Nixon Visions Foundation

🌟 Spotlight: Dr. Andrew Goldberg 🌟

We are proud to feature Dr. Andrew Goldberg of Oakland University, an inaugural grant recipient of the new PRPH2 and Associated Diseases Program, established in partnership with the Nixon Visions Foundation and the Foundation Fighting Blindness. Dr. Goldberg’s research is making critical strides towards understanding and treating PRPH2-associated retinal diseases.

🔬 Project Overview:
Dr. Goldberg's project, "Natural History and AAV-Mediated Intervention for Dominant Negative and Haploinsufficient Mouse Models of PRPH2-Associated Disease," is at the forefront of genetic therapy. His work focuses on two types of mutations in the PRPH2 gene that lead to retinal degenerations: loss-of-function mutations causing insufficient protein for photoreceptor structure and dominant negative mutations that impair protein function.

💡 Groundbreaking Approach:
Through a meticulous natural history study of mouse models and subsequent trials of AAV-mediated gene therapy, Dr. Goldberg aims to not only halt the progression of these debilitating diseases but to also restore visual function. This innovative approach could provide a foundation for future therapies and offers hope for those affected by inherited retinal diseases.

We commend Dr. Goldberg for his dedication and are eager to support his continued research. His efforts exemplify the commitment of Nixon Visions to propel forward the development of effective treatments that can dramatically improve patients' lives.

Follow us for more updates on how Dr. Goldberg’s research progresses toward new possibilities in the fight against blindness. 🌐👀

🌟 Spotlight: Dr. Yoshikazu Imanishi 🌟

Dr. Yoshikazu Imanishi of Indiana University is one of two distinguished recipients of inagural grants funded by the Nixon Visions Foundation in partnership with Foundation Fighting Blindness as part of its new PRPH2 and Associated Diseases Program. Dr. Imanishi's groundbreaking work is paving the way for significant advancements in the treatment of retinal diseases.

🔬 Project Focus:
Dr. Imanishi's project, "Elucidating Pathophysiological Mechanisms and Advancing High-Throughput Drug Discovery in PRPH2-Related Retinal Dystrophies," aims to deepen our understanding of PRPH2 gene mutations. These mutations are known to cause several dominantly inherited retinal diseases, including retinitis pigmentosa and macular dystrophies.

💡 Innovative Approach:
His research is focusing on improving how PRPH2 integrates into photoreceptor outer segments, essential for vision. By identifying compounds that enhance PRPH2 trafficking to these critical areas, Dr. Imanishi's work could lead to breakthrough therapies that restore vision and improve the quality of life for those affected by these challenging conditions.

We are looking forward to seeing the transformative discoveries Dr. Imanishi will make through his dedicated research. His work embodies our commitment to driving forward the science that will one-day cure blindness.

Stay tuned for more updates on this pioneering journey in vision health.

✨May is Vision Health Month. At Nixon Visions, we're dedicated to advancing research and providing resources that support eye health and tackle vision disorders.

This month, we're highlighting our ongoing efforts in the study of PRPH2 gene mutations and their impact on vision. Our commitment is not just to understand these complex conditions but to find ways to treat and prevent them.

Interested in learning more about Vision Health Month and the resources available? Visit the link below for more information from the National Eye Institute.

https://www.nei.nih.gov/learn-about-eye-health/outreach-resources/healthy-vision-resources/healthy-vision-month

🌟 Nixon Visions was proud to attend this week's ARVO conference in Seattle, the largest gathering of ophthalmology researchers worldwide. With over 10,000 members from 75 countries, ARVO's mission to advance research and tackle visual system disorders was palpable throughout the event.

Over five days, ARVO featured hundreds of exhibits, technical talks, and presentations showcasing the latest in ophthalmology research. A highlight for us was the significant focus on PRPH2 research—key to understanding photoreceptor health. The dedication of scientists and the depth of discussions on PRPH2 were truly inspiring.

It's invigorating to witness such dedicated global attention on advancing the science of vision.

We are excited to attend the Retinal Cell and Gene Therapy Innovation Summit 2024, co-organized by the Foundation Fighting Blindness and the Oregon Health & Science University Casey Eye Institute.

This prestigious event will gather top experts from the biotech, pharma, medical, and research communities to discuss the latest breakthroughs in ocular gene and cell therapies.

The summit will feature presentations from leading experts in retinal disease, exploring innovative therapies and strategies to advance them towards clinical applications. We look forward to engaging in discussions on the progress and future directions of these promising treatments.

Stay tuned for our key takeaways from the summit!

Dive deep into the future of gene therapy in this podcast episode, where Dr. Peter Quinn, a groundbreaking researcher at Columbia University, joins host Ben Shaberman to explore the cutting-edge advancements in CRISPR/Cas9 gene editing therapies. 🧬✨

From base to prime editing approaches, Dr. Quinn sheds light on how these innovative techniques pave the way for treating inherited retinal diseases. He also gives us an insider look at his lab's projects, focusing on mutations in CRB1 and PRPH2 genes, offering hope and potential solutions to those affected.

Don't miss this fascinating conversation on the promise of gene editing and its impact on the future of eye health. Tune in now to get inspired by the possibilities of science and technology in curing inherited retinal diseases. 🔬👀

🔗 Listen Now https://soundcloud.com/fndfightingblindness/eye-on-the-cure-podcast-episode-62-dr-peter-quinn

Recently diagnosed with a retinal disease or AMD? You're not alone.

At Nixon Visions Foundation, we recommend connecting with the Foundation Fighting Blindness for essential resources:

🔍 Explore disease info, research updates, and clinical trials on fightingblindness.org
👀 Find a retina specialist for expert care and trial opportunities.
🧬 Consider genetic testing to pinpoint your condition and open doors to trials.
📚 Join My Retina Tracker® Registry for insights into therapies and studies.
🤝 Meet others in similar journeys through Foundation Fighting Blindness chapters.
📢 Stay updated with FFB newsletters and podcasts.

Empower your journey with knowledge and community support. 💪

More information 🔗: https://www.fightingblindness.org/newly-diagnosed

🌍 Yesterday was , Let's Focus on Vision Health 🌟

World Health Day, established by the World Health Organization in 1948, emphasizes the need for universal health coverage and equitable access to health services. It's a day that reminds us health is a human right, not a privilege. Among the various aspects of health we advocate for, vision health stands out as essential yet often overlooked.

Vision impairment affects millions globally, impacting education, employment, and quality of life. At Nixon Visions Foundation, we're dedicated to ensuring that vision health is recognized as a critical part of global health discussions. By supporting research and promoting access to eye care, we aim to prevent blindness and vision impairment worldwide.

This World Health Day, join us in highlighting the importance of eye care for all, paving the way for a healthier, brighter future for everyone. 🌎💙

Last year, we hosted an essential workshop focused on PRPH2 and Associated Retinal Diseases, with the urgent mission of advancing research toward prevention, treatments, and cures for degenerative retinal diseases. It was a heartfelt gathering of individuals, families, academics, and industry experts all united in their quest to understand and combat PRPH2-related retinal dystrophies, including retinitis pigmentosa, cone-rod dystrophy, and pattern dystrophy.

🔍 Workshop Highlights:

- Raised crucial awareness and fostered a strong community.
- Facilitated vital knowledge sharing on disease pathology, disease models, and therapeutic approaches.
- Marked the beginning of a high-impact research funding initiative.
- Featured a roundtable on emerging therapies and invaluable perspectives from affected individuals and their families.
- This workshop was designed to illuminate the current landscape of PRPH2 disease research, identify gaps, and outline the next steps in the journey toward effective treatments. It also offered applicable insights into other autosomal dominantly inherited retinal degenerations.

🔍 Since the workshop, the Foundation Fighting Blindness scientific advisory committee has selected promising research projects focused on PRPH2, and we're excited to share updates on their groundbreaking work soon. Stay tuned for more developments!

📚 Access the Workshop Recording:
If you missed this groundbreaking event or wish to revisit the discussions, we invite you to request the workshop recording and materials in the link below.

🔗 Request Form: https://www.fightingblindness.org/prph2workshop -request-for-workshop-recording-1576

🚨 Nixon Visions Foundation Scholarship Closes Today March 6th! 🚨

Heads up, students of San Diego County! The deadline for the Nixon Visions Foundation Scholarship, funded by us and realized through our partnership with the San Diego Foundation , is today. This is your moment to secure financial support for your pursuit of higher education. 🎓✨

This scholarship represents our commitment to your academic success. Don't miss out on this opportunity to receive backing for your studies, whether you're aiming for a local college or a university further afield. Make sure to apply by March 6th to take your first step towards a brighter, more empowered future.

Your dreams are valid, and your ambitions are achievable. Click the link now to start your application journey.

https://www.sdfoundation.org/students/common-scholarship-application

🔬 This , let's focus on the PRPH2 gene, a critical piece of the puzzle in understanding certain types of inherited blindness and low vision. The PRPH2 gene provides instructions for making a protein essential for the structure and function of photoreceptors in the retina. Mutations in this gene can disrupt photoreceptor cells, leading to conditions like macular dystrophy and retinitis pigmentosa.

Despite its challenges, the study of PRPH2 opens doors to potential therapies and hope for those affected. By bringing attention to rare genetic disorders like those caused by PRPH2 mutations, we support the ongoing search for answers and treatments. 💡👀

Follow us Nixon Visions Foundation in spreading awareness and hope. 💙

Have you got your social media pledge cards ready? 📝🌍

Available to download from our website, our pledge cards are written in 8 languages, allowing you to show your passion for Rare Disease Day, in your local contexts!

Download them today alongside our other resources by clicking on our website here: https://www.rarediseaseday.org/downloads/. Show your support for the international rare disease community today! 💻💡

We're honored to highlight a pivotal moment in our journey toward conquering inherited retinal diseases. Our partnership with Shiley Eye Institute at UC San Diego Health has ignited the Nixon Visions Foundation Macular Dystrophy-PRPH2 Research Fund. This initiative is dedicated to unraveling the mysteries of the PRPH2 gene, a key player in many rare macular dystrophies, and exploring groundbreaking stem cell technologies for early diagnosis and potential cures.

Thanks to generous support from our founders, we are making strides in research that aims to transform the lives of those affected by this rare, yet impactful, eye condition. 📚💡

Let's celebrate the progress and stay tuned for the breakthroughs that lie ahead.
Read the full article here: https://health.ucsd.edu/news/press-releases/2021-12-15-major-gift-focuses-efforts-on-a-rare-but-devastating-genetic-eye-disease/

🎓 Scholarship Reminder: Apply Now for the Nixon Visions Foundation Scholarship! 🌟

As we move forward in our mission to empower education, we want to remind you that the Nixon Visions Foundation Scholarship application is open! Each year, in collaboration with the San Diego Foundation our scholarship helps five new scholars pursue their academic dreams. 📚

San Diego County residents, don't miss this unique opportunity to further your education with less financial burden. Whether you aim to study locally or nationally, we're here to help you succeed. Head over to The San Diego Foundation's common application link and take the first step towards a brighter future.

https://www.sdfoundation.org/students/common-scholarship-application

👁️ February is – A Time Close to Our Hearts at Nixon Visions Foundation 🌟

This is a time to bring into focus the 4.2 million Americans living with low vision. At Nixon Visions, we strive to form partnerships and drive research that will make a difference in the lives of individuals experiencing low vision. This month, we celebrate the strength of our community and an ever-brighter future.💙

Exciting progress being made in developing cell therapies, gene therapies and gene agnostic therapies for . Thank you to and the RD Fund for an informative program.

To learn about our support of research for and , tap link in bio.

We choose to raise awareness about PRPH2 gene mutations. PRPH2 is one of many genes responsible for the health of our eyes and function of our vision. Thousands of people worldwide suffer from mutations in this gene which affect their sight. We support research for treatments and cures. UC San Diego Shiley Eye Institute Foundation Fighting Blindness

Nixon Visions Foundation supports hope for rare diseases such as inherited retinal diseases that cause vision loss and blindness. Foundation Fighting Blindness UC San Diego Shiley Eye Institute

Nixon Visions Foundation updated their website address.