Aayusham

A female infant delivered at term by cesarean section

👉had a “blueberry muffin” rash at birth

👉 examination, multiple purple, papulonodular lesions measuring 5 to 10 mm in diameter were seen on her trunk, arms and legs, palms and soles, oral mucosa, and palpebral conjunctiva

👉 no lymphadenopathy or hepatosplenomegaly

👉 the results of funduscopy were normal.

👉 labs, including a cbc, a peripheral-blood smear, a reticulocyte count, a metabolic panel, and a coagulation test, were normal.

👉 chest radiograph was normal, as were the results of ultrasonography of the head and abdomen

👉Neither rubella nor cytomegalovirus IgM or IgG was detected in the mother or the infant

👉 biopsy
a dense infiltrate of histiocytes with grooved, kidney-shaped nuclei

Immunohistochemical staining of the specimen was positive for S100+ CD1a+ and negative for CD43 👉 myeloperoxidase, findings that confirmed a diagnosis of skin-limited congenital Langerhans-cell histiocytosis

👉because of the lack of extracutaneous involvement, the lesions were expected to resolve without treatment

👉 follow-up 6 weeks after delivery, the skin lesions had resolved

The infant continues to be followed for signs of recurrence.
♦️
Congenital Langerhans-Cell Histiocytosis

Different Types of skin lesions

Molluscum contagiosum

-Spotty crops frustrate
-Pink nodules umbilicate
-Spreads from skin-to-skin
-Scratch autoinoculates
-Liquid nitrogen ablates

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