Monarch Global

Monarch Global updated their address.

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Though there is still no cure for cystic fibrosis, those who suffer are living longer and healthier lives. Life expectancy has dramatically improved amd there are now more adults than children LIVING with cystic fibrosis. Continue fighting! And LIVE MORE!

Check out www.monarchglobal.org to see how you can help those affected with cystic fibrosis.


.mortimer

CF affects the cells that produce mucus, sweat and digestive juices.
These secreted fluids are normally thin and slippery. But in people with CF, a defective gene causes the secretions to become sticky and thick.
Symptoms may include a persistent cough that produces thick mucus (sputum), wheezing, exercise intolerance, repeated lung infections, inflamed nasal passages or a stuffy nose, and recurrent sinusitis.
Risk factors include family history and most common in white people of Northern European ancestry.
Diagnosis includes newborn screening and older children, if not screened before.
Treatment includes combination products such as Trikafta, Symdeko, Orkambi, and Kalydeco. Pulmonary rehabilitation may also be an option
Surgery options include nasal and sinus surgery, oxygen therapy, non-invasive ventilation, feeding tube, bowel surgery, and lung transplant.
.mortimer
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So thankful for this amazing young girl. Her & her brother have been diagnosed with Cystic Fibrosis years ago so she decided to use her 1 make a wish from The Make Wish Foundation to donate to Monarch Global Foundation set up in her & her brother’s honor for CF patients….

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.mortimer .tommy.world

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We are doing our 2nd annual fundraiser for Cystic Fibrosis.
Calling all sponsors & anyone looking to donate anything for our event this March! 💜 Please DM me or go to monarchglobal.org for more information on our events & how you can help. 🙏

What is cystic fibrosis?

Cystic fibrosis is a life-threatening genetic disease that causes thick, sticky mucus to build up in the body, most frequently in the lungs and pancreas. It may also affect sweat glands and the reproductive system in men. It is one of the most common chronic lung diseases in children and young adults, and it is also the most common deadly genetic disease among whites in the United States, particularly among those of northern or central European descent.

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What is cystic fibrosis?

Cystic fibrosis is a life-threatening genetic disease that causes thick, sticky mucus to build up in the body, most frequently in the lungs and pancreas. It may also affect sweat glands and the reproductive system in men. It is one of the most common chronic lung diseases in children and young adults, and it is also the most common deadly genetic disease among whites in the United States, particularly among those of northern or central European descent.

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.mortimer .tommy.world


Big shoutout to for inspiring us all!! There is no limit to what we can do!!

We are so excited joining forces with in our fight to help people with Cystic Fibrosis! Stay tuned as we get closer to revealing what we are working on...




Thank you so much!

Please take a look at our foundation & social media pages...& if you or anyone you know would like more info or join us, we would be honored!! 🙂 ‬

Tα1 reduces inflammation and corrects genetic defects

CF occurs as a result of a mutation in the genetic code of a protein called cystic fibrosis transmembrane conductance regulator (CFTR). This protein normally regulates the activity of the chloride channel, which is responsible for the balance between salt and water in the lungs.

In CF, the mutation – called “p.Phe508del” – makes the CFTR protein degrade prematurely, which causes poor chloride permeability and can lead to lung inflammation.

In the new study, the researchers point out that the complex pathogenic mechanisms behind CF call for a therapeutic approach that combines several drugs. The authors add that until now, however, no single drug with multiple beneficial effects has been discovered for CF.

However, the researchers report that their study shows that Tα1 can correct the defects in the tissue of mice with CF, as well as the defects of cells from human patients that have the p.Phe508del mutation.

The study found that Tα1’s beneficial action is twofold: the drug was able to simultaneously reduce the inflammation typical of CF and improve the activity, maturation, and stability of CFTR.

Tα1 – known as “Zadaxin” on the market – has been clinically approved for more than 15 years in 35 countries, and it is widely used for treating viral infections, immunodeficiency disorders, and HIV.

Zadaxin is not currently available in the U.S., but the researchers say that the drug has “an excellent safety profile in the clinic when used as an adjuvant or an immunotherapeutic agent.”

CF is most common among people of Northern European ancestry and affects about one out of every 3,000 newborns.[1] About one in 25 people is a carrier.[3] It is least common in Africans and Asians.[1] It was first recognized as a specific disease by Dorothy Andersen in 1938, with descriptions that fit the condition occurring at least as far back as 1595.[5] The name "cystic fibrosis" refers to the characteristic fibrosis and cysts that form within the pancreas.

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An inherited life-threatening disorder that damages the lungs and digestive system.
Cystic fibrosis affects the cells that produce mucus, sweat, and digestive juices. It causes these fluids to become thick and sticky. They then plug up tubes, ducts, and passageways.
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.mortimer .tommy.world

It's now easier to contact Monarch Global.

.mortimer .tommy.world lmonarchglobal.org

Hello everyone, we would like to take this time to thank .mortimer the most amazing artist for donating these 2 amazing pieces of artwork that he’s created In his quest & ours to help bring awareness to Cystic Fibrosis!! We are so grateful & are so honored that you are a part of our team! Thank you for all that you do!!

Everyone make sure to follow .mortimer 💜💜💜

Thank you so much! Please take a look at our foundation & social media pages...& if you or anyone you know would like more info or join us, we would be honored!! :) Please help us find a cure.. http://instagram.com/monarch_global_foundation


www.monarchglobal.org .mortimer

.mortimer monarchglobal.org

One of a kind custom West Coast Customs Porsche Whale Tail is available for purchase! Proceeds benefit those fighting cystic fibrosis. Interested? Contact us at www.monarchglobal.org

Monarch Global has made it to Porsche Monterey. We are hosting a raffle event and proceeds will benefit those fighting cystic fibrosis. If you’d like to participate, win an amazing prize, or simply donate- please visit us at www.monarchglobal.org

Visit us at www.monarchglobal.org and enter our raffle for a chance to win some amazing prizes! Live raffle will be held at Porsche Monterey tomorrow! Proceeds will benefit those fighting cystic fibrosis.

Monarch Global is making our way to Monterey Car Week. We would love your support! 💜Please visit us at www.monarchglobal.org to see how we are helping fight cystic fibrosis.