Neuromics

Our "in-vivo like" Blood-Brain Barrier (BBB) is being used to study the link between Periodontitis (PD) and Alzheimer's Disease (AD).

With the help of our model, the scientists found that not only do PD-induced exosomes cross the BBB, but they also compromise its integrity. TEER readings and expression of tight-junction proteins both decrease after exposure to the exosomes. These findings give some insight into how PD may contribute to the development of AD.

Image: TEER readings in Neuromics BBB model at different time points when blood side is exposed to PD exosomes (PD EXO) and health exosomes (Con EXO). Exposure to PD EXO decreases TEER readings.

Check our BBB Model-https://www.neuromics.com/3D45002. David Rupp Kathleen Stark Neuroscience News and Research Society for Neuroscience

Researchers at Augusta University published a study earlier this year utilizing our 3D Human Blood-Brain Barrier (BBB) Model in Alzheimer’s Disease research. They studied the link between periodontitis and Alzheimer's.

Learn more here: https://www.neuromics.com/alzheimer-s-research-with-our-3d-bbb-model

Neuromics' Cancer-Associated Fibroblasts (CAFS) in Action

Researchers used our Human Kidney CAFS to show their impact on Tumor Growth-https://www.neuromics.com/our-immortalized-cafs-in-action

Findings: When treated with the anti-CTLA-4 antibody (immunotherapy), the CAF-positive mice had a large tumor size. OM-RCA-01 was able to target both CAF-dependent and CAF-independent resistance to immunotherapy in the renal cancer in vivo model.

Check them out https://www.neuromics.com/fibroblasts-cafs-cancer-cells

Despite being on the market for less than a year, researchers just published a study citing our Immortalized Human Kidney Cancer Associated Fibroblasts (CAFs) (cat. CAF110-IM) for the first time. The scientists investigated the therapeutic potential of the anti-fibroblast growth factor receptor 1 (FGFR1) monoclonal antibody OM-RCA-01, including in mice injected with our CAFs. Learn more in our blog post.

https://www.neuromics.com/our-immortalized-cafs-in-action

Through the end of September, Neuromics is offering 15% off ALL our human cells. We provide a diverse range of high-quality and reliable human cells across various research areas. With customer citations to prove it, these cells play a critical role in advancing scientific understanding.

Learn more: https://www.neuromics.com/save-big-on-human-cells-this-september

It's time to plan for fall research projects! You'll need fetal bovine serum (FBS) if you have any cell culturing lined up. Our FBS continues to demonstrate its reliability through customer citations. Two new studies are highlighted in our most recent blog post.

https://www.neuromics.com/rely-on-our-fbs-for-fall-research

I am proud to announce I have broken through and have 10,000 members in my LI Network (https://www.facebook.com/ #. I would like to thank my friends, colleagues, and clients. David Rupp Kathy Stark Neuromics
www.neuromics.com

Neuromics Proven reagents for results you trust and understand

Last month, we highlighted the release of six human iPSC-derived brain cells and two immortalized cancer associated fibroblast (CAF) types in our blog. Believe it or not, the cell releases keep coming, as we've got six more iPSC-derived cell types to offer.

https://www.neuromics.com/even-more-ipsc-brain-cells

Glioblastomas are one of the most insidious forms of cancer. Today is Neuromics

Neuromics is excited to announce the release of two more immortalized cancer-associated fibroblast (CAF) types. We are now offering immortalized versions of our human ovarian CAFs and lung squamous cell carcinoma CAFs. While normal CAFs can be passaged 3-5 times, immortalized CAFs can be passaged >10 times.

Learn more in our blog post: https://www.neuromics.com/more-immortalized-caf-types

Yes, there is a day for the brain. Neuromics is a proud provider of iPSC-derived and human primary cells, defined media, and supplements (https://www.neuromics.com/human-cells-tissue). Many Bio-pharmas are using these to discover new therapies. David Rupp Kathy Stark Society for Neuroscience Neuroscience News and Research

Neuromics Strep-Tactin is used to purify proteins involved in diphtheria (https://journals.asm.org/doi/full/10.1128/jb.00244-13).
Check out our options for antibody/protein purification and expansion solutions (https://www.neuromics.com/protein-purification-expansion-and-expression-vectors)

Cool Science-https://www.madmicrobe.com/ Neuromics

https://www.linkedin.com/posts/cellectis_cancer-celltherapy-activity-7217140205202403330-5JO7/?utm_source=share&utm_medium=member_desktop

www.linkedin.com

As IBA Lifesciences US distributor, Neuromics offers cutting-edge protein purification products. Strep-Tactin® 4Flow® High Capacity is now available as a new and improved version of IBA's top-selling protein purification product.

Learn more: https://www.neuromics.com/iba-s-new-protein-purification-resin

Neuromics offering of iPSC-derived neural cells is growing. In addition to the cells we released earlier this year, we've just released another six types of iPSC-derived cells. Learn more in our new blog post.

https://www.neuromics.com/another-round-of-new-ipsc-brain-cells

Neuromics continues to grow our offerings of solutions designed for Neuroscientists. We are pleased to announce the addition of motor, sensory, dopaminergic, glutaminergic, and GABAergic neurons (https://www.neuromics.com/neurons-astrocytes-schwann-cells-microglia).

We serve Neuroscientists in many Bio-Pharmas, Academic and National Labs. Society for Neuroscience Neuroscience News and Research Medical Alley The Michael J. Fox Foundation for Parkinson's Research Alzheimer's Association David Rupp Kathy Stark

After several months on backorder, our Exosome Free Fetal Bovine Serum (cat. FBS002-X) is back in stock. No matter your cell culturing application, we've got you covered with our many FBS options. Check out all our products!

https://www.neuromics.com/fetal-bovine-serum-fbs-other-sera

Neuromics CAFS (https://www.neuromics.com/fibroblasts-cafs-cancer-cells) are used to Bio-print active colorectal tumors. An important step for discovering new therapies.The use of these cells is featured in "Nature Scientific Reports." Check it out-https://lnkd.in/gQH--WMW. David Rupp Kathleen Stark Cancer / Medical Research

Our Human Brain Astrocytes, Pericytes, and Microvascular Endothelial Cells were used in a newly released paper studying the effects of hyperglycemia on the blood-brain barrier (BBB). The scientists built an in vitro BBB model by co-culturing the three cell types, finding disruptions to the integrity of the BBB after exposure to high glucose conditions.

Learn more in our new blog post:

https://www.neuromics.com/human-brain-cells-that-make-discoveries

Hypoglycemia and the breakdown of the Blood-Brain Barrier (BBB). This study shows how this breakdown contributes to stroke (https://doi.org/10.1080/21688370.2024.2350821). It features the use of our Brain Microvascular Endothelial Cells and Astrocytes (https://www.neuromics.com/neurons-astrocytes-schwann-cells-microglia) to demonstrate this breakdown. David Rupp Neuromics Society for Neuroscience Neuroscience News and Research Medical Alley

Hyperglycaemia perturbs blood-brain barrier integrity through its effects on endothelial cell characteristics and function Breakdown of blood-brain barrier (BBB) represents a key pathology in hyperglycemia-mediated cerebrovascular damage after an ischemic stroke. As changes in the level and nature of vasoactive agents ...

I am pleased that my "Stem Cell Clinical Trials" Group on LI has surpassed 12,000 members. Check it out https://www.linkedin.com/groups/4117443/. Neuromics

We are grateful to see our siRNA Transfection Kit (https://www.neuromics.com/transfection-kits) used in important research. Here, our kit is used to knock out a gene involved in alcohol-induced adolescent anxiety- EZH2-dependent epigenetic reprogramming in the central nucleus of amygdala regulates adult anxiety in both sexes after adolescent alcohol exposure (https://www.nature.com/articles/s41398-024-02906-y).
This research shows the impact of alcohol on mental health and potential treatments.

Neuromics raison d'etre is providing human cells and related 3-D models to drug hunters and researchers. We serve many Bio-pharmas and academic/government labs. We proudly announce the addition of Insulin Secreting Human Fibroblast Pancreatic Islet Cells (https://www.neuromics.com/hpf002). We continue to add cells and models. Stay tuned. Diabetes Research Institute Foundation

Our Human Retinal Microvascular Endothelial Cells (HRMECs) (cat. HEC09) have a history of performing for researchers studying diabetic retinopathy. That continues, as another publication using them was released this month.

Learn more: https://www.neuromics.com/our-hrmecs-enable-diabetes-research

Neuromics Human Microvascular Endothelial (https://www.neuromics.com/HEC09-T25Cells) used to study diabetic retinopathy (https://tvst.arvojournals.org/article.aspx?articleid=2793546). Neuroscience News and Research Image: Hsa_circ_0000880 silencing decreased the production of HG-induced ROS and suppressed the apoptosis of RMECs under HG conditions.

Eclipse day in Waco. Big thank you to Siri Lehmann, Sally Miller Walden, and Susan King. They allowed 80+ family and friends to gather at Moon River Ranch. They arranged everything! Big thank you!!!

Planning any cell culturing projects this Spring? Now is the time to save big on our Preferred Fetal Bovine Serum (FBS). Neuromics Preferred FBS is the best bang for your buck and is now only $250/500 ml through the end of May.

Learn more: https://www.neuromics.com/save-on-preferred-fbs-this-spring

Dr. Sonia Weimann and her team at Lehigh University published an important study on the mechanisms of hearing. The study appeared in the "Journal of Neuroscience" (https://www.jneurosci.org/content/44/8/e0356232023.abstract). They made the cover, which features an image of our MAP-2 antibody. This study could build the foundation for future therapies. Society for Neuroscience Neuroscience News and Research Neuromics

A Developmental Switch in Cholinergic Mechanisms of Modulation in the Medial Nucleus of the Trapezoid Body The medial nucleus of the trapezoid body (MNTB) has been intensively investigated as a primary source of inhibition in brainstem auditory circuitry. MNTB-derived inhibition plays a critical role in the computation of sound location, as temporal features of sounds are precisely conveyed through the c...

Potent and effective! Check out this incredible media developed by Neuromics that stimulates neurite formation and promotes the understanding of neurite outgrowth biology. Using this media, three-dimensional neurite tube structures can be formed in vitro in less than 18 hours. Neurons extend numerous processes that differentiate into dendrites and axons, essential for communication between neurons. This media can shed light on mechanisms underlying certain neurodegenerative diseases. Learn more about it here: https://www.neuromics.com/HNM004 Neuromics Neuroscience News and Research David Rupp