Clancy Lab

Festivities with Clancy and Vorobyov labs.

Our most recent study on digital twins:

Toward Digital Twin Technology for Precision Pharmacology The authors demonstrate the feasibility of technological innovation for personalized medicine in the context of drug-induced arrhythmia. The authors u…

So psyched to share our latest work and very grateful for the commentary: https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP284391

https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP285309

Super excited about this collaborative work led by Pei-Chi Yang PhD: https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP284391

Exciting new paper out led by Steffen Docken PhD:

Rate-dependent effects of state-specific sodium channel blockers in cardiac tissue: Insights from idealized models A common side effect of pharmaceutical drugs is an increased propensity for cardiac arrhythmias. Many drugs bind to cardiac ion-channels in a state-sp…

Our very own Khoa Ngo representing the Clancy and Vorobyov labs at the World Congress of Pharmacology earlier this month. I'm so glad he got to meet dear friend and colleague Professor Junko Kurokawa!

A new pre-print describing a new model for vascular smooth muscle and mechanisms of s*x specific hypertension - Led by Dr. Hernandez-Hernandez!

A computational model predicts s*x-specific responses to calcium channel blockers in mesenteric vascular smooth muscle The function of the smooth muscle cells lining the walls of systemic arteries and arterioles is to regulate the diameter of the vessels to control blood flow and blood pressure. Here, we describe an in silico model, which we call the “Hernandez-Hernandez model”, of electrical and Ca2+ signaling ...

Representing at the Multiscale Modeling Meeting at NIH!

https://twitter.com/vorobyovucd/status/1636890027476267008?s=46&t=mfNJ5_fo2Wa_4XrS8xu87A

Igor Vorobyov on Twitter “An awesome poster presentation earlier today by Dr. Gonzalo Hernandez-Hernandez from lab in at the 8th Annual UC Davis Postdoctoral Research Symposium!”

Superb visit by Leon Glass - had a huge inspirational impact on me in the very early years !!

Congratulations to Igor Vorobyov Lab!

https://www.pnas.org/doi/10.1073/pnas.2215916120?fbclid=IwAR3PywiqDdFjSLFFT02p2gdX1U8WdSj8E9Nmt1mtegsuMJKyV14i5S3qA_I

Elucidation of a dynamic interplay between a beta-2 adrenergic receptor, its agonist, and stimulatory G protein | Proceedings of the National Academy of Sciences G protein-coupled receptors (GPCRs) represent the largest group of membrane receptors for transmembrane signal transduction. Ligand-induced activat...

It’s an amazing thing. Three wins in a row for Khoa Ngo! Best poster at CVRI HeartDay!!

Great times celebrating Dr. Hernandez-Hernandez with his family’s special Mole - it was incredible!! Especially with great friends and colleagues !!

Fantastic talks by Khoa Ngo and Dr. Gonzalo Hernandez-Hernandez at the PMB retreat in Lake Tahoe!

So excited for Khoa Ngo in the Vorobyov and Clancy Labs for his poster award at Wood’s Hole!!

Science talk with his eminence Alan Garfinkel - he literally wrote the book.

Congratulations!!!! We are so proud!!

Congratulations to Dr. Gonzalo Hernandez-Hernandez who wowed during his PhD exit seminar!!!! Paper coming soon!!!

Happy birthday to Khoa Ngo! And our first in person lab lunch meeting in years- it was so great!!

First time in two years, we’re all together enjoying laughs, nerves and so much promise with graduations and papers and big talks! At

Excited to share our recent work showing how low dimensional computational models can capture complex drug dynamics led by Steffen Docken!

: Rate-dependent effects of lidocaine on cardiac dynamics: Development and analysis of a low-dime ... https://dx.plos.org/10.1371/journal.pcbi.1009145

Rate-dependent effects of lidocaine on cardiac dynamics: Development and analysis of a low-dimensional drug-channel interaction model Author summary Cardiac arrhythmias are often treated with drugs that block and alter the kinetics of membrane sodium channels. However, different drugs interact with sodium channels in different ways, and the complexity of the drug-channel interactions make it difficult to predict whether a particul...

Our newest work led by Parya Aghasafari showing how deep learning can be applied to translate and classify cardiac electrophysiology!

 https://elifesciences.org/articles/68335

A deep learning algorithm to translate and classify cardiac electrophysiology The development of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) has been a critical in vitro advance in the study of patient-specific physiology, pathophysiology and pharmacology. We designed a new deep learning multitask network approach intended to address the low throughput, hi...

New study led by Igor Vorobyov lab!! https://www.sciencedirect.com/science/article/abs/pii/S0022282821001097?fbclid=IwAR2xMnNz5cayJWcCKNAdF9Ietc_u3avBFXBminad4QlfYsp91dowLNkWsHA

Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline Drug isomers may differ in their proarrhythmia risk. An interesting example is the drug sotalol, an antiarrhythmic drug comprising d- and l- enantiome…

So excited to share our latest work on the mechanisms of negative cardiac isotropy induced by Na+ channel blockers!

Mechanisms of flecainide induced negative inotropy: An in silico study It is imperative to develop better approaches to predict how antiarrhythmic drugs with multiple interactions and targets may alter the overall electri…

https://www.oracle.com/a/ocom/docs/uc-davis-drug-cardiotoxicity.pdf?source=:so:tw:or:awr:ore:::TwitterUSCCardiotoxicityCaseStudy

www.oracle.com

https://twitter.com/oracleresearch/status/1392544358013054977?s=21

Oracle for Research on Twitter “ & at experience faster, more efficient drug cardiotoxicity prediction simulations leveraging . Read their guest authored blog to learn more. https://t.co/VqtL7RhNXq”

New paper out from Emily Meyer in our group - a soon to be graduated PhD student in applied math!

https://www.sciencedirect.com/science/article/pii/S0022519321000412

Dynamics of adrenergic signaling in cardiac myocytes and implications for pharmacological treatment Dense innervation of the heart by the sympathetic nervous system (SNS) allows cardiac output to respond appropriately to the needs of the body under v…

Who knew atmospheric dynamics and protein dynamics had so much in common!?

Watch the winners of this year’s ‘Dance Your Ph.D.’ contest The competition got a new COVID-19 category this year