Leonhardt Ventures

Lionheart Longevity 📍Based in Newport Beach CA and NYC
🌟 Where Beauty Meets Science
🌱Regenerative Aesthetics
💋Medical Aesthetics
🧬Longevity / Healthspan Optimzation

Klotho Conference - The Future Of Klotho-Based Therapies Klotho Conference and Scientific Seminar with a mission to highlight klotho related research for improving health.

Early peek at Draft Klotho Conference web site - November 2025

https://klothoconference.cl

Klotho Conference - The Future Of Klotho-Based Therapies Klotho Conference and Scientific Seminar with a mission to highlight klotho related research for improving health.

We are on the map!

Lionheart Health Announces Additions to its Board and Leadership Team - Lionheart Health Stim Lionheart Health announced today additions to its board of directors and executive leadership team including Scott Hoots as co-CEO, Tessa Sphar as Onboarding Specialist for Licensees, Dr. Jwala Karnik to our Board of Directors and Chad Hacker to both Board of Directors and to our Marketing Team.

Lionheart Health Announces Additions to its Board and Leadership Team - citybuzz Lionheart Health announced today additions to its board of directors and executive leadership team including Scott Hoots as co-CEO, Tessa Sphar as Onboarding Specialist for Licensees, Dr. Jwala Karnik to our Board of Directors and Chad Hacker to both Board of Directors and to our Marketing Team.

Heading to present at Newport Beach Investor Conference today

Lionheart VetStim Animal Vet Clinic Licensing Opportunities

US Patent for Bioelectric stimulator Patent (Patent # 12,109,410 issued October 8, 2024) - Justia Patents Search Described is a low voltage, pulsed electrical stimulation device for controlling expression of, for example, follistatin, a muscle formation promotion protein, by tissues. Epicardial stimulation is especially useful for heart treatment. Follistatin controlled release is also useful for treating othe...

ANOTHER PATENT ISSUED for BIOELECTRIC STIMULATOR for organ regeneration including skin and hair, healing including joint health and healthspan extension October 8th, 2014 by the USPTO! https://patents.justia.com/patent/12109410 with 15 new claims Claims
1. A method of using a bioelectric stimulator to stimulate target tissue of a subject to control stem cell homing, proliferation, or differentiation and/or upregulate expression of at least one protein by the target tissue, wherein the protein is selected from the group consisting of activin, epidermal growth factor (EGF), follistatin, hepatocyte growth factor (HGF), insulin-like growth factor 1 (IGF-1), platelet-derived growth factor (PDGF), receptor activator of nuclear factor kappa-B ligand (RANKL), stromal cell-derived factor 1 (SDF1), tropoelastin, vascular endothelial growth factor (VEGF) and any combination thereof, the method comprising:

delivering at least one bioelectric signal to the target tissue so as to control stem cell homing, proliferation, or differentiation and/or to upregulate expression of at least one protein in the target tissue, wherein the bioelectric signal(s) comprise(s) at least one bioelectric signal(s) selected from the group consisting of
(a) 2 Hz, square biphasic wave, pulse width 1,000 μs so as to upregulate expression of RANKL by the target tissue;
(b) within 15%, 30 Hz, square biphasic wave, pulse width 100 μs so as to upregulate expression of SDF1 to the target tissue and stimulate stem cell homing to the target tissue;
(c) within 15%, 100 Hz, square biphasic wave, pulse width 100 μs so as to upregulate expression of PDGF and stimulate stem cell homing to the target tissue;
(d) 20 Hz, square wave, pulse width 200 to 700 μs so as to stimulate stem cell proliferation;
(e) 10 Hz, square biphasic wave, pulse width 200 μs so as to upregulate expression of PDGF by the target tissue and stem cell homing to the target tissue;
(f) within 15%, 150 Hz, monophasic square wave, pulse width 100 μs so as to upregulate expression of activin by the target tissue;
(g) within 15%, 500 Hz, square biphasic wave, pulse-width 180 μs so as to upregulate expression of EGF by the target tissue;
(h) within 15%, 22 Hz, square monophasic wave, pulse width 50% duty cycle so as to upregulate expression of IGF-1 by the target tissue;
(i) 70 Hz, square wave, pulse width 10%-50% duty cycle,
(j) 200 picoamps with a pulse having an amplitude of 5 V and a width of 0.5 milliseconds so as to stimulate stem cell proliferation;
(k) 50 Hz, square wave so as to upregulate expression of follistatin, tropoelastin, VEGF and HGF by the target tissue, and
(l) any combination(s) thereof.
2. The method according to claim 1, further comprising:

separately delivering to the subject an admixture comprising any combination of the following: stem cells, endothelial progenitor cells, selected exosomes, selected alkaloids, selected anti-inflammatory agents, nutrient hydrogel, organ specific matrix, selected growth factors, amniotic fluid, placenta fluid, cord blood, and embryonic sourced growth factors and cells.
3. The method according to claim 1, wherein the target tissue is selected from the group consisting of brain, scalp, eye, ear, skin, tooth, dental gum, tooth root, sub-mucosa, breast, aorta, limb, artery, heart, heart valve, kidney, pancreas, bladder, liver, joint, bone, and any combination thereof.

4. The method according to claim 1, wherein the bioelectric signal(s) comprise(s): a signal of 2 Hz, square biphasic wave, pulse width 1,000 μs so as to upregulate expression of RANKL.

5. The method according to claim 1, wherein the bioelectric signal(s) comprise(s), within 15%, 30 Hz, square biphasic wave, pulse width 100 μs so as to upregulate expression of SDF-1.

6. The method according to claim 1, wherein the bioelectric signal(s) comprise(s): a signal of 100 Hz, square biphasic wave, pulse width 100 μs so as to upregulate expression of PDGF.

7. The method according to claim 1, wherein the bioelectric signal(s) comprise(s): a signal of 20 Hz, square wave, pulse width 200 to 700 μs so as to increase stem cell proliferation.

8. The method according to claim 1, wherein the bioelectric signal(s) comprise(s): a signal of 10 Hz, square biphasic wave, pulse width 200 μs so as to upregulate expression of PDGF.

9. The method according to claim 1, wherein the bioelectric signal(s) comprise(s), within 15%, 150 Hz, monophasic square wave, pulse width 100 μs so as to upregulate expression of activin.

10. The method according to claim 1, wherein the bioelectric signal(s) comprise(s), within 15%, 500 Hz, square biphasic wave, pulse-width 180 μs so as to upregulate expression of EGF.

11. The method according to claim 1, wherein the bioelectric signal(s) comprise(s), within 15%, 22 Hz, square monophasic wave, pulse width 50% duty cycle so as to upregulate expression of IGF-1.

12. The method according to claim 1, wherein the bioelectric signal(s) comprise(s) a signal of 70 Hz, square wave, pulse width 10%-50% duty cycle so as to increase stem cell proliferation.

13. The method according to claim 1, wherein the bioelectric signal(s) comprise(s) a signal of 200 picoamps with a pulse having an amplitude of 5 V and a width of 0.5 milliseconds so as to induce stem cell differentiation.

14. The method according to claim 1, wherein the bioelectric signal(s) comprise(s), within 15%, 50 Hz, square wave so as to upregulate expression of follistatin, tropoelastin, and/or VEGF.

15. The method according to claim 1, wherein the bioelectric signal(s) comprise(s): a signal of within 15%, 50 Hz, square biphasic wave, pulse width 100 μs, with surge delivery of 10 seconds on and 30 seconds off so as to upregulate expression of HGF.

US Patent for Bioelectric stimulator Patent (Patent # 12,109,410 issued October 8, 2024) - Justia Patents Search Described is a low voltage, pulsed electrical stimulation device for controlling expression of, for example, follistatin, a muscle formation promotion protein, by tissues. Epicardial stimulation is especially useful for heart treatment. Follistatin controlled release is also useful for treating othe...

Lionheart VetStim Animal Vet Clinic DRAFT Licensing Opportunities Slide Deck

Lionheart VetStim Animal Vet Clinic Licensing Opportunities

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Mind of an Innovator Slide Deck for Teaching Course

Mind of an Innovator March 2022