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Potential of Exosomes in . Given the development and success of exosome , engineered exosomes are attracting increasing attention, especially in fields, due to their spatial and temporal targeting ability. Although natural can deliver antitumor drugs, they mostly retain in the liver or spleen rather than in tissue.
Additionally, the therapeutic efficacy is attenuated due to the heterogeneity and complicated components of natural . Hence, engineering technologies confer exosomes more specifically targeting property and clinical translational potential.

Engineered exosomes from different sources for cancer-targeted therapy - Signal Transduction and Targeted Therapy Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes modified with surface decoration and internal therapeutic molecules. After appropriate modification, engineered exosomes are abl...

The FDA Modernization Act 2.0 has paved the way for alternative methods to bolster the preclinical data pipeline, aiming to reduce the dependence on animal models that have frequently resulted in therapeutic dead ends. This comprehensive legislation permits the utilization of specific alternatives to animal testing, including cell- based assays, such as human induced pluripotent stem cells (iPSCs), primary human cells, organoids and organs-on-chips (OoCs), and advanced artificial intelligence (AI) methods

https://www.jci.org/articles/view/175824

Ditch the outdated methods and dive into the future of liver safety assessment!

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Publication Alert: Stem cell-derived exosomes (SC-Exo) inherit similar therapeutic effects from their parental cell of origin, e.g., anti-inflammation, immunomodulation and . Collectively, stem cell-derived exosomes are a potent surrogate for without exhibiting the disadvantages their cellular counterparts present.
Stem cell-derived have demonstrated tremendous potential in treating numerous disorders in surgery (e.g., fracture, , and ); neurosurgery (e.g., ischemic , traumatic brain injury, and ’s disease); plastic surgery (e.g., wound healing); general surgery (e.g., acute liver injury); cardiothoracic surgery (e.g., myocardial infarction); urology (e.g., chronic ); head and neck surgery (e.g., sensorineural hearing loss); ophthalmology (e.g., acquired optic neuropathies), and gynecology (e.g., primary ovarian insufficiency).

Clinical applications of stem cell-derived exosomes - Signal Transduction and Targeted Therapy Although stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery, it nevertheless comes with inescapable drawbacks that might limit its clinical translation. Compared to stem cells, stem cell-derived exosomes possess nume...

Ditch the outdated methods of testing cosmetics on animals! There's a new revolution in town: advanced skin models developed from human cells and stem cells!

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3D bioprinting is used to construct intricate biological structures towards functional liver models, specifically engineered for deployment as alternative models in drug screening, toxicological investigations, and tissue engineering.

Learn more about: https://www.sciencedirect.com/science/article/pii/S2590006424000504

Organoids are structures grown from human cells that mimic real organs. This allows researchers to test drugs on a more human-relevant platform, leading to faster and more reliable . It is opening new doors for even more and effective treatments!

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Imagine a fingertip-sized lab performing complex experiments! This is the future of drug discovery with microfluidic chips.

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Printing Organs for a Healthier Future: Can bioprinting revolutionize drug discovery?

Explore how 3D bioprinting creates human-like tissues for drug testing, potentially leading to more accurate results and faster development of life-saving medications.

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The FDA Modernization Act ushers in a new era! Animal testing is no longer mandatory. Explore these innovative alternative testing methods that scientists are utilizing to gain crucial insights into drug efficacy and safety. It is paving the way for a more humane and potentially more accurate drug discovery process.

Swipe to learn more!

Drug Discovery Revolution: What does the FDA Modernization Act 2.0 Mean for the Future?

Dive into the infographic to discover the act's impact on testing methods and drug development timelines.

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Our high-quality primary cells are the perfect match for microfluidic platforms, making drug testing faster, easier, and more accurate. These specialized cells closely mimic human biology, providing a more precise and predictive platform for your microfluidic experiments.

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Selecting the right cells is crucial for successful drug testing. It helps is understand how the drug interacts with a living system. But with a vast array of cell types available, how do you choose the best ones for your experiment?

We have covered some key considerations, but there is always more to learn! Share your experiences and factors you consider when choosing cells for drug testing in the comments below.

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Are you looking for a reliable and versatile tool to advance your research in drug metabolism, , or pharmacokinetics? Look no further than C57 mouse intestine microsomes.

These powerful research resources offer the maximum number of benefits for investigating various aspects of intestinal physiology and drug metabolism.

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Role Of C57 Mouse Intestine Microsomes In Drug Research C57 mouse intestine microsomes for in vitro studies! Learn about limitations, & considerations of them for drug discovery & toxicology research.

Are you struggling to identify contaminant in your cultures? Swipe through to learn about key methods to pinpoint the culprit. Early detection is crucial to save your experiments!

Which method do you use most often? Share your tips in the comments!

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