University of Minnesota MSTP (MD/PhD)

Check out the co-author paper by Anders Lindstedt in Journal of Immunotherapy for Cancer titled "Enhanced IL-15-mediated NK cell activation and proliferation by an ADAM17 function-blocking antibody involves CD16A, CD137, and accessory cells".

Enhanced IL-15-mediated NK cell activation and proliferation by an ADAM17 function-blocking antibody involves CD16A, CD137, and accessory cells - PubMed Our data reveal for the first time that CD16A and CD137 underpin Medi-1 enhancement of IL-15-driven NK cell activation and proliferation, respectively, with the latter requiring PBMC accessory cells. The use of Medi-1 represents a novel strategy to enhance IL-15-driven NK cell proliferation, and it....

Congratulations to Andrea Maxwell, one of 5 winners of the 2024 Lasker Foundation Essay Contest. The Lasker Essay Contest engages early career scientists and clinicians from the US and around the globe in a discussion about big questions in biology and medicine and the role of biomedical research in our society today. This year's contest asked early-career scientists and health professionals to identify a scientific question that is insufficiently addressed in biomedical research today.

The title of Andrea's essay is "What happens to the brain during pregnancy?"

Meet the Winners of the 2024 Essay Contest and Read the Essays - Lasker Foundation This year, we asked early-career scientists and health professionals to identify a scientific question that is insufficiently addressed in biomedical research today. The winning essays are published in the July 15th issue of The Journal of Clinical Investigation. After reading their essays, we were....

https://www.mprnews.org/story/2024/07/09/new-minnesota-state-fair-foods

Ready, set, eat: Here are the new foods that'll be at the 2024 Minnesota State Fair Sweet corn cola floats, sweet heat bacon, Swedish ice cream sundaes and a host of other creative culinary concoctions: Start planning your taste tour, the list of new food offerings at this year’s Minnesota State Fair is out.

Check out the first author review by Minna Ding in Journal of Fungi titled "In**ed mouse models in Cryptococcus neoformans research".
https://pubmed.ncbi.nlm.nih.gov/38921412/

Our MD-PhD Information and Q&A Session is tonight (Tuesday, June 25) at 7:00 PM CDT on Zoom. Meet with MSTP Director Dr. Yoji Shimizu and current students. Still time to register at http://z.umn.edu/mstpinfo

Our MD-PhD Information and Q&A Session is next Tuesday, June 25 at 7:00 PM CDT on Zoom. Meet with MSTP Director Dr. Yoji Shimizu and current students. Register at http://z.umn.edu/mstpinfo

Congratulations to Jenna Dick, who successfully defended her PhD. The title of her thesis is "Investigating the mechanisms underlying antibody-mediated effector functions in malaria and Multisystem Inflammatory Syndrome in Children (MIS-C)".

Check out the co-author paper by Mike Patterson in JCI Insight titled "Adrenal gland macrophages regulate glucocorticoid production through Trem2 and TGFβ". https://pubmed.ncbi.nlm.nih.gov/38869957/

https://bringmethenews.com/minnesota-lifestyle/sebastian-joes-and-little-bird-gelato-add-new-ice-cream-options-in-south-minneapolis

Sebastian Joe's and Little Bird Gelato add new ice cream options in south Minneapolis New ice cream is arriving in Minneapolis. Sebastian Joe's Kingfield Social opens this week, and Little Bird Gelato is now being served at Café Ceres.

Congratulations to Rebecca Butler, who successfully defended her PhD. The title of her thesis is "Elucidating the Pathways Underlying Action Tremor Control with Deep Brain Stimulation for Essential Tremor".

Check out the co-author paper by Lexi Luo in Cardiovascular Revascularization Medicine titled "Patients with metastatic cancer have worse short-term coronary artery bypass grafting outcomes: a population-based study of National Inpatient Sample from 2015 to 2020".
https://pubmed.ncbi.nlm.nih.gov/38796318/

Check out the co-author paper by Mike Anderson in ACS Synthetic Biology titled "HUHgle: an interactive substrate design tool for covalent protein-ssDNA labeling using HUH-Tags".
https://pubmed.ncbi.nlm.nih.gov/38820192/

https://twincities.eater.com/maps/best-ice-cream-shops-minneapolis-st-paul-twin-cities

Where to Eat Ice Cream in the Twin Cities From classic soft serve stands to chocolate-dipped paletas.

Congratulations to Mike Anderson, who successfully defended his PhD. The title of his thesis is "Mechanobiological Analysis of the Dystrophin-Glycoprotein Complex in Muscular Dystrophies".

Check out the co-first author paper by John Lozada in Cancer Research Communication titled "Pan cancer interrogation of B7-H3 (CD276) as an actionable therapeutic target across human malignancies"
https://pubmed.ncbi.nlm.nih.gov/38709075/

Check out the co-author paper from Liz Okafor in Clinical Diabetes and Endocrinology titled "Metformin mitigates dementia risk among individuals with type 2 diabetes"
https://pubmed.ncbi.nlm.nih.gov/38725077/

Check out the first author paper from Mike Patterson in Arteriosclerosis, Thrombosis, and Vascular Biology titled "Trem2 agonist reprograms foamy macrophages to promote atherosclerotic plaque stability"
https://pubmed.ncbi.nlm.nih.gov/38695172/

Congratulations to our graduating students!

Congratulations to Taylor Brown, who successfully defended her PhD. The title of her thesis is "Astrocyte pathophysiology in Huntington’s disease".

Congratulations to Mike Patterson, who successfully defended his PhD. The title of his thesis is "Trem2 regulates foamy macrophage function in atherosclerosis".

Check out the co-author paper from Dominique Earland in Wellcome Open Research titled "Association of anthelmintic treatment with malaria prevalence in Rural Sussundenga, Mozambique."

Association of anthelmintic treatment with malaria prevalence in Rural Sussundenga, Mozambique - PubMed Background: Mozambique has the 4 th highest malaria incidence and mortality globally. Despite the existing malaria control strategies, malaria prevalence remains stagnant. These challenges have increased calls for innovative strategies in areas with the highest disease burden...

Check out the first author review from José Valentín López in Journal of Steroid Biochemistry and Molecular Biology titled "Androgen receptor and estrogen receptor variants in prostate and breast cancers."

Androgen Receptor and Estrogen Receptor Variants in Prostate and Breast Cancers - PubMed The androgen receptor (AR) and estrogen receptor alpha (ERα) are steroid receptor transcription factors with critical roles in the development and progression of prostate and breast cancers. Advances in the understanding of mechanisms underlying the ligand-dependent activation of these transcriptio...

Check out the first author paper from Allison Dona in PloS One titled "Logistic burdens of cancer care: a qualitative study."

Logistic burdens of cancer care: A qualitative study - PubMed Cancer treatment often creates logistic conflicts with everyday life priorities; however, these challenges and how they are subjectively experienced have been largely unaddressed in cancer care. Our goal was to describe time and logistic requirements of cancer care and whether and how they interfere...

Check out the first author paper from Mike Patterson in Journal of Heart and Lung Transplantation titled "Noninvasive assessment of liver stiffness in right heart failure: a New phenotype requiring further exploration."

Noninvasive Assessment of Liver Stiffness in Right Heart Failure: A New Phenotype Requiring Further Exploration - PubMed Noninvasive Assessment of Liver Stiffness in Right Heart Failure: A New Phenotype Requiring Further Exploration

Check out the narrative from Sara Bolivar Wagers in Family Medicine titled "Finding my sense of belonging."

Finding My Sense of Belonging - PubMed Finding My Sense of Belonging

We are excited to share with you the MSTP's Match Day 2024 results. Congratulations!! We are so proud of you!

Sara Bolivar Wagers, PhD
Children's Hospital of Philadelphia - Pediatrics (PSTP)

Dieter Brandner, PhD
University of California - San Francisco - Opthalmology

Julie Brekke-Riedl, PhD
Brown University - Psychiatry

Alexander Dwyer, PhD
Johns Hopkins Hospital - Otolaryngology

Robin Lee, PhD
University of Minnesota - Internal Medicine (PSTP)

Stephanie Rhee, PhD
Mayo Clinic - Diagnostic Radiology

Megan Schmit, PhD
University of Minnesota - Pediatrics (PSTP)

Javier Sierra Pagan, PhD
University of Pennsylvania - Internal Medicine (PSTP)

Philip Titcombe, PhD
Yale University - Internal Medicine (Physician Scientist)

Brian Trieu, PhD
Mayo Clinic - Psychiatry

Kelsey Wanhainen, PhD
UCLA - Internal Medicine

Check out the co-author paper from Sinibaldo Romero Arocha in Journal of Osteopathic Medicine titled "Prevalence and quality of medical Spanish education in US osteopathic medical schools: a national survey."

Prevalence and quality of medical Spanish education in US osteopathic medical schools: a national survey - PubMed Most osteopathic schools provide medical Spanish education, but work is needed to improve consistency, quality, and sustainability. Future research should focus on osteopathic student language proficiency assessment, improve medical Spanish accessibility for students at rural programs, and explore t...

Check out the co-author paper from John Lozada in Prostate Cancer and Postatic Diseases titled "Natural killer cell infiltration in prostate cancers predict improved patient outcomes."

Natural Killer Cell Infiltration in Prostate Cancers Predict Improved Patient Outcomes - PubMed Using the largest available dataset to date, we demonstrated that NK cells infiltrate a broad range of tumors, including both primary and metastatic PCa. NK cell infiltration is associated with improved PCa patient outcomes. This study demonstrates that NK cells are capable of trafficking to both pr...

Check out the first author paper from Allison Dona in Prevention Medicine titled "Rural-urban differences in meeting of physical activity recommendations by sun exposure and protection behaviors in the United States."

Rural-urban differences in meeting of physical activity recommendations by sun exposure and protection behaviors in the United States - PubMed Meeting PA recommendations was associated with greater sun exposure in both rural and urban populations. Additional exercise location (indoors/outside) data is needed to inform PA and skin cancer prevention interventions to reduce unintended increases in sun exposure and reductions in PA, respective...