Global Cannabinoid Research Center

Endocannabinoids: A Promising Impact for Traumatic Brain Injury: "Traumatic brain injury (TBI) pathology remains mostly refractory to currently available drugs, perhaps due to its heterogeneous nature in etiology, clinical presentation, and severity. Here, we review pre-clinical studies assessing the therapeutic potential of cannabinoids and manipulations of the endocannabinoid system to ameliorate TBI pathology.

Specifically, manipulations of endocannabinoid degradative enzymes (e.g., fatty acid amide hydrolase, monoacylglycerol lipase, and α/β-hydrolase domain-6), CB1 and CB2 receptors, and their endogenous ligands have shown promise in modulating cellular and molecular hallmarks of TBI pathology such as; cell death, excitotoxicity, neuroinflammation, cerebrovascular breakdown, and cell structure and remodeling.

TBI-induced behavioral deficits, such as learning and memory, neurological motor impairments, post-traumatic convulsions or seizures, and anxiety also respond to manipulations of the endocannabinoid system.

As such, the endocannabinoid system possesses potential drugable receptor and enzyme targets for the treatment of diverse TBI pathology."

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314139/

"Almost half of Cannabis consumers age 21 and up have replaced or reduced their alcohol consumption with cannabis in the past year: The Harris Poll found that one-third of those who use cannabis recreationally prefer cannabis to drinking alcohol. Parents are turning to cannabis at higher rates than those without children, according to the results of the survey.

More than half of the respondents (52%) who have ever used cannabis and have kids under the age of 18 said that they had started or increased their consumption of ma*****na since the pandemic, while 33% of those without children under 18 said the same.

More than half of parents who have ever consumed cannabis (57%) reported that their use of ma*****na replaced or reduced alcohol consumption.

Stacia Woodcock, who has a doctorate in pharmacy and is a dispensary manager for Curaleaf in New York, noted that the company’s staff is ready to help consumers find the cannabis formulations that fit their needs.

“Educating consumers around cannabis consumption is so important,” said Woodcock. “Curaleaf’s pharmacists and committed dispensary associates make it a priority to educate our patients and consumers and help them find the right products to make cannabis a part of their lives.”

The survey illustrates that attitudes about cannabis are evolving as the green wave of ma*****na legalization continues to sweep across the United States.

Another recent poll commissioned by California cannabis and h**p company, the Glass House Group, found that nearly two-thirds of respondents planned to replace alcohol use with cannabis during the holiday season, while 67% said their replacement of alcohol with cannabis would increase this year over 2019."

-Mike Robinson, Founder Nanobles Corp. / Global Cannabinoid Research Center (GCRC) ResearcherOG.com The420Guide.com

"We've got to look at the addiction pandemic for what it is, and that's the rampant movement of a disease of uncontrolled pain from one nation to another; people are in pain both physical and emotional, and they're not getting the option they need - Cannabis." -Mike Robinson, Founder Nanobles Corp. / Global Cannabinoid Research Center (GCRC) The420Guide.com

“Love doesn’t make the world go ‘round. Love is what makes the ride worthwhile.” -Franklin P. Jones

"It's an amazing thing to watch with Genevieve as nature allows a child's life to flourish and to know that it wasn't any concocted creation of drugs initially made to treat psychosis that worked... it was simply a plant. The prescribing of harsh antipsychotics to kids with Autism is very dangerous; not only can they be a trigger and cause seizures, but the strong drugs create young addicts engulfed in their many dangerous side effects." -Mike Robinson, Founder Nanobles Corp. / Global Cannabinoid Research Center (GCRC) The420Guide.com

Have you ever wondered about the intricate world of the Endocannabinoid system and its various receptors? It's a fascinating field of study that continues to unveil new insights every day.

“A recent study has shown the expression of GPR43 in myometrium and fetal membranes after the onset of labor and a significant upregulation of GPR43 in preterm fetal membranes with evidence of infection.

This study also suggests an anti-inflammatory role of SCFAs (short chain fatty acids) through GPR43 that may reduce the risk of preterm labor induced by pathogens (Voltolini et al., 2012).

This anti-inflammatory role of GPR43 is in accordance with research findings on the exacerbated inflammatory phenotypes of GPR43 within mice with colitis and arthritis models (Maslowski et al., 2009).

Many are still learning the function of the CB1 and CB2 receptors that modulate all of the endogenous and most of the exogenous cannabinoids. Various other receptors allow other plant constituents to exert other physiological functions.”

-Mike Robinson, Founder Nanobles Corp. / Global Cannabinoid Research Center (GCRC) The420Guide.com

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Global Cannabinoid Research Center

"How many kids and adults with Epilepsy must perish to seizures that Cannabis can stop before a nation that led the world into prohibiting a plant does the right thing and puts a hefty tax on both Alcohol and To***co that both cause health problems that Cannabis can treat? Removing all taxes on a plant or its extracted medicine while increasing them upon substances of abuse or any drugs that 'may cause death' as a side effect would be an effective way to fund the necessary research our government says we need to take the plant off of all schedules completely. Free the W**d." -Mike Robinson, Founder Nanobles Corp. / Global Cannabinoid Research Center (GCRC) ResearcherOG.com

"For the most part, Cannabinoids are deemed acceptable in palliative medicine due to their analgesic and antiemetic effects, but an increasing number of preclinical studies and now even trials indicate their anticancer properties. Cannabinoids exhibit their action by modulating the signaling pathways crucial in the control of cell proliferation and survival." -Mike Robinson, Cancer Survivor and Founder GCRC

This is Gen's page; those of you who love her smile, you'll be able to see it by following the cool posts. https://www.facebook.com/carouselchallengedotcom

Genevieve's Dream, The Carousel Challenge The Carousel is truly Genevieve's Dream. We're making her CBGa Brand to fund her Carousel Challenge!!

"Insomnia is now the Number one reason to use Cannabis - putting pain in #2. Countless studies have shown that cannabis helps treat insomnia and sleep issues. That’s not new - and the last 18 months have made all prior research somewhat moot as the number of people suffering from sleep disorders has risen from 10-15% to a whopping 50%+ according to the American Sleep Association.

With its long history as a medicinal herb, cannabis has been employed for countless centuries to help people and even animals who have trouble falling asleep and staying asleep, to make sleep more refreshing, and to extend sleep’s duration.

Insomnia is thought to always be a co-morbidity - meaning there's a reason an individual can't sleep or maintain sleep that is a separate diagnosis. Generally, this is pain, anxiety, depression, or other illness.

A study published in 2019 found that of those who were using cannabis to improve sleep, 84% said it was “very” or “extremely” helpful. And 83% of people who reported having used over-the-counter sleep medications in the past could either reduce or eliminate those drugs from their routines when they began using cannabis for sleep.

The Importance of discontinuing OTC sleep aides is monumental as research has linked them as a casual cause of Alzheimer's disease.

Aromatherapy induces sleep: Several different terpenes found in cannabis have also been shown to have sedative effects. Terpenes are tiny molecules found across the plant world. They give taste and aroma to plants and fruit. They also have therapeutic abilities, from pain and inflammation relief to anxiety reduction."

-Mike Robinson, Founder GCRC

Now that Cannabis and its extracts have become legal and accessible in most of the United States, there's still a gap that needs to be filled, and it's a trifecta between authority, healthcare, and patients. -Mike Robinson, GCRC
ResearcherOG.com

Cannabicyclol, is a minor cannabinoid found in very low concentrations in cannabis. CBL is a photochemical product formed from degradation—when CBC (cannabichromene) is exposed to light, oxidation, or acid conditions, CBL is created. Cannabicyclol, therefore only occurs in trace amounts in live trichomes and is found in higher concentrations in a cannabis plant after harvesting.

CBL was first isolated by Korte and Sieper in 1964, but since then, research unfurling the properties of this minor cannabinoid has been slow to progress. Relatively little is known about the properties and therapeutic qualities of CBL.

Most of what is known about cannabicyclol is focused on its molecular structure. CBL does not contain any double bonds in its molecular composition; in both Δ9-THC and Δ8-THC, double bonds are responsible for the intoxicating psychoactive properties those cannabinoids are associated with. CBL is, therefore, most likely non-intoxicating because it lacks this double-bond structure.
——
CBL research is vastly R&D for future pharmaceutical applications, so very few published studies exist.

-Mike Robinson, Founder Global Cannabinoid Research Center ResearcherOG.com

"Three months later, June 2024: Today, I feel great, motivated, and happy. I no longer have the burden of thinking about Opioids, I do have pain, and it does cause issues. Right now, I'm in as much pain as I was when I'd give in, take the dose of Norco, and then go lay in bed for the balance of the day. I'm not longer a prisoner; I'm not an emotional mess like I was while using them, nor am I as gullible as I was while on them.

I made less than great significant decisions while using even small doses as they hinder our thought process and make Cannabis a very, very innocent plant in comparison. I am glad to be Opioid Free now as I move forward with Genevieve's Dream and the relaunching of Researcher OG!

Using opioids, whether they are necessary or not, hinders our judgment. If we can find a way to handle our issues without them, we're so much better off, as are the relationships we get into. The desperation of the person using the pills or pharma products like those moves over into both personal and business life - far away from the need to stop the pain, and this is where I believe we all make somewhat poor decisions about business and life while under the influence.

Nowadays, I feel like the drugs should only be used clinically, and after exit from the hospital, almost all patients should be on a weaning dose, if not off of them completely. We've learned too much in the past decade, lost too many friends, and buried too many family members. Even a prescribed dose of the drugs can be deadly; even the 5mg Norco I was taking came with so many precautions, including using it separately from other medications due to 'CNS depression that could cause death.'

It seems like we should be in a situation where we are dying to even consider these drugs, but pain to date has not been controlled well by Western Medicine with all its bazillions, trillions, scientists, experts, and more. I find it Ironic that a bunch of hippies in the woods led a movement that slowly moved into people's homes and became a billion-dollar industry. What's shocking is that this happened 2.5 decades ago, and we're still waiting for an alternative for 1/3rd of the population that suffers from pain."

Returning To My Opioid-Free Life After Cancer: Thank you Cannabis As I celebrated my 58th birthday, a significant milestone marked more than just another year of life; it symbolized a renewed commitment to an opioid-free existence. This decision wasn't made lightly nor without deep int...

"Robinson's influence now extends beyond the confines of his immediate environment. His international collaborations in South America and Tel Aviv are pivotal in globalizing cannabinoid medicine, and his educational efforts have put him on Symposium stages worldwide over the last five years.

His efforts are not merely about expanding his business footprint; they are about ensuring the availability of cannabinoid medicine worldwide, embodying his belief in the global community's interconnectedness. Robinson divulged that he's planning on Endocannabinoid educational platforms to accompany the growth operations in other nations and believes they are a critical element.

"I'm working to start bringing ECS Balance Control and The Researcher OG brand and cultivars to South America as I want people to learn about much more than THC - ECS Balance is critical. At the same time, I'm in talks with farms in the Netherlands and stores in Amsterdam while I create multiple new entities for the future that I'm putting loosely under one umbrella that I call the Endo Care Society."

Love, Compassion, and Devotion: Researcher OG & Genevieve's Dream "If she didn't want this ride so bad, I would be fishing." -The Researcher OG; he's had a fishing pole in the corner of his office for seven years.

"Cannabielsoin Acid A (CBEA-A) is formed from Cannabigerovarinic Acid (CBGVA), the precursor molecule to the varin cannabinoids. This rare minor cannabinoid, which can be further broken down through the process of oxidization to create Cannabielsoin (CBE), plays a crucial role in the plant's chemical makeup. But how is it made by the plant? Let's delve into this intriguing process.

Cannabinoid biosynthesis generally occurs within the trichomes, which are small glandular outgrowths appearing on cannabis buds and leaves. In the late flowering stages, trichomes are like a sea of resin with cannabinoids, terpenes, flavonoids, and more.

How Does CBEA get produced? It starts with the production of CBGA and CBGVA:

Cannabinoid production begins when fatty acids are converted to either hexanoyl-CoA or n-butyl-CoA. Olivetolic acid, added to hexanoyl-CoA, starts the following conversion process to the mother major, the precursor molecule cannabinoid CBGA.

Divarinoic acid turns n-butyl-CoA into the stem cell cannabinoid CBGVA. Once these two are made, the balance of cannabinoids is created through processes known as biosynthesis, decarboxylation, and degradation.

CBGA and CBGVA are then converted into different cannabinoids via three different synthase enzymes:

• THCA synthase turns CBGA into THCA and CBGVA into THCVA
• CBDA synthase turns CBGA into CBDA and CBGVA into CBDVA
• CBCA synthase turns CBGA into CBCA and CBGVA into CBCVA
• No synthase: CBGA without an enzymatic conversion process can still be chemically converted into CBG via harvesting, drying, and heating."

-Mike Robinson, Founder Nanobles Corp. / Global Cannabinoid Research Center (GCRC)

“Think of it: a disability is usually defined in terms of what is missing. … But Autism … is as much about what is abundant as what is missing, an over-expression of the very traits that make our species unique.” -Paul Collins

"Cannabinoids like THC, CBD, and CBG are not the only compounds that can affect your high. Terpenes, which are found in all plants, can also have a significant impact on the way you feel when you consume cannabis - especially when it's inhaled. Ultimately, terpenes work together with cannabinoids to make the effects of THC (or other cannabinoids) stronger.

THC is synergistic with terpenes (which are fundamental in the very creation of cannabinoids), together multiple constituents of the Cannabis plant give us effects, which is why focusing only on how much THC is in a product misleads consumers into thinking something is 'better'.

When the compounds are combined, they make the anti-stress, anti-anxiety, energizing, focusing, or sedative effects of the terpenes themselves stronger - it's a two-way street between Cannabis and Terpenes.

That's why full-spectrum THC and CBD products, enriched with terpenes, offer a more potent experience, elevating your high or medicinal benefits (depending on your purpose) compared to isolates or distillates alone. In essence, without terpenes, cannabinoids can be lackluster, underscoring the unique advantages of full-spectrum products.

Here's the scientific breakdown of all the goodies in the plant:l
"More than 500 compounds have been reported from C. sativa, of which 125 cannabinoids have been isolated and/or identified as cannabinoids. Cannabinoids are C21 terpeno-phenolic compounds specific to Cannabis. The non-cannabinoid constituents include non-cannabinoid phenols, flavonoids, terpenes, alkaloids, and others." (Radwan, et al, 2021)

The bottom line? Terpenes, the molecules that give plants and essential oils their smell, seriously matter—so find the ones that best suit your needs and TERP UP!!"

-Mike Robinson, Founder GCRC, The Researcher OG

"Keep on beginning and failing. Each time you fail, start all over again, and you will grow stronger until you have accomplished a purpose - not the one you began with perhaps, but one you'll be glad to remember." -Anne Sullivan

"When I found out it was a plant that stopped two decades of seizures that continually put me in the hospital, I didn't know whether to be extremely happy or pi**ed off at the government, so I went with happy. Once the excitement of that toned down, I realized that for 18 years I had been lied to by doctors who told me Cannabis was dangerous while they continually wrote addictive prescriptions that never worked." -Mike Robinson, Founder Global Cannabinoid Research Center and Epilepsy Warrior

"CBDV, a cannabinoid being heavily investigated for use in Autism & Epilepsy, is structurally very similar to CBD and is also nonintoxicating with similar but bolder characteristics in efficacy. A member of the Varin family of cannabinoids, it's birthed from the precursor molecule (or stem cell) CBGVa.

CBDV is found mainly in Indica landrace cultivars from Asia and Africa and it's naturally in THC plants at low percentages. Cannabis or h**p that is high in CBD also tends to be higher in CBDV.

In an animal study published in 2019 in the Journal of Psychopharmacology, CBDV was found to rescue memory defects in mice with the same genetic defect as people with Rett syndrome. In another British study in 2019, CBDV was found to benefit patients with Duchenne muscular dystrophy (DMD), which causes chronic inflammation and irreversible skeletal muscle damage and degeneration.

CBDV, in research, reduces inflammation, restores and even enhances muscle function, and improves locomotion. Due to these findings, this cannabinoid is thought to have great potential in treating multiple childhood disabilities, developmental delays, and all various types of neurological disorders in people of all ages."
-Mike Robinson, Founder GCRC, The Researcher OG

"When I got PET results just days ago that stated a large mass had vanished, and no positive reaction to the test was high enough to continue calling it Cancer, the feeling was overwhelming. For nearly the past year, my identity has been as a cancer patient, a warrior, and a survivor - but that first word patient I've found dethrones us from our position of power. Suddenly, our mindset starts wrapping around the word 'patient' - and we start counting on outside parties to assist us.

It's not just doctors that come into play with this; it's everyone. "But I have Cancer" becomes call words when people have upset you, or you've just annoyed yourself and used people as the reason. It's a psychological phenomenon why patients do this, but the most straightforward route away from all of it isn't too tricky. It's to no longer be a patient.

When we're being seen by medical professionals, we're always the patient treated by the doctor - or are we? My PET Results are evident in the conclusion, "These changes are likely due to the Treatment plan." Now, when I peer back to the history of 2023, the only treatment came from the patient and my lovely lady Anne Mari, who prepared meals after painstaking time to ensure every food and ingredient was researched.

As my oncologist read through everything yesterday, he made a statement that bothered me, "We'll have to redact the PET findings that state this is due to a Treatment because we gave you none, and the Cancer Treatment Center doesn't recognize Cannabis as a Treatment." I responded, "Do you recognize dietary changes as treatments, especially vast ones that include conversion to gluten and dairy-free with high Omega fishes being the only meats?"

He looked at me, puzzled, "The PET findings may stand; you are correct that a diet is a treatment. We have dieticians here and recognize the science behind healing with diets and spontaneous remissions caused by them."

PET Conclusion: "You're in Remission - Due to your Treatment" Fighting Cancer is one of the most emotion-riddled journeys that can be taken in life, especially when you only look tired as people aren't going to roll out the red carpet when about 50% of us will end up with some form...

"There's so much more than Cannabinoids and Terpenes; part of my current treatment includes polyphenols (Flavonoids are a class of them) from various fruits and vegetables - including Cannabis.

They're a big part of the Thermodynamic aspect of my own Cancer Fighting protocol. Research has shed light on the potential of flavonoids as the next big thing in the world of medical cannabis - R&D is being done on mice by Scientists - but I'm using myself at the perfect time.

Polyphenols have two general classes: flavonoids and phenolic acids. Flavonoids are then further divided into several subtypes: flavones, flavonones, flavonols, flavanols, and isoflavones. Phenolic acids have one of these two classifications -hydroxybenzoic and hydroxycinnamic acids.

Published in Phytochemistry, a study led by professors Tariq Akhtar and Steven Rothstein employed biochemistry and genomics to understand how these molecules are produced within the cannabis plant. Flavonoids, present in various plants, including cannabis, are known for their pigmentation and antioxidant properties.⁣

The potential benefits of these Cannflavins are particularly significant for individuals dealing with chronic pain. Unlike opioids, which can lead to adverse side effects and addiction, Cannflavins target pain by directly reducing inflammation. This novel approach holds promise for developing non-addictive pain relief medications.⁣

⁣It's also important to note that Cannflavins are non-psychoactive, meaning they don't produce mind-altering effects like opioids or THC. This makes them an even more compelling option for pain management.⁣

With ongoing research, cannflavins could pave the way for innovative painkillers that offer a safer alternative to current options. The potential to alleviate pain without the associated risks of addiction is a significant development in the medical field.⁣

The word may fool many; terpenes are responsible for the sweet taste and flavors of Cannabis, and most Cannflavins are very tart or bitter."

-Mike Robinson, Founder Nanobles Corp. / Global Cannabinoid Research Center (GCRC)

"This table presents compelling evidence of the potential of CBGA and CBD in safeguarding the structure of kidneys afflicted by UUO, a condition that mimics kidney disease in mice.

In simple terms:

(a) This figure section shows pictures of kidney cells from mice treated with CBGA, CBD, a combination of CBGA and CBD, or a vehicle (like a placebo, with no active substances). The pictures were taken from healthy kidneys (CLK) and those with UUO. The scale bars are like a ruler for the images - they show that the actual size of the stuff in the picture is 50 micrometers (µm) - that's small!

(b, c) These sections count the number of dilated (or swollen) and total kidney tubes (tubules) in the healthy (CLK) and UUO kidneys to see if the treatments affected the number of these tubes.

(d) This part of the figure looks at the percentage of the area within the kidney (both healthy and UUO ones) that is filled with collagen (a protein that provides structure). It does this by looking at sections of the kidney that were stained for collagen type I.

In all sections of the figure, the presence of * or **denotes a significant finding, indicating that the observed difference is unlikely to occur by chance. In this study, the kidneys with UUO treated with CBGA, CBD, or both showed markedly different results compared to those treated with the vehicle. This suggests that CBGA and CBD have a tangible impact, underscoring their potential for future therapeutic applications.

While research studies show promise for future medicines, they are not a guide on how to use Cannabis or cannabinoids or a confirmation of how one may work in any individual's system. Investigative treatment focuses on answers, solutions, and the potential of what's being studied rather than making any medical claim."

-Mike Robinson, Founder Global Cannabinoid Research Center

Most who smoke Cannabis or use concentrates know that sometimes we can get a little edgy or paranoid due to Anandamide signal disruption. THC looks like the same endocannabinoid, so this is to be expected. Re**er Madness used this to inaccurately spread that Cannabis is the cause of mental health disorders rather than having some effects that make some users uncomfortable - and are temporary.

So, I'd have to disagree with the Re**er Madness research.

A more rational statement would be that certain people could further a situation like that by only smoking Cannabis high in THC and not smoking or ingesting other Cannabinoids as it's causing too much of a fluctuation of Anandamide 'tone.'

This research does prove that inhaling Cannabis alters Anandamide Tone;

But,

Even more accurate would be to state that the individual experiencing these effects from THC Cannabis use may have:

Such a healthy ECS Tone that THC use is flooding the receptor system, damaging vs. helping. There are people with a healthy ECS that do not use Cannabis.

Or,

Such a low level of exercise and a bad diet to boot - and then it doesn't take as much THC to cause this, as the person already has a decimated Anandamide level.

Or,

It's all a bunch of guessing, and everyone will respond differently.
Some will be just fine, others will need a full array of Cannabinoids, and others have a physiology that doesn't get along with plant extracts or the plant at all.

-Mike Robinson, GCRC Founder

"Our findings suggest that anandamide signaling is altered following cannabis use differentially in light and heavy users, and psychotic-like symptoms are related to levels of this endocannabinoid in the brain. These findings suggest that healthy individuals who smoke cannabis and have lower levels of anandamide - either endogenously or through their cannabis use - may be more vulnerable to the acute and chronic psychotomimetic effects of cannabis, and therefore potentially more vulnerable to psychosis."

Citation: "Cerebrospinal fluid anandamide levels, cannabis use and psychotic-like symptoms" [Morgan et al, 2018] Fig 1: Cerebrospinal fluid (CSF) anandamide levels across the three groups.

"Ingestion is critical, but research has proven Cannabis smoke intake has treated the damaging effects of smoking ci******es:

There's quite a bit of inflammation involved with pulmonary fibrosis, so anti-inflammatory medications and treatments are usually adequate.

Researchers have found THC to have anti-inflammatory properties, which they feel accounts for the pulmonary function improvement in patients using cannabis.

Donald Tashkin at the University of California Los Angeles, way back in the '70s, performed studies that found both orally ingested and inhaled THC provided bronchodilation for several hours after being administered.

In many other studies, it's been found that activating the CB1 receptor inhibits smooth muscle contraction of the lungs, which offers a potential acute bronchodilation mechanism linked with cannabis intake.

Cannabinoids provide anti-inflammatory qualities. The highest-effecting cannabinoids are CBGA, CBDA, and THCA, which are ingested raw plant acidic cannabinoids.

Studies show that cannabis and its extracts may act as a way to reduce acute airway constriction attacks and become a viable preventative therapy for COPD patients.

Much more research needs to be done, but it becomes evident in reviewing the existing research that Cannabis can repair some of the damage from Ci******es and treat severe health conditions that arise due to other lung incidences."
-Mike Robinson, GCRC Founder