's visiting both new and existing customers. If you come across him, please greet him and share details about your current workflows and research, and discuss how they might benefit from the Evosep One.
Welcome to the team, Nikunj!

From to discovery with .

The success of heavily relies on simple and reproducible workflows for identification and quantification of proteins.

Efficient digestion is a fundamental component in such a workflow and by implementing an automated digestion protocol, you can achieve deep proteome coverage reproducibly and cost-efficiently. Important when analyzing large sample cohorts.

In our next webinar, we will demonstrate the power of fully automated, end-to-end sample preparation workflows made possible by the Evotip Pure.

Register here:

Evosep Webinars I Join in to get the latest update from Evosep Join our Evosep Webinars to get the latest update from Evosep One users and our collaboraters. Each month we will zoom in on a new exciting topic.

Understanding disease mechanisms is essential to develop new treatment.
This week at European Molecular Biology Laboratory - EMBL Wellcome Connecting Science Conference Nicolai Bache presents new workflow developments in the automation of plasma proteomics analysis.
Make sure to stop by our booth, where Evosep sales specialist Dr. Britta Diedrich is ready to discuss the wide range of applications the Evosep One offers.

Learn how our users used the 30 SPD method to analyze the proteogenomic profile of 242 high-grade serous ovarian cancers to understand chemotherapy resistance. The study identified a 64-protein signature predicting resistance to initial platinum-based treatments. Additionally, it discovered 5 unique HGSOC clusters pointing to different resistance mechanisms, implicating potential therapeutic vulnerabilities.

Read publication:https://www.cell.com/cell/pdf/S0092-8674(23)00737-7.pdf

Welcome to Andries Russchen, our new Field Service Engineer!

With his background in Analytical Chemistry and over 20 years of experience as a laboratory technician and with LC-MS instrumentation, Andries has a broad knowledge of laboratory environments. He supports researchers in creating optimal working conditions in the laboratory and looks forward to ensuring that the Evosep One runs smoothly for our users.

At Evosep, we believe that our strongest asset is our team of dedicated professionals.

Last week our field-based commercial colleagues visited our office in Odense to discuss goals, strategies, and insights from proteomic communities around the world.
Besides the professional discussions, the meeting was also a chance to strengthen bonds, share experiences, and foster a sense of togetherness across the teams.

We are proud to have such passionate and collaborative teams working towards our common mission - advancing proteomics for a better world.

Researchers from the Max Planck Institute have used the Evosep One for high-throughput to enable faster and deeper Dynamic Organellar Mapping by .

They combine cell fractionation and shotgun-proteomics for global profiling of protein subcellular localization. This results in a user friendly workflow that allows non-proteomic specialists to apply organellar profiling in biological studies.

https://www.nature.com/articles/s41467-023-41000-7

This week we attend the CFABS 2023 Post-ASMS Mass Spectrometry Symposiums in Toronto, Montreal, and Vancouver. If you happen to be in one of the cities, be sure to stop by our booth and say hello to Evosep sales specialist Nikunj Gevariya and Michael Barrett Andersen and discuss how the Evosep One benefits your workflows.

See the full programme and learn more about the symposiums at: https://cfabs.org/ms_group_meetings.php

Mass Spectrometry Meeting/Symposiums Brand your Company as a Leader in Mass Spectrometry and Showcase your Experience and Knowledge in the Canadian Mass Spectrometry Community!