Bethyl Laboratories, Inc.

The Bethyl team was proud to sponsor last week’s 4th International Antibody Validation Meeting at the University of Bath! We heard what we’ve always believed: that releasing high-quality antibodies that pass stringent validation standards saves the research community time and money and reduces the risk of generating false data. It’s also clear that antibody users and antibody providers are in this together.

At Bethyl, every antibody we’ve sold over the past 50 years was manufactured and validated on-site by our team in the USA. Learn more about our best practices for antibody validation and reproducibility: https://www.fortislife.com/antibody-validation

Antibody Validation | Pillars | Fortis Life Sciences Learn about the Pillars we apply in the lab for Antibody Validation. Multiple Pillars are used to validate each antibody. Learn more about Fortis Life Science.

Meet the Bethyl team at next week’s 4th International Antibody Validation Meeting at the University of Bath. We are excited to engage with the international antibody manufacturing community to share best practices for antibody validation and support your research and development pipeline. Dave Potter and Benjamin Sanyaolu will be in attendance and you can also look for our tabletop display with more details on antibody validation best practices from Bethyl!

https://www.antibodyvalidation.co.uk/

antibodyvalidation.co.uk

Bethyl is amongst the finalists for The Antibody Society 2023 Imaging Competition! Ours is the image titled “Immune profiling of axillary lymph tissues”. Vote for ours and take a look at all of the other amazing images at

The Antibody Society 2023 Imaging Competition Survey Web survey powered by SurveyMonkey.com. Create your own online survey now with SurveyMonkey's expert certified FREE templates.

Check out this new publication in Cell, which describes how ZBP1 contributes to cardiac IFN-I responses and chemotherapy-related heart failure. Dr. A. Phillip West’s group from Texas A&M collaborated with the team at Bethyl to perform multiplex imaging of murine cardiac tissue to visualize non-cardiomyocyte cell populations, including myeloid and lymphoid cells, endothelial cells, and fibroblasts. To perform this study, Bethyl characterized rabbit antibodies to develop the multiplex panel. This imaging showed that chemotherapy induces cardiac remodeling via changes in the frequency of lymphoid cells, endothelial cells, and fibroblasts in the heart.

Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity Mitochondrial DNA (mtDNA) is a potent agonist of the innate immune system; however, the exact immunostimulatory features of mtDNA and the kinetics of …

We are excited to announce our partnership with Lunaphore! Now, scientists will have access to our highly qualified antibodies and services with the capabilities of Lunaphore's COMET™ platform. We look forward to ensuring that even more researchers can access the power of spatial biology, now paired with the quality antibodies and service that Bethyl is known for.

Learn more about how you can benefit from this exciting collaboration!

https://lunaphore.com/news/lunaphore-and-bethyl-laboratories-announce-partnership-to-leverage-library-of-primary-antibodies-on-comet-platform-and-expand-spatial-biology-services/

Free posters for you: 4 new posters highlighting key signaling pathways. Visualize the apoptosis, MAPK, mTOR, and p53 pathways with these detailed posters. They’d be a great addition to print out and hang in your lab!

https://www.fortislife.com/products/posters

What pathways would you like us to highlight next? Let us know in the comments below.

Poster Resources Posters

Are you at ? Stop by poster 2493 this afternoon to learn about Bethyl’s optimized, IHC-validated antibody panels for visualizing immune cells in murine melanoma and cardiac tissue.

Danielle Fails, IHC Data Specialist, will present her poster “Design and Optimization of Mouse Markers for Use in Melanoma, Cardiac Applications” today until 5 PM in the Tumor-Host Interactions and Disease Progression section.

New antibodies are being added to our catalog all the time! Multiple pillars of validation are used in a complementary fashion to validate each antibody so that you can make a more confident purchase. Find the highly validated antibody you need for your next IHC/ICC, ELISA, Western blot, IP or flow cytometry experiment from Fortis.

Check out the new antibodies for March: https://www.fortislife.com/products/new-antibodies

New Antibodies New Antibodies

New antibodies are being added to our catalog all the time! Multiple pillars of validation are used in a complementary fashion to validate each antibody so that you can make a more confident purchase. Find the highly validated antibody you need for your next IHC/ICC, ELISA, Western blot, IP or flow cytometry experiment from Fortis.

Check out the new antibodies for February: https://www.fortislife.com/products/new-antibodies

New Antibodies New Antibodies

New antibodies are being added to our catalog all the time! Multiple pillars of validation are used in a complementary fashion to validate each antibody so that you can make a more confident purchase. Find the highly validated antibody you need for your next IHC/ICC, ELISA, Western blot, IP or flow cytometry experiment from Fortis.

Check out the new antibodies for January: https://www.fortislife.com/products/new-antibodies

New Antibodies New Antibodies

New antibodies are being added to our catalog all the time! Multiple pillars of validation are used in a complementary fashion to validate each antibody so that you can make a more confident purchase. Find the highly validated antibody you need for your next IHC/ICC, ELISA, Western blot, IP or flow cytometry experiment from Fortis.

Check out the new antibodies for December: https://www.fortislife.com/products/new-antibodies

New Antibodies New Antibodies

New antibodies are being added to our catalog all the time! Multiple pillars of validation are used in a complementary fashion to validate each antibody so that you can make a more confident purchase. Find the highly validated antibody you need for your next IHC/ICC, ELISA, Western blot, IP or flow cytometry experiment from Fortis.

Check out the new antibodies for November: https://www.fortislife.com/products/new-antibodies

New Antibodies New Antibodies

Are you studying single-cells in suspension?

Flow Cytometry could be the method to use. Have a look at this guide from Bethyl Laboratories, Inc. on the best practices & considerations for experimental design ⬇️
https://www.bioscience.co.uk/resources/flow-cytometry-principles-best-practices-considerations.pdf

Fortis Life Sciences

New antibodies are being added to our catalog all the time! Multiple pillars of validation are used in a complementary fashion to validate each antibody so that you can make a more confident purchase. Find the highly validated antibody you need for your next IHC/ICC, ELISA, Western blot, IP or flow cytometry experiment from Fortis.

Check out the new antibodies for October: https://www.fortislife.com/products/new-antibodies?utm_source=facebook&utm_medium=fd3bfc47-fa01-4de3-b256-b1582fd9db64&utm_campaign=Bethyl_Antibody_Leadership_2022

New Antibodies New Antibodies

New antibodies are being added to our catalog all the time! Multiple pillars of validation are used in a complementary fashion to validate each antibody so that you can make a more confident purchase. Find the highly validated antibody you need for your next IHC/ICC, ELISA, Western blot, IP or flow cytometry experiment from Fortis.

Check out the new antibodies for August: https://www.fortislife.com/products/new-antibodies

New Antibodies New Antibodies

Using custom has played an integral role in understanding the etiology and treatment of various diseases. To gain insight into their unique applications, we interviewed Lori Kobayashi at Valted Seq, who is using single-cell sequencing data to diagnose neurodegenerative disorders to develop precision therapies that will revolutionize human health.

Read our full interview here: https://www.fortislife.com/products/articles/raising-the-bar-for-biomarkers-and-early-diagnostics-in-neurodegenerative-disease/Neurodegenerative-Disease

Raising the Bar for Biomarkers and Early Diagnostics in Neurodegenerative Disease Identifying novel biomarkers of Parkinson’s disease enables early diagnosis and treatment monitoring.

It’s no surprise is a popular technique for measuring the presence and concentration of antibodies, antigens, proteins and glycoproteins within biological samples. After all, the benefits are abundant:

• Highly sensitive
• Reproducible and consistent results
• High throughput
• Versatile – can be performed manually or automated
• Simultaneous analysis, reducing average analytical time

Want to learn more? Our NEW eBook provides a comprehensive guide to the ELISA technique, covering everything from basic principles and troubleshooting to optimization. Download now:

A Comprehensive Guide to ELISAs - Enzyme-Linked Immunosorbent Assays Download our eBook to learn more about the benefits of using an ELISA assay for your research needs and how to get started.

Flow cytometry is a technique commonly used by immunologists to analyse a range of properties of individual cells based on the presence of a specific protein either on the cell surface or within the cell. Learn more about flow cytometry and our discover our array of supporting products and resources here: https://www.fortislife.com/flow-cytometry

Flow Cytometry | Immunologists | Cells Flow Cytometry is a technique commonly used by Immunologists to analyse a range of properties of individual cells. Click here to learn more.

New pre-clinical and clinical trials are indicating that OX40 agonism is effective in combination therapies for cancer and overcoming resistance to immunotherapy.

Read our article to learn more: https://www.fortislife.com/products/articles/role-of-ox40-in-t-cell-biology-of-cancer-and-infectious-disease/Role-of-OX40

Role of OX40 in T Cell Biology of Cancer and Infectious Disease In this article learn why OX40 is now a key candidate for cancer and immune disease therapy

Join our webinar TODAY, 16:00 BST / 17:00 CEST / 11:00 EDT / 08:00 PDT, covering an overview of antibody development technologies and the available antibody formats, including how recombinant DNA technology has been applied to monoclonal antibody development and how they compare to hybridoma-derived antibodies, and more.

Click here to register: https://www.fortislife.com/products/webinars/recombinant-monoclonal-antibodies-versatile-tools-for-research-diagnostics-and-disease-therapy/webinar007

Poorly characterized antibodies result in unreliable performance, inconsistent data, and a lack of reproducibility, jeopardizing lab resources and research breakthroughs – this poster provides quick tips and considerations when it comes to antibody validation.

Download here: https://www.fortislife.com/products/posters/validate-your-antibodies/poster002

Join our webinar this week, covering an overview of antibody development technologies and the available antibody formats, including how recombinant DNA technology has been applied to monoclonal antibody development and how they compare to hybridoma-derived antibodies, and more.

Click here to register: https://www.fortislife.com/products/webinars/recombinant-monoclonal-antibodies-versatile-tools-for-research-diagnostics-and-disease-therapy/webinar007

With the risk of cardiovascular disease affecting millions worldwide, advancing innovative therapeutics is critical. Discover how Fortis’ robust portfolio of lipoproteins and apolipoproteins can help support your mission of creating tomorrow’s science today. Click here to learn more: https://www.fortislife.com/apolipoproteins-lipoproteins?utm_source=facebook&utm_campaign=apolipoproteins

The last decade has seen a rise in immune checkpoint inhibitors. With PBRM1’s high mutation rate, it has become a promising biomarker. Still, there is much to learn. Our scientific review examines its function and how it may shape the cancer landscape.

Read more:

The Many Sides of PBRM1 - Fortis Life Sciences

Quantifying BSA with ELISA? Read our NEW white paper (https://bit.ly/3wNP6V8) to enhance your knowledge about the significance of BSA in biomedical research, BSA quantification with sandwich ELISA, and resources/technical tips for reproducible BSA ELISA! Get your copy: https://bit.ly/3wNP6V8

Multiplex IHC with fluorescence detection (mIF) is a powerful tool for simultaneous detection of several antigens within a single sample/test. Download our white paper on 7-color mIF to save time on optimization of your mIF-based experiments: https://bit.ly/3hCuCG8

At Fortis, we offer antibodies to 3000+ unique protein targets. To simplify your immunoassays-based experimental design, we can conjugate any of our antibodies to over 17 different fluorescent, enzymatic or small molecule labels. Try our antibody conjugation service: https://bit.ly/3LzHQBa

The Researchers’ Choice - CiteAb Awards 2021 was won by Bethyl Laboratories, Inc., a Fortis Life Sciences company. Still loving highly validated antibodies & other products/services from us? Nominate Fortis Life Sciences for 2022 CiteAb Awards in “Researchers’ Choice” category: http://ow.ly/q88H50HZb5P

Researchers’ Choice - CiteAb Awards 2022 Putting the spotlight on the reagent supplier that researchers have been most impressed by in 2021.