Neuronet

Have a read of the latest Innovative Health Initiative (IHI) funded publication investigating the association between different AD polygenic risk scores (PRS) and amyloid accumulation in the Flemish Prevent AD Cohort KU Leuven (F-PACK).

Congratulations to the authors Emma Luckett, Yasmina A., Mariska Reinartz, Kasia Adamczuk, Jolien Schaeverbeke, Sare Verstockt, Steffi De Meyer, Koen Van Laere, Patrick Dupont, Isabelle Cleynen & Rik Vandenberghe!

Association of Alzheimer’s disease polygenic risk scores with amyloid accumulation in cognitively intact older adults - Alzheimer's Research & Therapy Background Early detection of individuals at risk for Alzheimer’s disease (AD) is highly important. Amyloid accumulation is an early pathological AD event, but the genetic association with known AD risk variants beyond the APOE4 effect is largely unknown. We investigated the association between di...

Have a read of the latest Innovative Health Initiative (IHI) funded study, investigating the performance of participants with and without diabetes on a task of allocentric spatial processing.

Congratulations to the authors Sarah Gregory, Kaj Blennow, Natalie Homer, Craig Ritchie, Graciela Muniz Terrera and the whole consortium!

Self‐reported diabetes is associated with allocentric spatial processing in the European Prevention of Alzheimer’s Dementia Longitudinal Cohort Study Type 2 diabetes is a robust predictor of cognitive impairment. Impairment in allocentric processing may help identify those at increased risk for Alzheimer’s disease dementia. The objective of this s...

📢 Mobilise-D Webinar: Multiple Sclerosis 📢

Just one week until our first webinar this autumn!

📅 Wednesday, September 7
⌚️ 16:00 CET
🆓 Free and open to the public

Haven't signed up yet? Register now👇

🔗https://www.mobilise-d.eu/webinar-series-mobilise-d-presents-its-four-patient-cohorts

Read the latest Innovative Health Initiative (IHI) funded publication that found a significant interaction between APOE status, s*x, and CSF Aβ on CSF p-tau levels

Congratulations Tyler Saunders, Natalie Jenkins, Kaj Blennow, Craig Ritchie and Graciela Muniz Terrera!

Interactions between apolipoprotein E, s*x, and amyloid-beta on cerebrospinal fluid p-tau levels in the European prevention of Alzheimer's dementia longitudinal cohort study (EPAD LCS) An interaction between s*x and cerebrospinal fluid Aβ may mediate the relationship between APOE status and CSF p-tau. These data suggest tau accumulation may be independent of Aβ in females, but not males.

The goal of the Innovative Health Initiative (IHI) funded PRISM 2 project is to build on the achievements of the original PRISM project. Specifically, it aims to validate PRISM’s findings on social dysfunction in schizophrenia and Alzheimer’s disease, and investigate whether they also apply to major depressive disorder.

https://vimeo.com/687937223

What is it like to work as a communication expert on public-private partnerships in life sciences?

Read our communication blog with Cindy Birck from Alzheimer Europe who is involved in Innovative Health Initiative (IHI) flagship projects on neurodegeneration

Spotlight on Communication experts: A Neuronet Blog with Cindy Birck Neuronet is a Coordination and Support Action for the Innovative Medicines Initiative’s research projects on

Have a read of the latest Innovative Health Initiative (IHI) funded publication outlining the current knowledge around the vital role of the apoptosis-inducing factor by primarily focusing on currently reported human diseases that have been linked to AIFM1 deficiency.

Congratulations to the authors Lena Wischhof, Enzo Scifo, Dan Ehninger, Daniele Bano and the whole consortium!

https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00413-3/fulltext

📢Four NEW Mobilise-D webinars this autumn📢

We will show you the project cohorts and the status of the clinical trials. In the first webinar we present our cohort.

Save the dates(s) and register now⤵️

📅 September 7th
⌚️16:00 CET

🔗https://www.mobilise-d.eu/webinar-series-mobilise-d-presents-its-four-patient-cohorts

The Biomedical Knowledge Miner (BiK>Mi) has been developed as part of the Innovative Health Initiative (IHI) funded project at Fraunhofer SCAI.
This platform provides tools to access & validate knowledge pertaining to 's disease.

Find out more:

The Biomedical Knowledge Miner (BiK>Mi) A tool to access & validate knowledge pertaining to Alzheimer's disease. Check it out now.

What is it like to work as a communication expert on public-private partnerships in life sciences?

Read our communication blog with Yoanna de Geus from Lygature who is involved in Innovative Health Initiative (IHI) flagship projects on neurodegeneration 🧠 RADAR-CNS & RADAR-AD ⤵️

Spotlight on Communication experts: A Neuronet Blog with Yoanna de Geus Neuronet is a Coordination and Support Action for the Innovative Medicines Initiative’s research projects on

The Alzheimer’s Association International Conference is the largest and most influential international meeting dedicated to advancing dementia science. Each year, AAIC convenes the world’s leading basic science and clinical researchers, next-generation investigators, clinicians and the care research community to share research discoveries that’ll lead to methods of prevention and treatment and improvements in the diagnosis of Alzheimer’s disease. This year, the conference took place from 31st July to 4th August as a hybrid event (online and in San Diego, US) and attracted over 10,000 attendees.

We were pleased that several EPAD researchers presented their respective work at the Alzheimer’s Association International Conference

– Sarah Gregory (UEDIN): “Does adherence to the Mediterranean diet have differential effects on brain health for those living within and outside of the Mediterranean region?”

– Luigi Lorenzini (VUmc): “Concerted alterations of functional connectivity and WM integrity in relationship to early amyloid deposition”

– Luigi Lorenzini (VUmc): “Functional eigenvector centrality dynamics are related to amyloid deposition in preclinical Alzheimer’s Disease.”

– Gonzalo Sánchez Benavides (BBRC) “Re-examining the impact of adjusting for education and s*x the RBANS delayed memory score: Implications on the cut-offs used to detect cognitive impairment in prodromal Alzheimer’s disease. Data from the EPAD-LCS study.”

– Irene Cumplido Mayoral (BBRC) “Biological Brain Age Prediction Using Machine Learning on Structural Neuroimaging Data: Multi-Cohort Validation Against Biomarkers of Alzheimer’s Disease and Neurodegeneration.

https://www.imi-neuronet.org/epad-presented-at-aaic2022/

Our Innovative Health Initiative (IHI) funded IMI2_Neuronet Decision Tool provides a clickable overview of the processes and procedures for Health Technology Assessment & regulatory interactions at different stages of the development pipeline

https://kb.imi-neuronet.org/admin/decision_tool

Mobility impairment is a strong modifiable predictor for incident disability in older adults (Braun et al. 2022).
➡️Assessments of mobility capacity may help identify older people at risk of incident disability
➡️Mobility assessment should be routinely established in regular health examinations.

Read the full systematic review here⤵️
https://www.sciencedirect.com/science/article/pii/S1568163722001465?dgcid=author

Mobilise-D Scoping Review: Existing evidence on the clinical utility of digital mobility outcomes Walking on common ground: a cross-disciplinary scoping review on the clinical utility of digital mobility outcomes (Polhemus et al. 2021)Read more here:https...

Why Mobility Matters Mobility is often said to be a sixth vital sign, just as important as other vital signs such as blood pressure and heart rate, and the key to independence in...

The latest Innovative Health Initiative (IHI) funded publication demonstrates the importance of using well-optimised NMeds targeted with novel ligands to advance delivery & pharmaceutical effects against diseased cells while minimising the risk for nearby healthy cells.

Congratulations to the authors Jason Duskey, Arianna Rinaldi, Ilaria Ottonelli, Riccardo Caraffi, Chiara Alessia De Benedictis, PhD, Ann-Katrin Sauer, Giovanni Tosi, Maria Angela Vandelli, barbara ruozi, Andreas Grabrucker and the whole consortium!

Glioblastoma Multiforme Selective Nanomedicines for Improved Anti-Cancer Treatments Glioblastoma Multiforme (GBM) is a devastating disease with a low survival rate and few efficacious treatment options. The fast growth, late diagnostics, and off-target toxicity of currently used drugs represent major barriers that need to be overcome to provide a viable cure. Nanomedicines (NMeds)....

What is Mobilise-D - Mobility as a vital sign Prof. Lynn Rochester and Dr. Ronenn Roubenoff explain how mobility is a vital sign and the benefits of being able to measure people's mobility in a reliable ...

Mobilise-D protocol for validation of Digital Mobility Outcomes Mazzà et al. (2021). Technical validation of real-world monitoring of gait: a multicentric observational study Full text: https://bmjopen.bmj.com/content/11/...

The Mobilise-D journey! Watch how Mobilise-D develops innovative digital technology to measure mobility in daily life, thereby transforming clinical research and contributing to per...

Mobiliser Ashley Polhemus had a successful PhD defense on July 5!😍 Amongst other topics, Ashley discussed her extensive review work on methods and considerations for selecting novel digital mobility outcomes.

You can read the review here:

➡ https://www.nature.com/articles/s41746-021-00513-5

Have a read of the latest Innovative Health Initiative (IHI) funded paper "The Open-Access European Prevention of Alzheimer’s Dementia (EPAD) MRI dataset and processing workflow"

Highlights:

• overview of the MRI image processing and QC pipeline for the open-access EPAD study.

• evaluation of data sanity by comparison with non-imaging dementia indicators.

• This work is a methodological reference for investigators accessing public EPAD data.

Congratulations to the authors Luigi Lorenzini, Silvia Ingala, Alle Meije Wink, Joost Kuijer, Viktor Wottschel, Mathijs Dijsselhof, Carole Sudre, Sven HALLER, Jose Luis Molinuevo, Juan Domingo Gispert, David Cash, David Thomas, Sjoerd Vos, Ferran Prados, Jan Petr, Robin Wolz, Alessandro Palombit, Adam Schwarz, Gaël Chételat, Pierre Payoux, Carol Di Perri, Joanna Wardlaw, Giovanni Frisoni, Christopher Foley, Fox Nick, Craig Ritchie, Cyril Pernet, Adam D B Waldman, Frederik Barkhof, Henk(-Jan) Mutsaerts, and the whole EPAD consortium !

Redirecting

Would you like to learn what the public-private partnership between the 🇪🇺 European Union & 🧪 EFPIA - European Federation of Pharmaceutical Industries and Associations: the Innovative Health Initiative (IHI) is delivering in 🧠 neurodegeneration research?

Check out our Knowledge Base: https://kb.imi-neuronet.org/admin

kb.imi-neuronet.org

A busy day for our Mobiliser Lisa Alcock 👏 She is presenting two posters on Parkinson's Disease, 1) changes in physical actkvity and falls pre-post Covid-19, 2) turning in PD classifying the fall and the faller.

Time flies! The Innovative Health Initiative (IHI) funded project formally ends in July 2022, so project partners gathered in Copenhagen from 28 – 29 June for a final meeting:

PD-MitoQUANT holds Final Project Meeting in Copenhagen – Neuronet Time has certainly flown! With the PD-MitoQUANT project formally ending in July 2022, project partners

Are you interested in the latest developments in research?
Check out our Knowledge Base with an up-to-date overview of all public Innovative Medicine Initiative project deliverables (447) on neurodegeneration: https://kb.imi-neuronet.org/admin/deliverables

kb.imi-neuronet.org

Mobilise-D TVS team rocks at 🤘🤩

One of our Mobilise-D stars, Ashley Polhemus from the University of Zürich, has her public PhD defense on Tuesday, July 5, 15-16 CET. Amongst other topics, Ashley will discuss her extensive review work into methods and considerations for selecting novel digital mobility outcomes which are meaningful to patients and in clinical settings. Anyone interested can follow on Zoom!

PhD Defense of Ashley Polhemus
"Digital Mobility Outcome Validation: Advancing Harmonized Theory and Methodology"
Time: July 5th, 2022, 15.00-16.00 CET
Room: Rämistrasse 59, RAA-G-15

Zoom: https://uzh.zoom.us/j/63269353448?pwd=d2dST1VFOVY5aUw0c3RFMHloWEcyQT09
Meeting ID: 632 6935 3448
Passcode: 796321

The baseline paper of the AMYPAD Diagnostic Study has been published The Amyloid Imaging to Prevent Alzheimer’s Disease (AMYPAD) consortium recently published a paper which presents the participants’ baseline features o

Have you developed or implemented a project to address the attached to 🧠 ?

Apply for Alzheimer Europe's 💰 EUR 5,000
Anti-Stigma Award ⤵️
https://www.imi-neuronet.org/alzheimer-europe-launches-anti-stigma-award/

Alzheimer Europe launches Anti-Stigma Award – Neuronet On 22 June, Alzheimer Europe launched its Anti-Stigma Award. The award recognises an outstanding initiative