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Huntington's disease affects 30,000 people in the United States alone. Around 75,000 people carry the gene that causes the development of the disease. Currently, there is no cure for this fatal disease. Read more: https://buff.ly/3ynTjwZ

Cancer research can benefit from artificial intelligence by relying on big data to establish relationships among imaging information and genomics. An emerging field of science called "radiogenomics" takes advantage of radiological imaging technologies and huge amount of genomic data. Analyzing these two sets of information can complement the limitations of each. Read the full article here: https://buff.ly/3oqEZzv

Carl Sagan is an astronomer controversial for his extraterrestrial life theories and research.

Decrease in sweating is accompanied by negative impact on wound repair. Read more: https://buff.ly/3tLWrzd

Fibromyalgia is mainly characterized by widespread pain, which is worsened by stress level, weather changes, and level of physical activity. Among other symptoms are extreme sensitivity, stiffness, fatigue, and headaches.

Gene therapy is possible because of extensive studies in our DNA. Genes and their functions and our relationships with other organisms are known thanks to the field of genomics. Learn more about genomics below. https://buff.ly/3uKYcOC

When mice were genetically modified to lack cholesterol transporters in microglia (cells in the brain and spinal cord that play a role in pain activation), researchers found excessive amounts of cholesterol in mice, which consequently experienced pain. Researchers from University of California San Diego may have found a way to use this information for pain therapeutics in cancer patients undergoing chemotherapy. Read more: https://buff.ly/2SGMfeK

SafeDQN is a navigation system developed by computer scientists at the University of California San Diego to help robots work well in the worst case scenarios in the emergency room. The SafeDQN algorithm was trained using videos of ER reality shows from YouTube. The team's next step is testing the system on a physical robot in a realistic environment. Read more: https://buff.ly/3bjoUpK

"There is no stronger risk factor for cancer than age. At the time of diagnosis, the median age of patients across all cancers is 66. That moment, however, is the culmination of years of clandestine tumor growth, and the answer to an important question has thus far remained elusive: When does a cancer first arise?" Read more: https://buff.ly/3vTeYLA

How do you age gracefully? Here are 11 secrets to healthy aging according to science. Read more: https://wb.md/2Q3tm4I

Researchers from Washington State University is developing a new approach to 3D printing tissues for custom-made replacement skin, cartilage, or others for treatment of patients. Bioinks are made from biological material and are used to print scaffolds for cells to grow on. Limitations in adjusting the softness or stiffness of the scaffold is a problem faced by researchers. New material made from gelatin, gum Arabic, and sodium alginate are being explored to solve this problem. Read more: https://buff.ly/2R75Mob

The new base pairs created by Synthorx.com can be "replicated, maintained, transcribed, and subsequently translated in vivo." The expanded genetic alphabet can increase DNA information storage and produce new proteins, which can be an additional source of new therapeutics for certain diseases.

"RLR is a simpler, more flexible gene editing tool that can be used for highly multiplexed experiments, which eliminates the toxicity often observed with CRISPR and improves researchers' ability to explore mutations at the genome level." - Max Schubert, Ph.D., a postdoc in the lab of Wyss Core Faculty member George Church, Ph.D

What are Retrons and RLR? Read more: https://buff.ly/3ecq1cC

"She (Doudna) told me she always felt like an outsider and kept asking, How do I fit into things? And I think all of us feel like outsiders at times. We should use that feeling to spark our curiosity about the world around us and to ask how we fit in."

Author Walter Isaacson shares snippets of what's in his book "The Code Breaker," telling the stories of CRISPR developers and the ethical questions the revolutionary gene editing tool pose to the society. Designer babies and issues about when should gene editing be used and not used? Read more: https://buff.ly/2S6oj3Z

Patients with chronic pain ranging from lower back pain to rare neuropathic pain disorders are often treated with opioids. However, the body develops tolerance to it over time and makes the person more sensitive to pain after sometime, making them need higher doses.

A non-permanent gene therapy was tested in mice by researchers from UC San Diego. "It increased pain tolerance in mice, lowered their sensitivity to pain and provided months of pain relief without causing numbness." Read more: https://buff.ly/3ezaJj2

Diabetes mellitus is a health condition where your body has difficulty converting sugar to energy. There are typically three kinds of diabetes:

1. Type 1 diabetes (T1DM) is a chronic health condition in which your body’s endocrine part of the pancreas doesn’t produce enough of the hormone insulin, and your blood sugar (glucose) level becomes too high.
2. Type 2 diabetes (T2DM) is a chronic condition in which your body develops resistance to insulin, and your blood sugar level becomes too high as a result.
3. Gestational diabetes (GDM) is DM that occurs during a pregnancy, and the blood sugar level is too high during this time.

What is Type 3 diabetes? Read more: https://buff.ly/3nsnU7A

"Starting out from the DNA sequence of the Herceptin antibody, the ETH researchers created about 40,000 related antibodies using a CRISPR mutation method they developed a few years ago. Experiments showed that 10,000 of them bound well to the target protein in question, a specific cell surface protein. The scientists used the DNA sequences of these 40,000 antibodies to train a machine learning algorithm." Read more: https://buff.ly/3eChMFQ

Gene editing in early human embryos may result in low efficiency of mutation repair, high rates of mosaicism, and the possibility of unintended editing outcomes or "off-targets" that may have pathologic consequences. In a study published by PNAS, ~16% of studied human embryo cells have off-targets. Read more: https://buff.ly/3t9fhRm

Let's keep doing science!

If epigenetics is the study of how behavior and environment can affect your gene expression, what is epigenomics?

Constant lack of sleep is linked to higher risk of obesity, Alzheimer's, heart disease, depression, and diabetes. Get that beauty sleep tonight. Have a nice weekend!

Stress affects the brain and ultimately leads to health conditions like physical pain, physical limitations, loneliness and cardiovascular disease. Read more: https://buff.ly/3xaZNPh

Did you know that physical pain is an illness in itself?

Instead of drugs and surgery, gene therapy modifies the DNA to cure a disease. What is its scope?

Through a method they called Repair-seq, researchers from Salk institute found approximately 65,000 "hot spots" for DNA repair in stem cell-derived neurons. Read more: https://buff.ly/3sZj2ZK

Neurons cannot renew themselves, so they constantly work to repair their DNA. What is this mechanism's connection to aging? Read more: https://buff.ly/3sZj2ZK

Nevertheless, the participants accepted advice regardless of the source. What do you think about this? Read more: https://buff.ly/3tzn5Mv

What is machine learning, and why is it important?
Read more: https://buff.ly/3tvW3Wk

CRISPR-Cas9 produces permanent changes in the DNA. CRISPRoff has a different approach. Read more: https://buff.ly/3ecP12t

A game changer! CRISPRoff is reversible and does not change the DNA sequence.
Read more: https://buff.ly/3uOOCtO