MACE Patología e Inmunohistoquímica

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☘️ Shamrock Fibroblasts ☘️

For each petal on the shamrock
This brings a wish your way
Good health. Good luck. Happiness.
For today and every day.

Happy St. Patrick’s!

i♡histo
www.ihearthisto.com

This image shows some artistically arranged fibroblasts. The cells have been labeled with phalloidin that has been conjugated to a green fluorescent dye. Phalloidin is a protein that binds to the filamentous form of the protein actin and is commonly used to demonstrate the cytoskeletal architecture of cells. The nucleus is stained with another common immunofluorescent DNA stain called DAPI (4′,6-diamidino-2-phenylindole).

Fibroblasts are one of the most common cells in the body. They synthesize and secrete the collagen fibers and ground substance (extracellular matrix) of our connective tissue.

🍕Happy Pizza Day 🍕

Sometimes cells remind me of food.

These are epithelial cells from an adenocarcinoma of the lung.

i♡histo
www.ihearthisto.com

An adenocarcinoma is a tumor that is derived from the epithelial cells of glandular tissues. The pizza was obtained from a nodule on the lung. An endoscope with an ultrasound attached to it was used to guide a needle directly into the nodule and some cells were then sucked out for observation. The technique is called endoscopic ultrasound fine needle aspiration or EUS/FNA for short. Aspirates like this allow pathologists to determine whether the cells in the nodule looked normal or cancerous so they can recommend appropriate treatment and/or surgery to remove the tumor.

This pie was fresh out of 's microscope.

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Exigimos justiacia pronta, antes actos tan lamentables qué suceden en nuestro país.

Cortesía: Laura J Tafe, MD

Buen día.
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🌸🌸 Re**al Daisies 🌸🌸

A bouquet with a unique fragrance.

Here's the 🔬 story behind these pretty flowers...

i♡histo
www.ihearthisto.com

Microscopically, the mucosal lining of the re**um & colon exhibits many intestinal glands or crypts of Lieberkuhn (the flowers) that are lined with mucus secreting goblet cells (the petals).

Mucus collects in the lumen of the gland (center of flower) and is squeezed out when the muscular wall contracts to push the f***l material out.

As the f***s move through the colon, water is reabsorbed making them drier to conserve the water. As a result, the mucus secreted from these crypts is super important in this region because it ensures that the tube is well lubricated to allow the dry f***s to be passed along the colon easily without causing any damage (the mucus decreases friction).

If you slice up the colon or re**um in a way that ensures you cut through the mucosa parallel with its surface then your re**um looks much more like a field full of daisies with pretty goblet cell petals than a chute for passing along p**p 💩

😅

🍑 Bubble Butt Adenoma 🍑

A posterior view of a tubulovillous adenoma in the colon.

i♡histo
www.ihearthisto.com

If you have ever had a colonoscopy then your doctor may have informed you that they found a number of polyps.

Polyps are slow growing lumps of tissue that grow on the inside wall of the colon and protrude, often from stalks, into the lumen of the colon like tiny mushrooms.
They are most often benign but can be an early warning sign for colorectal cancer.

To the naked eye, most polyps look similar but they can be classified based upon their microscopic appearance which means that it is important to biopsy a polyp to determine exactly what it is.

Some polyps may be described as tubular adenomas. These types of polyps look like that are composed of the many numerous tubular glands that line the rest of the colon. Except they look more irregular and contain few of the mucous secreting goblet cells you would expect to find in a regular intestinal gland (crypt of Lieberkuhn). The legs, arm and butt in the image left are the tubular gland part of this adenoma.

Some polyps may be described as being a villous adenoma. These look more shaggy/lumpy grossly. They look like this because under the microscope you will find that they are composed of many long, branching finger-like projections called villi. Villi are not a typical finding in the colon and imply a faster rate of polyp growth.

A polyp that has features of both types is often referred to by doctors as a 'tubulovillous' adenoma.

It is important to know the type of adenoma causing the polyp because villous adenoma have a higher chance of becoming cancer quicker than tubular adenomas.

Original 📷: [Twitter]

MACE Patología e Inmunohistoquímica updated their phone number.

🙄

🤣🤣🤣🤣🤣🤣

Basal cell carcinoma showing some volcanic-like activity 🌋

Did you know H&E was borrowed from the clothing industry?

Attributed to an English Schoolmaster W.H. Poole in 1875 who combined hematoxylin from the logwood tree (Hematoxylum Campechianum) with synthetic eosin (tetrabromofluorescein).

Si profe, se ve clarito...

En esta fotomicrografía tenemos un corte de intestino delgado a nivel del íleon en donde se observa todo el espesor de su pared. El espécimen fue fijado posterior a la perfusión de tinta china roja por vía periférica, lo cual permite que podamos apreciar la basta vascularización presente predominantemente en la lámina propia y en menor escala en la submucosa (con vasos de mayor calibre) de esta región del tubo digestivo, la cual es necesaria para el transporte de todos los nutrimentos absorbidos por el epitelio.

(imagen modificada de la original tomada de Histology Guide)