NRC - Neuronano Research Center - Lund University, Sweden

Congratulations to Michael Andersen and Jens Schouenborg. For publishing their work on polydimethylsiloxane (PDMS) as a more biocompatible alternative to glass for optogenetics in Nature Scientific Reports.
Read the full article here:

Polydimethylsiloxane as a more biocompatible alternative to glass in optogenetics - Scientific Reports Optogenetics is highly useful to stimulate or inhibit defined neuronal populations and is often used together with electrophysiological recordings. Due to poor pe*******on of light in tissue, there is a need for biocompatible wave guides. Glass wave guides are relatively stiff and known to cause gli...

Powerful pain management with no noticeable side effects!
Congratulations to Matilde Forni, Palmi Thor Thorbergsson, Lina Gällentoft, Jonas Thelin and Jens Schouenborg for publishing "Sustained and potent analgesia with negligible side effects enabled by adaptive individualized granular stimulation in rat brainstem"
Read the full article here:

Sustained and potent analgesia with negligible side effects enabled by adaptive individualized granular stimulation in rat brainstem - IOPscience Published 18 May 2023 • © 2023 The Author(s). Published by IOP Publishing Ltd Journal of Neural Engineering, Volume 20, Number 3 Citation Matilde Forni et al 2023 J. Neural Eng. 20 036014 DOI 10.1088/1741-2552/acd3b2

Professor Jens Schouenborg was intervjued by TT on Friday, May 26th. The intervju was regarding the fact that Elon Musks company Neuralink has got a FDA-approval for clinical trials. The NRC and Neuronano AB works for getting an approval and start clinical trials within a year.
Read the intervju here:
in English https://newsbeezer.com/swedeneng/elon-musks-company-is-allowed-to-test-brain-implants/
in Swedish https://www.di.se/digital/elon-musks-foretag-far-testa-hjarnimplantat-pa-manniskor/

Elon Musks företag får testa hjärnimplantat på människor Den kontroversielle entreprenören Elon Musks företag Neuralink har fått klartecken att testa sitt hjärnimplantat på människor. Än så länge är det inte klart exakt vad försöken går ut på, men hans förhoppning är bland annat att ge blinda synen tillbaka.

NRC doctor Matilde Forni won the award for Best Thesis in Neuroscience 2022! Congratulations! Please join us in celebrating this on Thursday May 25th!
You can read Matilde Forni's thesis here:https://lucris.lub.lu.se/ws/portalfiles/portal/129271841/Thesis.pdf

Listen to Prof. Jens Schouenborg on Swedish radio talking about brain implantation.
In Swedish:

Därför drömmer Elon Musk om chip i hjärnan - I hjärnan på Louise Epstein Louise Epstein och Anders Hansen synar entreprenören Elon Musks vision om att mikrochip ska kunna optimera människors hjärnor.

NRC's newest doctor:
PhD Matilde Forni
You did a great job today, as always!
In the picture is Matilde Forni with her Faculty Opponent Prof. Sten Grillner.

Congratulations to Matilde Forni who “nailed her thesis to the wall” today!
Thesis defence is on December 19th.

With the DBS (deep brain stimulation) technology used at Neuronano, we never miss the target.

While ensuring electrode coverage of the target area in the brain, optimal symptom relief is achieved by fine-tuning the stimulating pattern electrode by electrode. Stay tuned on our website to find out more about how we work for exact precision technology within DBS.

At Neuronano we work hard every day to find new and modern treatments for diseases such as Parkinson and other neurological conditions.

Read more about our exciting work at neuronano.se

Professor Jens Schouenborg, leading the NRC, has been invited to participate in a panel discussion with Brilliant Minds about ”Decoding the senses”.
Brilliant Minds Foundation is a global platform for the most creative individuals to unite on world-changing ideas. So we are really proud to be a part of this discussion.
https://brilliantminds.co/events/

It is gratifying to see that our work is recieving worldwide attension. Please see Universal-Sci: https://www.universal-sci.com/article/relieving-chronic-pain-with-microelectrodes
To read the full scientific article in Science Advances by Forni et.al. please see post below (October 11).

No more painkillers? Scientists developed a side-effect free method to relieve pain Swedish scientists achieved a major breakthrough with a drug free technique to relieve intense pain with no discernable side effects

Press release (in Swedish) for Matilde Forni et.al. "3D microelectrode cluster and stimulation paradigm yield powerful analgesia without 4 noticeable adverse effects"
https://www.lu.se/artikel/smartlindring-utan-biverkningar-med-sjograsmjuk-teknik

Smärtlindring utan biverkningar med sjögräsmjuk teknik Lunds universitet. Studien, som är gjord på råttor, publiceras i den vetenskapliga tidskriften Science Advances. I Lund har ett forskarteam, lett av Jens Schouenborg, professor i neurofysiologi, utvecklat en metod mot smärta via individanpassad stimulering med ultratunna och vävnadsvänliga mik...

Congratulations to Matilde Forni et.al. on the publication of "3D microelectrode cluster and stimulation paradigm yield powerful analgesia without noticeable adverse effects" in Science Advances!
https://www.science.org/doi/full/10.1126/sciadv.abj2847
In short: We report that strong and highly specific analgesia, with no sign of sedation or adverse behavioral effects, can indeed be accomplished by stimulating highly specific subregions of neural tissue through an appropriate individual subset of microelectrodes selected from a flexible microelectrode cluster implanted in PAG/DRN.

3D microelectrode cluster and stimulation paradigm yield powerful analgesia without noticeable adverse effects Powerful pain relief without noticeable adverse effects is attainable with high-definition granular brain stimulation.

Prof. Jens Schouenborg at NRC and Neuronano AB was in the news this Friday evening. (In Swedish) Please see the news feature and hear about our electrodes here:
(SVT Rapport 19th February 2021)

https://www.youtube.com/watch?v=YqPFlL1hvUs

Spetsforskning mot Parkinsons sjukdom och kronisk smärta på Neuronano Research Center Reportage i Rapport, Svt, februari 2021 från Neuronano Research Center. Medverkande: Professor Jens Schouenborg, Neuronano Research CenterJournalist: Thomas ...

Article in Svenska Dagbladet today (in Swedish)
"– Vi behövde en implanterbar teknik som kunde sitta i vävnaden utan att störa, berättar han. Om implantatet stör vävnaden förstör den samtidigt möjligheten att lyssna på hur nervceller agerar och reagerar normalt. .... – Jag skulle hävda att den teknik vi utvecklat är redo att användas i forskning och i behandling. Nu handlar det bara om hur snabbt vi kan göra en produkt av tekniken så att den kan bli användbar, säger han."
https://www.svd.se/svenske-forskaren-som-tavlar-med-elon-musk

Svensken som förverkligar Elon Musks idé | SvD Teslagrundaren Elon Musks försök att integrera en dator med en hjärna har avfärdats som drömmar. Men ambitionen blir allt mindre osannolik. I Lund finns en forskare som just nu förverkligar delar av idén.

17 million SEK for Neuronano (article in Swedish)
Tunna mikroelektroder som stimulerar hjärnans nervsystem kan snart komma att lindra symtom för Parkinsonpatienter. Bakom teknologin står forskarteamet i Lundabaserade Neuronano som precis tagit in 19 miljoner kronor för att slutföra djurstudier innan elektroderna kan testas på patienter.
– Vi ligger omkring ett och ett halvt år ifrån kliniska studier, säger Neuronanos grundare Jens Schouenborg, professor i neurofysiologi vid Lunds universitet och koordinator för Neuronano Research Center (NRC).
Läs hela artikeln här: http://www.rapidus.se/17-miljoner-till-neuronano/

Rapidus » 17 miljoner till Neuronano 17 miljoner till Neuronano 2020-12-15 Tunna mikroelektroder som stimulerar hjärnans nervsystem kan snart komma att lindra symtom för Parkinsonpatienter. Bakom teknologin står forskarteamet i Lundabaserade Neuronano som precis tagit in 19 miljoner kronor för att slutföra djurstudier innan elektr...

The NRC hattrick!
In Swedish but hopefully soon in English.
https://www.lu.se/artikel/tre-i-rad-hattrick-hjarnelektroder

Tre i rad – hattrick för hjärnelektroder Hjärnan är den mest komplicerade struktur vi känner till och den ligger bakom vår intelligens, kreativitet, tankar, minnen, känslor och våra sinnesintryck. Man har liknat den vid en dator men likheten haltar eftersom vi inte ens är nära att förstå hur vår hjärna fungerar. En viktig pusse...

NRC's third PhD in 2 weeks!
Huge congratulations to Dr Johan Agorelius!!
You did a great job and secured our hat-trick!

Congratulations to NRC's newest PhD!!
Dr Mohsin Mohammed!
Very well done!!

Now is the news regarding drug loaded nano-particles available in English: https://www.lunduniversity.lu.se/article/nanoparticles-deliver-drugs-brain
Amazing release time over 30 days and virtually no immune response.

Nanoparticles deliver drugs to the brain The brain is both our most complex organ and the most difficult one to study. By developing flexible electrodes thinner than a human strand of hair, researchers at Lund University are working to find new methods capable of registering signals from the brain’s nerve cells in order to learn more abo...

Today Johan Agorelius "nailed his thesis to the wall".
Congratulations!
The dissertation will take place on December 3rd.

Congratulations to the newest doctor at the NRC!! Alexander Dontsios Holmkvist!
Well done! and impressive work!

NRC is in the news! (In Swedish)
Nanoparticles containing anti-inflammatory drugs to be delivered locally in the brain. In the article you will find a link to the english publication. You are also welcome to hear all about this at the PhD-defence of Alexander Dontsios Holmkvist on November 19th.
https://www.lu.se/artikel/nanopartiklar-kommer-lastade-med-lakemedel-till-hjarnan?ref=pressrelease

Nanopartiklar kommer lastade – med läkemedel till hjärnan Hjärnan är vårt mest komplicerade organ och också det som är svårast att studera. Genom att utveckla flexibla elektroder tunnare än hårstrån, arbetar forskare vid Neuronano Research center vid Lunds universitet med att ta fram nya metoder som kan registrera signaler från hjärnans nervcell...

On Friday 6th of November Mohsin Mohammed "nailed his thesis to the wall"! Congratulations!
The dissertation will take place on Monday November 30th 2020.

Alexander Holmkvist ”nailed his thesis to the wall” today.
“Nanoparticle-based drug delivery systems for neural interfaces - a novel approach for improved biocompatibility”
Congratulation!!

Congratulations to Mohsin Mohammed et.al, on the publication of "Ice coating –A new method of brain device insertion to mitigate acute injuries"!
Read the full article here: https://www.sciencedirect.com/science/article/pii/S016502702030265X?via%3Dihub
In short:
- We have developed a novel, low-friction coating around frozen, gelatin embedded needles. By introducing a layer of thawing ice onto the gelatin, decreasing surface friction, we mitigate damage caused by the implantation.

Ice coating –A new method of brain device insertion to mitigate acute injuries Reduction of insertion injury is likely important to approach physiological conditions in the vicinity of implanted devices intended to interface with…

Congratulations to Mengliang Zhang, Hiroyuki Watanabe et.al for the publication on "Hindlimb motor responses to unilateral brain injury: spinal cord encoding and left-right asymmetry"! Read the full article here:
https://academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcaa055/5827452

Hindlimb motor responses to unilateral brain injury: spinal cord encoding and left-right asymmetry Abstract. Mechanisms of motor deficits (e.g. hemiparesis and hemiplegia) secondary to stroke and traumatic brain injury remain poorly understood. In early anim

Our latest research on nanoparticles and neural interfaces has just been published with in Journal of Nanobiotechnology. Congratulations to Alexander D. Holmkvist et.al.! Read the full article here: https://link.springer.com/epdf/10.1186/s12951-020-0585-9?author_access_token=XJcJDemy9vprwGNSPvQZ1m_BpE1tBhCbnbw3BuzI2RNlxrFQy5mCbtcCEc2gXi93Y7nTEzdeKh3pTNmJZz8AqO7lzjgFrTEo29Ksz92DhHSrJY7TMVEpU_3g8FRyJetN_DdqcSdPoksgcziqEKkdIQ%3D%3D

Local delivery of minocycline-loaded PLGA nanoparticles from gelatin-coated neural implants attenuates acute brain tissue responses in mice

NRC - Neuronano Research Center - Lund University, Sweden updated their website address.

A lot to celebrate: good results, accepted paper and a birthday! A new “venue”, The Cozy Friday Corner!

Our newest PhD: Doctor Bengt Ljungquist
Gongratulations!
Well done!!

Right now Bengt Ljungquist defending his thesis: Bitcoding the brain.

On August 23 Bengt Ljungquist nailed his thesis "Bitcoding the brain" to the wall at Neuronal Research Center!
On September 13th he will defend it in the Lecture Hall at Medicon Village in Lund, Sweden, 9:00 am.

Bengt Ljungquist et al made it not only to the print version of the journal but also to the cover!
Congratulations!

Nedjeljka Ivica dissertation today in Segerfalk Hall, BMC, Lund

How to record 1 million neurons in real time

"A giant leap for neuroscience"
Medical News Today, report on NRCs last article.
https://www.medicalnewstoday.com/articles/321268.php

medicalnewstoday.com A newly developed method may allow neuroscientists to listen in to more than 1 million neurons at once and unfurl the data in real time.

Ny metod hanterar och lagrar data från miljoner nervceller - i realtid

Pressrelease!
Bengt Ljungquist et.al have been able to code signals from neurons in the brain directly to bit-code and by this made it possible to register, decode and react on over one million nerve cells within milliseconds!
This will have huge effect on for example stopping an epileptic seizure or helping someone paralysed to control an robotic arm.
Please find the pressrelease below (in Swedish) it also links to the full article (in English).
https://www.lu.se/article/ny-metod-hanterar-och-lagrar-data-fran-miljoner-nervceller-i-realtid

lu.se Utvecklingen inom neurovetenskapen ställer höga krav på sofistikerad datahantering, inte minst då man med implanterbara så kallade Brain Machine Interfaces upprättar elektronisk kommunikation mellan hjärnans nervceller och datorer. En ny metod som utvecklats av forskare vid Lunds universitet ...

Gelatin promotes rapid restoration of the blood brain barrier after acute brain injury - ScienceDirect

Congratulations Lucas Kumosa to a new NRC publication! "Gelatin promotes rapid restoration of the blood brain barrier after acute brain injury"
http://www.sciencedirect.com/science/article/pii/S1742706117306372?via%3Dihub
See the Press Release in Swedish: http://www.lu.se/article/gelatin-paskyndar-lakning-av-blodhjarnbarriaren-vid-akut-hjarnskada

sciencedirect.com JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page.Acta BiomaterialiaAvailable online 14 October 2017In Press, Corrected ProofFull length articleGelatin promotes rapid restoration of the blood brain barrier after acute brain injuryAuthor links open…

Heterogenic Distribution of Aromatic L-Amino Acid Decarboxylase Neurons in the Rat Spinal Cord

Congratulations to Mengliang Zhang for a new publication!
"Heterogenic distribution of aromatic L-amino acid decarboxylase neurons in the rat spinal cord"
http://journal.frontiersin.org/article/10.3389/fnint.2017.00031/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Integrative_Neuroscience&id=298771

frontiersin.org Aromatic L-amino acid decarboxylase (AADC) is an essential enzyme in the synthesis of serotonin, dopamine and certain trace amines and is present in a variety of organs including the brain and spinal cord. It is previously reported that in mammalian spinal cord AADC cells (called D cells) were large...

Advances in Neurotechnology for Understanding Brain Functions and Disorders | Lunds universitet

Please join us on this one-day NRC symposium on 7th of September 2017, at Medicon Village in Lund. "Advances in Neurotechnology for Understanding Brain Functions and Disorders".
Register no later than noon 1st of September.
http://www.lu.se/event/advances-in-neurotechnology-for-understanding-brain-functions-and-disorders

lu.se Understanding how the brain functions in normal conditions and in disease is one of the major scientific challenges. During the last decade an impressive development has occurred in innovative neurotechnology which is likely to revolutionize neuroscience and neurology in the near future.

Elektronik i hjärnan revolutionerar forskning - P4 Malmöhus

Today Prof Jens Schouenborg was on Swedish radio P4. Listen to him talking about our research here (In swedish)
http://sverigesradio.se/sida/artikel.aspx?programid=96&artikel=6692078

sverigesradio.se Hypertunna elektroder i hjärnan som kan stoppa smärta, förbättra minnet och avlyssna hjärnverksamheten. Den nya tekniken kan revolutionera kunskapen om ...