Research to Understand Stroke due to Haemorrhage - RUSH

The British Heart Foundation has published an 'ask the experts' series on 'Transient Ischaemic attack (TIA): what is a mini stroke? The article written by Al-Shahi Salman is available to read at the link below..

Transient ischaemic attack (TIA): what is a mini stroke? You may have heard of a mini stroke or 'TIA', but what exactly is it? We speak to an expert to find out.

Many congratulations to Professor Rustam Al-Shahi Salman, leader of the RUSH research team, who has been elected as a new Fellow of the Academy of Medical Sciences. This year the Academy has elected 58 exceptional biomedical & health scientists to its prestigious Fellowship and Rustam is one of them! After an exciting week at the ESO - European Stroke Organisation where Rustam delivered a talk on the results of the CARE trial, this is a well deserved honour for the research carried out by Rustam and his team. You can read the CARE results published in https://www.sciencedirect.com/science/article/pii/S1474442224000966?via%3Dihub

The team are very proud of the boss!

Cavernoma Alliance UK - CAUK Annual Conference takes place on Saturday 22 June 2024 from 10 - 4pm. See the flyer for further information. Find out what we learnt from the CARE study from our recent publications in The Lancet Neurology: https://doi.org/10.1016/S1474-4422(24)00096-6 and also https://doi.org/10.1016/j.eclinm.2024.102557

It's taken >25 years of research to reach the completion of the NIHR (National Institute for Health and Care Research)-funded CARE feasibility study and pilot phase trial for
📕 Read the results here: https://lnkd.in/emaU4adY
📽 Watch the plain language video here https://lnkd.in/eECJfvvy
🙏 The Lancet Neurology, Society of British Neurological Surgeons, Cavernoma Alliance UK - CAUK, Alliance to Cure Cavernous Malformation, Edinburgh Clinical Trials Unit, the QuinteT group in Bristol, The University of Edinburgh, NHS Lothian, University of Edinburgh College of Medicine and Veterinary Medicine, Edinburgh Medical School, Emerge Research Edinburgh
❓ Would you run or participate in an international, definitive, main phase randomised trial?

Greening our lifestyles as individuals, and lobbying policymakers for greener societies can fix this...

Climate Change and Stroke: A Topical Narrative Review The impacts of accumulating atmospheric greenhouse gases on the earth’s climate are now well established. As a result, there have been increases in ambient temperatures and resultant higher frequency

Like sabbaticals, academic retreats refresh the parts of the mind and soul that other activities cannot reach. Huge thanks to the The Landmark Trust Futures scheme for our Cerebrovascular Research Group retreat. https://www.landmarktrust.org.uk/get-involved/landmark-futures/

I'm not sure what Rabbie would have thought, but on Burns Night Dave Newby, Nick Mills and I are "flying the flag" for the British Heart Foundation - Scotland British Heart Foundation with their tartan tie (which is actually the result of Patient & Public Involvement in our research!)

Professor Rustam Al-Shahi Salman will be giving a presentation during the session for Young Stroke Physicians and Researchers and will talk about 'Applying for grants', at the forthcoming ESO - European Stroke Organisation Conference on 15-17 May 2024 in Basel, Switzerland. further information and full programme can be found at https://eso-stroke.org/esoc2024/
;

Happy New Year to you all!
2023 was another great year for the RUSH team!
📰 Our 2023 newsletter is available on the website now. You can also read it on the photos below or alternatively go to our webpage for the newsletter and lots of additonal informaiton about our ongoing research projects:
👉 Research to Understand Stroke due to Haemorrhage - RUSH

🏔 A quarter of a century since starting research on cavernomas! https://lnkd.in/e8YDUeRs
🥁 We exceeded the CARE pilot trial recruitment target http://ed.ac.uk/care-study
🙂 👏 We reflected on the results at our joint meeting of the Trial Steering Committee, Data Monitoring Committee, Patient/Carer and Public Involvement Advisory Group, and Trial Management Groups yesterday: you may spot some retired mega-trialists in there, whose wisdom in wondering about, "What next?" was hugely appreciated.
👀 Results at the Society of British Neurological Surgeons meeting in April (https://www.sbns.org.uk/index.php/conferences/edinburgh-2024/) and European Stroke Organisation meeting in May (https://eso-stroke.org/esoc2024/general/about-esoc-2024/)

Cavernoma Alliance UK - CAUK Cavernoma Ireland

World Stroke Campaign We work to improve public awareness and understanding of stroke with a focus on stroke prevention, symptom awareness and the needs of stroke survivors.

The RUSH team are raising money for the Stroke Association by running the Edinburgh half marathon...

Cerebrovascular research at the University of Edinburgh: RUSH and Row Fogo Help Marja Main raise money to support Stroke Association

We've updated this Cochrane review and concluded ... wait for it ... more clinical trials are needed!

The good news, though, is that:

1. A bunch of them are ongoing: ENRICH-AF, ASPIRE, PRESTIGE-AF, A3ICH, and STATICH.

2. I now have confirmation that the Antiplatelet Secondary Prevention International Randomised trial after INtracerebral haemorrhaGe (ASPIRING) will be funded by British Heart Foundation, Hartstichting, and Canadian Institutes of Health Research | Instituts de recherche en santé du Canada.

3. I'm looking for more national leaders and funding agencies for ASPIRING, to start 1 February 2024, with thanks to many so far in India, Sri Lanka, Brazil, and Malaysia. Hopefully more to come...

Antithrombotic treatment after stroke due to intracerebral haemorrhage - Cochrane, A - 2023 | Cochrane Library Our site uses cookies to improve your experience. You can find out more about our use of cookies in About Cookies, including instructions on how to turn off cookies if you wish to do so. By continuing to browse this site you agree to us using cookies as described in About Cookies.

This survey shows that there's every reason to be ASPIRING (Antiplatelet Secondary Prevention International trial after INtracerebral haemorrhaGe)...

✔ External pilot phase ongoing with Graeme Hankey at The University of Western Australia, Craig Anderson & Lily Song at The George Institute for Global Health, and Cheng Xin at Huashan Hospital, Fudan University, where 72/120 have been recruited to date: https://aspiringtrial.org/ https://clinicaltrials.gov/ct2/show/NCT04522102

🤞 Announcement of main phase funding is pending from the British Heart Foundation Global Cardiovasular Forum Multinational Clinical Trials Initiative: https://www.bhf.org.uk/for-professionals/information-for-researchers/gcrff-multinational-clinical-trials-initiative.

http://dx.doi.org/10.1002/hsr2.1059

Antithrombotic treatment after intracerebral hemorrhage: Surveys among stroke physicians in Scandinavia and the United Kingdom Background and Aims It is unclear whether patients with previous intracerebral hemorrhage (ICH) should receive antithrombotic treatment to prevent ischemic events. We assessed stroke physicians' opi...

Even during the ambulance strikes - stroke requires an emergency response. If you see the signs of stroke, you must continue to Act FAST and call 999. It's the best way to get the right support.

⚠️ Even if the symptoms seem to resolve you should continue to wait for an emergency response.
📞 If you experience a delay, you can call again and ask what they advise you to do depending on your location and the condition of the person.
⌚ You should note what time symptoms first started as this will be vital information once they reach hospital for what treatment they receive.

The FAST test helps to spot the three most common symptoms of stroke – Face, Arms and Speech. But there are other signs that you should always take seriously, you can find out more about the symptoms of stroke here: https://bit.ly/2TJwpLP

🧑‍🎄 Season's greetings to all!
🎄 2022 was another great year for the RUSH team!
📰 Our 2022 newsletter will be up on the website soon
👉 Research to Understand Stroke due to Haemorrhage - RUSH

Festive cheer this week, celebrating the successes of inspiring early-mid career researchers in the www.RUSH.ed.ac.uk research programme! Post-doctoral neurology trainee Tom Moullaali won the The George Institute for Global Health John Chalmers Doctoral Award for his work on BP variability after intracerebral haemorrhage & medical student Alexia Cochrane won The UK Stroke Forum Stroke Association e-Poster prize for her update of the Cochrane Library systematic review of antithrombotic drugs after intracerebral haemorrhage 👏👏👏

Congratulations to the two winners of the 2022 Arthur Fonville Award for Stroke Research, for their inspirational enthusiasm and high-quality dissertations in a competitive year:

Serena Baker for her dissertation, "Are There S*x Differences in Thrombectomy Utilisation in Treatment of Acute Ischaemic Stroke? A Systematic Review"
&
Mohshin Syed for his dissertation, "Selective outcome reporting in randomised controlled trials including participants with stroke or transient ischaemic attack: a systematic review"



https://www.ed.ac.uk/clinical-brain-sciences/research/rush-research-group-overview/arthur-fonville-award

This week, Diana Aguiar de Sousa, Arthur Liesz and I began planning the 2023 European Stroke Organisation Stroke Science Workshop with Michèle Schaub Jackson and Sabrina Mutter. It will happen face-to-face at the Eibsee Hotel 30 November - 2 December 2023. As chairperson, I intend the meeting to emulate the, "Bavarian coziness, warm hospitality and traditional flair" of the Eibsee Hotel https://www.eibsee-hotel.de/en/, but with a strong focus on 'rising star' mid-career researchers, equality, diversity and inclusion. Feel free to send us any innovative ideas for the programme...

Latest publication... Could Nrf2 activation be the magic bullet to target inflammation after due to intracerebral haemorrhage via pathway 2 in the figure?

Activation of Nrf2 to Optimise Immune Responses to Intracerebral Haemorrhage Haemorrhage into the brain parenchyma can be devastating. This manifests as spontaneous intracerebral haemorrhage (ICH) after head trauma, and in the context of vascular dementia. Randomised controlled trials have not reliably shown that haemostatic treatments aimed at limiting ICH haematoma expansi...

So why is it that intracerebral haemorrhage (ICH) expansion is strongly associated with poor clinical outcome, yet interventions that reduce expansion haven't yet been proven to improve clinical outcome in trials? One of the many conundrums about ICH, mentioned in our latest article... https://lnkd.in/eiymFmAu

Will we ever need APOE in clinical practice? Latest collaboration with UCL found an association between APOE e2/e4 alleles and Finger-Like Projections from lobar ICH, a radiographic marker of CAA in our Edinburgh diagnostic criteria (https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(18)30006-1/fulltext) 🖐️👇👉🏼 https://n.neurology.org/content/99/12/e1290/tab-figures-data

Latest paper with David Gaist: major adverse cardiovascular events are common after due to intraparenchymal haemorrhage, especially early on. That's why all of these randomised controlled trials of antithrombotic drugs are needed: https://www.ed.ac.uk/clinical-brain-sciences/research/so-start/for-collaborators. You can read the full paper here: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2796934

Teaching students always teaches you something. Thanks to Annelies Ruijs and Floris Schreuder from Radboud University for asking me to take time out to inspire 25 students from the Radboud University Honours programme in Medical, Dental and Biomedical Sciences. Potentially, it was an existential dilemma, but it reminded me why on Earth I decided to become a clinical academic, what gets me out of bed at 6am (on weekdays!), and the one thing I wished I'd known earlier: we can thrive on failure...

Discover Careers starts tomorrow – we open at 12pm, with something to offer all students! Look out for our event sponsor NatWest outside McEwan Hall with free coffees too. Find out more at https://edin.ac/3BuTXwc

Eat your green bugs: Why Europeans should eat more insects The environmental gains are significant - swap beef for bugs and get the same protein and nutrients at a fraction of the impact. But do Westerners have the stomach for it?