Creative biogene

With its state-of-the-art GMP manufacturing facilities and rich experience in CRISPR gene editing technology, Creative Biogene provides a one-stop CHO Recombinant Protein Production Service to global biopharmaceutical and biotechnology companies to ensure efficient and high-quality drug discovery and development. https://www.creative-biogene.com/crispr-cas9/drug-discover/recombinant-protein-expression-service-in-cho-cells.html

Creative Biogene offers a range of premade control lentiviral particles. Our negative controls are used in target overexpression, shRNA knockdown, and optional inducible expression. https://www.creative-biogene.com/products/control-lentiviral-particles.html

Exosomes are 30 to 150 nm membrane-wrapped extracellular vesicles found in biological fluids and cell cultures. Generated from late endosomes, they carry DNA, RNA, lipids, and proteins, including CD9, CD63, and CD81. Exosomes facilitate cell-to-cell communication, influencing immune response and antigen presentation. Creative Biogene offers lentivirus particles with exosome biomarkers for efficiently studying release, uptake, and biodistribution mechanisms. https://www.creative-biogene.com/products/exosome-marker-lentiviral-particles.html

mRNA is being explored for various therapeutic purposes, including immuno-oncology targeted drugs, vaccines, proteins, and gene-editing drugs. Previous studies have identified the presence of certain by-products that could trigger cellular immune responses during in vitro synthesis, including dsRNA, which has been proven to be a major trigger of immunity signaling pathways. Creative Biogene's Residual dsRNA Quantitative Detection Kit uses a double-antibody sandwich enzyme-linked immunosorbent assay to detect the residues of double-stranded RNA (dsRNA).

Residual dsRNA Quantitative Detection Kit (ELISA) (RDQDK-0001) - Creative Biogene IntegrateRNA This kit uses double-antibody sandwich enzyme-linked immunosorbent assay to detect the residues of double-stranded RNA (dsRNA).

Creative Biogene's high-throughput recombinant antibody expression and purification services in CHO cells combine high-throughput gene synthesis, vector construction, and optimized transient antibody expression technology. We can rapidly produce recombinant antibodies from milligram to kilogram scale, meeting our clients' high-throughput and large-scale production needs. https://www.creative-biogene.com/crispr-cas9/drug-discover/cho-cell-antibody-drug-production-service.html

Yeast two-hybrid cDNA library is a powerful molecular biology tool for studying protein interactions, finding the domain that plays a key role in protein-protein interaction or discovering a new protein interaction with target proteins. As a professional supplier of cDNA library construction services, Creative Biogene can provide you with the most affordable yeast two-hybrid cDNA library construction services with the fastest turnaround time to satisfy your downstream needs. https://www.creative-biogene.com/Services/Yeast-two-hybrid-cDNA-Library-Construction-Service

Creative Biogene offers a comprehensive animal model efficacy assessment service, aiding in understanding the pharmacokinetics, pharmacodynamics, and therapeutic potentials of new drugs. We utilize a variety of animal models including genetically modified mice, zebrafish, and other species to accurately simulate human disease conditions. Our research focuses on evaluating drug efficacy in vivo, measuring key endpoints such as tumor growth inhibition, survival rates, and organ-specific responses. https://www.creative-biogene.com/crispr-cas9/drug-discover/drug-screening-in-animal-models.html

Based on advanced IVT RNA synthesis and pseudovirus packaging platforms, Creative Biogene offers custom Armored RNA standard and Armored DNA standard. https://integraterna.creative-biogene.com/custom-armored-rna-dna-standard.html

Creative Biogene's chemically synthesized sgRNA products are meticulously designed for 100% sequence accuracy and efficient protein knockout capabilities. With added thiol and methoxy modifications at both ends, our sgRNA ensures enhanced stability and reduced off-target effects, providing scientists worldwide with trusted tools for successful gene editing experiments. https://www.creative-biogene.com/crispr-cas9/products/custom-synthesized-sgrna.html

Creative Biogene provides custom 2'-O-hexadecyl (C16)-siRNA conjugates where a hexadecyl (C16) lipid moiety is attached to the 2'-O position of the ribose sugar, to improve the stability, cellular uptake, and targeting ability of your siRNA/oligonucleotide molecules. https://integraterna.creative-biogene.com/2-o-hexadecyl-c16-sirna-conjugation.html

Creative Biogene provides Phosphorodiamidate Morpholino Oligomers (PMO) synthesis process development and manufacturing services from research to pre-clinical. Leveraging our know-how together with our proprietary solid support, cleavage and deprotection process as well as customized reactors, we can manufacture PMO efficiently from mg scale to kg scale with high quality and high purity. https://integraterna.creative-biogene.com/phosphorodiamidate-morpholino-oligomers-synthesis-service.html

Creative Biogene has many years of experience in providing professional RNA solutions, high-quality products and services for academic research, biotech research and pharmaceutical drug discovery. We can offer dual-targeting siRNA design, synthesis and functional screening services. https://integraterna.creative-biogene.com/dual-targeting-sirna-service.html

Creative Biogene's custom Next Generation Sequencing (NGS) oligonucleotide service includes various types of primers and probes suitable for all stages of NGS experiments, ensuring high quality, high purity, and low cross-contamination. https://integraterna.creative-biogene.com/custom-ngs-oligonucleotide-service.html

Creative Biogene's sophisticated equipment, advanced technologies and highly experienced staffs are available to provide comprehensive antisense oligonucleotide synthesis services, such as flexible synthesis scale, comprehensive oligonucleotide backbones, and modifications. https://www.creative-biogene.com/services/Antisense-Oligonucleotides-Synthesis-Service.html

Creative Biogene offers a broad selection of zebrafish monoclonal and polyclonal antibodies directed against the majority of key targets/proteins in the spectrum of fish scientific community research. https://zebrafish.creative-biogene.com/zebrafish-antibodies.html

Under our AI-Antibody Engineering Fusion initiative, Creative Biogene's AI-Assisted Drug Design Platform is dedicated to overcoming the challenges in contemporary antibody engineering. Our platform offers clients efficient and reliable solutions for antibody drug design, accelerating the development process, mitigating risks, and providing robust support for developing and commercializing novel therapeutics. https://www.creative-biogene.com/ai/ai-antibody-engineering-fusion.html

Creative Biogene can offer tailored circular single-stranded DNA (ssDNA) services ranging from pmol to nmol with lengths from 35-120 nt using our unique and proprietary process. https://www.creative-biogene.com/services/circular-single-stranded-dna-ssdna-production-service.html

Transgenic zebrafish is an advanced system for monitoring environmental pollutants. Creative Biogene has developed a variety of response elements to detect different specific environmental pollutants. After microinjected recombinant constructed plasmids, the zebrafish line stably inherited fluorescent protein gene could be obtained by screening. We can use the transgenic reporter zebrafish lines to measure exposure to organic chemicals, endocrine disruptors, heavy metals, and electrophilic agents. Transgenic lines have been used not only to detect the presence of toxins, but also to improve investigations into the molecular mechanisms underlying pathology associated with environmental exposures. https://zebrafish.creative-biogene.com/zebrafish-ecotoxicity-assay.html

Innovative AI technologies are used by Creative Biogene to deliver complete solutions for gene editing and biotechnology research. We provide accurate sgRNA design, mRNA sequence optimization, Cas protein characterization, transformation, and intelligent editing outcome prediction. To promote scientific innovation, we seek to address a variety of obstacles in gene editing and biotechnology, whether it be improving efficiency, specificity, or gene expression. https://www.creative-biogene.com/ai/ai-driven-gene-editing-and-therapy.html

Creative Biogene provides comprehensive circRNA stable cell line development services, from circRNA design, vector construction to stable cell line generation and validation. All of our circRNA stable cell lines are fully validated by sequencing and real-time qPCR to ensure sequence accuracy and high expression levels. https://www.creative-biogene.com/services/circrna-overexpression-stable-cell-line-development.html

At Creative Biogene, our scientists have developed a panel of HPV Pseudoviruses (PsVs) that cover multiple HPV types such as HPV6, HPV11, HPV16, HPV18, HPV31, HPV33 etc. The viral genome of our PsVs was replaced with a pseudogenome which encodes a fluorescent and/or a bioluminescent reporter protein(s). These PsVs can analyze neutralization or infectious entry pathways using the reporter signal as a readout. https://www.creative-biogene.com/products/hpv-pseudoviruses.html

Creative Biogene offers comprehensive Cas protein identification and characterization services tailored to diverse research needs. Through bioinformatic analysis and experimental assessment, optimal Cas proteins are selected and evaluated for activity and specificity. Key properties like thermal stability and nuclease activity are assessed, ensuring suitability for diverse applications and providing a reliable foundation for biotechnological studies. https://www.creative-biogene.com/crispr-cas9/service/cas-protein-identification-and-characterization-service.html

Creative Biogene offers diverse dsRNA controls as reliable positive controls for precise dsRNA assays. These controls empower researchers to induce RNA interference, study gene functions, and facilitate gene silencing studies. https://www.creative-biogene.com/products/dsrna-control.html

Based on expertise in the synthesis, bioconjugation and purification, Creative Biogene offers custom antibody-oligonucleotide conjugates (AOCs) for global customers. We have developed methods to link the oligos to the target antibody via terminal functional groups such as protected sulfhydryls, and maleimide. Additionally, to deliver high-quality conjugates and maximize performance for your application, we offer various options for purification and characterization of AOCs, including analytical size exclusion chromatography, PAGE gel analysis, mass spec, RP-HPLC and LC-MS, depending on the AOCs and your requirements. https://integraterna.creative-biogene.com/services/antibody-oligonucleotide-conjugation.html

Creative Biogene offers a comprehensive oligonucleotide modification service, including ribose, base, phosphate linkage modifications, and oligonucleotide analogues replacement. To deliver high quality oligonucleotides, all products are manufactured under strict quality control processes.

Oligonucleotide Modification Service - Creative Biogene IntegrateRNA IntegrateRNA offers a comprehensive oligonucleotide modification service, including ribose, base, phosphate linkage modifications, and oligonucleotide analogues replace.

Creative Biogene has been devoted to manufacturing pharmaceutical-grade circular RNA for superior protein expression and therapeutic potency. We provide a one-stop solution of circular RNA from sequence design, synthesis, purification, and quality control to LNP formulation and cell-based evaluation, to ensure the most optimized circular RNA-LNP product. https://integraterna.creative-biogene.com/pharmaceutical-grade-circular-rna.html

Creative Biogene provides high-quality microRNA sponge services, including the design, synthesis and customization of microRNA sponges for specific research purposes. The microRNA sponge service we offer is designed to provide researchers with a tool to efficiently and specifically modulate microRNA activity in their research. https://integraterna.creative-biogene.com/service/microrna-sponge-service.html

We have been enjoying making connections with you at the ASGCT 27th Annual Meeting in Baltimore, MD today! Follow Creative Biogene' footprints to Booth #214.

We are here 27th Annual Meeting (May 7-11). Meet and talk with us at Booth #214! 😁