CD Bioparticles

The self-renewal and differentiation properties of cancer stem cells (CSCs) can lead to chemotherapy resistance in breast cancer. Although many drugs targeting CSCs have been developed, their delivery efficiency and enrichment effect in the lesion site are still poor. In view of this, the researchers constructed a thermoresponsive hydrogel by co-encapsulating a photothermal agent with aggregation-induced emission (AIE) activity and thioridazine (THZ), and demonstrated that the controllable delivery system triggered by the AIE agent can enhance THZ-mediated CSC ablation.
https://www.cd-bioparticles.net/bioactive-matrixes/responsive-hydrogels

CuInZnS/ZnS quantum dots have a broad absorption spectrum but a narrow and symmetrical emission spectrum, and also have high and stable fluorescence intensity as well as high quantum field. Our CuInZnS/ZnS quantum dots can be used in highly sensitive cellular imaging, photovoltaic devices, solar cells and light-emitting devices.
https://www.cd-bioparticles.com/products/cuinzns-zns-quantum-dots-313.html

Nanoparticle drug delivery system (NDDS) can achieve multi-drug combination therapy, and researchers have also developed a variety of multi-factor delivery strategies that can target pathological processes, which have shown great application potential in the field of LF treatment. Combining the pathogenesis of liver fibrosis (LF) and the current status of clinical treatment, the researchers systematically explained the targeting mechanism of NDDS for the treatment of LF.
https://www.cd-bioparticles.net/biodegradable-polymers

CuInS/ZnS quantum dots provided by CD Bioparticles have strong lattice strength and stable performance. The internal pressure caused by lattice defects of quantum dots is effectively reduced, so the quantum dots have high luminescence efficiency and stability. Our CuInS/ZnS quantum dots can be used in highly sensitive cellular imaging, photovoltaic devices, solar cells and light-emitting devices.
https://www.cd-bioparticles.com/products/cuins-zns-quantum-dots-312.html

Milk exosomes (mExos) have been demonstrated as oral delivery vehicles for protein and peptide drugs due to their superior ability to cross the epithelial barrier. However, certain challenges remain due to their intrinsic characteristics, including suboptimal drug loading efficiency, insufficient mucus pe*******on, and susceptibility to membrane protein loss. Here, researchers introduce a hybrid vesicle (mExos@DSPE-Hyd-PMPC) with adaptive surface properties, designed by fusing functionalized liposomes with native mExos, aiming to overcome the limitations associated with mExos and unleash their full potential in oral peptide delivery.
https://www.cd-bioparticles.net/p/14157/exomilk

CD Bioparticles provides Cu-doped quantum dots with an emission range from 450 nm to 820 nm. Cu-doped quantum dots are functional group functionalized quantum dots consisting of Cu-doped ZnS core encapsulated by ZnS shells. The product has a broad absorption spectrum, but a narrow and symmetrical emission spectrum, and also has high and stable fluorescence intensity as well as high quantum field.
https://www.cd-bioparticles.com/products/cu-doped-quantum-dots-311.html

CD Bioparticles provides CsPbX3 perovskite nanocrystals with an emission range from 400 nm to 640 nm. The key properties of CsPbX3 perovskite nanocrystals are the high luminescence quantum yields of up to 90%, narrow emission line widths providing pure colors, and the coverage of a wide color spectrum.
https://www.cd-bioparticles.com/product/cspbx3-perovskite-nanocrystals-list-209.html

Lipid nanoparticles (LNPs) are an important non-viral delivery system approved by the U.S. Food and Drug Administration (FDA), which has greatly promoted the progress of gene therapy. However, since lipid components often cause immune-related adverse events such as inflammation and allergy, the potential immunogenicity of LNPs has severely limited their clinical application. In view of this, the researchers added dexamethasone (Dex) to LNPs formulations targeting the liver, spleen, and lung, which have excellent specific organ targeting and the ability to deliver multiple types of RNA (such as mRNA and siRNA), and constructed a variety of low-immunogenicity dLNPs.
https://www.cd-bioparticles.net/lipids

Nanostructures composed of soft materials, such as liposomes and lipid nanoparticles, can deliver or release a variety of substances through external stimulation or site-specific methods. This assembly structure is very simple, including spherical capsules or lipid clusters. Since structure is closely related to function, the lack of complex structures leads to richer properties. In view of this, the researchers reported an engineering strategy that combined microfluidics and conjugated chemistry to synthesize nanoliposomes containing two independent compartments.
https://www.cd-bioparticles.net/liposome-system

CD Bioparticles provides non-toxic I-III-VI2 type CIS(Se), CIGS(Se), and CZTS(Se) semiconductor quantum dots with excellent optical property, large absorption coefficient and stable performance.
https://www.cd-bioparticles.com/product/cis-se-cigs-se-czts-se-quantum-dots-list-210.html

Lipid nanoparticles (LNPs) are commonly used to deliver mRNA, and cationic lipids can significantly affect biodistribution, cellular uptake, endosomal escape, and transfection efficiency. However, cationic lipids are difficult to synthesize in the laboratory, which limits the discovery of suitable lipids and hinders large-scale production. In view of this, the researchers reported a one-pot series of multi-component reaction and designed a multi-component conjugation of amine-thiol-acrylate, which enabled the rapid synthesis (1 h) of degradable lipids containing amidines at room temperature.
https://www.cd-bioparticles.net/liposomes-for-dna-rna-delivery

CD Bioparticles provides CdTe/CdS core-shell quantum dots with an emission range from 540 nm to 640 nm. These quantum dots are composed of CdTe as the core and CdS as the shell, and the QDs surface is surrounded by 3-Mercaptopropionic acid (MPA).
https://www.cd-bioparticles.com/products/cdte-cds-quantum-dots-310.html

CD Bioparticles offers a new kind of cadmium based core/shell quantum dots, CdSeTe/ZnS. These quantum dots are fluorescent nanomaterials composed of CdSeTe as the core and ZnS as the shell, and the QDs surface is surrounded by hydrophobic ligands, so they are always supported in toluene buffer or other specified organic solutions.
https://www.cd-bioparticles.com/product/cdsete-zns-quantum-dots-list-252.html

Drug delivery across the blood-brain barrier (BBB) is a serious challenge for the treatment of brain injury after cardiac arrest (CA) and return of spontaneous circulation (ROSC). Inspired by the propensity of melanoma to metastasize to the brain, the researchers camouflaged B16F10 cell membranes on 2-methoxyestradiol (2ME2)-loaded, reactive oxygen species (ROS)-triggered "Padlock" nanoparticles constructed from D-a-tocopheryl polyethylene glycol succinate (TPGS-PBAP) conjugated with pinacol phenylboronic acid ester.
https://www.cd-bioparticles.net/ros-response

Existing tissue adhesives generally have problems such as weak wet adhesion, slow adhesion formation, cytotoxicity, and lack of antibacterial properties, and therefore cannot effectively deal with uncontrolled bleeding and wound infection after severe trauma. In view of this, researchers have developed an injectable hydrogel based on ε-polylysine and poly(ethylene glycol) derivatives (referred to as ES gel), which has rapid and robust adhesive sealing and antibacterial activity.
https://www.cd-bioparticles.net/bioactive-matrixes/functional-biomatrixes

CD Bioparticles provides cadmium selenide (CdSe) semiconductor quantum dots with size-dependent emission range. Our CdSe quantum dots are core type II-VI semiconductor materials with size dependent optical/electronic properties, uniform size distribution and high quantum yield.
https://www.cd-bioparticles.com/product/cdse-quantum-dots-list-200.html

Obesity and overweight are an increasingly serious public health problem that can lead to a variety of diseases. However, existing anti-obesity drugs (quercetin, capsaicin, catecholamines, etc.) still have limited efficacy and systemic toxicity. Selective targeting of adipose tissue to increase local energy expenditure is an effective treatment for obesity and is expected to overcome the limitations of current weight loss methods. In view of this, scientists have developed a thermosensitive hydrogel loaded with recombinant high-density lipoprotein (rHDL) that can target the fat browning activator resveratrol to adipose tissue.
https://www.cd-bioparticles.net/temperature-response

CD Bioparticles provides CdS/ZnS core-shell semiconductor quantum dots with emission ranges from 400 nm to 460 nm. Our CdS/ZnS quantum dots are gradient alloyed semiconductor materials with size dependent optical/electronic properties, uniform size distribution and high quantum yield.
https://www.cd-bioparticles.com/product/cds-zns-quantum-dots-list-201.html

Active targeted drug delivery systems based on specific endogenous cells (such as macrophages) have good tumor homing and biocompatibility and are a promising tumor treatment strategy. In view of this, the researchers developed an active tumor-targeted drug delivery system that carries doxorubicin-loaded nanoparticles (DOX@MPF127-MCP-1, DMPM) on the surface of macrophages (RAW264.7) by mediating the interaction with the CCR2/MCP-1 axis.
https://www.cd-bioparticles.net/ab-diblock-copolymers

CD Bioparticles provides CdS quantum dots with an emission range from 365 nm to 490 nm. Our CdS quantum dots are Cadmium Sulfide (CdS) quantum dots stabilized by oleic acid in toluene. The product has a broad absorption spectrum, but a narrow and symmetrical emission spectrum, and also has uniform particle size, biocompatibility, high and stable fluorescence intensity, and high quantum field.
https://www.cd-bioparticles.com/product/cds-quantum-dots-list-239.html

CD Bioparticles is the leading manufacturer and supplier of Ag2S Quantum Dots for R&D and commercialization in a wide variety of applications.
https://www.cd-bioparticles.com/product/ag2s-quantum-dots-list-256.html

Glioblastoma (GBM) is a primary malignant brain tumor with limited treatment options. Local drug delivery is a potential approach for GBM treatment, but its efficacy is still hampered by limited drug diffusion and retention. In view of this, Natalie Artzi at MIT developed a dual-sensitive nanoparticle (Dual-NP) system consisting of dendrimers and dextran NPs connected by dual-sensitive [matrix metalloproteinase (MMP) and pH] linkers that can be rapidly degraded in the tumor microenvironment.
https://www.cd-bioparticles.net/enviromental-responsive-copolymers

CD Bioparticles provides a range of ZnO quantum dots in a variety of surface materials for research and commercial applications, including cancer therapy and diagnostics.
https://www.cd-bioparticles.com/products/zno-quantum-dots-343.html

Photochemical internalization is an effective strategy that relies on photodynamic reaction to promote siRNA endosomal escape to successfully achieve RNA interference gene regulation, which can improve the synergy and effectiveness of gene-photodynamic combined therapy. However, how to simultaneously improve the delivery efficiency of siRNA and organic photosensitizers remains a severe challenge. In view of this, the researchers designed a micellar nanostructure (PSNA) self-assembled from polymer-DNA molecule chimeras.
https://www.cd-bioparticles.net/biopolymers-synthetic-polymers

The pathogenesis of drug-induced liver injury (DILI) is closely related to the excessive production of highly active hypochlorite (ClO-) in the liver. However, how to perform bioluminescence imaging of endogenous hypochlorite in non-transgenic native mice remains a very challenging problem. In view of this, the researchers designed a bioluminescent probe using carboxyl fluorescein (ClO-Luc) and lipid nanoparticles (LNPs) loaded with firefly luciferase (fLuc) mRNA to image ClO- in living cells and DILI mice.
https://www.cd-bioparticles.net/mrna-lipid-nanoparticles

Hydrophobic magnetic particles are useful tools for the magnetic separation of biomolecules based on interactions of external hydrophobic regions of proteins, peptides, enzymes or nucleic acids. To increase the hydrophobicity of magnetic beads, alkyl chains of different lengths are attached to the surface of the beads, including methyl (C1), ethyl (C2), propyl (C3), octyl (C8), and Octadecyl(C18).
https://www.cd-bioparticles.com/product/hydrophobe-magnetic-particles-list-18.html

How to design an effective nanocarrier to target multiple types of cancer is a serious challenge in cancer nanomedicine development. Most nanoparticles (NPs) administered systemically are rapidly cleared by the liver, making them less effective in targeting tumors. They also have serious side effects. In view of this, the researchers designed and synthesized a fluorescent bottlebrush polymer and screened nine polymer-derived nanoparticles with different sizes and surface coatings for tumor imaging and targeted delivery.
https://www.cd-bioparticles.net/biopolymers-synthetic-polymers

Affinity magnetic particles can be used for affinity purification and separation of antibodies, antigens, proteins and DNA/RNA, etc. Affinity magnetic particles have high selectivity and capacity, making them ideal tools for the separation of various biomolecules. Scientists at CD Bioparticles are proficient in conjugating various bioaffinity ligands to magnetic beads to meet our customers’ needs.
https://www.cd-bioparticles.com/product/affinity-magnetic-particles-list-17.html

CD Bioparticles provides magnetic particles functionalized with various terminal active groups for further conjugation of affinity ligands. The conjugation between particles and ligands can be achieved by direct conjugation, click chemistry, and linker chemistry. In the direct conjugation strategy, the surface of magnetic beads can be functionalized with amine, carboxyl, sulfhydryl, aldehyde, and active hydrogen functional groups.
https://www.cd-bioparticles.com/product/active-magnetic-particles-list-20.html

Stroke is one of the leading causes of death and severe disability worldwide. However, current strategies for treating ischemic stroke often lack specific targeting functions, have poor immune evasion capabilities, and have limited drug-controlled release properties. In view of this, researchers have developed a ROS-responsive nanocarrier and used it for targeted delivery of the neuroprotective agent rapamycin (RAPA) to alleviate ischemic brain injury.
https://www.cd-bioparticles.net/ros-response