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✍ How Should Your Diet Change as You Get Older?

Why do your nutritional needs change as you get older?

As we age, most of us become less active. This means that we burn fewer calories and need to eat less daily. However, as we get older, our ability to absorb many nutrients decreases, which means that older adults actually need the same or more of certain vitamins and nutrients.

Older adults also often develop lower appetites and other barriers to eating food. So how should we approach thinking about food intake as we age? It’s more important than ever to focus on having a nutrient-dense diet.

Read below to find out how to choose healthy foods that will meet your body’s needs as you get older.
What nutrients do you need more of with age?

The quality of your diet can have a big effect on your health as you age. It’s important to target these key nutrients in the diet:

Calcium: Older adults are at risk for osteoporosis, which can lead to bone fractures. Increased calcium intake can lower your risk for bone fractures. Dairy foods and drinks and some leafy greens are rich sources of calcium. Read more...👇

https://www.healthywayrx.com/how-should-your-diet-change-as-you-get-older/

Written by Karen Hovav, MD, FAAP | Reviewed by Mandy Armitage, MD | Photo by Amina Filkins on pexels

How Should Your Diet Change as You Get Older? - HealthyWayRx.com As we age, most of us become less active. This means that we burn fewer calories and need to eat less daily.

✍ Tirzepatide Lowers Weight Across All Groups With Obesity

Weight loss with tirzepatide was fairly uniform across different body mass index (BMI) ranges, ages, and number of obesity-related comorbidities in patients with overweight/obesity without type 2 diabetes.

These were the main findings in a session about tirzepatide — the dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) agonist — for obesity, presented at ObesityWeek®.

In May, tirzepatide (Mounjaro), a once-weekly subcutaneous injection, was approved by the US Food and Drug Administration for glycemic control in patients with type 2 diabetes based on the SURPASS clinical trials.

Then in June, at the American Diabetes Association 2022 annual meeting, researchers reported “unprecedented” weight loss with tirzepatide in patients without type 2 diabetes, in the phase 3 SURMOUNT-1 clinical trial.

A month ago (October 6), the US Food and Drug Administration (FDA) granted fast-track status (expedited review) to tirzepatide for use as an anti-obesity drug.
Now these new analyses from SURMOUNT-1 show that “regardless of BMI, regardless of age, regardless of number of obesity-related complications, there was a clear dose-related weight loss that was pretty consistent across groups,” Session Chair Patrick M. O’Neil, PhD, who was not involved with this research, summarized.

“The absolute levels of these weight losses are higher than we’ve seen thus far with [anti-obesity] medications,” O’Neil, who is professor of psychiatry and behavioral sciences and director of the Weight Management Center at the Medical University of South Carolina, in Charleston, added.

“Semaglutide took things up one big notch, and this is up a little notch above that,” he told Medscape Medical News in an interview.

“I’m a psychologist. It should be remembered that in all cases, the FDA approvals are predicated to using [drugs] as an adjunct to diet and exercise change as well,” he stressed.

“I don’t think people should expect that any medication that is currently available will have a lasting effect when it’s no longer taken,” he continued.

“We don’t expect any of these [anti-obesity] medications to be making any permanent physiological changes,” O’Neil added, but patients could “use this medication to help themselves make some long-lasting behavioral changes, so that when they come off the medication, hopefully they’ll be able to continue these new patterns.”

“Clearly the medications are having a significant impact,” he emphasized.

BMI, Age, Comorbidity Subgroups, and Overall QoL in SURMOUNT-1

SURMOUNT-1 compared the efficacy and safety of tirzepatide 5, 10, and 15 mg subcutaneous once-weekly to placebo, as an adjunct to a reduced-calorie diet and increased physical activity. The study included 2539 adults without type 2 diabetes who had obesity (BMI ≥ 30 kg/m2) or overweight (BMI ≥ 27 kg/m2) with at least one obesity-related complication (hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease). Read more...👇

https://www.healthywayrx.com/tirzepatide-lowers-weight-across-all-groups-with-obesity/

Marlene Busko November 07, 2022 | Photo by Diana Polekhina on Unsplash

Tirzepatide Lowers Weight Across All Groups With Obesity - HealthyWayRx.com The US Food and Drug Administration (FDA) granted fast-track status (expedited review) to tirzepatide for use as an anti-obesity drug.

✍ Your heart and kidneys have a reciprocal relationship: Heart problems can hurt the kidneys, and kidney problems can damage the cardiovascular system. If you have heart or kidney disease, it’s important to know the tips for lowering your risk of kidney failure and heart damage.
What Is Kidney Failure?
The most serious complication of chronic kidney disease is kidney failure.
“The goal activity of the kidneys is to filter the blood and to get toxins out of the blood. When the kidney is not able to function normally, you can develop first acute [and] then chronic kidney disease,” says Lawrence Phillips, MD, cardiologist at NYU Langone Health. “When it progresses to a point where you’re not able to appropriately filter the blood, we call that end-stage renal disease or kidney failure.”
People with kidney failure require frequent dialysis treatments, which is when a machine filters waste from the blood and returns it back to your bloodstream.
Kidney Damage + the Heart
“Kidney damage will affect the heart in several ways. First, it will affect it by being unable to clean out the blood or remove the toxins or keep equilibrium in the electrolytes and the blood, which can damage the heart,” says Dr. Phillips.
The second way kidney damage affects the heart is by worsening blood pressure. The kidneys actually release a hormone that helps control blood pressure. When this hormone is limited due to kidney damage, blood pressure may rise. This has a negative effect on both the heart and the kidneys.
Finally, the kidneys also release a hormone that helps with the production of red blood cells. When kidneys are damaged, it may lead to anemia or decreased blood cell counts. “[This] makes the heart work harder to get blood and nutrients to the rest of the body,” says Dr. Phillips. Read more...👇

https://www.healthywayrx.com/how-to-lower-your-risk-of.../

Cardiologist Lawrence Phillips, MD | Reviewed by Mera Goodman, MD, FAAP

How to Lower Your Risk of Kidney Failure and Heart Damage - HealthyWayRx.com Your heart and kidneys have a reciprocal relationship: Heart problems can hurt the kidneys, and kidney problems can damage the cardiovascular

✍ The US Food and Drug Administration approved tirzepatide for use in improving blood sugar control in patients with type 2 diabetes.

The US Food and Drug Administration approved tirzepatide for use in improving blood sugar control in patients with type 2 diabetes. This made it the first approved dual agonist for the two principal human incretins: the glucagon-like peptide-1 (GLP-1) receptor and the glucose-dependent insulinotropic polypeptide (GIP). Not long after, the results of the SURMOUNT-1 trial were presented at the American Diabetes Association (ADA) 82nd Scientific Sessions. They showed tirzepatide’s efficacy for weight loss in patients without diabetes. The findings were called “unprecedented” and sparked a wave of impressed reactions.
SURMOUNT-1 was a placebo-controlled trial that included more than 2500 participants with obese or overweight who had at least one weight-related complication. At baseline, the mean body weight was 231 lb (104.8 kg) and the mean BMI was 38. Study results at 72 weeks of treatment showed:

The mean percentage change in weight was −15% (95% CI, −15.9 to −14.2) with 5-mg weekly doses of tirzepatide, −19.5% (95% CI, −20.4 to −18.5) with 10-mg doses, and −20.9% (95% CI, −21.8 to −19.9) with 15-mg doses.
Weight reduction of 5% or more was reported in 85% (95% CI, 82% -89%) of the 5-mg group, 89% (95% CI, 86% -92%) of the 10-mg group, and 91% (95% CI, 88% -94%) of the 15-mg group.
In the 10-mg and 15-mg groups, 50% (95% CI, 46% -54%) and 57% (95% CI, 53% -61%) of participants, respectively, had a reduction in body weight of 20% or more.

Experts have called the results “amazing” and pointed out that they are in the range of weight loss achieved with bariatric surgery. The authors of an accompanying editorial stated, “It is remarkable that the magnitude of weight loss with tirzepatide was similar to that with gastric bypass, which raises the potential for alternative medical approaches to the treatment of obesity.” Semaglutide is another similar, recently approved medical approach. It is a single-incretin agonist, with its activity focused exclusively on the GLP-1 receptor. The combined activity that activates GLP-1 and GIP has led to the “twin-cretin” nickname for tirzepatide. Read more...👇

https://www.healthywayrx.com/tirzepatide/

Ryan Syrek, July 01, 2022 | Photo by Pavel Danilyuk on pexels

✍ New Non-Statin Cholesterol Lowering Drugs: How to Use Them

his is important guidance. We now have two new US Food and Drug Administration (FDA)–approved cholesterol-lowering medicines over the past 2 years that our patients are seeing advertised on TV, and until now, there has not been much consensus or guidance on how they should be used.

First, we’ll talk about the new medications, and then we’ll talk about the recommendations for use.

Bempedoic acid is an oral medicine, and inclisiran is a subcutaneous injection.

Bempedoic acid works upstream from HMG-CoA reductase to reduce low-density lipoprotein (LDL) cholesterol. Importantly, in distinction from statins, it doesn’t cause myalgias. Used alone, it decreases LDL by about 25%, and when added to statins, it decreases LDL cholesterol by about an additional 15% over statins alone. It is available to be combined with ezetimibe 10 mg, and then when added to a statin, there is an additional 38% reduction in LDL cholesterol. This is potentially very exciting, because many patients on statin monotherapy do not get to their LDL cholesterol goals, and the combination of bempedoic acid with ezetimibe is an attractive noninjectable option for many of those patients.

Side effects of bempedoic acid include a slight increase in tendon rupture, gout, benign prostatic hyperplasia (BPH), and atrial fibrillation (AFib). The randomized controlled trial (RCT) of bempedoic acid with cardiovascular endpoints isn’t expected to be completed until the end of 2022. Read more...👇

https://www.healthywayrx.com/new-non-statin-cholesterol-lowering-drugs-how-to-use-them/

Neil Skolnik, MD, September 27, 2022 | Photo by Mufid Majnun on Unsplash

✍ ‘Stop Pretending’ There’s a Magic Formula to Weight Loss

s there a diet or weight-loss program out there that doesn’t work for those who stick with it during its first 12 weeks?

Truly, the world’s most backward, upside-down, anti-science, nonsensical diets work over the short haul, fueled by the fact that short-term suffering for weight loss is a skill set that humanity has assiduously cultivated for at least the past 100 years. We’re really good at it!

It’s the keeping the weight off, though, that’s the hitch. Which leads me to the question, why are medical journals, even preeminent non-predatory ones, publishing 12-week weight-loss program studies as if they have value? And does anyone truly imagine that after over 100 years of trying, there’ll be a short-term diet or program that’ll have the durable, reproducible results that no other short-term diet or program ever has? Why are we still pretending that there’s a magic bullet out there? Read more...👇

https://www.healthywayrx.com/stop-pretending-theres-a-magic-formula-to-weight-loss/

Written by Yoni Freedhoff, MD, August 17, 2022 | Photo by Farhad Ibrahimzade on Unsplash

✍ Is the Pandemic Over? If Only It Were That Simple

President Joe Biden says the pandemic is over. The World Health Organization says the end is in sight. Many of us would rather talk about almost anything else, and even New York City has dropped most of its COVID protocols.

Biden’s claim (made to reporter Scott Pelley on Sunday on 60 Minutes ) has caused the debate over COVID-19 to explode yet again, even though he’s twice now tried to soften it. It has roiled the already divided public, fueled extensive coverage on television news, and led pundits to take sides.

But to many, a pandemic can’t be declared “over” when the U.S. alone is averaging more than 71,000 new cases and more than 400 deaths a day, and there are 500,000 cases and nearly 2,000 deaths each day around the world.
Biden’s comment has split experts in medicine and public health. Some adamantly disagree that the pandemic is over, pointing out that COVID-19 remains a public health emergency in the United States, the World Health Organization still considers it a global pandemic, and most significantly, the virus is still killing over 400 people a day in the U.S.

Others point out that most of the country is protected by vaccination, infection, or a combination, at least for now. They say the time is right to declare the pandemic’s end and recognize what much of society has already decided. The sentiment is perhaps captured best in a controversial new COVID health slogan in New York: “You Do You.”

In fact, a new poll from media site Axios and its partner, Ipsos, released Sept. 13, found that 46% of Americans say they’ve returned to their pre-pandemic lives — the highest percentage since the pandemic began. Meanwhile 57% say they’re still at least somewhat concerned about the virus. Read more...👇

https://www.healthywayrx.com/is-the-pandemic-over-if-only-it-were-that-simple/

Kathleen Doheny, September 22, 2022, | Photo by Jon Tyson on Unsplash

Is the Pandemic Over? If Only It Were That Simple - HealthyWayRx.com President Joe Biden says the pandemic is over. The World Health Organization says the end is in sight. Many of us would rather talk about almost anything else, and even New York City has dropped most of its COVID protocols.Biden's claim (made to reporter Scott Pelley on Sunday on 60 Minutes ) has ca...

✍ Why Won’t More Older Americans Get Their Covid Booster?

Even as top U.S. health officials say it’s time America learns to live with the coronavirus, a chorus of leading researchers say faulty messaging on booster shots has left millions of older people at serious risk.

Approximately 1 in 3 Americans 65 and older who completed their initial vaccination round still have not received a first booster shot, according to the Centers for Disease Control and Prevention. The numbers have dismayed researchers, who note this age group continues to be at the highest risk for serious illness and death from covid-19.

People 65 and older account for about 75% of U.S. covid deaths. And some risk persists, even for seniors who have completed an initial two-dose series of the Moderna or Pfizer vaccine or gotten one dose of the Johnson & Johnson vaccine. Among older people who died of covid in January, 31% had completed a first vaccination round but had not been boosted, according to a KFF analysis of CDC data.

The failure to boost more of this group has resulted in the loss of tens of thousands of lives, said Dr. Eric Topol, founder and director of the Scripps Research Translation Institute. “The booster program has been botched from day one,” Topol said. “This is one of the most important issues for the American pandemic, and it has been mismanaged.”

“If the CDC would say, ‘This could save your life,'” he added, “that would help a lot.”

Although the initial one- or two-dose vaccination course is effective at preventing hospitalization and death, immunity fades over time. Boosters, which renew that protection, are especially important for older people now that covid cases are rising again, more transmissible omicron sub-variants are proliferating, and Americans are dropping their masks, Topol said.

Some older people, who were prioritized for initial vaccination in January 2021, are now more than a year from their last shot. Adding to the confusion: The CDC defines “fully vaccinated” as people who have completed an initial one- or two-dose course even though a first booster is considered crucial to extending covid immunity.

Numerous studies have confirmed that the first booster shot is a critical weapon against covid. A study of older veterans published in April found that those who received the third dose of an mRNA vaccine were as much as 79% less likely to die from covid than those who received only two shots. Read more...👇

https://www.healthywayrx.com/why-wont-more-older-americans-get-their-covid-booster/

Liz Szabo, May 12, 2022 | Photo by CDC on Unsplas

✍ How Diet Alone Can Achieve Remission in Diabetes

Every year, roughly 1.4 million US adults are diagnosed with type 2 diabetes. But when doctors discuss treatment options with newly diagnosed patients, they often fail to include an intensive whole-food and predominately plant-based dietary intervention as a potential strategy to achieve remission without medications or procedures.
That’s a shame because remission should be the primary clinical goal of type 2 diabetes treatment, and evidence demonstrates that a person’s diet is a significant driver of type 2 diabetes morbidity and mortality worldwide. But a lack of physician training, false assumptions that patients are not willing to engage in intensive interventions, and misguided quality measures that ultimately penalize successful outcomes through nutritional lifestyle interventions frequently result in treatment plans that approach type 2 diabetes more like an irreversible chronic illness.
Fortunately, the medical community is recognizing the need for change. In May, the American College of Lifestyle Medicine published an expert consensus statement “Dietary Interventions to Treat Type 2 Diabetes in Adults with a Goal of Remission” that was endorsed by the American Association of Clinical Endocrinology, supported by the Academy of Nutrition and Dietetics, and co-sponsored by the Endocrine Society.
Diet recommendations as a treatment for diabetes generally focus on prevention and disease management. The expert panel behind the consensus statement focused on a diet — without medications or procedures — as a primary means of achieving lasting remission of diabetes rather than its more common role as an adjunctive therapy. Read more...👇

https://www.healthywayrx.com/how-diet-alone-can-achieve.../

WritteCate Collings, MD. July 12, 2022, | Photo by Nataliya Vaitkevich on pexels

✍ B Vitamins Show Promise Against Advanced Fatty Liver Disease

Researchers have discovered a mechanism that leads to an advanced form of fatty liver disease and a potential way to reverse the process.

They found that elevated blood levels of homocysteine correlate strongly with the severity of nonalcoholic steatohepatitis (NASH) and determined that vitamin B12 and folic acid may have a role in preventing or delaying disease progression.

“Our findings are both exciting and important because they suggest that a relatively inexpensive therapy, vitamin B12 and folic acid, could be used to prevent and/or delay the progression of NASH,” study investigator Brijesh Singh, PhD, with Duke-NUS Medical School in Singapore, says in a news release.

“Additionally, serum and hepatic homocysteine levels could serve as a biomarker for NASH severity,” Singh states.
Nonalcoholic fatty liver disease (NAFLD) involves fat buildup in the liver not caused by alcohol. Owing to its association with diabetes and obesity, it is a leading cause of liver transplants worldwide.

NASH is known to be associated with elevated blood levels of homocysteine, but the precise relationship between hyperhomocysteinemia and NASH is poorly understood.

In their study, Singh and colleagues confirmed the association of homocysteine with NASH progression in preclinical models and humans.

They also observed that as hepatic homocysteine levels increase, the amino acid attaches to various liver proteins, changing their structure and impeding their functioning.

In particular, when homocysteine attaches to the syntaxin 17 (Stx17) protein, it blocks the protein from transporting and digesting fat (a process known as autophagy), which in turn induces the development and progression of fatty liver disease to NASH, they noted.

In the preclinical models, supplementing the diet with vitamin B12 and folic acid increases hepatic Stx17 levels, restores its role in autophagy, and slows NASH progression and reverses liver inflammation and fibrosis, they further found.

“The potential for using vitamin B12 and folate, which have high safety profiles and are designated as dietary supplements by the US Food and Drug Administration, as first-line therapies for the prevention and treatment of NASH could result in tremendous cost savings and reduce the health burden from NASH in both developed and developing countries,” study investigator Paul M. Yen, MD, with Duke-NUS, says in the news release.

“Currently, the only treatment for patients with end-stage liver disease is to receive a transplant,” adds Patrick Casey, PhD, senior vice dean for research at Duke-NUS, who was not involved in the study.

These findings, Casey says, “demonstrate that a simple, affordable and accessible intervention could potentially halt or reverse the damage to the liver, bringing new hope to those suffering from fatty liver diseases.” Read more...👇


https://www.healthywayrx.com/b-vitamins-show-promise-against-advanced-fatty-liver-disease/

Written by Megan Brooks | Photo by julien Tromeur on Unspla

B Vitamins Show Promise Against Advanced Fatty Liver Disease - HealthyWayRx.com Researchers found that elevated blood levels of homocysteine correlate strongly with the severity of nonalcoholic steatohepatitis (NASH) and determined that vitamin B12 and folic acid may have a role in preventing or delaying disease progression.

Vitamin D

Experts have suggested that the interest in vitamin D supplementation is so strong that it is seemingly impervious to evidence. Nevertheless, research into the connection between the nutrient and various health conditions continues. Recent findings have examined links to diabetes, obesity, breast cancer, and COVID. Interest in those studies resulted in vitamin D once more becoming the top trending clinical topic of the week. Among the notable research was a new study reiterating an old finding.
The new findings come from the prospective Diabetes Prevention with active Vitamin D (DPVD) trial of more than 1200 Japanese participants with impaired glucose tolerance. Data show that vitamin D supplementation also failed to improve the rate of regression to normoglycemia compared with placebo. In an accompanying editorial, Tatiana Christides, MD, PhD, writes that the new trial is “well conducted, with rigorously defined and tested diagnostic criteria, and of sufficient duration, but it may have been underpowered to detect a small effect.” She points to a recent meta-analysis of intervention trials, which found a significant 10% reduction in risk for type 2 diabetes with vitamin D supplementation. Christides adds that this was “a difference too small to be detected by the new trial…Although a 10% risk reduction is modest, it may be valuable at the population level and justifies further study.”

A separate study, which has not yet been peer reviewed, found that 25-hydroxyvitamin D (25[OH]D) levels were inversely associated with glucagon and connecting peptide (C-peptide) levels in 4670 Chinese patients with type 2 diabetes and abdominal obesity. The lowest quartile had 25(OH)D levels ≤ 30.79 ng/mL; the highest quartile had levels ≥ 48.92 ng/mL. Among patients with type 2 diabetes without abdominal obesity, vitamin D levels were inversely and significantly associated with fasting plasma glucose, A1c, glucagon, and beta-cell function, after adjusting for multiple variables... Read more...👇

https://www.healthywayrx.com/vitamin-d/

Writen by Ryan Syrek June 10, 2022 | Photo by Nataliya Vaitkevichpexels